The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2SEVENTY BIO INC COMMON STOCK 901384107 532 40,273 SH   DFND 1,2 40,273 0 0
ABCELLERA BIOLOGICS INC COM 00288U106 133 12,521 SH   DFND 1,2 12,521 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 422 29,984 SH   DFND 1,2 29,984 0 0
AFFIMED N V COM N01045108 225 81,172 SH   DFND 1,2 81,172 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105 339 41,950 SH   DFND 1,2 41,950 0 0
ARGENX SE SPONSORED ADR 04016X101 421 1,110 SH   DFND 1,2 1,110 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 387 4,168 SH   DFND 1,2 4,168 0 0
BEIGENE LTD SPONSORED ADR 07725L102 1,946 12,022 SH   DFND 1,2 12,022 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 507 6,115 SH   DFND 1,2 6,115 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104 2,381 1,166,952 SH   DFND 1,2 1,166,952 0 0
CERUS CORP COM 157085101 75 14,172 SH   DFND 1,2 14,172 0 0
CHEMOCENTRYX INC COM 16383L106 888 35,830 SH   DFND 1,2 35,830 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 946 370,950 SH   DFND 1,2 370,950 0 0
EARGO INC COM 270087109 2,171 2,886,724 SH   DFND 1,2 2,886,724 0 0
ENTRADA THERAPEUTICS INC COM 29384C108 2,114 173,582 SH   DFND 1,2 173,582 0 0
EXELIXIS INC COM 30161Q104 1,337 64,200 SH   DFND 1,2 64,200 0 0
EXSCIENTIA PLC ADS 30223G102 8,387 770,200 SH   DFND 1,2 770,200 0 0
FIBROGEN INC COM 31572Q808 156 14,756 SH   DFND 1,2 14,756 0 0
GALERA THERAPEUTICS INC COM 36338D108 797 613,223 SH   DFND 1,2 613,223 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104 31,017 635,978 SH   DFND 1,2 635,978 0 0
HASHICORP INC COM CL A 418100103 383 13,001 SH   DFND 1,2 13,001 0 0
ILLUMINA INC COM 452327109 21,975 119,196 SH   DFND 1,2 119,196 0 0
INCYTE CORP COM 45337C102 2,613 34,391 SH   DFND 1,2 34,391 0 0
INVITAE CORP COM 46185L103 28 11,337 SH   DFND 1,2 11,337 0 0
IVERIC BIO INC COM 46583P102 2,285 237,484 SH   DFND 1,2 237,484 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 775 78,720 SH   DFND 1,2 78,720 0 0
KARUNA THERAPEUTICS INC COM 48576A100 28,552 225,688 SH   DFND 1,2 225,688 0 0
KODIAK SCIENCES INC COM 50015M109 150 19,622 SH   DFND 1,2 19,622 0 0
OTONOMY INC COM 68906L105 1,770 851,080 SH   DFND 1,2 851,080 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108 640 144,840 SH   DFND 1,2 144,840 0 0
RANI THERAPEUTICS HLDGS INC COM CL A 753018100 5,099 493,584 SH   DFND 1,2 493,584 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 251 8,265 SH   DFND 1,2 8,265 0 0
REPLIMUNE GROUP INC COM 76029N106 2,713 155,199 SH   DFND 1,2 155,199 0 0
SAREPTA THERAPEUTICS INC COM 803607100 294 3,917 SH   DFND 1,2 3,917 0 0
SATSUMA PHARMACEUTICALS INC COM 80405P107 592 142,900 SH   DFND 1,2 142,900 0 0
SEAGEN INC COM 81181C104 8,333 47,096 SH   DFND 1,2 47,096 0 0
SNOWFLAKE INC CL A 833445109 2,671 19,210 SH   DFND 1,2 19,210 0 0
SOMALOGIC INC CLASS A COM 83444K105 7,668 1,696,558 SH   DFND 1,2 1,696,558 0 0
SYNLOGIC INC COM 87166L100 79 68,634 SH   DFND 1,2 68,634 0 0
TCR2 THERAPEUTICS INC COM 87808K106 56 19,335 SH   DFND 1,2 19,335 0 0
XENON PHARMACEUTICALS INC COM 98420N105 3,479 114,380 SH   DFND 1,2 114,380 0 0