The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2SEVENTY BIO INC COMMON STOCK 901384107 21,120 1,600,000 SH   SOLE 1,600,000 0 0
ABVC BIOPHARMA INC COM 00091F106 1,158 1,092,745 SH   SOLE 1,092,745 0 0
ACLARION INC *W EXP 04/21/202 655187110 198 550,000 SH   SOLE 550,000 0 0
ADDEX THERAPEUTICS LTD SPONSORED ADS 00654J107 291 253,017 SH   SOLE 253,017 0 0
ADOBE SYSTEMS INCORPORATED COM 00724F101 43,927 120,000 SH   SOLE 120,000 0 0
ADVANCED MICRO DEVICES INC COM 007903107 8,259 108,000 SH   SOLE 108,000 0 0
ADVANTAGE SOLUTIONS INC COM CL A 00791N102 9,637 2,536,000 SH   SOLE 2,536,000 0 0
AEROCLEAN TECHNOLOGIES INC COM 007744105 19,650 1,500,000 SH   SOLE 1,500,000 0 0
AEROJET ROCKETDYNE HLDGS INC COM 007800105 22,736 560,000 SH   SOLE 560,000 0 0
AGRIFORCE GROWING SYSTEMS LT *W EXP 02/01/202 C00948114 218 600,000 SH   SOLE 600,000 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 28,420 250,000 SH   SOLE 250,000 0 0
ALKERMES PLC SHS G01767105 87,106 2,924,000 SH   SOLE 2,924,000 0 0
ALPHABET INC CAP STK CL A 02079K305 15,255 7,000 SH   SOLE 7,000 0 0
ALPHATEC HLDGS INC COM NEW 02081G201 19,123 2,924,000 SH   SOLE 2,924,000 0 0
AMAZON COM INC COM 023135106 22,102 208,098 SH   SOLE 208,098 0 0
AMERICAN REBEL HOLDINGS INC *W EXP 01/20/202 02919L117 74 481,927 SH   SOLE 481,927 0 0
AMRYT PHARMA PLC SPONSORED ADS 03217L106 8,234 1,178,000 SH   SOLE 1,178,000 0 0
ANHEUSER BUSCH INBEV SA/NV SPONSORED ADR 03524A108 61,287 1,136,000 SH   SOLE 1,136,000 0 0
APPLIED DNA SCIENCES INC COM 03815U300 295 400,000 SH   SOLE 400,000 0 0
APPTECH PMTS CORP *W EXP 01/04/202 03834B127 101 715,000 SH   SOLE 715,000 0 0
ARAVIVE INC COM 03890D108 1,300 1,316,129 SH   SOLE 1,316,129 0 0
ARGENX SE SPONSORED ADR 04016X101 71,229 188,000 SH   SOLE 188,000 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 55,235 836,000 SH   SOLE 836,000 0 0
AVALO THERAPEUTICS INC COM 05338F108 23,788 47,576,000 SH   SOLE 47,576,000 0 0
AVANTOR INC COM 05352A100 31,100 1,000,000 SH   SOLE 1,000,000 0 0
BIOFRONTERA INC COM 09077D100 1,420 763,637 SH   SOLE 763,637 0 0
BIOGEN INC COM 09062X103 48,130 236,000 SH   SOLE 236,000 0 0
BIOLASE INC COM 090911405 2,959 646,113 SH   SOLE 646,113 0 0
BIONTECH SE SPONSORED ADS 09075V102 14,910 100,000 SH   SOLE 100,000 0 0
BIT MINING LIMITED SPON ADR REP A 055474100 3,192 5,146,756 SH   SOLE 5,146,756 0 0
BLUCORA INC COM 095229100 13,587 736,000 SH   SOLE 736,000 0 0
BOOKING HOLDINGS INC COM 09857L108 5,597 3,200 SH   SOLE 3,200 0 0
BOSTON BEER INC CL A 100557107 9,695 32,000 SH   SOLE 32,000 0 0
BRIACELL THERAPEUTICS CORP *W EXP 02/24/202 10778Y112 975 375,000 SH   SOLE 375,000 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 89,012 1,156,000 SH   SOLE 1,156,000 0 0
BROOKLYN IMMUNOTHERAPEUTICS COM 114082100 2,248 4,342,561 SH   SOLE 4,342,561 0 0
BURLINGTON STORES INC COM 122017106 40,313 295,921 SH   SOLE 295,921 0 0
CARTERS INC COM 146229109 6,178 87,662 SH   SOLE 87,662 0 0
CATALYST PHARMACEUTICALS INC COM 14888U101 71,502 10,200,000 SH   SOLE 10,200,000 0 0
CEA INDUSTRIES INC *W EXP 02/11/202 86887P119 108 700,000 SH   SOLE 700,000 0 0
CELULARITY INC COM CL A 151190105 6,352 1,868,128 SH   SOLE 1,868,128 0 0
CENTRAL GARDEN & PET CO CL A NON-VTG 153527205 64,976 1,624,000 SH   SOLE 1,624,000 0 0
CHIMERIX INC COM 16934W106 7,330 3,524,000 SH   SOLE 3,524,000 0 0
CINGULATE INC *W EXP 12/10/202 17248W113 96 410,000 SH   SOLE 410,000 0 0
CISCO SYS INC COM 17275R102 10,916 256,000 SH   SOLE 256,000 0 0
COLGATE PALMOLIVE CO COM 194162103 37,826 472,000 SH   SOLE 472,000 0 0
CREATIVE MED TECHNOLOGY HLDG COM NEW 22529Y309 933 1,244,175 SH   SOLE 1,244,175 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 60,770 1,000,000 SH   SOLE 1,000,000 0 0
CROWDSTRIKE HLDGS INC CL A 22788C105 7,080 42,000 SH   SOLE 42,000 0 0
DATADOG INC CL A COM 23804L103 6,667 70,000 SH   SOLE 70,000 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 71,010 5,400,000 SH   SOLE 5,400,000 0 0
DERMATA THERAPEUTICS INC *W EXP 08/13/202 249845116 36 325,000 SH   SOLE 325,000 0 0
DERMATA THERAPEUTICS INC COM 249845108 414 637,147 SH   SOLE 637,147 0 0
DIGITAL BRANDS GROUP INC *W EXP 05/01/202 25401N119 120 722,890 SH   SOLE 722,890 0 0
DIRECT DIGITAL HOLDINGS INC *W EXP 02/15/202 25461T113 351 900,000 SH   SOLE 900,000 0 0
DOLLAR GEN CORP NEW COM 256677105 75,631 308,143 SH   SOLE 308,143 0 0
EAGLE PHARMACEUTICALS INC COM 269796108 6,665 150,000 SH   SOLE 150,000 0 0
EDESA BIOTECH INC COM 27966L108 1,647 1,023,275 SH   SOLE 1,023,275 0 0
EDIBLE GARDEN AG INC *W EXP 04/18/202 28059P113 320 800,000 SH   SOLE 800,000 0 0
ELECTRONIC ARTS INC COM 285512109 4,866 40,000 SH   SOLE 40,000 0 0
ELYS GAME TECHNOLOGY CORP COM 290734102 1,660 2,258,484 SH   SOLE 2,258,484 0 0
ENANTA PHARMACEUTICALS INC COM 29251M106 97,849 2,070,000 SH   SOLE 2,070,000 0 0
ENERGIZER HLDGS INC NEW COM 29272W109 21,659 764,000 SH   SOLE 764,000 0 0
ENERGY FOCUS INC COM 29268T409 796 612,311 SH   SOLE 612,311 0 0
ESPORTS ENTMT GROUP INC *W EXP 03/02/202 29667K132 324 2,700,000 SH   SOLE 2,700,000 0 0
EVERBRIDGE INC COM 29978A104 14,949 536,000 SH   SOLE 536,000 0 0
EYENOVIA INC COM 30234E104 3,772 1,934,261 SH   SOLE 1,934,261 0 0
FGI INDUSTRIES LTD *W EXP 01/21/202 G3302D111 369 933,333 SH   SOLE 933,333 0 0
FIBROGEN INC COM 31572Q808 43,212 4,092,000 SH   SOLE 4,092,000 0 0
FIVE9 INC COM 338307101 5,924 65,000 SH   SOLE 65,000 0 0
FOOT LOCKER INC COM 344849104 11,348 449,420 SH   SOLE 449,420 0 0
FORMA THERAPEUTICS HLDGS INC SHS 34633R104 32,631 4,736,000 SH   SOLE 4,736,000 0 0
FRESHPET INC COM 358039105 41,512 800,000 SH   SOLE 800,000 0 0
G MED INNOVATIONS HLDGS LTD *W EXP 06/30/202 G39462117 90 1,000,000 SH   SOLE 1,000,000 0 0
GEOVAX LABS INC COM 373678507 1,128 1,358,439 SH   SOLE 1,358,439 0 0
GOLD ROYALTY CORP *W EXP 99/99/999 38071H114 202 448,000 SH   SOLE 448,000 0 0
GREENLANE HLDGS INC CL A 395330103 1,863 9,484,245 SH   SOLE 9,484,245 0 0
GROM SOCIAL ENTERPRISES INC *W EXP 06/17/202 39878L118 72 723,000 SH   SOLE 723,000 0 0
HEART TEST LABORATORIES INC *W EXP 06/15/202 42254E112 176 352,941 SH   SOLE 352,941 0 0
HEARTBEAM INC *W EXP 10/31/202 42238H116 219 500,000 SH   SOLE 500,000 0 0
HUBSPOT INC COM 443573100 5,412 18,000 SH   SOLE 18,000 0 0
I MAB SPONSORED ADS 44975P103 37,561 3,324,000 SH   SOLE 3,324,000 0 0
ILLUMINA INC COM 452327109 62,498 339,000 SH   SOLE 339,000 0 0
IMEDIA BRANDS INC COM CL A 452465206 1,462 1,208,275 SH   SOLE 1,208,275 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105 9,999 268,000 SH   SOLE 268,000 0 0
INCYTE CORP COM 45337C102 151,940 2,000,000 SH   SOLE 2,000,000 0 0
INMED PHARMACEUTICALS INC COM NEW 457637502 450 956,118 SH   SOLE 956,118 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 29,705 148,000 SH   SOLE 148,000 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 567,356 33,500 SH   SOLE 33,500 0 0
IVEDA SOLUTIONS INC *W EXP 04/01/202 46583A113 34 145,000 SH   SOLE 145,000 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 43,371 278,000 SH   SOLE 278,000 0 0
JOHNSON & JOHNSON COM 478160104 45,443 256,000 SH   SOLE 256,000 0 0
KRAFT HEINZ CO COM 500754106 58,125 1,524,000 SH   SOLE 1,524,000 0 0
LOCAFY LIMITED *W EXP 03/29/202 Q56120118 61 242,425 SH   SOLE 242,425 0 0
LOWES COS INC COM 548661107 24,025 137,545 SH   SOLE 137,545 0 0
LULULEMON ATHLETICA INC COM 550021109 62,311 228,573 SH   SOLE 228,573 0 0
M & T BK CORP COM 55261F104 29,965 188,000 SH   SOLE 188,000 0 0
MACROGENICS INC COM 556099109 18,078 6,128,000 SH   SOLE 6,128,000 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 78,738 1,100,000 SH   SOLE 1,100,000 0 0
MARIS TECH LTD *W EXP 02/04/202 M68057112 411 1,261,058 SH   SOLE 1,261,058 0 0
MEATECH 3D LTD SPONSORED ADS 583435102 1,947 587,949 SH   SOLE 587,949 0 0
MEDIGUS LTD *W EXP 07/23/202 58471G128 318 1,285,715 SH   SOLE 1,285,715 0 0
MEDTRONIC PLC SHS G5960L103 71,800 800,000 SH   SOLE 800,000 0 0
META PLATFORMS INC CL A 30303M102 12,094 75,000 SH   SOLE 75,000 0 0
MICROSOFT CORP COM 594918104 34,929 136,000 SH   SOLE 136,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 137,482 2,048,000 SH   SOLE 2,048,000 0 0
MONDELEZ INTL INC CL A 609207105 46,940 756,000 SH   SOLE 756,000 0 0
MONSTER BEVERAGE CORP NEW COM 61174X109 7,787 84,000 SH   SOLE 84,000 0 0
NATERA INC COM 632307104 23,816 672,000 SH   SOLE 672,000 0 0
NETFLIX INC COM 64110L106 8,744 50,000 SH   SOLE 50,000 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 129,064 1,324,000 SH   SOLE 1,324,000 0 0
NEXGEL INC *W EXP 12/01/202 65344E115 154 550,000 SH   SOLE 550,000 0 0
NLS PHARMACEUTICS LTD *W EXP 09/25/202 H57830111 60 500,000 SH   SOLE 500,000 0 0
NLS PHARMACEUTICS LTD SHS H57830103 714 1,216,411 SH   SOLE 1,216,411 0 0
NOVAN INC COM NEW 66988N205 3,046 1,307,103 SH   SOLE 1,307,103 0 0
ONION GLOBAL LTD SPONSORED ADS 68277G107 830 943,390 SH   SOLE 943,390 0 0
OREILLY AUTOMOTIVE INC COM 67103H107 91,972 145,581 SH   SOLE 145,581 0 0
PACIRA BIOSCIENCES INC COM 695127100 34,514 592,000 SH   SOLE 592,000 0 0
PALO ALTO NETWORKS INC COM 697435105 5,927 12,000 SH   SOLE 12,000 0 0
PARAMOUNT GLOBAL CLASS B COM 92556H206 20,632 836,000 SH   SOLE 836,000 0 0
PASITHEA THERAPEUTICS CORP *W EXP 08/12/202 70261F111 65 1,000,000 SH   SOLE 1,000,000 0 0
PAYCOM SOFTWARE INC COM 70432V102 5,602 20,000 SH   SOLE 20,000 0 0
PETVIVO HLDGS INC *W EXP 08/13/202 716817119 66 200,000 SH   SOLE 200,000 0 0
PFIZER INC COM 717081103 23,908 456,000 SH   SOLE 456,000 0 0
POLARITYTE INC COM NEW 731094207 203 140,163 SH   SOLE 140,163 0 0
POST HLDGS INC COM 737446104 44,140 536,000 SH   SOLE 536,000 0 0
PTC THERAPEUTICS INC COM 69366J200 132,038 3,296,000 SH   SOLE 3,296,000 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 4,275 1,500,000 SH   SOLE 1,500,000 0 0
RAIL VISION LTD *W EXP 03/27/202 M8186D114 194 1,089,500 SH   SOLE 1,089,500 0 0
REGENERON PHARMACEUTICALS COM 75886F107 111,132 188,000 SH   SOLE 188,000 0 0
RELIANCE GLOBAL GROUP INC COM NEW 75946W207 2,818 1,335,446 SH   SOLE 1,335,446 0 0
RESHAPE LIFESCIENCES INC COM 76090R101 82 142,991 SH   SOLE 142,991 0 0
ROCKWELL MED INC COM NEW 774374300 266 206,510 SH   SOLE 206,510 0 0
ROSS STORES INC COM 778296103 14,065 200,268 SH   SOLE 200,268 0 0
SAVERONE 2014 LTD *W EXP 05/04/202 80516T113 85 242,100 SH   SOLE 242,100 0 0
SCISPARC LTD COM M82618105 714 335,000 SH   SOLE 335,000 0 0
SCPHARMACEUTICALS INC COM 810648105 13,014 2,700,000 SH   SOLE 2,700,000 0 0
SEQLL INC *W EXP 08/31/202 81734C114 7 50,000 SH   SOLE 50,000 0 0
SERVICENOW INC COM 81762P102 6,420 13,500 SH   SOLE 13,500 0 0
SHARPS TECHNOLOGY INC *W EXP 04/13/202 82003F119 327 1,176,000 SH   SOLE 1,176,000 0 0
SHOPIFY INC CL A 82509L107 7,498 240,000 SH   SOLE 240,000 0 0
SKECHERS U S A INC CL A 830566105 6,632 186,386 SH   SOLE 186,386 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 1,263,788 33,500 SH   SOLE 33,500 0 0
SPECTRUM PHARMACEUTICALS INC COM 84763A108 13,338 17,100,000 SH   SOLE 17,100,000 0 0
SPLASH BEVERAGE GROUP INC *W EXP 06/15/202 84862C112 651 904,000 SH   SOLE 904,000 0 0
STRAN & COMPANY INC *W EXP 11/01/202 86260J110 145 545,000 SH   SOLE 545,000 0 0
STRYVE FOODS INC CLASS A COM 863685103 1,072 1,217,038 SH   SOLE 1,217,038 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108 136,271 4,712,000 SH   SOLE 4,712,000 0 0
TARO PHARMACEUTICAL INDS LTD SHS M8737E108 5,930 164,000 SH   SOLE 164,000 0 0
TC BIOPHARM HOLDINGS PLC *W EXP 02/08/202 87807D111 381 1,882,352 SH   SOLE 1,882,352 0 0
TENAX THERAPEUTICS INC COM NEW 88032L209 479 1,597,049 SH   SOLE 1,597,049 0 0
TERNS PHARMACEUTICALS INC COM 880881107 801 323,016 SH   SOLE 323,016 0 0
THE REALREAL INC COM 88339P101 747 300,000 SH   SOLE 300,000 0 0
THE VERY GOOD FOOD CO INC COM 88340B109 3,093 13,100,000 SH   SOLE 13,100,000 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 34,770 64,000 SH   SOLE 64,000 0 0
TOAST INC CL A 888787108 19,048 1,472,000 SH   SOLE 1,472,000 0 0
TOP SHIPS INC COM Y8897Y180 695 1,832,962 SH   SOLE 1,832,962 0 0
TRACTOR SUPPLY CO COM 892356106 51,802 267,225 SH   SOLE 267,225 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 128,904 5,320,000 SH   SOLE 5,320,000 0 0
TREVI THERAPEUTICS INC COM 89532M101 1,169 416,000 SH   SOLE 416,000 0 0
TWILIO INC CL A 90138F102 4,693 56,000 SH   SOLE 56,000 0 0
UBER TECHNOLOGIES INC COM 90353T100 40,920 2,000,000 SH   SOLE 2,000,000 0 0
ULTA BEAUTY INC COM 90384S303 25,608 66,431 SH   SOLE 66,431 0 0
UNITEDHEALTH GROUP INC COM 91324P102 25,682 50,000 SH   SOLE 50,000 0 0
UPHEALTH INC *W EXP 06/08/202 91532B119 1 10,000 SH   SOLE 10,000 0 0
VERASTEM INC COM 92337C104 2,320 2,000,000 SH   SOLE 2,000,000 0 0
VERIFYME INC COM NEW 92346X206 1,542 786,896 SH   SOLE 786,896 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 87,918 312,000 SH   SOLE 312,000 0 0
VIATRIS INC COM 92556V106 5,235 500,000 SH   SOLE 500,000 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 15,153 2,564,000 SH   SOLE 2,564,000 0 0
WALMART INC COM 931142103 42,657 350,858 SH   SOLE 350,858 0 0
WHOLE EARTH BRANDS INC COM CL A 96684W100 12,127 1,956,000 SH   SOLE 1,956,000 0 0
WYNN RESORTS LTD COM 983134107 9,801 172,000 SH   SOLE 172,000 0 0
XERIS BIOPHARMA HOLDINGS INC COM 98422E103 8,969 5,824,000 SH   SOLE 5,824,000 0 0
YUM BRANDS INC COM 988498101 17,221 151,713 SH   SOLE 151,713 0 0
ZYMEWORKS INC COM 98985W102 30,592 5,772,000 SH   SOLE 5,772,000 0 0