The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIOMED INC COM 003654100 122,368 494,397 SH   SOLE   494,397 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 23,646 1,678,196 SH   SOLE   1,678,196 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 642 160,800 SH   SOLE   160,800 0 0
ALIGN TECHNOLOGY INC COM 016255101 10,486 44,305 SH   SOLE   44,305 0 0
ALIMERA SCIENCES INC COM 016259202 1,099 200,919 SH   SOLE   200,919 0 0
ALKERMES PLC COM G01767105 17,975 603,400 SH   SOLE   603,400 0 0
AMICUS THERAPEUTICS INC COM 03152W109 105,765 9,847,774 SH   SOLE   9,847,774 0 0
ANAPTYSBIO INC COM 032724106 8,750 431,024 SH   SOLE   431,024 0 0
BIOGEN INC COM 09062X103 73,618 360,981 SH   SOLE   360,981 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 170,826 2,061,373 SH   SOLE   2,061,373 0 0
CLOVIS ONCOLOGY INC COM 189464100 8,053 4,473,967 SH   SOLE   4,473,967 0 0
CYTOKINETICS INC COM 23282W605 4,389 111,717 SH   SOLE   111,717 0 0
EHEALTH INC COM 28238P109 15,438 1,654,693 SH   SOLE   1,654,693 0 0
EPIZYME INC COM 29428V104 9,959 6,774,541 SH   SOLE   6,774,541 0 0
GOSSAMER BIO INC COM 38341P102 14,653 1,750,651 SH   SOLE   1,750,651 0 0
GRITSTONE ONCOLOGY INC COM 39868T105 5,640 2,330,504 SH   SOLE   2,330,504 0 0
INSMED INC COM 457669307 115,173 5,840,398 SH   SOLE   5,840,398 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 25,353 5,621,533 SH   SOLE   5,621,533 0 0
KEZAR LIFE SCIENCES INC COM 49372L100 5,427 656,200 SH   SOLE   656,200 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 519 432,300 SH   SOLE   432,300 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q200 152 31,330 SH   SOLE   31,330 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 1,259 64,700 SH   SOLE   64,700 0 0
NOVAVAX INC COM 670002401 643 12,500 SH   SOLE   12,500 0 0
PROTHENA CORP PLC COM G72800108 45,652 1,681,477 SH   SOLE   1,681,477 0 0
REVANCE THERAPEUTICS INC COM 761330109 60,878 4,405,039 SH   SOLE   4,405,039 0 0
SAGE THERAPEUTICS INC COM 78667J108 27,501 851,409 SH   SOLE   851,409 0 0
STAAR SURGICAL CO COM 852312305 78,489 1,106,567 SH   SOLE   1,106,567 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 11,786 612,600 SH   SOLE   612,600 0 0
TACTILE SYSTEMS TECHNOLOGY I COM 87357P100 198 27,100 SH   SOLE   27,100 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 4,024 166,069 SH   SOLE   166,069 0 0
UNITED THERAPEUTICS CORP COM 91307C102 149,586 634,806 SH   SOLE   634,806 0 0
UROGEN PHARMA LTD COM M96088105 201 24,500 SH   SOLE   24,500 0 0
VANDA PHARMACEUTICALS INC COM 921659108 27,154 2,491,200 SH   SOLE   2,491,200 0 0