The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109 18,217 639,654 SH   SOLE 1,2,3 639,654 0 0
2SEVENTY BIO INC COMMON STOCK 901384107 17,889 1,229,508 SH   SOLE 1,2,3 1,229,508 0 0
5 01 ACQUISITION CORP COM CL A 33836P105 3,920 392,000 SH   SOLE 1,2,3 392,000 0 0
908 DEVICES INC COM 65443P102 5,132 312,000 SH   SOLE 1,2,3 312,000 0 0
AADI BIOSCIENCE INC COM 00032Q104 10,805 764,701 SH   SOLE 1,2,3 764,701 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 60,057 3,670,938 SH   SOLE 1,2,3 3,670,938 0 0
ADICET BIO INC COM 007002108 60,314 4,241,472 SH   SOLE 1,2,3 4,241,472 0 0
AKOYA BIOSCIENCES INC COM 00974H104 5,685 483,815 SH   SOLE 1,2,3 483,815 0 0
ALLAKOS INC COM 01671P100 10,058 1,643,500 SH   SOLE 1,2,3 1,643,500 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 336,942 1,683,362 SH   SOLE 1,2,3 1,683,362 0 0
APYX MEDICAL CORPORATION COM 03837C106 15,258 3,398,279 SH   SOLE 1,2,3 3,398,279 0 0
ARGENX SE SPONSORED ADR 04016X101 164,943 467,195 SH   SOLE 1,2,3 467,195 0 0
ARYA SCIENCES ACQU CORP IV CL A G31659108 4,955 500,000 SH   SOLE 1,2,3 500,000 0 0
ARYA SCIENCES ACQUISITN CORP CLASS A ORD SHS G31658100 4,900 500,000 SH   SOLE 1,2,3 500,000 0 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 1,806 3,015,987 SH   SOLE 1,2,3 3,015,987 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 28,767 5,741,939 SH   SOLE 1,2,3 5,741,939 0 0
AVIDITY BIOSCIENCES INC COM 05370A108 84,439 5,170,784 SH   SOLE 1,2,3 5,170,784 0 0
AXONICS INC COM 05465P101 62,338 884,974 SH   SOLE 1,2,3 884,974 0 0
AXSOME THERAPEUTICS INC COM 05464T104 83,982 1,882,164 SH   SOLE 1,2,3 1,882,164 0 0
BCLS ACQUISITION CORP COM CL A G0904B105 6,137 612,500 SH   SOLE 1,2,3 612,500 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 29,686 1,276,276 SH   SOLE 1,2,3 1,276,276 0 0
BRAINSWAY LTD SPONSORED ADS 10501L106 5,785 1,602,381 SH   SOLE 1,2,3 1,602,381 0 0
C4 THERAPEUTICS INC COM STK 12529R107 24,727 2,819,472 SH   SOLE 1,2,3 2,819,472 0 0
CASTLE BIOSCIENCES INC COM 14843C105 13,483 516,995 SH   SOLE 1,2,3 516,995 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 86,697 3,084,215 SH   SOLE 1,2,3 3,084,215 0 0
CINCOR PHARMA INC COM 17240Y109 45,610 1,389,705 SH   SOLE 1,2,3 1,389,705 0 0
CUTERA INC COM 232109108 80,730 1,770,400 SH   SOLE 1,2,3 1,770,400 0 0
CYTOKINETICS INC COM NEW 23282W605 124,720 2,574,198 SH   SOLE 1,2,3 2,574,198 0 0
DERMTECH INC COM 24984K105 12,350 3,118,666 SH   SOLE 1,2,3 3,118,666 0 0
ESSA PHARMA INC COM NEW 29668H708 2,387 1,311,294 SH   SOLE 1,2,3 1,311,294 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 129,379 2,369,138 SH   SOLE 1,2,3 2,369,138 0 0
EXAGEN INC COM 30068X103 2,842 1,048,662 SH   SOLE 1,2,3 1,048,662 0 0
FULCRUM THERAPEUTICS INC COM 359616109 32,246 3,985,910 SH   SOLE 1,2,3 3,985,910 0 0
GH RESEARCH PLC ORDINARY SHARES G3855L106 25,203 2,168,957 SH   SOLE 1,2,3 2,168,957 0 0
GLOBUS MED INC CL A 379577208 44,540 747,685 SH   SOLE 1,2,3 747,685 0 0
GUARDANT HEALTH INC COM 40131M109 39,074 725,887 SH   SOLE 1,2,3 725,887 0 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 9,900 1,000,000 SH   SOLE 1,2 1,000,000 0 0
ILLUMINA INC COM 452327109 107,677 564,375 SH   SOLE 1,2,3 564,375 0 0
IMMATICS N.V SHS N44445109 3,500 350,000 SH   SOLE 1,2,3 350,000 0 0
IMMUNIC INC COM 4525EP101 8,728 2,761,968 SH   SOLE 1,2,3 2,761,968 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105 208,953 4,451,483 SH   SOLE 1,2,3 4,451,483 0 0
IVERIC BIO INC COM 46583P102 65,033 3,625,000 SH   SOLE 1,2,3 3,625,000 0 0
JOHNSON & JOHNSON COM 478160104 2,961 18,127 SH   SOLE 1,2,3 18,127 0 0
JOUNCE THERAPEUTICS INC COM 481116101 11,949 5,106,341 SH   SOLE 1,2,3 5,106,341 0 0
LANDOS BIOPHARMA INC COM 515069102 2,584 3,975,722 SH   SOLE 1,2,3 3,975,722 0 0
MASIMO CORP COM 574795100 203,269 1,439,993 SH   SOLE 1,2,3 1,439,993 0 0
MEDICUS SCIENCES ACQUISITION *W EXP 02/12/202 G5960S124 1 33,331 SH   SOLE 1,2,3 33,331 0 0
MEDICUS SCIENCES ACQUISITION CL A SHS G5960S108 2,970 300,000 SH   SOLE 1,2,3 300,000 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 39,656 4,315,102 SH   SOLE 1,2,3 4,315,102 0 0
MIRATI THERAPEUTICS INC COM 60468T105 131,485 1,882,663 SH   SOLE 1,2,3 1,882,663 0 0
MIROMATRIX MED INC COM 60471P108 1,226 280,000 SH   SOLE 1,2,3 280,000 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102 9,923 1,214,572 SH   SOLE 1,2,3 1,214,572 0 0
MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104 3,880 500,000 SH   SOLE 1,2,3 500,000 0 0
NATERA INC COM 632307104 96,811 2,209,283 SH   SOLE 1,2,3 2,209,283 0 0
NAUTILUS BIOTECHNOLOGY INC COM 63909J108 1,272 600,000 SH   SOLE 1,2,3 600,000 0 0
NYXOAH S A SHS B6S7WD106 2,173 344,911 SH   SOLE 1,2,3 344,911 0 0
OLINK HLDG AB SPONSORED ADS 680710100 11,920 981,918 SH   SOLE 1,2,3 981,918 0 0
OUTSET MED INC COM 690145107 14,491 909,652 SH   SOLE 1,2,3 909,652 0 0
OYSTER PT PHARMA INC COM 69242L106 11,489 2,044,312 SH   SOLE 1,2,3 2,044,312 0 0
PENUMBRA INC COM 70975L107 132,411 698,371 SH   SOLE 1,2,3 698,371 0 0
PMV PHARMACEUTICALS INC COM 69353Y103 51,847 4,356,920 SH   SOLE 1,2,3 4,356,920 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 188,219 3,189,605 SH   SOLE 1,2,3 3,189,605 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 35,211 4,176,837 SH   SOLE 1,2,3 4,176,837 0 0
PTC THERAPEUTICS INC COM 69366J200 282,153 5,620,580 SH   SOLE 1,2,3 5,620,580 0 0
PULMONX CORP COM 745848101 7,678 460,847 SH   SOLE 1,2,3 460,847 0 0
REGENXBIO INC COM 75901B107 48,773 1,845,366 SH   SOLE 1,2,3 1,845,366 0 0
RELMADA THERAPEUTICS INC COM 75955J402 97,898 2,644,475 SH   SOLE 1,2,3 2,644,475 0 0
RENOVACOR INC *W EXP 99/99/999 75989E114 28 350,000 SH   SOLE 1,2,3 350,000 0 0
RENOVACOR INC COM 75989E106 7,562 3,000,803 SH   SOLE 1,2,3 3,000,803 0 0
RESEARCH ALLIANCE CORP II COM CL A 760873109 6,262 637,000 SH   SOLE 1,2,3 637,000 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 252,213 15,802,802 SH   SOLE 1,2,3 15,802,802 0 0
ROIVANT SCIENCES LTD SHS G76279101 2,585 802,717 SH   SOLE 1,2,3 802,717 0 0
SCIENCE 37 HOLDINGS INC COM 808644108 6,969 4,328,387 SH   SOLE 1,2,3 4,328,387 0 0
SIGHT SCIENCES INC COM 82657M105 4,225 665,323 SH   SOLE 1,2,3 665,323 0 0
STOKE THERAPEUTICS INC COM 86150R107 46,889 3,651,823 SH   SOLE 1,2,3 3,651,823 0 0
SUMMIT HEALTHCRE ACQUISTN CO UNIT 06/03/2026 G8566R128 4,925 500,000 SH   SOLE 1,2,3 500,000 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 15,408 322,000 SH   SOLE 1,2,3 322,000 0 0
TARSUS PHARMACEUTICALS INC COM 87650L103 34,637 2,023,179 SH   SOLE 1,2,3 2,023,179 0 0
TELA BIO INC COM 872381108 3,326 390,364 SH   SOLE 1,2,3 390,364 0 0
TENAYA THERAPEUTICS INC COM 87990A106 7,130 2,458,750 SH   SOLE 1,2,3 2,458,750 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 220,881 435,500 SH   SOLE 1,2,3 435,500 0 0
THIRD HARMONIC BIO INC COM 88427A107 11,566 609,687 SH   SOLE 1,2,3 609,687 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 97,727 2,359,996 SH   SOLE 1,2,3 2,359,996 0 0
UROGEN PHARMA LTD COM M96088105 7,134 857,464 SH   SOLE 1,2,3 857,464 0 0
VENTYX BIOSCIENCES INC COM 92332V107 54,173 1,551,778 SH   SOLE 1,2,3 1,551,778 0 0
VERICEL CORP COM 92346J108 71,918 3,099,904 SH   SOLE 1,2,3 3,099,904 0 0