The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
2SEVENTY BIO INC COMMON STOCK 901384107 4,365 300,000 SH   OTR 1 0 300,000 0
ACELRX PHARMACEUTICALS INC COM 00444T100 81 388,468 SH   OTR 1 0 388,468 0
ADMA BIOLOGICS INC COM 000899104 2,413 992,840 SH   OTR 1 0 992,840 0
ALBIREO PHARMA INC COM 01345P106 21,287 1,099,516 SH   OTR 1 0 1,099,516 0
ALDEYRA THERAPEUTICS INC COM 01438T106 3,738 700,000 SH   OTR 1 0 700,000 0
ALECTOR INC COM 014442107 946 100,000 SH   OTR 1 0 100,000 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102 4,000 50,000 SH   OTR 1 0 50,000 0
ALIGOS THERAPEUTICS INC COM 01626L105 1,842 1,674,166 SH   OTR 1 0 1,674,166 0
ALLAKOS INC COM 01671P100 8,099 1,323,393 SH   OTR 1 0 1,323,393 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 20,016 100,000 SH   OTR 1 0 100,000 0
ALTIMMUNE INC COM NEW 02155H200 33,208 2,600,450 SH   OTR 1 0 2,600,450 0
ANAPTYSBIO INC COM 032724106 67,058 2,628,678 SH   OTR 1 0 2,628,678 0
ANI PHARMACEUTICALS INC COM 00182C103 3,214 100,000 SH   OTR 1 0 100,000 0
ARCUS BIOSCIENCES INC COM 03969F109 5,232 200,000 SH   OTR 1 0 200,000 0
ARVINAS INC COM 04335A105 890 20,000 SH   OTR 1 0 20,000 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 6,824 66,090 SH   OTR 1 0 66,090 0
ASLAN PHARMACEUTICALS LTD ADS 04522R101 3,386 5,654,925 SH   OTR 1 0 5,654,925 0
ASTRAZENECA PLC SPONSORED ADR 046353108 8,226 150,000 SH   OTR 1 0 150,000 0
ATYR PHARMA INC COM NEW 002120202 3,340 1,113,453 SH   OTR 1 0 1,113,453 0
AURINIA PHARMACEUTICALS INC COM 05156V102 1,504 200,000 SH   OTR 1 0 200,000 0
AXSOME THERAPEUTICS INC COM 05464T104 3,123 70,000 SH   OTR 1 0 70,000 0
BEAM THERAPEUTICS INC COM 07373V105 2,382 50,000 SH   OTR 1 0 50,000 0
BEIGENE LTD SPONSORED ADR 07725L102 14,156 105,000 SH   OTR 1 0 105,000 0
BELLUS HEALTH INC NEW COM NEW 07987C204 2,112 200,000 SH   OTR 1 0 200,000 0
BIO RAD LABS INC CL A 090572207 26,697 64,000 SH   OTR 1 0 64,000 0
BIOATLA INC COM 09077B104 15,146 1,967,051 SH   OTR 1 0 1,967,051 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 15,120 1,200,000 SH   OTR 1 0 1,200,000 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 42,328 280,000 SH   OTR 1 0 280,000 0
BIONTECH SE SPONSORED ADS 09075V102 4,046 30,000 SH   OTR 1 0 30,000 0
BLUEBIRD BIO INC COM 09609G100 40,104 6,335,528 SH   OTR 1 0 6,335,528 0
BLUEPRINT MEDICINES CORP COM 09627Y109 2,636 40,000 SH   OTR 1 0 40,000 0
BOLT BIOTHERAPEUTICS INC COM 097702104 296 200,000 SH   OTR 1 0 200,000 0
BRIDGEBIO PHARMA INC COM 10806X102 5,819 585,424 SH   OTR 1 0 585,424 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 4,504 160,219 SH   OTR 1 0 160,219 0
CHEMOCENTRYX INC COM 16383L106 2,583 50,000 SH   OTR 1 0 50,000 0
CLENE INC COMMON STOCK 185634102 3,080 1,100,000 SH   OTR 1 0 1,100,000 0
COHERUS BIOSCIENCES INC COM 19249H103 7,208 750,000 SH   OTR 1 0 750,000 0
CONCERT PHARMACEUTICALS INC COM 206022105 6,720 1,003,017 SH   OTR 1 0 1,003,017 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 3,268 50,000 SH   OTR 1 0 50,000 0
CTI BIOPHARMA CORP COM 12648L601 1,746 300,000 SH   OTR 1 0 300,000 0
CYTOMX THERAPEUTICS INC COM 23284F105 5,075 3,500,000 SH   OTR 1 0 3,500,000 0
CULLINAN ONCOLOGY INC COM 230031106 8,000 624,016 SH   OTR 1 0 624,016 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109 8,012 400,000 SH   OTR 1 0 400,000 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 1,044 100,000 SH   OTR 1 0 100,000 0
EAGLE PHARMACEUTICALS INC COM 269796108 3,140 118,857 SH   OTR 1 0 118,857 0
ENANTA PHARMACEUTICALS INC COM 29251M106 7,142 137,700 SH   OTR 1 0 137,700 0
EQUILLIUM INC COM 29446K106 1,332 600,000 SH   OTR 1 0 600,000 0
ESPERION THERAPEUTICS INC NE COM 29664W105 3,350 500,000 SH   OTR 1 0 500,000 0
EVOLUS INC COM 30052C107 294 36,514 SH   OTR 1 0 36,514 0
FORTRESS BIOTECH INC COM 34960Q109 3,607 4,194,483 SH   OTR 1 0 4,194,483 0
GALAPAGOS NV SPON ADR 36315X101 9,592 224,950 SH   OTR 1 0 224,950 0
GENFIT S A ADS 372279109 4,371 1,197,522 SH   OTR 1 0 1,197,522 0
GOSSAMER BIO INC COM 38341P102 2,995 250,000 SH   OTR 1 0 250,000 0
GRAPHITE BIO INC COM 38870X104 3,487 1,100,000 SH   OTR 1 0 1,100,000 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104 13,730 310,000 SH   OTR 1 0 310,000 0
HEALTH SCIENCES ACQ CORP 2 ORD SHS G4411D109 3,886 392,500 SH   OTR 1 0 392,500 0
HERON THERAPEUTICS INC COM 427746102 28,865 6,840,000 SH   OTR 1 0 6,840,000 0
HOMOLOGY MEDICINES INC COM 438083107 346 214,898 SH   OTR 1 0 214,898 0
IMMUNOCORE HLDGS PLC ADS 45258D105 19,039 405,600 SH   OTR 1 0 405,600 0
IMMUNOGEN INC COM 45253H101 7,170 1,500,000 SH   OTR 1 0 1,500,000 0
INSMED INC COM PAR $.01 457669307 10,770 500,000 SH   OTR 1 0 500,000 0
INSPIRATO INCORPORATED COM CL A 45791E107 1,445 612,345 SH   OTR 1 0 612,345 0
INSPIRATO INCORPORATED *W EXP 02/11/2027 45791E115 88 365,000 SH   OTR 1 0 365,000 0
INTRA-CELLULAR THERAPIES INC COM 46116X101 29,779 640,000 SH   OTR 1 0 640,000 0
IONIS PHARMACEUTICALS INC COM 462222100 8,846 200,000 SH   OTR 1 0 200,000 0
ITEOS THERAPEUTICS INC COM 46565G104 17,859 937,500 SH   OTR 1 0 937,500 0
KALVISTA PHARMACEUTICALS INC COM 483497103 26,118 1,800,000 SH   OTR 1 0 1,800,000 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 7,704 600,000 SH   OTR 1 0 600,000 0
LEAP THERAPEUTICS INC COM 52187K101 1,100 1,250,000 SH   OTR 1 0 1,250,000 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 3,264 80,000 SH   OTR 1 0 80,000 0
METACRINE INC COM 59101E103 833 1,718,220 SH   OTR 1 0 1,718,220 0
MIRATI THERAPEUTICS INC COM 60468T105 1,397 20,000 SH   OTR 1 0 20,000 0
MIRUM PHARMACEUTICALS INC COM 604749101 9,455 450,000 SH   OTR 1 0 450,000 0
MOLECULAR PARTNERS AG ADS 60853G106 105 15,681 SH   OTR 1 0 15,681 0
MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104 2,010 259,054 SH   OTR 1 0 259,054 0
NEKTAR THERAPEUTICS COM 640268108 1,376 430,037 SH   OTR 1 0 430,037 0
NKARTA INC COM 65487U108 8,723 662,872 SH   OTR 1 0 662,872 0
OLEMA PHARMACEUTICALS INC COM 68062P106 880 318,926 SH   OTR 1 0 318,926 0
ORCHARD THERAPEUTICS PLC SPON ADS 68570P101 1,000 2,000,000 SH   OTR 1 0 2,000,000 0
PARDES BIOSCIENCES INC COM 69945Q105 925 500,000 SH   OTR 1 0 500,000 0
PYXIS ONCOLOGY INC COMMON STOCK 747324101 2,781 1,411,569 SH   OTR 1 0 1,411,569 0
RELMADA THERAPEUTICS INC COM 75955J402 14,808 400,000 SH   OTR 1 0 400,000 0
REVANCE THERAPEUTICS INC COM 761330109 7,763 287,500 SH   OTR 1 0 287,500 0
ROCKET PHARMACEUTICALS INC COM 77313F106 20,204 1,265,900 SH   OTR 1 0 1,265,900 0
SILVERBACK THERAPEUTICS INC COM 82835W108 2,162 409,463 SH   OTR 1 0 409,463 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 3,424 120,000 SH   OTR 1 0 120,000 0
TARSUS PHARMACEUTICALS INC COM 87650L103 35,778 2,089,856 SH   OTR 1 0 2,089,856 0
TCR2 THERAPEUTICS INC COM 87808K106 6,735 3,741,606 SH   OTR 1 0 3,741,606 0
TRITIUM DCFC LIMITED ORDINARY SHARES Q9225T108 1,276 400,000 SH   OTR 1 0 400,000 0
TSCAN THERAPEUTICS INC COM 89854M101 1,702 557,915 SH   OTR 1 0 557,915 0
TWITTER INC COM 90184L102 13,152 300,000 SH   OTR 1 0 300,000 0
VANDA PHARMACEUTICALS INC COM 921659108 2,536 256,696 SH   OTR 1 0 256,696 0
VERU INC COM 92536C103 12,672 1,100,000 SH   OTR 1 0 1,100,000 0
VINCERX PHARMA INC COM NEW 92731L106 1,422 1,030,634 SH   OTR 1 0 1,030,634 0
VIRIDIAN THERAPEUTICS INC COM 92790C104 18,109 882,925 SH   OTR 1 0 882,925 0