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The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
1Life Healthcare, Inc. Common 68269G107   522,455 31,266 SH   SOLE   522,455 0 0
Abbott Laboratories Common 002824100   76,090,069 693,051 SH   SOLE   76,090,069 0 0
AbbVie Inc. Common 00287Y109   77,304,851 478,342 SH   SOLE   77,304,851 0 0
Acadia Healthcare Company, Inc. Common 00404A109   11,622,678 141,189 SH   SOLE   11,622,678 0 0
ACADIA Pharmaceuticals Inc. Common 004225108   1,149,822 72,225 SH   SOLE   1,149,822 0 0
Adaptive Biotechnologies Corp. Common 00650F109   3,226,227 422,281 SH   SOLE   3,226,227 0 0
Addus HomeCare Corp. Common 006739106   4,216,386 42,380 SH   SOLE   4,216,386 0 0
Adicet Bio, Inc. Common 007002108   360,541 40,329 SH   SOLE   360,541 0 0
Affimed N.V. Common N01045108   726,687 586,038 SH   SOLE   726,687 0 0
Agilent Technologies, Inc. Common 00846U101   6,463,533 43,191 SH   SOLE   6,463,533 0 0
AlerisLife Inc. Common 33832D205   13,330 24,237 SH   SOLE   13,330 0 0
Align Technology, Inc. Common 016255101   10,718,782 50,824 SH   SOLE   10,718,782 0 0
Alkermes plc Shares G01767105   8,090,188 309,613 SH   SOLE   8,090,188 0 0
Allscripts Healthcare Solutions, Inc. Common 01988P108   7,560,151 428,580 SH   SOLE   7,560,151 0 0
Alnylam Pharmaceuticals, Inc. Common 02043Q107   34,034,807 143,214 SH   SOLE   34,034,807 0 0
ALX Oncology Holdings Inc. Common 00166B105   746,198 66,211 SH   SOLE   746,198 0 0
Amerisourcebergen Corp. Common 03073E105   3,383,301 20,417 SH   SOLE   3,383,301 0 0
Amgen Inc. Common 031162100   133,598,665 508,676 SH   SOLE   133,598,665 0 0
Apellis Pharmaceuticals, Inc. Common 03753U106   3,434,888 66,426 SH   SOLE   3,434,888 0 0
ARCA biopharma, Inc. Common 00211Y506   76,608 32,461 SH   SOLE   76,608 0 0
Arcutis Biotherapeutics, Inc. Common 03969K108   2,203,335 148,874 SH   SOLE   2,203,335 0 0
Ardelyx, Inc. Common 039697107   1,537,313 539,408 SH   SOLE   1,537,313 0 0
argenx SE Sponsored ADR 04016X101   31,829,675 84,021 SH   SOLE   31,829,675 0 0
Arrowhead Pharmaceuticals, Inc. Common 04280A100   4,073,116 100,422 SH   SOLE   4,073,116 0 0
Arvinas, Inc. Common 04335A105   1,470,962 42,998 SH   SOLE   1,470,962 0 0
Ascendis Pharma A/S Sponsored ADR 04351P101   15,118,595 123,791 SH   SOLE   15,118,595 0 0
Assertio Holdings, Inc. Common 04546C205   1,765,473 410,575 SH   SOLE   1,765,473 0 0
AstraZeneca PLC Sponsored ADR 046353108   69,308,889 1,022,255 SH   SOLE   69,308,889 0 0
Avantor, Inc. Common 05352A100   9,690,602 459,488 SH   SOLE   9,690,602 0 0
Beam Therapeutics Inc. Common 07373V105   618,603 15,817 SH   SOLE   618,603 0 0
BeiGene, Ltd. Sponsored ADR 07725L102   4,608,183 20,952 SH   SOLE   4,608,183 0 0
Bellicum Pharmaceuticals, Inc. Common 079481404   4,320 6,000 SH   SOLE   4,320 0 0
Bicycle Therapeutics PLC Sponsored ADS 088786108   2,624,810 88,676 SH   SOLE   2,624,810 0 0
BioCryst Pharmaceuticals, Inc. Common 09058V103   7,722,653 672,705 SH   SOLE   7,722,653 0 0
Biogen Inc. Common 09062X103   54,118,476 195,430 SH   SOLE   54,118,476 0 0
Biohaven Ltd. Common G1110E107   487,008 35,087 SH   SOLE   487,008 0 0
BioMarin Pharmaceutical Inc. Common 09061G101   23,884,457 230,790 SH   SOLE   23,884,457 0 0
BioNTech SE Sponsored ADS 09075V102   15,601,549 103,858 SH   SOLE   15,601,549 0 0
Black Diamond Therapeutics, Inc. Common 09203E105   237,582 131,990 SH   SOLE   237,582 0 0
Blueprint Medicines Corp. Common 09627Y109   2,966,375 67,710 SH   SOLE   2,966,375 0 0
Boston Scientific Corp. Common 101137107   35,027,084 757,015 SH   SOLE   35,027,084 0 0
Bristol-Myers Squibb Company Common 110122108   49,467,712 687,529 SH   SOLE   49,467,712 0 0
Cardiovascular Systems, Inc. Common 141619106   2,381,580 174,859 SH   SOLE   2,381,580 0 0
Caribou Biosciences, Inc. Common 142038108   3,561,683 567,147 SH   SOLE   3,561,683 0 0
Catalent, Inc. Common 148806102   5,668,874 125,947 SH   SOLE   5,668,874 0 0
Cerevel Therapeutics Holdings, Inc. Common 15678U128   5,566,274 176,483 SH   SOLE   5,566,274 0 0
Charles River Laboratories International, Inc. Common 159864107   15,835,883 72,675 SH   SOLE   15,835,883 0 0
Cigna Corp. Common 125523100   60,512,956 182,631 SH   SOLE   60,512,956 0 0
Codexis Inc Common 192005106   322,123 69,125 SH   SOLE   322,123 0 0
Community Health Systems, Inc. Common 203668108   381,607 88,335 SH   SOLE   381,607 0 0
Community Healthcare Trust Inc. Common 20369C106   533,420 14,900 SH   SOLE   533,420 0 0
Corbus Pharmaceuticals Holdings, Inc. Common 21833P103   17,051 154,310 SH   SOLE   17,051 0 0
Crinetics Pharmaceuticals, Inc. Common 22663K107   839,256 45,861 SH   SOLE   839,256 0 0
CRISPR Therapeutics AG Namen AKT H17182108   2,239,002 55,080 SH   SOLE   2,239,002 0 0
CVS Health Corp. Common 126650100   8,724,541 93,621 SH   SOLE   8,724,541 0 0
Cytokinetics, Inc. Common 23282W605   3,442,869 75,139 SH   SOLE   3,442,869 0 0
Danaher Corp. Common 235851102   28,052,240 105,690 SH   SOLE   28,052,240 0 0
Denali Therapeutics, Inc. Common 24823R105   7,578,781 272,520 SH   SOLE   7,578,781 0 0
Dexcom, Inc. Common 252131107   24,688,019 218,015 SH   SOLE   24,688,019 0 0
Diversified Healthcare Trust Common 25525P107   231,373 357,720 SH   SOLE   231,373 0 0
Edgewise Therapeutics, Inc. Common 28036F105   1,743,524 195,025 SH   SOLE   1,743,524 0 0
Edwards Lifesciences Corp. Common 28176E108   12,787,259 171,388 SH   SOLE   12,787,259 0 0
Elevance Health, Inc. Common 036752103   7,511,933 14,644 SH   SOLE   7,511,933 0 0
Eli Lilly and Company Common 532457108   105,697,395 288,917 SH   SOLE   105,697,395 0 0
Fulcrum Therapeutics, Inc. Common 359616109   426,149 58,537 SH   SOLE   426,149 0 0
Fusion Pharmaceuticals Inc. Common 36118A100   136,691 43,394 SH   SOLE   136,691 0 0
G1 Therapeutics, Inc. Common 3621LQ109   2,301,609 423,869 SH   SOLE   2,301,609 0 0
Galera Therapeutics, Inc. Common 36338D108   1,338,577 898,374 SH   SOLE   1,338,577 0 0
Gilead Sciences, Inc. Common 375558103   129,671,274 1,510,440 SH   SOLE   129,671,274 0 0
Global Medical REIT Inc. Common 37954A204   1,658,024 174,897 SH   SOLE   1,658,024 0 0
GSK plc ADR Sponsored ADR 37733W204   1,470,679 41,852 SH   SOLE   1,470,679 0 0
Guardant Health, Inc. Common 40131M109   12,843,405 472,184 SH   SOLE   12,843,405 0 0
Harpoon Therapeutics, Inc. Common 41358P106   188,617 259,910 SH   SOLE   188,617 0 0
HCA Healthcare, Inc. Common 40412C101   25,196,520 105,003 SH   SOLE   25,196,520 0 0
Healthcare Realty Trust Inc. Common 42226K105   3,366,199 174,686 SH   SOLE   3,366,199 0 0
HealthEquity, Inc. Common 42226A107   6,793,591 110,214 SH   SOLE   6,793,591 0 0
Healthpeak Properties, Inc. Common 42250P103   3,770,327 150,392 SH   SOLE   3,770,327 0 0
Horizon Therapeutics plc Common G46188101   47,233,031 415,053 SH   SOLE   47,233,031 0 0
Humana Inc. Common 444859102   39,803,821 77,713 SH   SOLE   39,803,821 0 0
I-Mab Sponsored ADS 44975P103   679,584 162,580 SH   SOLE   679,584 0 0
Icon plc Shares G4705A100   1,813,130 9,334 SH   SOLE   1,813,130 0 0
IDEAYA Biosciences, Inc. Common 45166A102   2,419,971 133,185 SH   SOLE   2,419,971 0 0
IDEXX Laboratories, Inc. Common 45168D104   27,767,797 68,065 SH   SOLE   27,767,797 0 0
Illumina, Inc. Common 452327109   64,695,508 319,958 SH   SOLE   64,695,508 0 0
Intellia Therapeutics, Inc. Common 45826J105   5,382,445 154,269 SH   SOLE   5,382,445 0 0
Intercept Pharmaceuticals, Inc. Common 45845P108   644,069 52,067 SH   SOLE   644,069 0 0
Intra-Cellular Therapies, Inc. Common 46116X101   9,121,873 172,371 SH   SOLE   9,121,873 0 0
Intuitive Surgical, Inc. Common 46120E602   29,899,638 112,680 SH   SOLE   29,899,638 0 0
Ionis Pharmaceuticals, Inc. Common 462222100   3,317,717 87,840 SH   SOLE   3,317,717 0 0
IQVIA Holdings Inc. Common 46266C105   12,932,042 63,117 SH   SOLE   12,932,042 0 0
Ishares Biothechnology ETF Common 464287556   3,225,664 24,569 SH   SOLE   3,225,664 0 0
Jazz Pharmaceuticals plc Shares G50871105   29,119,000 182,782 SH   SOLE   29,119,000 0 0
Johnson & Johnson Common 478160104   112,999,295 639,679 SH   SOLE   112,999,295 0 0
Karuna Therapeutics, Inc. Common 48576A100   10,503,318 53,452 SH   SOLE   10,503,318 0 0
Koninklijke Philips N.V. NY Reg Shares 500472303   1,646,801 109,860 SH   SOLE   1,646,801 0 0
Kura Oncology, Inc. Common 50127T109   3,515,517 283,281 SH   SOLE   3,515,517 0 0
Laboratory Corporation of America Holdings Common 50540R409   10,394,558 44,142 SH   SOLE   10,394,558 0 0
Lantheus Holdings, Inc. Common 516544103   17,472,757 342,872 SH   SOLE   17,472,757 0 0
LTC Properties, Inc. Common 502175102   6,476,870 182,293 SH   SOLE   6,476,870 0 0
Mallinckrodt plc Shares G5890A102   271,622 35,048 SH   SOLE   271,622 0 0
McKesson Corp. Common 58155Q103   24,928,600 66,455 SH   SOLE   24,928,600 0 0
Medical Properties Trust, Inc. Common 58463J304   4,586,817 411,743 SH   SOLE   4,586,817 0 0
Medpace Holdings, Inc. Common 58506Q109   2,004,088 9,435 SH   SOLE   2,004,088 0 0
Medtronic plc Shares G5960L103   25,350,088 326,172 SH   SOLE   25,350,088 0 0
Merck & Co., Inc. Common 58933Y105   61,257,936 552,122 SH   SOLE   61,257,936 0 0
Mereo BioPharma Group plc ADS 589492107   1,163,312 1,551,082 SH   SOLE   1,163,312 0 0
Merus N.V. Common N5749R100   1,428,268 92,325 SH   SOLE   1,428,268 0 0
Mirati Therapeutics, Inc. Common 60468T105   2,967,352 65,490 SH   SOLE   2,967,352 0 0
Moderna, Inc. Common 60770K107   47,586,188 264,927 SH   SOLE   47,586,188 0 0
Molina Healthcare, Inc. Common 60855R100   24,309,145 73,615 SH   SOLE   24,309,145 0 0
MoonLake Immunotherapeutics AG Common 61559X104   3,150,000 300,000 SH   SOLE   3,150,000 0 0
Morphic Holding, Inc. Common 61775R105   1,193,719 44,625 SH   SOLE   1,193,719 0 0
MorphoSys AG Sponsored ADS 617760202   293,084 81,867 SH   SOLE   293,084 0 0
Natera, Inc. Common 632307104   1,979,256 49,272 SH   SOLE   1,979,256 0 0
National Health Investors, Inc. Common 63633D104   524,184 10,038 SH   SOLE   524,184 0 0
Neurocrine Biosciences, Inc. Common 64125C109   13,485,732 112,908 SH   SOLE   13,485,732 0 0
NexGel, Inc. Common 65344E107   5,304 4,243 SH   SOLE   5,304 0 0
Nkarta, Inc. Common 65487U108   173,638 28,988 SH   SOLE   173,638 0 0
Novartis AG Sponsored ADR 66987V109   12,358,332 136,225 SH   SOLE   12,358,332 0 0
Novavax, Inc. Common 670002401   655,864 63,800 SH   SOLE   655,864 0 0
Novo Nordisk A/S Sponsored ADR 670100205   17,664,983 130,523 SH   SOLE   17,664,983 0 0
Omega Healthcare Investors, Inc. Common 681936100   8,564,802 306,433 SH   SOLE   8,564,802 0 0
Option Care Health, Inc. Common 68404L201   1,955,098 64,975 SH   SOLE   1,955,098 0 0
Perrigo Company plc Shares G97822103   1,746,226 51,224 SH   SOLE   1,746,226 0 0
Pfizer Inc. Common 717081103   74,665,391 1,457,170 SH   SOLE   74,665,391 0 0
Physicians Realty Trust Common 71943U104   2,441,682 168,741 SH   SOLE   2,441,682 0 0
Pliant Therapeutics, Inc. Common 729139105   681,054 35,233 SH   SOLE   681,054 0 0
Praxis Precision Medicines, Inc. Common 74006W108   178,500 75,000 SH   SOLE   178,500 0 0
Precision BioSciences, Inc. Common 74019P108   267,195 224,534 SH   SOLE   267,195 0 0
Prometheus Biosciences, Inc. Common 74349U108   4,206,070 38,237 SH   SOLE   4,206,070 0 0
Protagonist Therapeutics, Inc. Common 74366E102   1,333,977 122,271 SH   SOLE   1,333,977 0 0
Pyxis Oncology, Inc. Common 747324101   949,126 708,303 SH   SOLE   949,126 0 0
R1 RCM Inc. Common 77634L105   2,215,743 202,351 SH   SOLE   2,215,743 0 0
Rallybio Corporation Common 75120L100   11,346,830 1,727,067 SH   SOLE   11,346,830 0 0
Regeneron Pharmaceuticals, Inc. Common 75886F107   87,200,724 120,862 SH   SOLE   87,200,724 0 0
Repare Therapeutics Inc. Common 760273102   428,797 29,150 SH   SOLE   428,797 0 0
ResMed Inc. Common 761152107   12,633,283 60,699 SH   SOLE   12,633,283 0 0
Sabra Health Care REIT, Inc. Common 78573L106   6,347,504 510,660 SH   SOLE   6,347,504 0 0
Sanofi Sponsored ADR 80105N105   5,978,877 123,454 SH   SOLE   5,978,877 0 0
Sarepta Therapeutics, Inc. Common 803607100   18,265,467 140,959 SH   SOLE   18,265,467 0 0
Scholar Rock Holding Corp. Common 80706P103   984,939 108,833 SH   SOLE   984,939 0 0
Seagen Inc. Common 81181C104   14,420,621 112,214 SH   SOLE   14,420,621 0 0
Smith & Nephew plc Sponsored ADR 83175M205   4,886,182 181,710 SH   SOLE   4,886,182 0 0
SPDR S&P Biotech ETF S&P Biotech ETF 78464A870   12,257,191 147,677 SH   SOLE   12,257,191 0 0
Spectrum Pharmaceuticals, Inc. Common 84763A108   42,256 114,670 SH   SOLE   42,256 0 0
STERIS plc Shares G8473T100   3,078,598 16,669 SH   SOLE   3,078,598 0 0
Stevanato Group Societa' Per Azioni Ordinary Shares T9224W109   1,279,284 71,190 SH   SOLE   1,279,284 0 0
Stryker Corp. Common 863667101   40,127,655 164,128 SH   SOLE   40,127,655 0 0
Sutro Biopharma, Inc. Common 869367102   1,192,050 147,531 SH   SOLE   1,192,050 0 0
Syndax Pharmaceuticals, Inc. Common 87164F105   2,995,898 117,717 SH   SOLE   2,995,898 0 0
Takeda Pharmaceutical Company Ltd. Sponsored ADS 874060205   1,639,139 105,073 SH   SOLE   1,639,139 0 0
Teva Pharmaceutical Industries Ltd. Sponsored ADR 881624209   4,192,017 459,651 SH   SOLE   4,192,017 0 0
Thermo Fisher Scientific Inc. Common 883556102   51,602,406 93,705 SH   SOLE   51,602,406 0 0
Theseus Pharmaceuticals, Inc. Common 88369M101   498,000 100,000 SH   SOLE   498,000 0 0
Travere Therapeutics, Inc. Common 89422G107   8,801,476 418,520 SH   SOLE   8,801,476 0 0
TScan Therapeutics, Inc. Common 89854M101   326,000 200,000 SH   SOLE   326,000 0 0
Ultragenyx Pharmaceutical Inc. Common 90400D108   3,107,121 67,065 SH   SOLE   3,107,121 0 0
uniQure N.V. Shares N90064101   14,790,951 652,446 SH   SOLE   14,790,951 0 0
United Therapeutics Corp. Common 91307C102   32,001,763 115,077 SH   SOLE   32,001,763 0 0
Unitedhealth Group Inc. Common 91324P102   143,438,078 270,546 SH   SOLE   143,438,078 0 0
Universal Health Realty Income Trust Common 91359E105   537,344 11,258 SH   SOLE   537,344 0 0
Vaxcyte, Inc. Common 92243G108   239,750 5,000 SH   SOLE   239,750 0 0
VectivBio Holding AG Common H9060V101   6,351,631 737,704 SH   SOLE   6,351,631 0 0
Ventas, Inc. Common 92276F100   3,003,979 66,681 SH   SOLE   3,003,979 0 0
Vertex Pharmaceuticals Inc. Common 92532F100   95,396,452 330,343 SH   SOLE   95,396,452 0 0
VYNE Therapeutics Inc. Common 92941V209   20,309 135,395 SH   SOLE   20,309 0 0
Welltower Inc. Common 95040Q104   2,719,276 41,484 SH   SOLE   2,719,276 0 0
Xencor, Inc. Common 98401F105   5,216,541 200,328 SH   SOLE   5,216,541 0 0
Xenon Pharmaceuticals Inc. Common 98420N105   3,300,843 83,714 SH   SOLE   3,300,843 0 0
Zai Lab Ltd. ADR 98887Q104   1,329,310 43,300 SH   SOLE   1,329,310 0 0
Zimmer Biomet Holdings, Inc. Common 98956P102   33,005,670 258,868 SH   SOLE   33,005,670 0 0
Zoetis Inc. Class A 98978V103   20,064,747 136,914 SH   SOLE   20,064,747 0 0