The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABCAM PLC ADS 000380204 BBG00XRJJM98 33,920,800 2,180,000 SH   SOLE   2,180,000 0 0
ACADIA HEALTHCARE COMPANY IN COM 00404A109 BBG001SNNWL7 69,601,560 845,500 SH   SOLE   845,500 0 0
ACCOLADE INC COM 00437E102 BBG00S2L1ZR1 15,097,020 1,938,000 SH   SOLE   1,938,000 0 0
ACELRX PHARMACEUTICALS INC COM NEW 00444T209 BBG001TFZCK5 715,200 316,460 SH   SOLE   316,460 0 0
ACLARIS THERAPEUTICS INC COM 00461U105 BBG003LF0QS8 62,389,672 3,961,249 SH   SOLE   3,961,249 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 BBG008G65WD1 3,907,743 2,676,536 SH   SOLE   2,676,536 0 0
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 BBG0067L94C1 1,535,916 3,413,906 SH   SOLE   3,413,906 0 0
AGILON HEALTH INC COM 00857U107 BBG00HCYVQR3 127,062,150 7,872,500 SH   SOLE   7,872,500 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 BBG001T8R687 84,144,303 2,996,592 SH   SOLE   2,996,592 0 0
AKERO THERAPEUTICS INC COM 00973Y108 BBG00L9211Z7 76,755,839 1,400,654 SH   SOLE   1,400,654 0 0
ALIGN TECHNOLOGY INC COM 016255101 BBG001SCF1B9 63,765,615 302,350 SH   SOLE   302,350 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 BBG001S7FTC8 79,018,625 332,500 SH   SOLE   332,500 0 0
ALTIMMUNE INC COM NEW 02155H200 BBG001SNS461 3,672,545 223,255 SH   SOLE   223,255 0 0
AMICUS THERAPEUTICS INC COM 03152W109 BBG001SN96V9 12,989,071 1,063,806 SH   SOLE   1,063,806 0 0
AMRYT PHARMA PLC SPONSORED ADS 03217L106 BBG00Q9V0S11 9,677,063 1,325,625 SH   SOLE   1,325,625 0 0
AMYLYX PHARMACEUTICALS INC COM 03237H101 BBG00DP10YW1 45,435,087 1,229,637 SH   SOLE   1,229,637 0 0
ANAPTYSBIO INC COM 032724106 BBG0026ZDHT8 17,868,834 576,600 SH   SOLE   576,600 0 0
APPLIED THERAPEUTICS INC COM 03828A101 BBG001SMJMY2 453,477 596,680 SH   SOLE   596,680 0 0
ARGENX SE SPONSORED ADR 04016X101 BBG00GHB88Y8 132,590,500 350,000 SH   SOLE   350,000 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 BBG007R7VP72 51,966,315 425,500 SH   SOLE   425,500 0 0
ATRECA INC CL A COM 04965G109 BBG003FJ19C1 290,242 362,530 SH   SOLE   362,530 0 0
AURA BIOSCIENCES INC COM 05153U107 BBG00226DGP2 10,707,449 1,019,757 SH   SOLE   1,019,757 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 BBG001S68013 2,071,613 479,540 SH   SOLE   479,540 0 0
AZENTA INC COM 114340102 BBG001S8F1B8 20,464,330 351,500 SH   SOLE   351,500 0 0
BAXTER INTL INC COM 071813109 BBG001S5P1K3 58,615,500 1,150,000 SH   SOLE   1,150,000 0 0
BEAM THERAPEUTICS INC COM 07373V105 BBG00KXC8655 4,358,027 111,430 SH   SOLE   111,430 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103 BBG001S7K151 21,705,661 1,890,737 SH   SOLE   1,890,737 0 0
BIOHAVEN LTD COM G1110E107 BBG017BXV3R8 9,284,512 668,913 SH   SOLE   668,913 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 BBG001S76R05 27,373,105 264,500 SH   SOLE   264,500 0 0
BIOMEA FUSION INC COM 09077A106 BBG00YS4WDD8 6,161,032 730,846 SH   SOLE   730,846 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 BBG001V11BV0 82,867,053 1,891,510 SH   SOLE   1,891,510 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 BBG001S7QN20 18,786,433 421,504 SH   SOLE   421,504 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128 BBG00VCYVLJ2 79,053,875 2,506,464 SH   SOLE   2,506,464 0 0
CHINOOK THERAPEUTICS INC COM 16961L106 BBG001T20HH5 13,296,814 507,512 SH   SOLE   507,512 0 0
CINCOR PHARMA INC COM 17240Y109 BBG00P4V66J1 13,722,744 1,116,578 SH   SOLE   1,116,578 0 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 BBG001T535S9 16,820,000 725,000 SH   SOLE   725,000 0 0
COMPASS THERAPEUTICS INC COM 20454B104 BBG00LPXKF34 26,825,936 5,333,188 SH   SOLE   5,333,188 0 0
COMPUGEN LTD ORD M25722105 BBG001S5PQC7 923,246 1,289,990 SH   SOLE   1,289,990 0 0
CONMED CORP COM 207410101 BBG001S5PZH2 18,171,200 205,000 SH   SOLE   205,000 0 0
CYTOKINETICS INC COM NEW 23282W605 BBG001SGMVF2 20,298,260 443,000 SH   SOLE   443,000 0 0
DESIGN THERAPEUTICS INC COM 25056L103 BBG00SNC49W7 4,723,612 460,391 SH   SOLE   460,391 0 0
DEXCOM INC COM 252131107 BBG001SKZG99 55,544,220 490,500 SH   SOLE   490,500 0 0
DISC MEDICINE INC COM 254604101 BBG00W9MJL04 6,752,595 339,497 SH   SOLE   339,497 0 0
DYNAVAX TECHNOLOGIES CORP COM NEW 268158201 BBG001S7HTB7 19,298,385 1,813,758 SH   SOLE   1,813,758 0 0
EDAP TMS S A SPONSORED ADR 268311107 BBG001SB3ML7 9,700,600 910,000 SH   SOLE   910,000 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108 BBG001SF2288 48,190,599 645,900 SH   SOLE   645,900 0 0
ESSA PHARMA INC COM NEW 29668H708 BBG0080GLFK7 1,322,859 524,944 SH   SOLE   524,944 0 0
EVOLENT HEALTH INC CL A 30050B101 BBG005CHLMB3 106,802,280 3,803,500 SH   SOLE   3,803,500 0 0
EXACT SCIENCES CORP COM 30063P105 BBG001SGCLB9 43,940,125 887,500 SH   SOLE   887,500 0 0
FATE THERAPEUTICS INC COM 31189P102 BBG001T888S2 1,109,900 110,000 SH   SOLE   110,000 0 0
FRESHPET INC COM 358039105 BBG001V04FM0 34,669,890 657,000 SH   SOLE   657,000 0 0
F-STAR THERAPEUTICS INC COM 30315R107 BBG0046HC897 4,751,938 751,889 SH   SOLE   751,889 0 0
FULCRUM THERAPEUTICS INC COM 359616109 BBG00DDY1RM7 2,799,815 384,590 SH   SOLE   384,590 0 0
GAMIDA CELL LTD SHS M47364100 BBG00M4RGJ53 5,314,649 4,119,883 SH   SOLE   4,119,883 0 0
GOSSAMER BIO INC NOTE 5.000% 6/0 38341PAA0   3,096,866 9,573,000 PRN   SOLE   9,573,000 0 0
GOSSAMER BIO INC COM 38341P102 BBG00MVWLMC1 816,024 376,048 SH   SOLE   376,048 0 0
GUARDANT HEALTH INC COM 40131M109 BBG006D97VZ8 5,440,000 200,000 SH   SOLE   200,000 0 0
HEALTH CATALYST INC COM 42225T107 BBG00LDPZMT5 9,884,837 929,900 SH   SOLE   929,900 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 BBG001T9M4T2 84,177,860 739,700 SH   SOLE   739,700 0 0
HUMANA INC COM 444859102 BBG001S5S1X6 218,449,035 426,500 SH   SOLE   426,500 0 0
ICOSAVAX INC COM 45114M109 BBG00QHK2J96 6,201,140 781,000 SH   SOLE   781,000 0 0
IDEXX LABS INC COM 45168D104 BBG001S5S4Y9 84,651,700 207,500 SH   SOLE   207,500 0 0
IMMATICS N.V SHS N44445109 BBG00VTL2J09 19,813,369 2,274,784 SH   SOLE   2,274,784 0 0
IMMUNOCORE HLDGS PLC ADS 45258D105 BBG00YYCXG54 189,533,237 3,321,066 SH   SOLE   3,321,066 0 0
INOZYME PHARMA INC COM 45790W108 BBG00J7QJMD0 3,240,328 3,086,027 SH   SOLE   3,086,027 0 0
INSULET CORP COM 45784P101 BBG001SRF439 154,333,958 524,250 SH   SOLE   524,250 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 BBG001S7XR78 79,206,975 298,500 SH   SOLE   298,500 0 0
INVITAE CORP COM 46185L103 BBG005DJFD52 5,761,397 3,097,525 SH   SOLE   3,097,525 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 BBG001TSQV70 28,986,182 309,450 SH   SOLE   309,450 0 0
KARUNA THERAPEUTICS INC COM 48576A100 BBG00NN875H9 81,304,233 413,762 SH   SOLE   413,762 0 0
KINNATE BIOPHARMA INC COM 49705R105 BBG00R4SGVH0 4,556,535 746,973 SH   SOLE   746,973 0 0
KYMERA THERAPEUTICS INC COM 501575104 BBG00SDHC8F9 30,645,364 1,227,779 SH   SOLE   1,227,779 0 0
LEAP THERAPEUTICS INC COM 52187K101 BBG00DQ929Z3 1,646,931 3,659,847 SH   SOLE   3,659,847 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 BBG00TTGH6N2 22,487,263 450,466 SH   SOLE   450,466 0 0
LIFESTANCE HEALTH GROUP INC COM 53228F101 BBG01138DHT2 13,338,000 2,700,000 SH   SOLE   2,700,000 0 0
MACROGENICS INC COM 556099109 BBG001S9C8R7 7,535,974 1,123,096 SH   SOLE   1,123,096 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 BBG001SNKQ42 101,042,120 348,121 SH   SOLE   348,121 0 0
MEREO BIOPHARMA GROUP PLC SPON ADS 589492107 BBG00KFWZCX7 4,683,673 6,244,897 SH   SOLE   6,244,897 0 0
MERSANA THERAPEUTICS INC COM 59045L106 BBG001TZ57P0 24,048,286 4,103,803 SH   SOLE   4,103,803 0 0
MIRATI THERAPEUTICS INC COM 60468T105 BBG001SF6HK7 36,475,637 805,024 SH   SOLE   805,024 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 BBG00MH7T2N6 35,016,794 1,795,733 SH   SOLE   1,795,733 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 BBG001S8W4X9 134,071,400 1,122,500 SH   SOLE   1,122,500 0 0
NEUROCRINE BIOSCIENCES INC NOTE 2.250% 5/1 64125CAD1   1,586,500 1,000,000 PRN   SOLE   1,000,000 0 0
NEVRO CORP NOTE 2.750% 4/0 64157FAC7   458,750 500,000 PRN   SOLE   500,000 0 0
NEVRO CORP COM 64157F103 BBG001V0KW81 42,684,840 1,077,900 SH   SOLE   1,077,900 0 0
NKARTA INC COM 65487U108 BBG00JXHS9H6 2,356,400 393,389 SH   SOLE   393,389 0 0
NOVAVAX INC COM NEW 670002401 BBG001SGL8G3 5,475,128 532,600 SH   SOLE   532,600 0 0
NOVOCURE LTD ORD SHS G6674U108 BBG009XW8QY0 9,168,750 125,000 SH   SOLE   125,000 0 0
NUVATION BIO INC *W EXP 07/07/202 67080N119   19,367 134,028 SH   SOLE   134,028 0 0
OLINK HLDG AB SPONSORED ADS 680710100 BBG00ZHZXZ84 36,674,100 1,445,000 SH   SOLE   1,445,000 0 0
PACIRA BIOSCIENCES INC COM 695127100 BBG001S77N12 39,868,686 1,032,600 SH   SOLE   1,032,600 0 0
PARATEK PHARMACEUTICALS INC COM 699374302 BBG001SQHLP7 3,242,649 1,734,037 SH   SOLE   1,734,037 0 0
PENUMBRA INC COM 70975L107 BBG001TRHPB0 113,065,295 508,250 SH   SOLE   508,250 0 0
PHREESIA INC COM 71944F106 BBG001TG2W25 42,148,900 1,302,500 SH   SOLE   1,302,500 0 0
PROMETHEUS BIOSCIENCES INC COM 74349U108 BBG00PPP6G63 113,470,500 1,031,550 SH   SOLE   1,031,550 0 0
PROTHENA CORP PLC SHS G72800108 BBG00393H6N0 45,396,086 753,462 SH   SOLE   753,462 0 0
PULMONX CORP COM 745848101 BBG001T4HJ52 5,499,732 652,400 SH   SOLE   652,400 0 0
RELAY THERAPEUTICS INC COM 75943R102 BBG00DSS08L8 10,069,052 673,966 SH   SOLE   673,966 0 0
RENEO PHARMACEUTICALS INC COM 75974E103 BBG00JVRSRD0 2,663,621 1,143,185 SH   SOLE   1,143,185 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 BBG007DLZ629 51,276,389 1,760,865 SH   SOLE   1,760,865 0 0
SAREPTA THERAPEUTICS INC COM 803607100 BBG001S6KJC6 56,496,880 436,000 SH   SOLE   436,000 0 0
SEAGEN INC COM 81181C104 BBG001S9M4Q6 51,429,702 400,200 SH   SOLE   400,200 0 0
SELECT SECTOR SPDR TR SBI HEALTHCARE 81369Y209 BBG001S7SCQ6 27,170,000 200,000 SH   SOLE   200,000 0 0
SHOCKWAVE MED INC COM 82489T104 BBG005XVXMM4 23,665,711 115,100 SH   SOLE   115,100 0 0
SPERO THERAPEUTICS INC COM 84833T103 BBG00HXSJ1S1 1,158,292 669,533 SH   SOLE   669,533 0 0
SPRUCE BIOSCIENCES INC COM 85209E109 BBG00HYZ1559 1,780,739 1,622,689 SH   SOLE   1,622,689 0 0
TEMPEST THERAPEUTICS INC COM 87978U108 BBG002NDK348 947,202 823,654 SH   SOLE   823,654 0 0
THESEUS PHARMACEUTICALS INC COM 88369M101 BBG00Z0GRC64 2,177,898 437,329 SH   SOLE   437,329 0 0
TRAVERE THERAPEUTICS INC NOTE 2.500% 9/1 761299AB2   3,000,075 3,250,000 PRN   SOLE   3,250,000 0 0
TRAVERE THERAPEUTICS INC COM 89422G107 BBG001SL72C5 20,013,200 951,650 SH   SOLE   951,650 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 BBG001V2MJJ2 59,778,626 1,290,279 SH   SOLE   1,290,279 0 0
UNITEDHEALTH GROUP INC COM 91324P102 BBG001S6WCJ1 143,148,600 270,000 SH   SOLE   270,000 0 0
VERVE THERAPEUTICS INC COM 92539P101 BBG00P33TD13 10,813,496 558,837 SH   SOLE   558,837 0 0
VIGIL NEUROSCIENCE INC COM 92673K108 BBG00YGBK4R3 5,899,475 471,958 SH   SOLE   471,958 0 0
VINCERX PHARMA INC COM NEW 92731L106 BBG00RRQXMY1 909,553 891,719 SH   SOLE   891,719 0 0
WARBY PARKER INC CL A COM 93403J106 BBG005DWN8L7 16,443,973 1,218,975 SH   SOLE   1,218,975 0 0
WEST PHARMACEUTICAL SVSC INC COM 955306105 BBG001S5XK22 43,657,425 185,500 SH   SOLE   185,500 0 0
XENON PHARMACEUTICALS INC COM 98420N105 BBG002VBMLS5 46,356,747 1,175,672 SH   SOLE   1,175,672 0 0
XILIO THERAPEUTICS INC COM 98422T100 BBG00M4D4XC8 3,666,142 1,362,878 SH   SOLE   1,362,878 0 0
ZAI LAB LTD ADR 98887Q104 BBG00HFX3P04 32,532,790 1,059,700 SH   SOLE   1,059,700 0 0