The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CL A COM 88025U109   11,833,744 324,746 SH   DFND 2 324,746 0 0
ABBOTT LABS COM 002824100   184,938,949 1,684,479 SH   DFND 2 1,684,479 0 0
ABBVIE INC COM 00287Y109   2,618,082 16,200 SH   DFND 2 16,200 0 0
ACADIA HEALTHCARE CO IN COM 00404A109   105,946 1,287 SH   DFND 2 1,287 0 0
ACCOLADE INC COM 00437E102   4,948,457 635,232 SH   DFND 2 635,232 0 0
ACCOLADE INC COM 00437E102   23,697,531 3,042,045 SH   DFND 3 3,042,045 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109   22,615,401 2,960,131 SH   DFND 3 2,960,131 0 0
AGILENT TECHNOLOGIES INC COM 00846U101   1,193,908 7,978 SH   DFND 2 7,978 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104   730,080 26,000 SH   DFND 2 26,000 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104   113,184,639 4,030,792 SH   DFND 1,2 4,030,792 0 0
AKERO THERAPEUTICS INC COM 00973Y108   2,337,220 42,650 SH   DFND 2 42,650 0 0
ALIGN TECHNOLOGY INC COM 016255101   16,702,015 79,194 SH   DFND 2 79,194 0 0
ALKERMES PLC SHS G01767105   1,580,865 35,500 SH   DFND 2 35,500 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   7,417,769 31,213 SH   DFND 2 31,213 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   211,508,500 890,000 SH   DFND 1,2 890,000 0 0
ALPHABET INC CAP STK CL C 02079K107   532,380 6,000 SH   DFND 2 6,000 0 0
AMEDISYS INC COM 023436108   6,360,234 76,134 SH   DFND 2 76,134 0 0
AMEDISYS INC COM 023436108   44,892,558 537,378 SH   DFND 3 537,378 0 0
AMERICAN WELL CORP CL A 03044L105   5,525,334 1,952,415 SH   DFND 2 1,952,415 0 0
AMERISOURCEBERGEN CORP COM 03073E105   1,691,899 10,210 SH   DFND 2 10,210 0 0
AMGEN INC COM 031162100   10,226,939 38,939 SH   DFND 2 38,939 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   1,835,705 35,500 SH   DFND 2 35,500 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   55,263,356 1,068,717 SH   DFND 3 1,068,717 0 0
ARCUS BIOSCIENCES INC COM 03969F109   1,362,068 65,864 SH   DFND 2 65,864 0 0
ARGENX SE SPONSORED ADR 04016X101   7,045,102 18,597 SH   DFND 2 18,597 0 0
ARGENX SE SPONSORED ADR 04016X101   338,106,911 892,503 SH   DFND 1,2 892,503 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100   863,928 21,300 SH   DFND 2 21,300 0 0
ARVINAS INC COM 04335A105   478,940 14,000 SH   DFND 2 14,000 0 0
ARVINAS INC COM 04335A105   73,086,655 2,136,412 SH   DFND 1,2 2,136,412 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108   4,648,252 68,500 SH   DFND 2 68,500 0 0
ATRICURE INC COM 04963C209   28,585,557 644,109 SH   DFND 3 644,109 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102   5,574,001 1,290,278 SH   DFND 3 1,290,278 0 0
AVANTOR INC COM 05352A100   9,946,487 471,621 SH   DFND 2 471,621 0 0
AXONICS INC COM 05465P101   49,286,271 788,202 SH   DFND 2 788,202 0 0
AXONICS INC COM 05465P101   69,924,735 1,118,259 SH   DFND 3 1,118,259 0 0
AXSOME THERAPEUTICS INC COM 05464T104   58,850 763 SH   DFND 2 763 0 0
AXSOME THERAPEUTICS INC COM 05464T104   33,620,581 435,895 SH   DFND 3 435,895 0 0
BAXTER INTL INC COM 071813109   16,345,111 320,681 SH   DFND 2 320,681 0 0
BEAM THERAPEUTICS INC COM 07373V105   140,796 3,600 SH   DFND 2 3,600 0 0
BEAM THERAPEUTICS INC COM 07373V105   27,107,962 693,121 SH   DFND 1,2 693,121 0 0
BECTON DICKINSON & CO COM 075887109   84,315,708 331,560 SH   DFND 2 331,560 0 0
BEIGENE LTD SPONSORED ADR 07725L102   7,714,819 34,500 SH   DFND 2 34,500 0 0
BELLUS HEALTH INC COM NEW 07987C204   369,119 44,905 SH   DFND 2 44,905 0 0
BERKELEY LTS INC COM 084310101   1,031,838 385,014 SH   DFND 2 385,014 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108   2,077,920 70,200 SH   DFND 2 70,200 0 0
BIOGEN INC COM 09062X103   7,865,636 28,404 SH   DFND 2 28,404 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   6,280,291 60,685 SH   DFND 2 60,685 0 0
BIONTECH SE SPONSORED ADS 09075V102   33,210,638 221,080 SH   DFND 2 221,080 0 0
BIO RAD LABS INC CL A 090572207   46,740,827 111,158 SH   DFND 3 111,158 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105   41,400 23,000 SH   DFND 2 23,000 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105   9,680,110 5,377,839 SH   DFND 1,2 5,377,839 0 0
BOSTON SCIENTIFIC CORP COM 101137107   180,588,293 3,902,924 SH   DFND 2 3,902,924 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108   3,615,847 50,255 SH   DFND 2 50,255 0 0
CARDINAL HEALTH INC COM 14149Y108   814,822 10,600 SH   DFND 2 10,600 0 0
CAREDX INC COM 14167L103   36,151,992 3,168,448 SH   DFND 3 3,168,448 0 0
CASTLE BIOSCIENCES INC COM 14843C105   22,229,104 944,312 SH   DFND 3 944,312 0 0
CELLDEX THERAPEUTICS INC COM NEW 15117B202   80,226,000 1,800,000 SH   DFND 1,2 1,800,000 0 0
CENTENE CORP DEL COM 15135B101   56,878,692 693,558 SH   DFND 2 693,558 0 0
CHARLES RIV LABS INTL INC COM 159864107   63,185,988 289,977 SH   DFND 3 289,977 0 0
CIGNA CORP NEW COM 125523100   52,557,482 158,621 SH   DFND 2 158,621 0 0
COOPER COS INC COM NEW 216648402   26,887,770 81,313 SH   DFND 2 81,313 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108   939,015 23,100 SH   DFND 2 23,100 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108   36,121,793 888,605 SH   DFND 1,2 888,605 0 0
CVS HEALTH CORP COM 126650100   19,029,864 204,205 SH   DFND 2 204,205 0 0
CYTOKINETICS INC COM NEW 23282W605   2,483,444 54,200 SH   DFND 2 54,200 0 0
DANAHER CORPORATION COM 235851102   97,236,617 366,350 SH   DFND 2 366,350 0 0
DENALI THERAPEUTICS INC COM 24823R105   862,110 31,000 SH   DFND 2 31,000 0 0
DESIGN THERAPEUTICS INC COM 25056L103   357,879 34,881 SH   DFND 2 34,881 0 0
DEXCOM INC COM 252131107   111,935,022 988,476 SH   DFND 2 988,476 0 0
DOLBY LABORATORIES INC COM CL A 25659T107   112,864 1,600 SH   DFND 2 1,600 0 0
DOXIMITY INC CL A 26622P107   15,054,311 448,579 SH   DFND 2 448,579 0 0
DR REDDYS LABS LTD ADR 256135203   6,430,506 125,500 SH   DFND 2 125,500 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108   79,394,814 1,064,131 SH   DFND 2 1,064,131 0 0
ELEVANCE HEALTH INC COM 036752103   41,733,187 81,356 SH   DFND 2 81,356 0 0
ELEVANCE HEALTH INC COM 036752103   34,915,303 68,065 SH   DFND 3 68,065 0 0
LILLY ELI & CO COM 532457108   4,044,361 11,055 SH   DFND 2 11,055 0 0
EQUINIX INC COM 29444U700   26,201 40 SH   DFND 2 40 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105   848,526 136,200 SH   DFND 2 136,200 0 0
ESPERION THERAPEUTICS INC NE COM 29664W105   26,129,019 4,194,064 SH   DFND 1,2 4,194,064 0 0
ESSA PHARMA INC COM NEW 29668H708   47,880 19,000 SH   DFND 2 19,000 0 0
ESSA PHARMA INC COM NEW 29668H708   19,856,549 7,879,583 SH   DFND 1,2 7,879,583 0 0
EVERTEC INC COM 30040P103   23,929 739 SH   DFND 2 739 0 0
EVOLENT HEALTH INC CL A 30050B101   12,413,410 442,073 SH   DFND 2 442,073 0 0
EVOLENT HEALTH INC CL A 30050B101   43,287,566 1,541,580 SH   DFND 3 1,541,580 0 0
EXACT SCIENCES CORP COM 30063P105   8,805,502 177,853 SH   DFND 2 177,853 0 0
EXACT SCIENCES CORP COM 30063P105   56,152,361 1,134,162 SH   DFND 3 1,134,162 0 0
EXELIXIS INC COM 30161Q104   304,760 19,000 SH   DFND 2 19,000 0 0
EXELIXIS INC COM 30161Q104   42,578,180 2,654,500 SH   DFND 1,2 2,654,500 0 0
FATE THERAPEUTICS INC COM 31189P102   216,935 21,500 SH   DFND 2 21,500 0 0
FATE THERAPEUTICS INC COM 31189P102   48,833,370 4,839,779 SH   DFND 1,2 4,839,779 0 0
GENERATION BIO CO COM 37148K100   74,670 19,000 SH   DFND 2 19,000 0 0
GENERATION BIO CO COM 37148K100   14,180,540 3,608,280 SH   DFND 1,2 3,608,280 0 0
GILEAD SCIENCES INC COM 375558103   11,189,947 130,343 SH   DFND 2 130,343 0 0
GLOBUS MED INC CL A 379577208   50,516,969 680,180 SH   DFND 2 680,180 0 0
GRUPO AEROPORTUARIO DEL SURE SPON ADR SER B 40051E202   157 135 SH   DFND 2 135 0 0
GUARDANT HEALTH INC COM 40131M109   3,684,376 135,455 SH   DFND 2 135,455 0 0
HALOZYME THERAPEUTICS INC COM 40637H109   46,242,630 812,700 SH   DFND 2 812,700 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104   32,850,179 596,192 SH   DFND 2 596,192 0 0
HCA HEALTHCARE INC COM 40412C101   79,500,188 331,306 SH   DFND 2 331,306 0 0
HOLOGIC INC COM 436440101   18,191,623 243,171 SH   DFND 2 243,171 0 0
HOMOLOGY MEDICINES INC COM 438083107   2,044,378 1,622,522 SH   DFND 1,2 1,622,522 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101   1,412,372 12,411 SH   DFND 2 12,411 0 0
HUMANA INC COM 444859102   56,616,970 110,539 SH   DFND 2 110,539 0 0
HUTCHMED CHINA LTD SPONSORED ADS 44842L103   284,255 17,800 SH   DFND 2 17,800 0 0
HUTCHMED CHINA LTD SPONSORED ADS 44842L103   28,143,506 1,762,344 SH   DFND 3 1,762,344 0 0
IDEXX LABS INC COM 45168D104   44,395,023 108,822 SH   DFND 2 108,822 0 0
ILLUMINA INC COM 452327109   19,190,195 94,907 SH   DFND 2 94,907 0 0
INCYTE CORP COM 45337C102   5,293,088 65,900 SH   DFND 2 65,900 0 0
INCYTE CORP COM 45337C102   232,211,305 2,891,077 SH   DFND 1,2 2,891,077 0 0
INFOSYS LTD SPONSORED ADR 456788108   20,607 1,130 SH   DFND 2 1,130 0 0
INHIBRX INC COM 45720L107   731,808 29,700 SH   DFND 2 29,700 0 0
INSMED INC COM PAR $.01 457669307   65,478,596 3,277,207 SH   DFND 3 3,277,207 0 0
INSPIRE MED SYS INC COM 457730109   101,190,775 401,742 SH   DFND 2 401,742 0 0
INSULET CORP COM 45784P101   101,794,174 345,780 SH   DFND 2 345,780 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101   2,686,060 50,757 SH   DFND 2 50,757 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101   174,185,069 3,291,479 SH   DFND 1,2 3,291,479 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602   224,526,168 846,151 SH   DFND 2 846,151 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602   29,436,602 110,935 SH   DFND 3 110,935 0 0
IONIS PHARMACEUTICALS INC COM 462222100   4,113,153 108,900 SH   DFND 2 108,900 0 0
IONIS PHARMACEUTICALS INC COM 462222100   363,913,950 9,635,000 SH   DFND 1,2 9,635,000 0 0
IPG PHOTONICS CORP COM 44980X109   99,404 1,050 SH   DFND 2 1,050 0 0
IQVIA HLDGS INC COM 46266C105   37,560,435 183,320 SH   DFND 2 183,320 0 0
ISHARES TR MSCI CHINA ETF 46429B671   194,750 4,100 SH   DFND 2 4,100 0 0
IVERIC BIO INC COM 46583P102   894,938 41,800 SH   DFND 2 41,800 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105   43,648,072 273,982 SH   DFND 2 273,982 0 0
JAZZ PHARMACEUTICALS PLC SHS USD G50871105   76,891,609 482,654 SH   DFND 3 482,654 0 0
JOHNSON & JOHNSON COM 478160104   4,597,670 26,027 SH   DFND 2 26,027 0 0
JUMIA TECHNOLOGIES AG SPONSORED ADS 48138M105   57,780 18,000 SH   DFND 2 18,000 0 0
KARUNA THERAPEUTICS INC COM 48576A100   1,434,450 7,300 SH   DFND 2 7,300 0 0
KEZAR LIFE SCIENCES INC COM 49372L100   218,240 31,000 SH   DFND 2 31,000 0 0
KEZAR LIFE SCIENCES INC COM 49372L100   21,120,000 3,000,000 SH   DFND 1,2 3,000,000 0 0
KOSMOS ENERGY LTD COM 500688106   2,024,388 318,300 SH   DFND 2 318,300 0 0
KRYSTAL BIOTECH INC COM 501147102   1,449,726 18,300 SH   DFND 2 18,300 0 0
LABORATORY CORP AMER HLDGS COM NEW 50540R409   784,148 3,330 SH   DFND 2 3,330 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102   17,711,067 354,789 SH   DFND 2 354,789 0 0
MACROGENICS INC COM 556099109   335,165 49,950 SH   DFND 2 49,950 0 0
MACROGENICS INC COM 556099109   59,920,052 8,929,963 SH   DFND 1,2 8,929,963 0 0
MARKETAXESS HLDGS INC COM 57060D108   184,625 662 SH   DFND 2 662 0 0
MCKESSON CORP COM 58155Q103   1,095,350 2,920 SH   DFND 2 2,920 0 0
MEDTRONIC PLC SHS G5960L103   48,063,602 618,420 SH   DFND 2 618,420 0 0
MERCADOLIBRE INC COM 58733R102   143,861 170 SH   DFND 2 170 0 0
MERCK & CO INC COM 58933Y105   749,023 6,751 SH   DFND 2 6,751 0 0
MERSANA THERAPEUTICS INC COM 59045L106   1,268,104 216,400 SH   DFND 2 216,400 0 0
MERSANA THERAPEUTICS INC COM 59045L106   23,827,932 4,066,200 SH   DFND 1,2 4,066,200 0 0
MERUS N V COM N5749R100   706,979 45,700 SH   DFND 2 45,700 0 0
MODERNA INC COM 60770K107   14,437,317 80,377 SH   DFND 2 80,377 0 0
MODERNA INC COM 60770K107   269,780,439 1,501,951 SH   DFND 1,2 1,501,951 0 0
MOLECULAR TEMPLATES INC COM 608550109   28,208 86,000 SH   DFND 2 86,000 0 0
MOLECULAR TEMPLATES INC COM 608550109   3,670,977 11,192,003 SH   DFND 1,2 11,192,003 0 0
MOLINA HEALTHCARE INC COM 60855R100   61,425,543 186,014 SH   DFND 2 186,014 0 0
MYOVANT SCIENCES LTD COM G637AM102   1,024,480 38,000 SH   DFND 2 38,000 0 0
MYOVANT SCIENCES LTD COM G637AM102   158,326,347 5,872,639 SH   DFND 1,2 5,872,639 0 0
NATERA INC COM 632307104   6,982,028 173,812 SH   DFND 2 173,812 0 0
NEKTAR THERAPEUTICS COM 640268108   33,448 14,800 SH   DFND 2 14,800 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109   5,171,035 43,294 SH   DFND 2 43,294 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109   326,071,200 2,730,000 SH   DFND 1,2 2,730,000 0 0
NEVRO CORP COM 64157F103   10,329,066 260,835 SH   DFND 2 260,835 0 0
NOVOCURE LTD ORD SHS G6674U108   660,000 9,000 SH   DFND 2 9,000 0 0
OLINK HLDG AB SPONSORED ADS 680710100   6,375,075 251,185 SH   DFND 2 251,185 0 0
OMNICELL COM COM 68213N109   26,136,921 518,384 SH   DFND 2 518,384 0 0
OPTHEA LTD SPONSORED ADS 68386J208   234,601 47,000 SH   DFND 2 47,000 0 0
OPTION CARE HEALTH INC COM NEW 68404L201   73,131,398 2,430,422 SH   DFND 3 2,430,422 0 0
OUTSET MED INC COM 690145107   25,999,578 1,006,955 SH   DFND 2 1,006,955 0 0
OUTSET MED INC COM 690145107   47,424,214 1,836,724 SH   DFND 3 1,836,724 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108   22,892,630 2,798,610 SH   DFND 2 2,798,610 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108   30,104,977 3,680,315 SH   DFND 3 3,680,315 0 0
PENUMBRA INC COM 70975L107   50,235,250 225,817 SH   DFND 2 225,817 0 0
PFIZER INC COM 717081103   40,411,605 788,673 SH   DFND 2 788,673 0 0
PHREESIA INC COM 71944F106   21,565,319 666,419 SH   DFND 2 666,419 0 0
PRIVIA HEALTH GROUP INC COM 74276R102   20,454,125 900,666 SH   DFND 2 900,666 0 0
PROCEPT BIOROBOTICS CORP COM 74276L105   30,802,616 741,517 SH   DFND 2 741,517 0 0
REGENERON PHARMACEUTICALS COM 75886F107   11,311,520 15,678 SH   DFND 2 15,678 0 0
RELAY THERAPEUTICS INC COM 75943R102   1,256,454 84,100 SH   DFND 2 84,100 0 0
RELAY THERAPEUTICS INC COM 75943R102   61,563,557 4,120,720 SH   DFND 1,2 4,120,720 0 0
RESMED INC COM 761152107   20,453,976 98,275 SH   DFND 2 98,275 0 0
REVOLUTION MEDICINES INC COM 76155X100   1,848,432 77,600 SH   DFND 2 77,600 0 0
REVOLUTION MEDICINES INC COM 76155X100   113,801,527 4,777,562 SH   DFND 1,2 4,777,562 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   716,262 36,600 SH   DFND 2 36,600 0 0
SAGE THERAPEUTICS INC COM 78667J108   724,660 19,000 SH   DFND 2 19,000 0 0
SAGE THERAPEUTICS INC COM 78667J108   112,523,603 2,950,278 SH   DFND 1,2 2,950,278 0 0
SAREPTA THERAPEUTICS INC COM 803607100   4,046,913 31,231 SH   DFND 2 31,231 0 0
SAREPTA THERAPEUTICS INC COM 803607100   85,779,109 661,978 SH   DFND 3 661,978 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103   174,665 19,300 SH   DFND 2 19,300 0 0
SCHOLAR ROCK HLDG CORP COM 80706P103   19,301,161 2,132,725 SH   DFND 1,2 2,132,725 0 0
SEAGEN INC COM 81181C104   2,907,667 22,626 SH   DFND 2 22,626 0 0
SEER INC COM CL A 81578P106   789,571 136,133 SH   DFND 2 136,133 0 0
SHOCKWAVE MED INC COM 82489T104   50,912,326 247,616 SH   DFND 2 247,616 0 0
SIGHT SCIENCES INC COM 82657M105   3,597,139 294,606 SH   DFND 2 294,606 0 0
SILK RD MED INC COM 82710M100   53,511,841 1,012,523 SH   DFND 3 1,012,523 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103   688,374 1,800 SH   DFND 2 1,800 0 0
SPDR SER TR S&P OILGAS EXP 78468R556   529,932 3,900 SH   DFND 2 3,900 0 0
STRYKER CORPORATION COM 863667101   120,346,291 492,234 SH   DFND 2 492,234 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108   3,961,011 111,046 SH   DFND 2 111,046 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100   1,249 770 SH   DFND 2 770 0 0
TANDEM DIABETES CARE INC COM NEW 875372203   26,554,932 590,766 SH   DFND 2 590,766 0 0
TANDEM DIABETES CARE INC COM NEW 875372203   53,970,746 1,200,684 SH   DFND 3 1,200,684 0 0
TELADOC HEALTH INC COM 87918A105   9,230,264 390,286 SH   DFND 2 390,286 0 0
TELEFLEX INCORPORATED COM 879369106   6,257,226 25,066 SH   DFND 2 25,066 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102   45,888,447 83,329 SH   DFND 2 83,329 0 0
TRANSMEDICS GROUP INC COM 89377M109   42,096,620 682,058 SH   DFND 2 682,058 0 0
UNITED MICROELECTRONICS CORP SPON ADR NEW 910873405   17,867 2,698 SH   DFND 2 2,698 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102   58,955 212 SH   DFND 2 212 0 0
UNITEDHEALTH GROUP INC COM 91324P102   76,235,643 143,792 SH   DFND 2 143,792 0 0
UNITEDHEALTH GROUP INC COM 91324P102   42,680,550 80,502 SH   DFND 3 80,502 0 0
VANECK ETF TRUST GOLD MINERS ETF 92189F106   527,344 18,400 SH   DFND 2 18,400 0 0
VANECK ETF TRUST JUNIOR GOLD MINE 92189F791   178,250 5,000 SH   DFND 2 5,000 0 0
VEEVA SYS INC CL A COM 922475108   30,058,155 186,257 SH   DFND 2 186,257 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100   12,773,606 44,233 SH   DFND 2 44,233 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100   35,020,928 121,272 SH   DFND 3 121,272 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100   268,716,432 930,523 SH   DFND 1,2 930,523 0 0
VIRIDIAN THERAPEUTICS INC COM 92790C104   1,346,581 46,100 SH   DFND 2 46,100 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105   31,461,206 4,494,458 SH   DFND 1,2 4,494,458 0 0
XENCOR INC COM 98401F105   661,416 25,400 SH   DFND 2 25,400 0 0
ZAI LAB LTD ADR 98887Q104   2,837,843 90,000 SH   DFND 2 90,000 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102   33,952,740 266,296 SH   DFND 2 266,296 0 0