The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109   50,800,003 314,337 SH   DFND 1 314,337 0 0
ACADIA HEALTHCARE COMPANY IN COM 00404A109   88,731,329 1,077,883 SH   DFND 1 1,077,883 0 0
ACADIA PHARMACEUTICALS INC COM 004225108   7,960,000 500,000 SH   DFND 1 500,000 0 0
ACTIVISION BLIZZARD INC COM 00507V109   29,170,679 381,067 SH   DFND 1 381,067 0 0
ADDUS HOMECARE CORP COM 006739106   37,797,544 379,913 SH   DFND 1 379,913 0 0
ADICET BIO INC COM 007002108   11,298,596 1,263,825 SH   DFND 1 1,263,825 0 0
ADVANCED MICRO DEVICES INC COM 007903107   245,288,783 3,787,074 SH   DFND 1 3,787,074 0 0
AFFILIATED MANAGERS GROUP IN COM 008252108   20,851,289 131,612 SH   DFND 1 131,612 0 0
AFLAC INC COM 001055102   41,365,500 575,000 SH   DFND 1 575,000 0 0
AIR PRODS & CHEMS INC COM 009158106   5,132,529 16,650 SH   DFND 1,2 16,650 0 0
AIR TRANS SVCS GROUP INC NOTE 1.125%10/1 00922RAB1   20,425,100 19,615,000 SH   DFND 1 19,615,000 0 0
AIRBNB INC COM CL A 009066101   54,607,055 638,679 SH   DFND 1 638,679 0 0
AKAMAI TECHNOLOGIES INC NOTE 0.125% 5/0 00971TAJ0   12,343,500 11,700,000 SH   DFND 1 11,700,000 0 0
AKOYA BIOSCIENCES INC COM 00974H104   12,589,048 1,315,470 SH   DFND 1 1,315,470 0 0
ALBEMARLE CORP COM 012653101   574,679 2,650 SH   DFND 1,2 2,650 0 0
ALCON AG ORD SHS H01301128   23,769,987 346,754 SH   DFND 1 346,754 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102   91,454,686 1,038,196 SH   DFND 1 1,038,196 0 0
ALKERMES PLC SHS G01767105   58,830,179 2,251,442 SH   DFND 1 2,251,442 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   70,700,875 297,500 SH   DFND 1 297,500 0 0
ALPHABET INC CAP STK CL C 02079K107   211,982,359 2,389,072 SH   DFND 1 2,389,072 0 0
ALPHABET INC CAP STK CL A 02079K305   186,888,168 2,118,193 SH   DFND 1 2,118,193 0 0
AMAZON COM INC COM 023135106   102,220,524 1,216,911 SH   DFND 1 1,216,911 0 0
AMDOCS LTD SHS G02602103   19,107,271 210,201 SH   DFND 1 210,201 0 0
AMETEK INC COM 031100100   17,195,899 123,074 SH   DFND 1 123,074 0 0
AMGEN INC COM 031162100   6,687,077 25,461 SH   DFND 1 25,461 0 0
ANALOG DEVICES INC COM 032654105   72,852,448 444,141 SH   DFND 1,2 444,141 0 0
AON PLC SHS CL A G0403H108   108,050,400 360,000 SH   DFND 1 360,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106   356,799 6,900 SH   DFND 1 6,900 0 0
APPLE INC COM 037833100   537,019,790 4,133,147 SH   DFND 1 4,133,147 0 0
APTARGROUP INC COM 038336103   14,454,891 131,432 SH   DFND 1 131,432 0 0
APTIV PLC SHS G6095L109   586,719 6,300 SH   DFND 2 6,300 0 0
ARCH CAP GROUP LTD ORD G0450A105   319,666,594 5,091,854 SH   DFND 1 5,091,854 0 0
ARCUTIS BIOTHERAPEUTICS INC COM 03969K108   29,685,500 2,005,777 SH   DFND 1 2,005,777 0 0
ARES CAPITAL CORP COM 04010L103   4,685,248 253,668 SH   DFND 1 253,668 0 0
ARES MANAGEMENT CORPORATION CL A COM STK 03990B101   4,556,051 66,570 SH   DFND 1 66,570 0 0
ARISTA NETWORKS INC COM 040413106   129,486,518 1,067,050 SH   DFND 1 1,067,050 0 0
ARRAY TECHNOLOGIES INC NOTE 1.000%12/0 04271TAB6   10,981,125 10,750,000 SH   DFND 1 10,750,000 0 0
ARRAY TECHNOLOGIES INC COM SHS 04271T100   3,063,805 158,500 SH   DFND 1,2 158,500 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100   508,906 12,547 SH   DFND 1 12,547 0 0
ASPEN TECHNOLOGY INC COM 29109X106   1,906,523 9,282 SH   DFND 1 9,282 0 0
ATLASSIAN CORPORATION CL A 049468101   39,199,917 304,631 SH   DFND 1 304,631 0 0
ATRICURE INC COM 04963C209   816,548 18,399 SH   DFND 1 18,399 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104   20,137,428 2,812,490 SH   DFND 1 2,812,490 0 0
AVANTOR INC COM 05352A100   44,307,580 2,100,881 SH   DFND 1 2,100,881 0 0
AXON ENTERPRISE INC COM 05464C101   6,131,114 36,950 SH   DFND 1 36,950 0 0
AXONICS INC COM 05465P101   44,417,310 710,336 SH   DFND 1 710,336 0 0
AZENTA INC COM 114340102   322,539 5,540 SH   DFND 1 5,540 0 0
BAKER HUGHES COMPANY CL A 05722G100   11,460,563 388,099 SH   DFND 1 388,099 0 0
BANK AMERICA CORP COM 060505104   27,170,224 820,357 SH   DFND 1 820,357 0 0
BANK OF NT BUTTERFIELD&SON L SHS NEW G0772R208   4,553,984 152,767 SH   DFND 1 152,767 0 0
BECTON DICKINSON & CO COM 075887109   62,961,120 247,586 SH   DFND 1 247,586 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204   24,965,990 3,037,225 SH   DFND 1 3,037,225 0 0
BENTLEY SYS INC NOTE 0.375% 7/0 08265TAD1   6,142,500 7,500,000 SH   DFND 1 7,500,000 0 0
BERKLEY W R CORP COM 084423102   136,975,875 1,887,500 SH   DFND 1 1,887,500 0 0
BERKSHIRE HATHAWAY INC DEL CL B NEW 084670702   98,768,304 319,742 SH   DFND 1 319,742 0 0
BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108   22,200,000 750,000 SH   DFND 1 750,000 0 0
BILL COM HLDGS INC COM 090043100   62,271,076 571,504 SH   DFND 1 571,504 0 0
BIO RAD LABS INC CL A 090572207   46,272,402 110,044 SH   DFND 1 110,044 0 0
BIOGEN INC COM 09062X103   41,538,000 150,000 SH   DFND 1 150,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   18,110,750 175,000 SH   DFND 1 175,000 0 0
BIOMARIN PHARMACEUTICAL INC NOTE 0.599% 8/0 09061GAH4   18,297,360 17,200,000 SH   DFND 1 17,200,000 0 0
BIOMEA FUSION INC COM 09077A106   4,215,000 500,000 SH   DFND 1 500,000 0 0
BLACKLINE INC NOTE 3/1 09239BAD1   31,275,938 36,500,000 SH   DFND 1 36,500,000 0 0
BLOCK INC CL A 852234103   49,432,960 786,648 SH   DFND 1 786,648 0 0
BLOOMIN BRANDS INC NOTE 5.000% 5/0 094235AB4   3,655,000 2,000,000 SH   DFND 1 2,000,000 0 0
BOOKING HOLDINGS INC COM 09857L108   15,846,147 7,863 SH   DFND 1 7,863 0 0
BOOKING HOLDINGS INC NOTE 0.750% 5/0 09857LAN8   6,684,520 5,000,000 SH   DFND 1 5,000,000 0 0
BOSTON SCIENTIFIC CORP COM 101137107   102,440,993 2,213,983 SH   DFND 1 2,213,983 0 0
BRAZE INC COM CL A 10576N102   3,295,806 120,814 SH   DFND 1 120,814 0 0
BRUKER CORP COM 116794108   305,866 4,475 SH   DFND 1 4,475 0 0
CANADIAN NAT RES LTD COM 136385101   21,922,133 394,780 SH   DFND 1 394,780 0 0
CANNAE HLDGS INC COM 13765N107   15,574,519 754,214 SH   DFND 1 754,214 0 0
CASTLE BIOSCIENCES INC COM 14843C105   315,389 13,398 SH   DFND 1 13,398 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202   69,083,500 1,550,000 SH   DFND 1 1,550,000 0 0
CENOVUS ENERGY INC COM 15135U109   22,375,769 1,138,716 SH   DFND 1 1,138,716 0 0
CENTENE CORP DEL COM 15135B101   21,348,597 260,317 SH   DFND 1 260,317 0 0
CEREVEL THERAPEUTICS HLDNG I COM 15678U128   14,865,275 471,315 SH   DFND 1 471,315 0 0
CERIDIAN HCM HLDG INC NOTE 0.250% 3/1 15677JAD0   11,459,500 13,000,000 SH   DFND 1 13,000,000 0 0
CERUS CORP COM 157085101   7,421,676 2,033,336 SH   DFND 1 2,033,336 0 0
CHART INDS INC 6.75DP CNV PFD B 16115Q407   3,798,000 75,000 SH   DFND 1 75,000 0 0
CHEGG INC NOTE 9/0 163092AF6   15,888,000 20,000,000 SH   DFND 1 20,000,000 0 0
CHEMED CORP NEW COM 16359R103   5,359,515 10,500 SH   DFND 1 10,500 0 0
CHUBB LIMITED COM H1467J104   242,841,113 1,100,821 SH   DFND 1 1,100,821 0 0
CITIZENS FINL GROUP INC COM 174610105   8,491,243 215,678 SH   DFND 1 215,678 0 0
CLOUDFLARE INC CL A COM 18915M107   61,284,687 1,355,556 SH   DFND 1 1,355,556 0 0
CLOUDFLARE INC NOTE 8/1 18915MAC1   29,110,000 35,500,000 SH   DFND 1 35,500,000 0 0
COGNEX CORP COM 192422103   7,878,724 167,241 SH   DFND 1,2 167,241 0 0
COMERICA INC COM 200340107   4,174,315 62,443 SH   DFND 1 62,443 0 0
CONFLUENT INC CLASS A COM 20717M103   16,064,352 722,318 SH   DFND 1 722,318 0 0
COUPA SOFTWARE INC NOTE 0.125% 6/1 22266LAC0   27,682,050 28,500,000 SH   DFND 1 28,500,000 0 0
CROWDSTRIKE HLDGS INC CL A 22788C105   89,352,779 848,635 SH   DFND 1 848,635 0 0
CULLEN FROST BANKERS INC COM 229899109   5,333,159 39,889 SH   DFND 1 39,889 0 0
CYBERARK SOFTWARE LTD SHS M2682V108   96,009,326 740,527 SH   DFND 1 740,527 0 0
CYTOKINETICS INC COM NEW 23282W605   124,849,282 2,724,777 SH   DFND 1 2,724,777 0 0
DATADOG INC CL A COM 23804L103   5,732,706 77,996 SH   DFND 1 77,996 0 0
DATADOG INC NOTE 0.125% 6/1 23804LAB9   4,604,250 4,200,000 SH   DFND 1 4,200,000 0 0
DAY ONE BIOPHARMACEUTICALS I COM 23954D109   30,118,273 1,399,548 SH   DFND 1 1,399,548 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101   20,487,500 1,250,000 SH   DFND 1 1,250,000 0 0
DEERE & CO COM 244199105   5,940,041 13,854 SH   DFND 1 13,854 0 0
DEXCOM INC COM 252131107   72,515,046 640,366 SH   DFND 1 640,366 0 0
DEXCOM INC NOTE 0.250%11/1 252131AK3   1,638,750 1,500,000 SH   DFND 1 1,500,000 0 0
DROPBOX INC NOTE 3/0 26210CAD6   8,960,000 10,000,000 SH   DFND 1 10,000,000 0 0
EAST WEST BANCORP INC COM 27579R104   5,263,565 79,872 SH   DFND 1 79,872 0 0
EDWARDS LIFESCIENCES CORP COM 28176E108   5,675,060 76,063 SH   DFND 1 76,063 0 0
ELASTIC N V ORD SHS N14506104   56,323,130 1,093,653 SH   DFND 1 1,093,653 0 0
ELEVANCE HEALTH INC COM 036752103   20,691,158 40,336 SH   DFND 1 40,336 0 0
EMERSON ELEC CO COM 291011104   14,551,841 151,487 SH   DFND 1 151,487 0 0
ENCORE CAP EUROPE FIN LTD NOTE 4.500% 9/0 29260UAA5   2,664,000 2,250,000 SH   DFND 1 2,250,000 0 0
ENERSYS COM 29275Y102   2,325,960 31,500 SH   DFND 1,2 31,500 0 0
ENPHASE ENERGY INC COM 29355A107   64,339,177 242,826 SH   DFND 1,2 242,826 0 0
ENTERPRISE FINL SVCS CORP COM 293712105   5,254,289 107,318 SH   DFND 1 107,318 0 0
ENVISTA HOLDINGS CORPORATION COM 29415F104   7,786,423 231,257 SH   DFND 1 231,257 0 0
ESQUIRE FINL HLDGS INC COM 29667J101   537,981 12,436 SH   DFND 1 12,436 0 0
ESSENT GROUP LTD COM G3198U102   125,874,000 3,237,500 SH   DFND 1 3,237,500 0 0
ETSY INC NOTE 0.125%10/0 29786AAJ5   5,733,150 3,700,000 SH   DFND 1 3,700,000 0 0
EVEREST RE GROUP LTD COM G3223R108   96,068,300 290,000 SH   DFND 1 290,000 0 0
EVOLENT HEALTH INC CL A 30050B101   1,310,578 46,673 SH   DFND 1 46,673 0 0
EXACT SCIENCES CORP COM 30063P105   214,626 4,335 SH   DFND 1 4,335 0 0
EXELIXIS INC COM 30161Q104   41,237,204 2,570,898 SH   DFND 1 2,570,898 0 0
FARFETCH LTD ORD SH CL A 30744W107   3,477,983 735,303 SH   DFND 1 735,303 0 0
FERGUSON PLC NEW SHS G3421J106   25,173,707 198,265 SH   DFND 1 198,265 0 0
FIRST AMERN FINL CORP COM 31847R102   54,957,000 1,050,000 SH   DFND 1 1,050,000 0 0
FIRST REP BK SAN FRANCISCO C COM 33616C100   15,778,782 129,451 SH   DFND 1 129,451 0 0
FIRST SOLAR INC COM 336433107   26,857,347 179,300 SH   DFND 1,2 179,300 0 0
FISERV INC COM 337738108   19,834,482 196,245 SH   DFND 1 196,245 0 0
FLYWIRE CORPORATION COM VTG 302492103   15,426,035 630,406 SH   DFND 1 630,406 0 0
FRESHWORKS INC CLASS A COM 358054104   42,565,327 2,893,632 SH   DFND 1 2,893,632 0 0
GITLAB INC CLASS A COM 37637K108   68,160,227 1,500,005 SH   DFND 1 1,500,005 0 0
GLOBANT S A COM L44385109   50,829,387 302,268 SH   DFND 1 302,268 0 0
GLOBUS MED INC CL A 379577208   53,730,929 723,454 SH   DFND 1 723,454 0 0
GOLUB CAP BDC INC COM 38173M102   3,730,005 283,435 SH   DFND 1 283,435 0 0
GUARDANT HEALTH INC NOTE 11/1 40131MAB5   11,440,925 18,250,000 SH   DFND 1 18,250,000 0 0
H WORLD GROUP LTD SPONSORED ADS 44332N106   479,176 11,296 SH   DFND 1 11,296 0 0
H WORLD GROUP LTD NOTE 3.000% 5/0 44332NAB2   6,127,500 5,000,000 SH   DFND 1 5,000,000 0 0
HAGERTY INC CL A COM 405166109   38,066,831 4,526,377 SH   DFND 1 4,526,377 0 0
HALOZYME THERAPEUTICS INC NOTE 0.250% 3/0 40637HAD1   2,432,813 2,500,000 SH   DFND 1 2,500,000 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104   29,441,308 534,325 SH   DFND 1 534,325 0 0
HASHICORP INC COM CL A 418100103   4,522,009 165,399 SH   DFND 1 165,399 0 0
HCA HEALTHCARE INC COM 40412C101   20,219,989 84,264 SH   DFND 1 84,264 0 0
HEALTH CATALYST INC COM 42225T107   283,183 26,640 SH   DFND 1 26,640 0 0
HUBSPOT INC COM 443573100   130,193,215 450,293 SH   DFND 1 450,293 0 0
HUMANA INC COM 444859102   11,426,447 22,309 SH   DFND 1 22,309 0 0
ICON PLC SHS G4705A100   17,186,075 88,474 SH   DFND 1 88,474 0 0
IMPINJ INC COM 453204109   5,264,878 48,222 SH   DFND 1 48,222 0 0
INCYTE CORP COM 45337C102   99,200,983 1,235,072 SH   DFND 1 1,235,072 0 0
INFINITY PHARMACEUTICALS INC COM 45665G303   1,149,539 2,071,242 SH   DFND 1 2,071,242 0 0
INSMED INC COM PAR $.01 457669307   30,796,153 1,541,349 SH   DFND 1 1,541,349 0 0
INSULET CORP COM 45784P101   3,711,080 12,606 SH   DFND 1 12,606 0 0
INTERCONTINENTAL EXCHANGE IN COM 45866F104   20,882,605 203,554 SH   DFND 1 203,554 0 0
INTRA-CELLULAR THERAPIES INC COM 46116X101   23,738,854 448,580 SH   DFND 1 448,580 0 0
INTUIT COM 461202103   15,874,727 40,786 SH   DFND 1 40,786 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602   68,357,079 257,611 SH   DFND 1 257,611 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106   538,603 5,750 SH   DFND 1 5,750 0 0
ITRON INC COM 465741106   3,190,950 63,000 SH   DFND 1,2 63,000 0 0
IVERIC BIO INC COM 46583P102   40,007,325 1,868,628 SH   DFND 1 1,868,628 0 0
JAMES RIV GROUP LTD COM G5005R107   24,569,250 1,175,000 SH   DFND 1 1,175,000 0 0
JD.COM INC SPON ADR CL A 47215P106   483,055 8,606 SH   DFND 1 8,606 0 0
JOHNSON & JOHNSON COM 478160104   63,803,507 361,186 SH   DFND 1 361,186 0 0
JPMORGAN CHASE & CO COM 46625H100   34,325,979 255,973 SH   DFND 1 255,973 0 0
KE HLDGS INC SPONSORED ADS 482497104   260,508 18,661 SH   DFND 1 18,661 0 0
KLA CORP COM NEW 482480100   160,267,158 425,078 SH   DFND 1 425,078 0 0
KORNIT DIGITAL LTD SHS M6372Q113   20,606,203 897,092 SH   DFND 1 897,092 0 0
LANTHEUS HLDGS INC COM 516544103   757,011 14,855 SH   DFND 1 14,855 0 0
LATTICE SEMICONDUCTOR CORP COM 518415104   129,516,765 1,996,251 SH   DFND 1,2 1,996,251 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102   52,958,481 1,060,867 SH   DFND 1 1,060,867 0 0
LIBERTY MEDIA CORP DEL COM SER C FRMLA 531229854   8,980,570 150,227 SH   DFND 1 150,227 0 0
LILLY ELI & CO COM 532457108   55,627,070 152,053 SH   DFND 1 152,053 0 0
LINDE PLC SHS G5494J103   24,732,925 75,826 SH   DFND 1,2 75,826 0 0
LITTELFUSE INC COM 537008104   8,300,219 37,694 SH   DFND 1 37,694 0 0
LIVANOVA PLC SHS G5509L101   38,422,516 691,799 SH   DFND 1 691,799 0 0
LIVENT CORP COM 53814L108   366,602 18,450 SH   DFND 1,2 18,450 0 0
LPL FINL HLDGS INC COM 50212V100   10,469,762 48,433 SH   DFND 1 48,433 0 0
MACOM TECH SOLUTIONS HLDGS I NOTE 0.250% 3/1 55405YAB6   3,978,000 4,000,000 SH   DFND 1 4,000,000 0 0
MARKEL CORP COM 570535104   167,979,975 127,500 SH   DFND 1 127,500 0 0
MARRIOTT VACATIONS WORLDWIDE NOTE 1/1 57164YAD9   3,430,000 3,500,000 SH   DFND 1 3,500,000 0 0
MARSH & MCLENNAN COS INC COM 571748102   220,467,349 1,332,290 SH   DFND 1 1,332,290 0 0
MARVELL TECHNOLOGY INC COM 573874104   94,213,351 2,543,557 SH   DFND 1,2 2,543,557 0 0
MASTERCARD INCORPORATED CL A 57636Q104   116,406,095 334,760 SH   DFND 1 334,760 0 0
MAXEON SOLAR TECHNOLOGIES LT SHS Y58473102   754,820 47,000 SH   DFND 1,2 47,000 0 0
MERCADOLIBRE INC COM 58733R102   91,041,884 107,584 SH   DFND 1 107,584 0 0
MERIT MED SYS INC COM 589889104   39,776,786 563,251 SH   DFND 1 563,251 0 0
MERUS N V COM N5749R100   11,602,500 750,000 SH   DFND 1 750,000 0 0
META PLATFORMS INC CL A 30303M102   58,423,385 485,486 SH   DFND 1 485,486 0 0
MICRON TECHNOLOGY INC COM 595112103   8,413,583 168,339 SH   DFND 1 168,339 0 0
MICROSOFT CORP COM 594918104   724,694,311 3,021,826 SH   DFND 1 3,021,826 0 0
MIDDLEBY CORP NOTE 1.000% 9/0 596278AB7   1,770,750 1,500,000 SH   DFND 1 1,500,000 0 0
MIRUM PHARMACEUTICALS INC COM 604749101   16,670,687 854,907 SH   DFND 1 854,907 0 0
MKS INSTRS INC COM 55306N104   9,537,802 112,567 SH   DFND 1 112,567 0 0
MOLINA HEALTHCARE INC COM 60855R100   66,679,013 201,923 SH   DFND 1 201,923 0 0
MONGODB INC CL A 60937P106   51,329,179 260,766 SH   DFND 1 260,766 0 0
MONOLITHIC PWR SYS INC COM 609839105   105,064,603 297,120 SH   DFND 1,2 297,120 0 0
MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD 61559X104   9,201,959 876,377 SH   DFND 1 876,377 0 0
MORGAN STANLEY COM NEW 617446448   8,529,036 100,318 SH   DFND 1 100,318 0 0
MORPHIC HLDG INC COM 61775R105   8,693,750 325,000 SH   DFND 1 325,000 0 0
MP MATERIALS CORP COM CL A 553368101   6,968,360 287,000 SH   DFND 1,2 287,000 0 0
MSCI INC COM 55354G100   11,425,040 24,561 SH   DFND 1 24,561 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109   30,116,486 3,778,731 SH   DFND 1 3,778,731 0 0
NATERA INC COM 632307104   1,013,007 25,218 SH   DFND 1 25,218 0 0
NCL CORP LTD NOTE 5.375% 8/0 62886HAX9   5,776,950 5,700,000 SH   DFND 1 5,700,000 0 0
NETEASE INC SPONSORED ADS 64110W102   273,670 3,768 SH   DFND 1 3,768 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109   20,776,110 173,946 SH   DFND 1 173,946 0 0
NORFOLK SOUTHN CORP COM 655844108   15,026,938 60,981 SH   DFND 1 60,981 0 0
NUTANIX INC NOTE 0.250%10/0 67059NAH1   30,302,415 36,010,000 SH   DFND 1 36,010,000 0 0
NVIDIA CORPORATION COM 67066G104   189,483,955 1,296,592 SH   DFND 1 1,296,592 0 0
NXP SEMICONDUCTORS N V COM N6596X109   521,499 3,300 SH   DFND 2 3,300 0 0
OMNICELL COM COM 68213N109   672,704 13,342 SH   DFND 1 13,342 0 0
ON SEMICONDUCTOR CORP COM 682189105   38,765,325 621,538 SH   DFND 1,2 621,538 0 0
OPTION CARE HEALTH INC COM NEW 68404L201   69,487,168 2,309,311 SH   DFND 1 2,309,311 0 0
ORGANON & CO COMMON STOCK 68622V106   588,150 21,058 SH   DFND 1 21,058 0 0
OVINTIV INC COM 69047Q102   23,629,947 465,982 SH   DFND 1 465,982 0 0
PACIRA BIOSCIENCES INC COM 695127100   486,293 12,595 SH   DFND 1 12,595 0 0
PALO ALTO NETWORKS INC COM 697435105   81,176,697 581,745 SH   DFND 1 581,745 0 0
PAYCOM SOFTWARE INC COM 70432V102   6,107,832 19,683 SH   DFND 1 19,683 0 0
PAYPAL HLDGS INC COM 70450Y103   278,969 3,917 SH   DFND 1 3,917 0 0
PENUMBRA INC COM 70975L107   79,398,866 356,913 SH   DFND 1 356,913 0 0
PINTEREST INC CL A 72352L106   54,976,111 2,264,255 SH   DFND 1 2,264,255 0 0
PLIANT THERAPEUTICS INC COM 729139105   31,569,060 1,633,164 SH   DFND 1 1,633,164 0 0
PLUG POWER INC COM NEW 72919P202   2,894,580 234,000 SH   DFND 1,2 234,000 0 0
PNC FINL SVCS GROUP INC COM 693475105   13,800,165 87,376 SH   DFND 1 87,376 0 0
POWER INTEGRATIONS INC COM 739276103   34,488,785 480,881 SH   DFND 1,2 480,881 0 0
PRIVIA HEALTH GROUP INC COM 74276R102   585,123 25,765 SH   DFND 1 25,765 0 0
PROASSURANCE CORP COM 74267C106   39,307,500 2,250,000 SH   DFND 1 2,250,000 0 0
PROGRESSIVE CORP COM 743315103   87,554,250 675,000 SH   DFND 1 675,000 0 0
PROGYNY INC COM 74340E103   453,482 14,558 SH   DFND 1 14,558 0 0
PURE STORAGE INC CL A 74624M102   84,420,280 3,154,719 SH   DFND 1 3,154,719 0 0
QIAGEN NV SHS NEW N72482123   18,364,079 368,239 SH   DFND 1 368,239 0 0
QORVO INC COM 74736K101   6,943,024 76,600 SH   DFND 1,2 76,600 0 0
QUALCOMM INC COM 747525103   100,469,878 913,861 SH   DFND 1 913,861 0 0
QUALTRICS INTL INC COM CL A 747601201   5,016,270 483,263 SH   DFND 1 483,263 0 0
QUIDELORTHO CORP COM 219798105   588,981 6,875 SH   DFND 1 6,875 0 0
R1 RCM INC COM 77634L105   9,737,901 889,306 SH   DFND 1 889,306 0 0
REGENERON PHARMACEUTICALS COM 75886F107   84,775,075 117,500 SH   DFND 1 117,500 0 0
REGIONS FINANCIAL CORP NEW COM 7591EP100   4,563,842 211,681 SH   DFND 1 211,681 0 0
REINSURANCE GRP OF AMERICA I COM NEW 759351604   104,791,375 737,500 SH   DFND 1 737,500 0 0
RENAISSANCERE HLDGS LTD COM G7496G103   202,297,805 1,098,072 SH   DFND 1 1,098,072 0 0
REPLIGEN CORP COM 759916109   423,275 2,500 SH   DFND 1 2,500 0 0
REVANCE THERAPEUTICS INC COM 761330109   89,505,765 4,848,633 SH   DFND 1 4,848,633 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105   36,400,000 1,250,000 SH   DFND 1 1,250,000 0 0
RLI CORP COM 749607107   36,755,600 280,000 SH   DFND 1 280,000 0 0
ROBLOX CORP CL A 771049103   29,623,672 1,040,888 SH   DFND 1 1,040,888 0 0
ROCKWELL AUTOMATION INC COM 773903109   5,076,190 19,708 SH   DFND 1 19,708 0 0
ROYAL BK CDA SUSTAINABL COM 780087102   6,664,608 70,885 SH   DFND 1 70,885 0 0
RYAN SPECIALTY HOLDINGS INC CL A 78351F107   57,076,250 1,375,000 SH   DFND 1 1,375,000 0 0
S&P GLOBAL INC COM 78409V104   6,172,274 18,428 SH   DFND 1 18,428 0 0
SABRE CORP COM 78573M104   6,435,067 1,041,273 SH   DFND 1 1,041,273 0 0
SALESFORCE INC COM 79466L302   59,352,853 447,642 SH   DFND 1 447,642 0 0
SANOFI SPONSORED ADR 80105N105   54,483,750 1,125,000 SH   DFND 1 1,125,000 0 0
SAREPTA THERAPEUTICS INC DEBT 1.250% 9/1 803607AC4   10,996,250 9,500,000 SH   DFND 1 9,500,000 0 0
SCHWAB CHARLES CORP COM 808513105   9,572,819 114,975 SH   DFND 1 114,975 0 0
SEA LTD SPONSORD ADS 81141R100   24,468,877 470,284 SH   DFND 1 470,284 0 0
SEA LTD NOTE 2.375%12/0 81141RAF7   5,131,880 5,200,000 SH   DFND 1 5,200,000 0 0
SEAGEN INC COM 81181C104   106,101,968 825,632 SH   DFND 1 825,632 0 0
SERVICE CORP INTL COM 817565104   12,290,672 177,765 SH   DFND 1 177,765 0 0
SERVICENOW INC COM 81762P102   187,154,294 482,021 SH   DFND 1 482,021 0 0
SHIFT4 PMTS INC NOTE 12/1 82452JAB5   8,213,906 8,250,000 SH   DFND 1 8,250,000 0 0
SHOPIFY INC CL A 82509L107   78,640,677 2,265,649 SH   DFND 1 2,265,649 0 0
SIGNATURE BK NEW YORK N Y COM 82669G104   9,422,461 81,778 SH   DFND 1 81,778 0 0
SILICON LABORATORIES INC NOTE 0.625% 6/1 826919AD4   3,940,070 3,141,000 SH   DFND 1 3,141,000 0 0
SITIME CORP COM 82982T106   51,844,492 510,180 SH   DFND 1 510,180 0 0
SMARTSHEET INC COM CL A 83200N103   76,185,334 1,935,603 SH   DFND 1 1,935,603 0 0
SNAP INC NOTE 0.750% 8/0 83304AAB2   1,276,125 1,500,000 SH   DFND 1 1,500,000 0 0
SNOWFLAKE INC CL A 833445109   69,413,647 483,584 SH   DFND 1 483,584 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104   70,525,449 248,969 SH   DFND 1,2 248,969 0 0
SOLAREDGE TECHNOLOGIES INC NOTE 9/1 83417MAD6   16,204,500 13,000,000 SH   DFND 1 13,000,000 0 0
SOUTHWEST AIRLS CO NOTE 1.250% 5/0 844741BG2   8,433,250 7,000,000 SH   DFND 1 7,000,000 0 0
SS&C TECHNOLOGIES HLDGS INC COM 78467J100   18,963,167 364,256 SH   DFND 1 364,256 0 0
SSR MNG INC NOTE 2.500% 4/0 784730AB9   11,268,778 10,039,000 SH   DFND 1 10,039,000 0 0
STEREOTAXIS INC COM NEW 85916J409   158,742 76,687 SH   DFND 1 76,687 0 0
STRYKER CORPORATION COM 863667101   7,203,164 29,462 SH   DFND 1 29,462 0 0
SUNPOWER CORP COM 867652406   2,199,660 122,000 SH   DFND 1,2 122,000 0 0
SUNRUN INC COM 86771W105   5,572,640 232,000 SH   DFND 1,2 232,000 0 0
SUPERNUS PHARMACEUTICALS INC COM 868459108   36,352,010 1,019,120 SH   DFND 1 1,019,120 0 0
SURGERY PARTNERS INC COM 86881A100   405,419 14,552 SH   DFND 1 14,552 0 0
TAKE-TWO INTERACTIVE SOFTWAR COM 874054109   1,200,098 11,525 SH   DFND 1 11,525 0 0
TANDEM DIABETES CARE INC COM NEW 875372203   921,745 20,506 SH   DFND 1 20,506 0 0
TE CONNECTIVITY LTD SHS H84989104   8,215,892 71,567 SH   DFND 1,2 71,567 0 0
TECK RESOURCES LTD CL B 878742204   12,906,415 341,259 SH   DFND 1 341,259 0 0
TENET HEALTHCARE CORP COM NEW 88033G407   10,831,038 221,993 SH   DFND 1 221,993 0 0
TERADYNE INC COM 880770102   46,600,614 533,493 SH   DFND 1 533,493 0 0
TESLA INC COM 88160R101   27,326,744 221,844 SH   DFND 1 221,844 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102   7,454,140 13,536 SH   DFND 1 13,536 0 0
T-MOBILE US INC COM 872590104   25,122,720 179,448 SH   DFND 1 179,448 0 0
TORONTO DOMINION BK ONT COM NEW 891160509   15,117,833 233,444 SH   DFND 1 233,444 0 0
TRAVELERS COMPANIES INC COM 89417E109   133,026,592 709,513 SH   DFND 1 709,513 0 0
TRIMBLE INC COM 896239100   404,480 8,000 SH   DFND 2 8,000 0 0
TRIP COM GROUP LTD ADS 89677Q107   60,711,459 1,764,868 SH   DFND 1 1,764,868 0 0
TRIPADVISOR INC COM 896945201   39,281,787 2,184,749 SH   DFND 1 2,184,749 0 0
TRUPANION INC COM 898202106   48,718,250 1,025,000 SH   DFND 1 1,025,000 0 0
UBER TECHNOLOGIES INC COM 90353T100   11,790,398 476,765 SH   DFND 1,2 476,765 0 0
UBS GROUP AG SHS H42097107   11,294,773 626,773 SH   DFND 1 626,773 0 0
UNION PAC CORP COM 907818108   13,905,786 67,155 SH   DFND 1 67,155 0 0
UNITED RENTALS INC COM 911363109   33,204,403 93,423 SH   DFND 1 93,423 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102   90,349,494 324,893 SH   DFND 1 324,893 0 0
UNITEDHEALTH GROUP INC COM 91324P102   60,146,270 113,445 SH   DFND 1 113,445 0 0
US BANCORP DEL COM NEW 902973304   10,004,701 229,413 SH   DFND 1 229,413 0 0
US FOODS HLDG CORP COM 912008109   26,847,665 789,173 SH   DFND 1 789,173 0 0
VAIL RESORTS INC NOTE 1/0 91879QAN9   35,901,250 38,500,000 SH   DFND 1 38,500,000 0 0
VEEVA SYS INC CL A COM 922475108   16,468,990 102,051 SH   DFND 1 102,051 0 0
VERADIGM INC COM 01988P108   491,362 27,855 SH   DFND 1 27,855 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100   83,746,200 290,000 SH   DFND 1 290,000 0 0
VERTIV HOLDINGS CO COM CL A 92537N108   7,629,110 558,500 SH   DFND 1,2 558,500 0 0
VISA INC COM CL A 92826C839   178,884,061 861,013 SH   DFND 1 861,013 0 0
VISTEON CORP COM NEW 92839U206   588,735 4,500 SH   DFND 2 4,500 0 0
WALMART INC COM 931142103   8,267,208 58,306 SH   DFND 1 58,306 0 0
WELLS FARGO CO NEW COM 949746101   21,015,536 508,974 SH   DFND 1 508,974 0 0
WORKDAY INC CL A 98138H101   76,793,594 458,935 SH   DFND 1 458,935 0 0
XENON PHARMACEUTICALS INC COM 98420N105   120,098,812 3,045,874 SH   DFND 1 3,045,874 0 0
Y-MABS THERAPEUTICS INC COM 984241109   9,720,614 1,991,929 SH   DFND 1 1,991,929 0 0
ZAI LAB LTD ADR 98887Q104   5,365,623 174,776 SH   DFND 1 174,776 0 0