EX-99.1 2 ea169983ex99-1_oramed.htm INVESTOR PRESENTATION DATED DECEMBER 12, 2022

Exhibit 99.1

Safe Harbor 1 Oramed Pharmaceuticals Inc. © 2022 This presentation contains forward - looking statements. For example, we are using forward - looking statements when we discuss clinical trials, including the timing thereof and potential approvals of products, catalysts and milestones, pipeline and the potential benefits of products, including in each case those of Oravax. These forward - looking statements are based on the current expectations of the management of Oramed only, and are subject to a number of factors and uncertainties that could cause actual results to differ materially from those described in the forward - looking statements, including the risks and uncertainties related to the progress, timing, cost, and results of clinical trials and product development programs; difficulties or delays in obtaining regulatory approval or patent protection for our product candidates; competition from other pharmaceutical or biotechnology companies; and our ability to obtain additional funding required to conduct our research, development and commercialization activities. In addition, the following factors, among others, could cause actual results to differ materially from those described in the forward - looking statements: changes in technology and market requirements; delays or obstacles in launching our clinical trials; changes in legislation; inability to timely develop and introduce new technologies, products and applications; lack of validation of our technology as we progress further and lack of acceptance of our methods by the scientific community; inability to retain or attract key employees whose knowledge is essential to the development of our products; unforeseen scientific difficulties that may develop with our process; greater cost of final product than anticipated; loss of market share and pressure on pricing resulting from competition; laboratory results that do not translate to equally good results in real settings; our patents may not be sufficient; and finally that products may harm recipients, all of which could cause the actual results or performance of Oramed to differ materially from those contemplated in such forward - looking statements. Except as otherwise required by law, Oramed undertakes no obligation to publicly release any revisions to these forward - looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events. For a more detailed description of the risks and uncertainties affecting Oramed, reference is made to Oramed’ s reports filed from time to time with the Securities and Exchange Commission.

Oramed Snapshot COMPANY OVERVIEW • Proprietary oral protein delivery platform • Diabetes first - initially targeting the lucrative insulin market • NASDAQ/TASE: ORMP COMPANY MANAGEMENT • Experienced management team backed by world - class scientific experts SIGNIFICANT PIPELINE, IP, AND CATALYSTS • Robust pipeline leveraging IP portfolio for additional significant market opportunities • 88 granted patents, 35 pending patent applications, worldwide • Multiple value - creation events for 2023 2 Oramed Pharmaceuticals Inc. © 2022 KEY FINANCIAL METRICS • Strong financial position • ~$160M 1 in cash and investments • No debt 1 As of September 30, 2022 (unaudited)

4Q’22 1Q’23 2Q’23 Upcoming Catalysts Oral Insulin: Phase 3 - 1 Top Line Data Oravax: Phase 1 Cohort B Data GLP - 1: Bioavailability Study Data 3 Oramed Pharmaceuticals Inc. © 2022 Oral Insulin: Phase 3 - 2 100% Enrollment

Proprietary Technology for Oral Drug Delivery Proteins and Peptides do Not Survive the Digestive System Oramed Technology Protects Drug Integrity and Increases Absorption Harsh pH Stomach acidity cleaves and shreds protein Protease attack Proteases attack and break down proteins Absorption barrier Therapeutic proteins fail to be absorbed via the intestinal wall (barrier) pH shield Sensitive enteric coating protects capsule contents before entering small intestine Protease protection Protease inhibitors protect the active agent Absorption enhancement Assists the permeation of proteins/ peptides across intestinal membrane and into bloodstream 4 Oramed Pharmaceuticals Inc. © 2022

Multiple Clinical - Stage Programs PHASE 1 PHASE 2 PHASE 3 ORMD - 0801 (Oral Insulin) Diabetes ORMD - 0801 (Oral Insulin) NASH ORMD - 0901 (Oral GLP - 1) Oravax’s Oral Covid - 19 Vaccine Phase 1 Trials Ongoing 5 Oramed Pharmaceuticals Inc. © 2022

Oram e Oram e d d Pharma c Pharma c e e ut i ut i c c a l a l s s I I n c n c . . © © 2 2 02 2 022 Diabetes: Millions of diabetics inject insulin today and wish for oral dosage 6

Oramed Pharmaceuticals Inc. © 2022 1 in 10 Adults Globally Have Diabetes In 2021 diabetes expenditure reached US $ 966 billion ~10 % Healthcare spent on diabetes +246 Million Expected increase 2021 2045 Every 5 SECONDS 1 adult dies from diabetes 6.7M deaths in 2021 WORLD 537 M People live with diabetes PREVALENCE 10% WP SEA MENA SACA EUR MAC AFR 7

Oram e Oram e d d Pharma c Pharma c e e ut i ut i c c a l a l s s I I n c n c . . © © 2 2 02 2 022 ORMD - 0801: Oral Insulin 8

Oral Insulin Mimics the Delivery of Endogenous Insulin ORMD - 0801 is delivered orally with first pass metabolism occurring in the liver, mimicking endogenous insulin regulation before reaching the bloodstream, thus reducing risks and complications associated with injectable insulin and enabling earlier patient engagement Injectable insulin is introduced directly to the bloodstream, with only a small fraction reaching the liver, where endogenous insulin is regulated Injectable Insulin Current Oral Insulin Future ORMD - 0801 delivered via POD technology Local absorption in small intestine Insulin reaches liver via portal vein First pass metabolism and regulation in the liver 9 Oramed Pharmaceuticals Inc. © 2022

Oral Insulin: Significant Advantages Over Injectable Insulins IMPROVED BLOOD GLUCOSE CONTROL Insulin is regulated endogenously in the liver, limiting the amount of excess systemic insulin that can lead to hypo/ hyper - glycemic events. NO WEIGHT GAIN Better insulin control prevents cells from absorbing excess glucose that can be converted to fat and lead to weight gain EASE OF ADMINISTRATION Oral delivery benefits diabetic patients with a fear of needles and should improve patient administration and compliance 10 Oramed Pharmaceuticals Inc. © 2022

ORMD - 0801 for Type 1 & Type 2 Diabetes 11 Oramed Pharmaceuticals Inc. © 2022 TYPE 1 DIABETES • T1D is autoimmune: The body destroys its own insulin - producing (beta) cells, leaving patients completely dependent on external insulin sources • 10% of diabetics have T1D: Up to 54 million people worldwide have T1D • Projected Market: $24 billion by 2029 Diabetes inhibits the production of sufficient insulin and causes elevated levels of glucose in the blood TYPE 2 DIABETES • T2D is metabolic: The body becomes insulin resistant. Injections may be used to make up for the pancreas’s inability to create sufficient insulin to keep blood sugar at normal levels • 483 million people worldwide need treatment • Projected Market: $92 billion by 2029

ORMD - 0801 for Type 1 Diabetes (T1D) T1D PATIENTS ARE TREATED WITH VARIOUS TYPES OF INSULIN REPLACEMENT THERAPY Long - acting insulin (basal) helps maintain stable insulin levels during fasting periods Rapid - acting insulin (bolus) prior to each meal to stabilize blood sugar Administration is via injection or pump 12 Oramed Pharmaceuticals Inc. © 2022 ORAMED ORAL INSULIN Easier use and reduced systemic exposure Potentially reducing multiple daily injections Tighter regulation and control of blood sugar levels by directly targeting liver glucose (TiR), due to portal administration

Phase 2a Trial in T1D Completed 25 T1D patients 7 Days of treatment 3 Times a day (at mealtime) By directly targeting liver glucose, ORMD - 0801 may provide tighter blood sugar regulation and control for the ~1.6M¹ Type 1 diabetes patients in the US – potentially reducing the need for multiple daily injections, including mealtime insulin. Oral Insulin Reduces Exogenous Insulin Requirements • Oral insulin met primary endpoint of reducing exogenous insulin requirements in Phase 2a T1D study • Oral insulin decreased use of rapid - acting insulin, level of post - meal glucose, and levels of daytime glucose • Additionally, day and night blood glucose levels were lower compared to control group T1D Phase 2a Highlights ² Delta basal insulin Delta bolus insulin Delta FPG 13 Oramed Pharmaceuticals Inc. © 2022

Phase 2 – Completed 180 Patient Trial for T2D ¹ Trial only had 1 dose level, but patients were given either a full dose, or 1.5 doses. ² Based on 2 nights of CGM data by comparison of the mean percent change between Baseline and Week 4 of ORMD - 0801 and placebo groups 33 US Sites 180 Patients 28 Day Treatment 2 Dose Groups 28 Day Treatment ¹ Design Study Population Endpoints Dose Cohorts Double - blind, randomized, placebo - controlled, 4 week, once daily (3 capsules) treatment Enrolled patients with T2D who (1) are being treated by diet and exercise, (2) are untreated with antidiabetic medications, or (3) are treated with metformin as a monotherapy or in combination with one other antidiabetic drug (excluding insulin) • Primary: mean nighttime glucose levels ² • Secondary: mean 24 - hour glucose ¹ , percent change in CGM mean fasting glucose between treatment and run - in; change from baseline to Week 4 of morning fasting c - peptide; percent change in A1C from Baseline to Week 4 • Placebo: 3x placebo capsules • Active: 16mg (1 dose/capsule) and 24mg (1.5 dose/capsule) 14 Oramed Pharmaceuticals Inc. © 2022

Phase 2 Trial Demonstrated No Drug Related Serious Adverse Events and Promising Efficacy on CGM Parameters • Achieved primary endpoint and showed significant positive effects • Safe/well - tolerated with no drug related serious adverse events • Dose groups 1 & 2 are pooled on weighted mean nighttime glucose levels • All ORMD - 0801 values statistically significant versus the placebo (p - Value<0.05) (*) Indicates statistically significant difference versus placebo (p - Value <0.05) • ORMD - 0801 showed promising reductions in mean 24 - hour, fasting, and daytime glucose levels • All ORMD - 0801 values statistically significant versus the placebo (p - Value<0.05) 1st Primary Endpoint 2nd Exploratory Endpoints 15 Oramed Pharmaceuticals Inc. © 2022

Phase 2b – Completed 298 Patient Trial for T2D (1) 36 Sites: 2 sites (49 subjects) were excluded due to significant treatment by center interaction; 347 subjects received primary treatment and had baseline A1c (included in ITT); 298 subjects included in primary analysis; 266 included in final analysis (Week 12 A1C results) 34 US Sites ¹ 298 Patients ¹ 90 Day Treatment 7 Dose Groups 28 Day Treatment Design Study Population Endpoints Dose Cohorts Double - blind, randomized, placebo - controlled, 12 - week, once/twice/or three times daily treatment Patients with T2D who are taking metformin only (at least 1500 mg or maximally tolerated dose) or metformin in addition to no more than two of the following: Glibenclamide, Glipizide, Empagliflozin, Pioglitazone, Glimepiride, Dapagliflozin, Sitagliptin, Glibomet, Ertugliflozin • Primary: mean change in A1C from Baseline to Week 12 of treatment period • Secondary: safety (AES, hypoglycemic events); fasting plasma glucose (FPG) + CGM; weight Placebo comparator for each cohort 8 mg/day (8 mg, 1x/day) 16 mg/day (8 mg, 2x/day or 16 mg, 1x/day) 32 mg/day (32 mg, 1x/day or 16 mg, 2x/day) 64 mg/day (32 mg, 2x/day) 96 mg/day (32 mg, 3x/day) 16 Oramed Pharmaceuticals Inc. © 2022

ORMD - 0801 Phase 2b Achieved Safety and Primary Endpoints • Achieved primary efficacy endpoint in reduction in A1C at Week 12 • The 8 mg once - daily and twice - daily arms achieved statistically significant values at Week 12 vs. Placebo (p - value 0.028 and 0.029, respectively) 17 Oramed Pharmaceuticals Inc. © 2022

ORMD - 0801 Phase 2b Exhibited Strong A1C Lowering Activity at 8 mg 1x/Day Dose Significant A1C lowering with 8 mg, 1x/day dose • 8 mg 1x/day showed 0.95 (0.81 placebo adjusted) reduction in A1C (p=0.028) • 8 mg 1x/day for patients with baseline A1C >9% showed 1.40 (1.26 placebo adjusted) reduction in A1C ORMD - 0801 upheld safety profile previously exhibited in first Phase 2 study No increase in Serious Adverse Events compared to Placebo No increase in Hypoglycemic Events compared to Placebo • 6.1% (5/82) of subjects in placebo group compared to 0% (0/15) of subjects in 8mg 1x/day had at least 1 hypoglycemic event No weight gain compared to Placebo at Week 12 18 Oramed Pharmaceuticals Inc. © 2022

FDA Phase 2b Trial Results Primary Endpoint Successfully Met Significant HbA1c lowering with 1X/daily treatment: • No increase in Adverse Events compared to Placebo • No increase in Hypoglycemic Events compared to Placebo • No weight gain compared to Placebo 19 Oramed Pharmaceuticals Inc. © 2022 Gain 12 - year marketing exclusivity upon FDA approval Safe and well tolerated FDA BLA Pathway: • Confirmatory Phase 3 Study • Submission to FDA

Oram e Oram e d d Pharma c Pharma c e e ut i ut i c c a l a l s s I I n c n c . . © © 2 2 02 2 022 Phase 3 Trials: Maximizing ORMD - 0801’s Success in the Market 20

Two Pivotal Phase 3 Trials will Maximize ORMD - 0801’s Success in the Market: ORA - D - 013 - 1 Patient Type Design & Dosing Trial Endpoints Type 2 Diabetes Mellitus with Inadequate Glycemic Control on Two or Three Oral Glucose - Lowering Agents • 710 subjects • Reached 100% randomization • US - based Double Blind, Double Dummy, 2:2:1:1 randomization 8 mg 2x/day at night and 45 mins before breakfast Placebo 2 x/day at night and 45 mins before breakfast • To compare the efficacy of ORMD - 0801 to a placebo in improving glycemic control over a 26 - week period • To evaluate the safety of ORMD - 0801 over a 52 - week period 8 mg 1x/day at night and placebo 45 mins before breakfast 21 Oramed Pharmaceuticals Inc. © 2022

Two Pivotal Phase 3 Trials will Maximize ORMD - 0801’s Success in the Market: ORA - D - 013 - 2 Patient Type Design & Dosing Trial Endpoints Type 2 Diabetes Mellitus with Inadequate Glycemic Control on Diet Control Alone or on Diet Control and Metformin Monotherapy • 450 subjects (including naïve patients to 1L therapy - metformin) • Reached over 50% randomization • US, European and Israel - based Double Blind, 1:1 randomization 8mg at night Placebo at night • To compare the efficacy of ORMD - 0801 to a placebo in improving glycemic control over a 26 - week period • To evaluate the safety of ORMD - 0801 over a 52 - week period 22 Oramed Pharmaceuticals Inc. © 2022

HCPs Were Receptive to Prescribing Oral Insulins and ORMD - 0801, If Approved Most of the prescribers (85%+) were willing to prescribe oral insulins or ORMD - 0801, if approved Future Willingness to Prescribe (n=170) Q: What is your willingness to prescribe oral insulins for T2D patients, if oral insulins were launched in the market? Q: What is your willingness to prescribe Product X (ORMD - 0801) for T2D patients, if it was launched in the market? Source: IQVIA market research of treating physicians (n=170 Endos and PCPs) in the US and Europe (UK/EU4), December 2021 No HCPs listed that they would definitely not prescribe the product, indicating high interest ORMD - 0801 appears to meet physician expectations for an oral insulin given minimal change in their response after seeing the ORMD - 0801 profile 24 Oramed Pharmaceuticals Inc. © 2022 Willingness to prescribe oral insulin (A) Willingness to prescribe ORMD - 0801 (B) Definitely would NOT prescribe 0% 0% Probably would NOT prescribe 2% 1% Might or might not prescribe 20% 22% Probably WOULD prescribe 53% 57% Definitely WOULD prescribe 23% 20%

ORMD - 0801’s Robust Clinical Development Program has Paved the way Towards Anticipated Approval ORMD - 0801 DEVELOPMENT Anticipated FDA Approval in 2025 NASH Phase 2 Completed T2D Phase 3 ORA - D - 013 - 2 study Ongoing T2D Phase 3 ORA - D - 013 - 1 study Ongoing Prep BLA & File > 900 Study Subjects ¹ > 10,000 Human Doses No Drug - Related SAEs Strong Efficacy Signals (1) Includes all clinical studies across all indications, including formulation studies 2021 202 2 1 2023 2024 DATA CSR DATA CSR DEVELOPMENT HIGHLIGHTS: • First T2D Phase 3 trial 100% randomization • Second T2D Phase 3 trial 50% randomization • Phase 2 in NASH and potential future T1D studies support additional upside 25 Oramed Pharmaceuticals Inc. © 2022 DATA

China License Deal: 500M patient potential License: Exclusive right to ORMD - 0801 in Greater China DIABETIC (10.9% of adult population) 114 M PREDIABETIC (35.7% of adult population) 26 Oramed Pharmaceuticals Inc. © 2022 ~388 M $50M PAYMENTS + ROYALTIES: • $12M in restricted stock (at premium) • $38M milestone payments • $33M received to date • Up to 10% royalties on net sales LICENSEE: HEFEI TIANHUI ("HTIT") Owns with Sinopharm a state - of - the - art GMP API insulin manufacturing facility • HTIT clinical trials of ORMD - 0801 underway

South Korea Commercial Distribution Agreement MILESTONE PAYMENTS + ROYALTIES: • $18M in potential milestone payments • $2M received to date • Up to 15% royalties on gross sales • Medicox to purchase ORMD - 0801 from Oramed at fixed transfer price Agreement: Exclusive distribution rights to ORMD - 0801 in South Korea 1 in 7 South Korean adults have diabetes South Korean Partner: Medicox Co., Ltd. • Medicox (Kosdaq: 054180) is an emerging 27 Oramed Pharmaceuticals Inc. © 2022 pharmaceutical R&D company • Has built an excellent consortium of partnerships across established leaders in South Korea • Responsible for local regulatory approval • 10 year license to commercialize oral insulin in South Korea

Phase 2 Trials for T2D with NASH Completed With direct action on the liver, ORMD - 0801 has the potential to address diabetics suffering from NASH, a population with increased mortality. Positive Phase 2 trial results reported: Safety & Efficacy of ORMD - 0801 Day Treatment Primary endpoint met: ORMD - 0801 was safe and well tolerated with no treatment - related adverse events Secondary endpoint met: Showed clinically meaningful reduction of liver fat from baseline at 12 weeks Endpoints Reached 32 Patients with T2D, fat concentration in the liver of moderate steatosis ( >8% liver with steatosis) Study Population • Double - blind, randomized, placebo - controlled, multi - center study • 90 - day treatment • 32 T2D patients with NASH • 8mg x1/ x1 morning & 8mg x1/ x1 night • US and Israel Design 32 Patients 90 Positive clinical results in completed pilot study of NASH* • Open label, 90 - day treatment , N = 9 T2D patients with NASH, 8mg x2/ x1 morning • Efficacy: 30% relative reduction measured by MRI - PDFF; 6.9 “ 6.8% mean reduction in liver fat content (p value: 0.035) • Safety: No drug - related serious adverse events 28 Oramed Pharmaceuticals Inc. © 2022

Positive Phase 2 NASH trial results reported: Achieved Safety and Primary Endpoints Safety Data Summary • Primary objective of safety met with no serious adverse events and no difference in the incidence rate of adverse events between ORMD - 0801 and placebo. Efficacy Data Summary • • Secondary objective of reducing liver fat content in patients with NASH and T2D Percent Change from Baseline to Week 12 in MR PDFF (%): • Liver Segment 3 (left lobe) showed placebo adjusted mean decrease of 1.8 with placebo adjusted median decrease of 5.7 for ORMD - 0801 Exploratory objective of median change from baseline in Fibroscan fibrosis levels: • • Median Change from Baseline to Week 12 in Fibrosis Median (kPa) showed placebo adjusted median decrease of 1.1 for ORMD - 0801. Median change from Baseline to Week 12 in Steatosis Median (dB/m) showed placebo adjusted median decrease of 29 for ORMD - 0801. Median Levels at Baseline Placebo ORMD - 0801 8.4 8.6 29 Oramed Pharmaceuticals Inc. © 2022 Median change in Fibroscan Fibrosis in kPa Levels

GLP - 1 Analog: ORMD - 0901 for Oral GLP - 1 (T2D) GLP - 1 Analog T2D medication Mimics the natural hormone in the body Compelling safety profile Decreases blood glucose levels Preserves beta cell function Effectively reduces HbA1c Promotes weight loss ORMD - 0901 Clinical Status IND Bioavailability study 30 Oramed Pharmaceuticals Inc. © 2022

Oral GLP - 1 - ORMD - 0901 Preserved the biological activity of orally delivered exenatide. ORMD - 0901 successfully curbed blood sugar excursions following glucose challenge Preclinical: Oral exenatide delivery amounted to a >50% reduction in mean glucose (similar to SC) Human (4 healthy volunteers) Area (mg/dl)/minutes *10 2 Area (mg/dl)/minutes *10 2 ORMD - 0901 formulations 31 Oramed Pharmaceuticals Inc. © 2022

| Novel Oral Vaccine Company The Oravax technology integrates Premas Biotech’s D - Crypt Œ technology with an oral delivery platform from Oramed Pharmaceuticals based on their proprietary POD Œ delivery technology. x JOINT VENTURE Oramed is the majority shareholder of Oravax (63%) LICENSE - Royalties: 7.5% of net sales - Sublicensing: 15% - Sales milestone: $25M - $100M 2021 $13.6 b 32 Oramed Pharmaceuticals Inc. © 2022

| Advantages Ease of scale up Straight - forward tech transfer Manufacturing and COGs optimization Consistent process Triple antigen vaccine expected to be effective against COVID variants No needles Easy to administer at home (no need for professional administration) No need for low temperature storage (freezer) Potential for further reduction in side effects (greater safety) Manufacturing Advantages Oral Format Safe, non - toxic, and efficacious in preclinical and GLP Tox studies in animals: • No temperature rise, no body weight loss/gain, no adverse events noted in any animal • Significant antibody response, as well as cellular immune response • Long term retention of the antibody response in animals, post 150 days 33 Oramed Pharmaceuticals Inc. © 2022

| Highlighted Milestones • Commercialize Oral COVID - 19 Vaccine in Mexico • Drive Business in LATAM • Contribute to oral vaccine’s clinical, regulatory, and commercial activities • Participate in a future investment in Oravax 50/50 Joint Venture with Genomma Lab Collaboration Agreement with Tan Tanh Holdings • Pre - purchase of 10 million oral COVID - 19 vaccines • TTH to commercialize Oral COVID - 19 Vaccine in ASEAN • Oravax obtained approval from Vietnam MOH to run P2/3 in Vietnam • TTH to contribute to funding of clinical trials 34 Oramed Pharmaceuticals Inc. © 2022

| Phase 1 Trial Ongoing South Africa Open - label N=24 naive participants (no prior COVID - 19 vaccine or infection) Endpoints: Safety & tolerability Efficacy Cohort A (12 participants) positive data received Q3 2022 Cohort B (12 participants) data expected Q1 2023 35 Oramed Pharmaceuticals Inc. © 2022

Management Team Nadav Kidron, Esq, MBA Chief Executive Officer & Director Entrepreneur whose experience includes decades of senior executive roles in a wide range of industries including business, law and technology Miriam Kidron, PhD Chief Scientific Officer & Director Senior Researcher at the Diabetes Unit of Hadassah Medical Center for more than 25 years David Silberman, CPA Chief Financial Officer Extensive experience in corporate financial management Josh Hexter Chief Operating & Business Officer More than 18 years of prominent leadership roles in biotech and pharma Netanel Derovan Chief Legal Officer Highly accomplished executive leader, having spent over 20 years in senior legal positions. Michael Rabinowitz Chief Commercial Officer Over two decades of experience in launching and marketing new medications and treatments 37 Oramed Pharmaceuticals Inc. © 2022

Board of Directors 38 Oramed Pharmaceuticals Inc. © 2022 LEONARD SANK Independent Director Entrepreneur and business leader; Director of Macsteel Service Centres SA (Pty) Ltd ARIE MAYER, PH.D Independent Director Managing Director and Chairman of the Board of Merck Life Science Israel NADAV KIDRON, ESQ, MBA Chief Executive Officer, President & Chairman Entrepreneur whose experience includes decades of senior executive roles in a wide range of industries including business, law and technology MIRIAM KIDRON, PH . D Chief Scientific Officer & Director Senior Researcher at the Diabetes Unit of Hadassah Medical Center for more than 25 years YADIN ROZOV Independent Director Investment professional with experience in capital markets, corporate finance, investment banking, and investment management. Founder and Managing Partner at Terrace Edge Ventures LLC.

Scientific Advisory Board ELE FERRANNINI, MD, PHD Professor, Internal Medicine, University of Pisa School of Medicine. Past President of the EASD. Alexander Fleming, MD Recognized authority in the metabolic and endocrine fields with extensive FDA experience. AVRAM HERSKHO, MD, PHD; NOBEL LAUREATE Distinguished professor in the biochemistry unit in the B. Rappaport Facility of Medicine, Technion, Haifa, Israel. HAROLD JACOB, MD Chief Medical Officer, NanoVibronix. Previously, Director, Medical Affairs at Given Imaging. JULIO ROSENSTOCK, MD Director, Dallas Diabetes Research Center, Professor, University of Texas Southwestern Medical Center; Associate Editor, Diabetes Care. JAY SKYLER, MD, MCAP Professor of Medicine, Division of Endocrinology, Diabetes & Metabolism, Department of Medicine, University of Miami. ANNE PETERS, MD 39 Oramed Pharmaceuticals Inc. © 2022 Professor of Medicine at Keck School of Medicine of USC and Director of the USC Clinical Diabetes Programs. ROY ELDOR, MD, PHD Director, Diabetes Unit, Institute of Endocrinology, Metabolism & Hypertension, Tel - Aviv Medical Center.

Oramed (NASDAQ/TASE: ORMP) Addressing the Multibillion - Dollar Injectable Drug Markets with Oral Formulations Diabetes First: Initially targeting the lucrative insulin market; additional markets in the pipeline 40 Oramed Pharmaceuticals Inc. © 2022 Strong financial position with ~$160M 1 in cash and investments, no debt – ~39M shares outstanding (~43M fully diluted) 2 Proprietary oral protein delivery platform Strong management team backed by world - class scientific experts Multiple near - term value - creation catalysts for this year Robust IP Portfolio Methods and compositions for oral administration of proteins Methods and compositions for oral administration of exenatide Methods and compositions (insulin + exenatide) Improved protease inhibitors 1 As of September 30, 2022 (unaudited) 2 As of September 30, 2022

Oram e Oram e d d Pharma c Pharma c e e ut i ut i c c a l a l s s I I n c n c . . © © 2 2 02 2 022 Thank you oramed.com 41