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BAKER BROS. ADVISORS LP
> ARQL
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2016 | ARQULE INC | ARQL | 0 | -1,294,467 | 0 | -3,612,000 | |
| 12/31/2015 | ARQULE INC | ARQL | 0 | -1,294,467 | 0 | -3,612,000 | |
| 09/30/2015 | ARQULE INC | ARQL | 0 | -1,294,467 | 0 | -3,612,000 | |
| 06/30/2015 | ARQULE INC | ARQL | 0 | -1,294,467 | 0 | -3,612,000 | |
| 03/31/2015 | ARQULE INC | ARQL | 0 | -1,294,467 | 0 | -3,612,000 | |
| 12/31/2014 | ARQULE INC | ARQL | 0 | -1,294,467 | 0 | -3,612,000 | |
| 09/30/2014 | ARQULE INC | ARQL | 0 | -1,294,467 | 0 | -3,612,000 | |
| 06/30/2014 | ARQULE INC | ARQL | 0 | -1,294,467 | 0 | -3,612,000 | |
| 03/31/2014 | ARQULE INC | ARQL | 0 | -1,294,467 | 0 | -3,612,000 | |
| 12/31/2013 | ARQULE INC | ARQL | 0 | -1,294,467 | 0 | -3,612,000 | |
| 09/30/2013 | ARQULE INC | ARQL | 0 | -879,805 | 0 | -2,041,000 | |
| 06/30/2013 | ARQULE INC | ARQL | 879,805 | -414,662 | 2,041,000 | -1,571,000 | $2.32 |
| 03/31/2013 | ARQULE INC | ARQL | 910,267 | -384,200 | 2,358,000 | -1,254,000 | $2.59 |
| 12/31/2012 | ARQULE INC | ARQL | 1,294,467 | 1,208,300 | 3,612,000 | 3,172,000 | $2.79 |
| 09/30/2012 | ARQULE INC | ARQL | 86,167 | 0 | 440,000 | -71,000 | $5.11 |
| 06/30/2012 | ARQULE INC | ARQL | 86,167 | 0 | 511,000 | -93,000 | $5.93 |
| 03/31/2012 | ARQULE INC | ARQL | 86,167 | 86,167 | 604,000 | 604,000 | $7.01 |
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