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BAKER BROS. ADVISORS LP
> BDSI
| Date | Name | Ticker | Shares | Change | Value | Change | Price |
| 06/30/2020 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 0 | -1,638,334 | 0 | -6,209,000 | |
| 03/31/2020 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 1,638,334 | 1,638,334 | 6,209,000 | 6,209,000 | $3.79 |
| 09/30/2018 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 0 | -210,021 | 0 | -620,000 | |
| 06/30/2018 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 210,021 | 0 | 620,000 | 0 | $2.95 |
| 12/31/2017 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 210,021 | 0 | 620,000 | 0 | $2.95 |
| 09/30/2017 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 210,021 | 0 | 620,000 | 32,000 | $2.95 |
| 06/30/2017 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 210,021 | 0 | 588,000 | 189,000 | $2.80 |
| 03/31/2017 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 210,021 | 0 | 399,000 | 31,000 | $1.90 |
| 12/31/2016 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 210,021 | 0 | 368,000 | -199,000 | $1.75 |
| 09/30/2016 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 210,021 | 0 | 567,000 | 71,000 | $2.70 |
| 06/30/2016 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 210,021 | 0 | 496,000 | -182,000 | $2.36 |
| 03/31/2016 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 210,021 | 0 | 678,000 | -328,000 | $3.23 |
| 12/31/2015 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 210,021 | -1,929,405 | 1,006,000 | -8,215,000 | $4.79 |
| 09/30/2015 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 210,021 | -1,929,405 | 1,168,000 | -8,053,000 | $5.56 |
| 06/30/2015 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 210,021 | -1,929,405 | 1,672,000 | -7,549,000 | $7.96 |
| 03/31/2015 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 255,866 | -1,883,560 | 2,686,000 | -6,535,000 | $10.50 |
| 12/31/2014 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 210,021 | -1,929,405 | 2,524,000 | -6,697,000 | $12.02 |
| 09/30/2014 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 210,021 | -1,929,405 | 3,589,000 | -5,632,000 | $17.09 |
| 06/30/2014 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 421,005 | -1,718,421 | 5,082,000 | -4,139,000 | $12.07 |
| 03/31/2014 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 421,005 | -1,718,421 | 3,553,000 | -5,668,000 | $8.44 |
| 12/31/2013 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 846,005 | -1,293,421 | 4,983,000 | -4,238,000 | $5.89 |
| 09/30/2013 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 846,005 | -1,293,421 | 4,594,000 | -4,627,000 | $5.43 |
| 06/30/2013 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 900,505 | -1,238,921 | 3,656,000 | -5,565,000 | $4.06 |
| 03/31/2013 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 1,714,505 | -424,921 | 7,218,000 | -2,003,000 | $4.21 |
| 12/31/2012 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 2,139,426 | 0 | 9,221,000 | -4,300,000 | $4.31 |
| 09/30/2012 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 2,139,426 | -455,618 | 13,521,000 | 1,895,000 | $6.32 |
| 06/30/2012 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 2,595,044 | 0 | 11,626,000 | 5,346,000 | $4.48 |
| 03/31/2012 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 2,595,044 | 0 | 6,280,000 | 4,191,000 | $2.42 |
| 12/31/2011 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 2,595,044 | 191,196 | 2,089,000 | -531,000 | $0.80 |
| 09/30/2011 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 2,403,848 | 0 | 2,620,000 | -5,144,000 | $1.09 |
| 06/30/2011 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 2,403,848 | 0 | 7,764,000 | -722,000 | $3.23 |
| 03/31/2011 | BIODELIVERY SCIENCES INTERNATIONAL INC | BDSI | 2,403,848 | 2,403,848 | 8,486,000 | 8,486,000 | $3.53 |
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