The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABCELLERA BIOLOGICS INC COM 00288U106   80,886 12,521 SH   DFND 1,2 12,521 0 0
ACADIA PHARMACEUTICALS INC COM 004225108   718,117 29,984 SH   DFND 1,2 29,984 0 0
AEROVATE THERAPEUTICS INC COM 008064107   822,102 47,936 SH   DFND 1,2 47,936 0 0
AFFIMED N V COM N01045108   222,813 372,472 SH   DFND 1,2 372,472 0 0
AKERO THERAPEUTICS INC COM 00973Y108   206,603 4,425 SH   DFND 1,2 4,425 0 0
ALX ONCOLOGY HLDGS INC COM 00166B105   315,045 41,950 SH   DFND 1,2 41,950 0 0
ARGENX SE SPONSORED ADR 04016X101   557,314 1,430 SH   DFND 1,2 1,430 0 0
ATHIRA PHARMA INC COM 04746L104   34,719 11,769 SH   DFND 1,2 11,769 0 0
BEIGENE LTD SPONSORED ADR 07725L102   2,143,523 12,022 SH   DFND 1,2 12,022 0 0
BIOCRYST PHARMACEUTICALS INC COM 09058V103   125,643 17,847 SH   DFND 1,2 17,847 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   313,348 3,615 SH   DFND 1,2 3,615 0 0
BIOMEA FUSION INC COM 09077A106   878,000 40,000 SH   DFND 1,2 40,000 0 0
BOLT BIOTHERAPEUTICS INC COM 097702104   1,493,699 1,166,952 SH   DFND 1,2 1,166,952 0 0
CABALETTA BIO INC COM 12674W109   530,898 41,123 SH   DFND 1,2 41,123 0 0
CERUS CORP COM 157085101   34,863 14,172 SH   DFND 1,2 14,172 0 0
CHINOOK THERAPEUTICS INC COM 16961L106   4,377,959 113,950 SH   DFND 1,2 113,950 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101   704,805 370,950 SH   DFND 1,2 370,950 0 0
EARGO INC COM NEW 270087208   729,167 147,904 SH   DFND 1,2 147,904 0 0
ENTRADA THERAPEUTICS INC COM 29384C108   743,101 49,082 SH   DFND 1,2 49,082 0 0
EXELIXIS INC COM 30161Q104   1,226,862 64,200 SH   DFND 1,2 64,200 0 0
EXSCIENTIA PLC ADS 30223G102   5,090,561 859,892 SH   DFND 1,2 859,892 0 0
FIBROGEN INC COM 31572Q808   167,686 62,106 SH   DFND 1,2 62,106 0 0
GALERA THERAPEUTICS INC COM 36338D108   1,913,256 613,223 SH   DFND 1,2 613,223 0 0
GERON CORP COM 374163103   1,245,480 388,000 SH   DFND 1,2 388,000 0 0
GITLAB INC CLASS A COM 37637K108   353,170 6,910 SH   DFND 1,2 6,910 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104   12,973,321 368,665 SH   DFND 1,2 368,665 0 0
ILLUMINA INC COM 452327109   22,348,058 119,196 SH   DFND 1,2 119,196 0 0
INCYTE CORP COM 45337C102   1,993,370 32,022 SH   DFND 1,2 32,022 0 0
IVERIC BIO INC COM 46583P102   4,405,451 111,984 SH   DFND 1,2 111,984 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103   1,842,480 204,720 SH   DFND 1,2 204,720 0 0
KARUNA THERAPEUTICS INC COM 48576A100   48,940,443 225,688 SH   DFND 1,2 225,688 0 0
KODIAK SCIENCES INC COM 50015M109   135,392 19,622 SH   DFND 1,2 19,622 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105   273,042 1,182 SH   DFND 1,2 1,182 0 0
MERUS N V COM N5749R100   3,975,830 151,000 SH   DFND 1,2 151,000 0 0
OCULIS HOLDING AG ORDINARY SHARES H5870P102   8,028,063 651,100 SH   DFND 1,2 651,100 0 0
PACIFIC BIOSCIENCES CALIF IN COM 69404D108   1,817,512 136,655 SH   DFND 1,2 136,655 0 0
RANI THERAPEUTICS HLDGS INC COM CL A 753018100   2,033,566 493,584 SH   DFND 1,2 493,584 0 0
REATA PHARMACEUTICALS INC CL A 75615P103   336,468 3,300 SH   DFND 1,2 3,300 0 0
REPLIMUNE GROUP INC COM 76029N106   4,289,640 184,739 SH   DFND 1,2 184,739 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105   660,754 40,070 SH   DFND 1,2 40,070 0 0
SEAGEN INC COM 81181C104   9,064,096 47,096 SH   DFND 1,2 47,096 0 0
SOMALOGIC INC CLASS A COM 83444K105   3,919,049 1,696,558 SH   DFND 1,2 1,696,558 0 0
XENON PHARMACEUTICALS INC COM 98420N105   4,403,630 114,380 SH   DFND 1,2 114,380 0 0