The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACRIVON THERAPEUTICS INC COMMON STOCK 004890109   6,242,534 481,677 SH   DFND   481,677 0 0
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107   15,798,795 17,079,778 SH   DFND   17,079,778 0 0
ADDEX THERAPEUTICS LTD SPONSORED ADS 00654J107   632,885 180,000 SH   DFND   180,000 0 0
AFFIMED NV COM N01045108   2,647,925 4,426,488 SH   DFND   4,426,488 0 0
AKARI THERAPEUTICS PLC SPONSORED ADR 00972G108   76,868 452,167 SH   DFND   452,167 0 0
ALLAKOS INC COM 01671P100   26,802,054 6,147,260 SH   DFND   6,147,260 0 0
ARCELLX INC COMMON STOCK 03940C100   118,425,184 3,745,262 SH   DFND   3,745,262 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102   38,427,993 3,969,834 SH   DFND   3,969,834 0 0
BERKSHIRE GREY INC COM CL A 084656107   53,838,062 38,183,023 SH   DFND   38,183,023 0 0
BLACK DIAMOND THERAPEUTICS INC COM 09203E105   22,466,223 4,448,757 SH   DFND   4,448,757 0 0
BRIGHT HEALTH GROUP INC COM NEW 10920V404   33,322,926 2,726,917 SH   DFND   2,726,917 0 0
BUZZFEED INC CLASS A COM 12430A102   7,743,615 15,333,892 SH   DFND   15,333,892 0 0
CELCUITY INC COM 15102K100   12,725,011 1,250,001 SH   DFND   1,250,001 0 0
CHAMPIONS ONCOLOGY INC COM NEW 15870P307   10,933,534 1,713,720 SH   DFND   1,713,720 0 0
COURSERA INC COM 22266M104   167,538,353 12,867,769 SH   DFND   12,867,769 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108   89,142,124 1,587,854 SH   DFND   1,587,854 0 0
CVRX INC COM 126638105   36,601,169 2,370,542 SH   DFND   2,370,542 0 0
DESKTOP METAL INC COM CL A 25058X105   25,486,101 14,407,594 SH   DFND   14,407,594 0 0
EARGO INC COM NEW 270087208   1,024,878 207,886 SH   DFND   207,886 0 0
GERON CORP COM 374163103   68,526,560 21,347,838 SH   DFND   21,347,838 0 0
GLYCOMIMETICS INC COM 38000Q102   8,290,126 4,764,440 SH   DFND   4,764,440 0 0
GOSSAMER BIO INC COM 38341P102   4,160,887 3,467,406 SH   DFND   3,467,406 0 0
INOZYME PHARMA INC COM 45790W108   13,577,928 2,437,689 SH   DFND   2,437,689 0 0
INVENTIVA SA ADS 46124U107   5,908,847 1,462,586 SH   DFND   1,462,586 0 0
LEXICON PHARMACEUTICALS INC COM NEW 528872302   5,455,435 2,382,286 SH   DFND   2,382,286 0 0
MARKER THERAPEUTICS INC COM NEW 57055L206   3,321,427 1,071,428 SH   DFND   1,071,428 0 0
MINERVA SURGICAL INC COM 60343F106   8,822,773 34,437,052 SH   DFND   34,437,052 0 0
MIRUM PHARMACEUTICALS INC COM 604749101   56,558,106 2,186,243 SH   DFND   2,186,243 0 0
MONTE ROSA THERAPEUTICS INC COM 61225M102   52,692,241 7,692,298 SH   DFND   7,692,298 0 0
NEXTNAV INC COMMON STOCK 65345N106   24,076,119 8,189,156 SH   DFND   8,189,156 0 0
NKARTA INC COM 65487U108   7,815,630 3,568,781 SH   DFND   3,568,781 0 0
PHATHOM PHARMACEUTICALS INC COM 71722W107   18,280,840 1,276,595 SH   DFND   1,276,595 0 0
REGULUS THERAPEUTICS INC COM 75915K200   2,860,001 1,945,579 SH   DFND   1,945,579 0 0
RENEO PHARMACEUTICALS INC COM 75974E103   28,253,557 4,785,494 SH   DFND   4,785,494 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105   47,985,174 2,909,956 SH   DFND   2,909,956 0 0
SAVARA INC COM 805111101   77,120,690 24,137,931 SH   DFND   24,137,931 0 0
SENTI BIOSCIENCES INC COM 81726A100   2,775,197 4,426,151 SH   DFND   4,426,151 0 0
SYNLOGIC INC COM 87166L100   1,818,444 4,228,940 SH   DFND   4,228,940 0 0
TREVI THERAPEUTICS INC COM 89532M101   27,175,199 11,370,376 SH   DFND   11,370,376 0 0
TUYA INC SPONSERED ADS 90114C107   9,326,470 4,934,640 SH   DFND   4,934,640 0 0
VERONA PHARMA PLC SPONSERED ADS 925050106   118,061,678 5,108,563 SH   DFND   5,108,563 0 0
WHEELS UP EXPERIENCE INC COM CL A 96328L205   124,167 106,126 SH   DFND   106,126 0 0
X4 PHARMACEUTICALS INC COM 98420X103   29,074,378 14,986,793 SH   DFND   14,986,793 0 0
ZEROFOX HLDGS INC COM 98955G103   18,068,513 18,068,513 SH   DFND   18,068,513 0 0