The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
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COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP FIGI (to the nearest dollar) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
4D MOLECULAR THERAPEUTICS IN COM 35104E100   18,070,000 1,000,000 SH   SOLE   1,000,000 0 0
ABCELLERA BIOLOGICS INC COM 00288U106   7,279,871 1,126,915 SH   SOLE   1,126,915 0 0
ALIBABA GROUP HLDG LTD SPONSORED ADS 01609W102   41,743,930 500,827 SH   SOLE   500,827 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107   22,485,667 118,383 SH   SOLE   118,383 0 0
AMICUS THERAPEUTICS INC COM 03152W109   26,324,504 2,095,900 SH   SOLE   2,095,900 0 0
ARCELLX, INC. COMMON STOCK 03940C100   31,620,000 1,000,000 SH   SOLE   1,000,000 0 0
APPLE INC COM 037833100   42,956,596 221,460 SH   SOLE   221,460 0 0
ASML HOLDING N V N Y REGISTRY SHS N07059210   143,326,560 197,760 SH   SOLE   197,760 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101   34,672,000 400,000 SH   SOLE   400,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109   28,364,413 448,804 SH   SOLE   448,804 0 0
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104   20,465,764 627,207 SH   SOLE   627,207 0 0
CABLE ONE INC COM 12685J105   61,833,199 94,103 SH   SOLE   94,103 0 0
CORCEPT THERAPEUTICS INC COM 218352102   75,155,338 3,377,768 SH   SOLE   3,377,768 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107   19,822,000 1,100,000 SH   SOLE   1,100,000 0 0
CYMABAY THERAPEUTICS INC COM 23257D103   21,900,000 2,000,000 SH   SOLE   2,000,000 0 0
CYTEIR THERAPEUTICS INC COM 23284P103   9,522,854 3,662,636 SH   SOLE   3,662,636 0 0
DISC MEDICINE, INC. COM 254604101   48,430,293 1,090,772 SH   SOLE   1,090,772 0 0
EDGEWISE THERAPEUTICS INC COM 28036F105   47,055,698 6,071,703 SH   SOLE   6,071,703 0 0
GALECTO INC COM 36322Q107   6,294,433 2,497,791 SH   SOLE   2,497,791 0 0
GALERA THERAPEUTICS INC COM 36338D108   6,552,000 2,100,000 SH   SOLE   2,100,000 0 0
INSMED INC COM PAR $.01 457669307   28,259,314 1,339,304 SH   SOLE   1,339,304 0 0
INSPIRE MED SYS INC COM 457730109   10,550,800 32,500 SH   SOLE   32,500 0 0
IO BIOTECH INC COM 449778109   6,408,357 3,277,932 SH   SOLE   3,277,932 0 0
KINNATE BIOPHARMA INC COM 49705R105   2,471,592 815,707 SH   SOLE   815,707 0 0
LANZATECH GLOBAL INC COM 51655R101   108,015,391 15,814,845 SH   SOLE   15,814,845 0 0
LAVA THERAPEUTICS NV SHS N51517105   4,872,000 2,400,000 SH   SOLE   2,400,000 0 0
MARQETA INC CLASS A COM 57142B104   2,150,387 441,558 SH   SOLE   441,558 0 0
MIRUM PHARMACEUTICALS INC COM 604749101   43,570,073 1,684,193 SH   SOLE   1,684,193 0 0
PHARVARIS N V COM N69605108   20,125,981 1,329,325 SH   SOLE   1,329,325 0 0
RALLYBIO CORP COM 75120L100   12,384,074 2,187,999 SH   SOLE   2,187,999 0 0
RENEO PHARMACEUTICALS INC COM 75974E103   21,847,273 3,330,377 SH   SOLE   3,330,377 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106   18,280,400 920,000 SH   SOLE   920,000 0 0
SALESFORCE.COM, INC. COM 79466L302   112,073,430 530,500 SH   SOLE   530,500 0 0
SEAGEN INC. COM 81181C104   30,790,906 159,986 SH   SOLE   159,986 0 0
SILK RD MED INC COM 82710M100   10,847,891 333,884 SH   SOLE   333,884 0 0
SPERO THERAPEUTICS INC COM 84833T103   679,908 468,902 SH   SOLE   468,902 0 0
SPRUCE BIOSCIENCES INC COM 85209E109   14,453,022 6,722,336 SH   SOLE   6,722,336 0 0
TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100   71,731,918 710,780 SH   SOLE   710,780 0 0
TREACE MED CONCEPTS INC COM 89455T109   9,208,800 360,000 SH   SOLE   360,000 0 0
VAXCYTE INC COM 92243G108   42,199,300 845,000 SH   SOLE   845,000 0 0
VERVE THERAPEUTICS INC COM 92539P101   9,375,000 500,000 SH   SOLE   500,000 0 0