The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | |||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | ||||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | FIGI | (to the nearest dollar) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 4D MOLECULAR THERAPEUTICS IN | COM | 35104E100 | 72,413,953 | 4,007,413 | SH | DFND | 1 | 0 | 4,007,413 | 0 | ||
| 89BIO INC | COM | 282559103 | 34,984,618 | 1,846,154 | SH | DFND | 1 | 0 | 1,846,154 | 0 | ||
| AC IMMUNE SA | SHS | H00263105 | 21,950,860 | 7,428,379 | SH | DFND | 1 | 0 | 7,428,379 | 0 | ||
| ACLARIS THERAPEUTICS INC | COM | 00461U105 | 34,852,958 | 3,360,941 | SH | DFND | 1 | 0 | 3,360,941 | 0 | ||
| ALLAKOS INC | COM | 01671P100 | 37,724,538 | 8,652,417 | SH | DFND | 1 | 0 | 8,652,417 | 0 | ||
| AN2 THERAPEUTICS INC | COM | 037326105 | 13,293,686 | 1,563,963 | SH | DFND | 1 | 0 | 1,563,963 | 0 | ||
| ARAVIVE INC | COM | 03890D108 | 6,028,110 | 4,784,214 | SH | DFND | 1 | 0 | 4,784,214 | 0 | ||
| ASLAN PHARMACEUTICALS LTD | SPON ADS NEW | 04522R200 | 3,832,496 | 1,049,999 | SH | DFND | 1 | 0 | 1,049,999 | 0 | ||
| AXSOME THERAPEUTICS INC | COM | 05464T104 | 153,140,846 | 2,131,100 | SH | DFND | 1 | 0 | 2,131,100 | 0 | ||
| BIONOMICS LIMITED | ADS | 09063M205 | 178,136 | 80,971 | SH | DFND | 1 | 0 | 80,971 | 0 | ||
| CALLIDITAS THERAPEUTICS AB | SPONSERED ADS | 13124Q106 | 11,775,000 | 750,000 | SH | DFND | 1 | 0 | 750,000 | 0 | ||
| CENTESSA PHARMACEUTICALS PLC | SPONSORED ADS | 152309100 | 58,329,701 | 9,423,215 | SH | DFND | 1 | 0 | 9,423,215 | 0 | ||
| CIDARA THERAPEUTICS INC | COM | 171757107 | 7,753,074 | 6,861,127 | SH | DFND | 1 | 0 | 6,861,127 | 0 | ||
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | 3,139,469 | 1,370,947 | SH | DFND | 1 | 0 | 1,370,947 | 0 | ||
| CULLINAN ONCOLOGY INC | COM | 230031106 | 34,396,503 | 3,196,701 | SH | DFND | 1 | 0 | 3,196,701 | 0 | ||
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 11,344,778 | 6,595,801 | SH | DFND | 1 | 0 | 6,595,801 | 0 | ||
| DELCATH SYS INC | COM NEW | 24661P807 | 6,872,328 | 1,178,787 | SH | DFND | 1 | 0 | 1,178,787 | 0 | ||
| ELEDON PHARMACEUTICALS INC | COM | 28617K101 | 5,927,593 | 4,326,710 | SH | DFND | 1 | 0 | 4,326,710 | 0 | ||
| ELEVATION ONCOLOGY INC | COM | 28623U101 | 3,514,544 | 2,312,200 | SH | DFND | 1 | 0 | 2,312,200 | 0 | ||
| ESSA PHARMA INC | COM NEW | 29668H708 | 23,621,298 | 8,748,629 | SH | DFND | 1 | 0 | 8,748,629 | 0 | ||
| GALAPAGOS NV | SPON ADR | 36315X101 | 88,033,332 | 2,165,109 | SH | DFND | 1 | 0 | 2,165,109 | 0 | ||
| GALMED PHARMACEUTICALS LTD | SHS NEW | M47238122 | 261,472 | 89,853 | SH | DFND | 1 | 0 | 89,853 | 0 | ||
| GH RESEARCH PLC | ORDINARY SHARES | G3855L106 | 110,049,750 | 9,275,158 | SH | DFND | 1 | 0 | 9,275,158 | 0 | ||
| GLYCOMIMETICS INC | COM | 38000Q102 | 16,607,016 | 9,544,262 | SH | DFND | 1 | 0 | 9,544,262 | 0 | ||
| IDEAYA BIOSCIENCES INC | COM | 45166A102 | 133,561,992 | 5,683,489 | SH | DFND | 1 | 0 | 5,683,489 | 0 | ||
| IKENA ONCOLOGY INC | COM | 45175G108 | 20,789,716 | 3,169,164 | SH | DFND | 1 | 0 | 3,169,164 | 0 | ||
| IMMUNIC INC | COM | 4525EP101 | 2,885,057 | 1,149,425 | SH | DFND | 1 | 0 | 1,149,425 | 0 | ||
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 1,337,442 | 6,353,645 | SH | DFND | 1 | 0 | 6,353,645 | 0 | ||
| INVENTIVA SA | ADS | 46124U107 | 2,771,602 | 686,040 | SH | DFND | 1 | 0 | 686,040 | 0 | ||
| IONIS PHARMACEUTICALS INC | COM | 462222100 | 116,771,995 | 2,846,015 | SH | DFND | 1 | 0 | 2,846,015 | 0 | ||
| ITEOS THERAPEUTICS INC | COM | 46565G104 | 23,975,455 | 1,810,835 | SH | DFND | 1 | 0 | 1,810,835 | 0 | ||
| JANUX THERAPEUTICS INC | COM | 47103J105 | 48,749,437 | 4,106,945 | SH | DFND | 1 | 0 | 4,106,945 | 0 | ||
| JASPER THERAPEUTICS INC | COM | 471871103 | 13,563,000 | 9,900,000 | SH | DFND | 1 | 0 | 9,900,000 | 0 | ||
| KRONOS BIO INC | COM | 50107A104 | 4,839,194 | 2,813,485 | SH | DFND | 1 | 0 | 2,813,485 | 0 | ||
| KURA ONCOLOGY INC | COM | 50127T109 | 71,213,800 | 6,730,983 | SH | DFND | 1 | 0 | 6,730,983 | 0 | ||
| KYMERA THERAPEUTICS INC | COM | 501575104 | 108,949,702 | 4,739,004 | SH | DFND | 1 | 0 | 4,739,004 | 0 | ||
| LEXICON PHARMACEUTICALS INC | COM NEW | 528872302 | 45,789,310 | 19,995,332 | SH | DFND | 1 | 0 | 19,995,332 | 0 | ||
| MERUS N V | COM | N5749R100 | 42,191,719 | 1,602,420 | SH | DFND | 1 | 0 | 1,602,420 | 0 | ||
| MOLECULAR PARTNERS AG | ADS | 60853G106 | 2,708,080 | 443,221 | SH | DFND | 1 | 0 | 443,221 | 0 | ||
| MOLECULAR TEMPLATES INC | COM | 608550109 | 2,398,351 | 4,996,565 | SH | DFND | 1 | 0 | 4,996,565 | 0 | ||
| MOONLAKE IMMUNOTHERAPEUTICS | CLASS A ORD | 61559X104 | 1,109,315,484 | 21,751,284 | SH | DFND | 1 | 0 | 21,751,284 | 0 | ||
| NEWAMSTERDAM PHARMA COMPANY | ORDINARY SHARES | N62509109 | 18,095,962 | 1,521,948 | SH | DFND | 1 | 0 | 1,521,948 | 0 | ||
| NLS PHARMACEUTICS LTD | SHS | H57830103 | 6,321,839 | 5,747,126 | SH | DFND | 1 | 0 | 5,747,126 | 0 | ||
| OLEMA PHARMACEUTICALS INC | COM | 68062P106 | 68,731,872 | 7,611,503 | SH | DFND | 1 | 0 | 7,611,503 | 0 | ||
| OVID THERAPEUTICS INC | COM | 690469101 | 22,471,447 | 6,851,051 | SH | DFND | 1 | 0 | 6,851,051 | 0 | ||
| PIERIS PHARMACEUTICALS INC | COM | 720795103 | 3,410,932 | 20,609,863 | SH | DFND | 1 | 0 | 20,609,863 | 0 | ||
| POINT BIOPHARMA GLOBAL INC | COM | 730541109 | 95,707,557 | 10,563,748 | SH | DFND | 1 | 0 | 10,563,748 | 0 | ||
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 104,290,358 | 3,775,900 | SH | DFND | 1 | 0 | 3,775,900 | 0 | ||
| RAIN ONCOLOGY INC | COM | 75082Q105 | 4,232,075 | 3,526,729 | SH | DFND | 1 | 0 | 3,526,729 | 0 | ||
| RELAY THERAPEUTICS INC | COM | 75943R102 | 39,193,744 | 3,120,521 | SH | DFND | 1 | 0 | 3,120,521 | 0 | ||
| REPARE THERAPEUTICS INC | COM | 760273102 | 87,729,233 | 8,291,988 | SH | DFND | 1 | 0 | 8,291,988 | 0 | ||
| REPLIMUNE GROUP INC | COM | 76029N106 | 49,761,296 | 2,143,036 | SH | DFND | 1 | 0 | 2,143,036 | 0 | ||
| REVOLUTION MEDICINES INC | COM | 76155X100 | 167,336,979 | 6,255,588 | SH | DFND | 1 | 0 | 6,255,588 | 0 | ||
| REZOLUTE INC | COM NEW | 76200L309 | 377,814 | 190,815 | SH | DFND | 1 | 0 | 190,815 | 0 | ||
| SILENCE THERAPEUTICS PLC | ADS | 82686Q101 | 8,296,288 | 1,508,416 | SH | DFND | 1 | 0 | 1,508,416 | 0 | ||
| STRUCTURE THERAPEUTICS INC | SPONSORED ADS | 86366E106 | 72,747,500 | 1,750,000 | SH | DFND | 1 | 0 | 1,750,000 | 0 | ||
| SUTRO BIOPHARMA INC | COM | 869367102 | 15,567,949 | 3,347,946 | SH | DFND | 1 | 0 | 3,347,946 | 0 | ||
| THIRD HARMONIC BIO INC | COM | 88427A107 | 21,000,138 | 4,365,933 | SH | DFND | 1 | 0 | 4,365,933 | 0 | ||
| TSCAN THERAPEUTICS INC | COM | 89854M101 | 7,473,685 | 2,989,474 | SH | DFND | 1 | 0 | 2,989,474 | 0 | ||
| TYRA BIOSCIENCES INC | COM | 90240B106 | 46,655,303 | 2,739,595 | SH | DFND | 1 | 0 | 2,739,595 | 0 | ||
| VERASTEM INC | COM NEW | 92337C203 | 12,538,029 | 1,685,219 | SH | DFND | 1 | 0 | 1,685,219 | 0 | ||
| VERVE THERAPEUTICS INC | COM | 92539P101 | 12,187,500 | 650,000 | SH | DFND | 1 | 0 | 650,000 | 0 | ||
| VIGIL NEUROSCIENCE INC | COM | 92673K108 | 17,048,150 | 1,813,633 | SH | DFND | 1 | 0 | 1,813,633 | 0 | ||
| VIRACTA THERAPEUTICS INC | COM | 92765F108 | 5,096,673 | 3,614,662 | SH | DFND | 1 | 0 | 3,614,662 | 0 | ||
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 70,376,383 | 1,827,958 | SH | DFND | 1 | 0 | 1,827,958 | 0 | ||
| XOMA CORP DEL | COM NEW | 98419J206 | 68,641,405 | 3,633,743 | SH | DFND | 1 | 0 | 3,633,743 | 0 | ||
| ZYMEWORKS INC | COM | 98985Y108 | 50,716,800 | 5,870,000 | SH | DFND | 1 | 0 | 5,870,000 | 0 | ||