-----BEGIN PRIVACY-ENHANCED MESSAGE----- Proc-Type: 2001,MIC-CLEAR Originator-Name: webmaster@www.sec.gov Originator-Key-Asymmetric: MFgwCgYEVQgBAQICAf8DSgAwRwJAW2sNKK9AVtBzYZmr6aGjlWyK3XmZv3dTINen TWSM7vrzLADbmYQaionwg5sDW3P6oaM5D3tdezXMm7z1T+B+twIDAQAB MIC-Info: RSA-MD5,RSA, NTb57CApX2fixgITdjVdJG7h5mvHmZ5lwmnw2y5BP5kMB9AOUaJjFguvf3wcpRZB dpuTn1ghFIJgIkGn0qWftw== 0001172661-11-000188.txt : 20110214 0001172661-11-000188.hdr.sgml : 20110214 20110214130539 ACCESSION NUMBER: 0001172661-11-000188 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 1 CONFORMED PERIOD OF REPORT: 20101231 FILED AS OF DATE: 20110214 DATE AS OF CHANGE: 20110214 EFFECTIVENESS DATE: 20110214 FILER: COMPANY DATA: COMPANY CONFORMED NAME: ORBIMED ADVISORS LLC CENTRAL INDEX KEY: 0001055951 IRS NUMBER: 133976876 STATE OF INCORPORATION: DE FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-06774 FILM NUMBER: 11604424 BUSINESS ADDRESS: STREET 1: 767 3RD AVENUE STREET 2: 30TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10017 BUSINESS PHONE: 2126845700 MAIL ADDRESS: STREET 1: 767 3RD AVENUE STREET 2: 30TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10017 13F-HR 1 orb4q10.txt FORM 13F HOLDINGS REPORT UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 13F Form 13F COVER PAGE Report for the Calendar Year or Quarter Ended: December 31, 2010 Check here if Amendment [ ]; Amendment Number: This Amendment (Check only one.): [ ] is a restatement. [ ] adds new holdings entries. Institutional Investment Manager Filing this Report: Name: OrbiMed Advisors, LLC Address: 767 3rd Avenue 30th Floor New York, NY 10017 13F File Number: 28-06774 The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form. Person Signing this Report on Behalf of Reporting Manager: Name: Samuel D. Isaly Title: Managing Member Phone: (212) 739-6400 Signature, Place, and Date of Signing: /s/ Samuel D. Isaly New York, NY February 14, 2011 Report Type (Check only one.): [ X] 13F HOLDINGS REPORT. [ ] 13F NOTICE. [ ] 13F COMBINATION REPORT. FORM 13F SUMMARY PAGE Report Summary: Number of Other Included Managers: 1 Form13F Information Table Entry Total: 101 Form13F Information Table Value Total: $2,774,682 (thousands) List of Other Included Managers: Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional managers with respect to which this report is filed, other than the manager filing this report. No. 13F File Number Name 1 28-10410 Orbimed Capital LLC FORM 13F INFORMATION TABLE VALUE SHARES/ SH/ PUT/ INVSTMT OTHER VOTING AUTHORITY NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DSCRETN MANAGERS SOLE SHARED NONE - ------------------------------ ---------------- --------- -------- -------- --- ---- ------- ------------ -------- -------- -------- 3SBIO INC SPONSORED ADR 88575Y105 5462 359800 SH DEFINED 1 317300 0 42500 ABBOTT LABS COM 002824100 17751 370500 SH SOLE 237000 0 133500 ACHILLION PHARMACEUTICALS IN COM 00448Q201 4345 1047100 SH DEFINED 1 703200 0 343900 AETNA INC NEW COM 00817Y108 22184 727100 SH DEFINED 1 593100 0 134000 AFFYMETRIX INC COM 00826T108 9624 1913300 SH DEFINED 1 1697500 0 215800 ALCON INC COM SHS H01301102 40850 250000 SH CALL DEFINED 1 250000 0 0 ALIGN TECHNOLOGY INC COM 016255101 32075 1641500 SH DEFINED 1 1341500 0 300000 ALLERGAN INC COM 018490102 80227 1168300 SH DEFINED 1 1023300 0 145000 ALLOS THERAPEUTICS INC COM 019777101 42449 9208000 SH DEFINED 1 7807000 0 1401000 ALNYLAM PHARMACEUTICALS INC COM 02043Q107 2465 250000 SH PUT DEFINED 1 250000 0 0 AMARIN CORP PLC SPONS ADR NEW 023111206 59819 7295000 SH SOLE 7295000 0 0 AMGEN INC COM 031162100 136064 2478400 SH DEFINED 1 1838400 0 640000 AMSURG CORP COM 03232P405 1990 95000 SH DEFINED 1 67000 0 28000 ANADYS PHARMACEUTICALS INC COM 03252Q408 7625 5369900 SH DEFINED 1 4519900 0 850000 ANTARES PHARMA INC COM 036642106 10346 6085700 SH DEFINED 1 3952800 0 2132900 ANTHERA PHARMACEUTICALS INC COM 03674U102 16835 3449734 SH SOLE 3449734 0 0 ARIAD PHARMACEUTICALS INC COM 04033A100 7533 1477000 SH DEFINED 1 1477000 0 0 ATHERSYS INC COM 04744L106 4459 1805100 SH SOLE 1805100 0 0 AVEO PHARMACEUTICALS INC COM 053588109 13941 953581 SH DEFINED 1 670681 0 282900 BAXTER INTL INC COM 071813109 43736 864000 SH DEFINED 1 614000 0 250000 BIOGEN IDEC INC COM 09062X103 19491 290700 SH DEFINED 1 100700 0 190000 BIOMARIN PHARMACEUTICAL INC COM 09061G101 91818 3409500 SH DEFINED 1 3080500 0 329000 BOSTON SCIENTIFIC CORP COM 101137107 9084 1200000 SH SOLE 0 0 1200000 BRISTOL MYERS SQUIBB CO COM 110122108 104755 3956000 SH DEFINED 1 3326000 0 630000 CAREFUSION CORP COM 14170T101 8096 315000 SH SOLE 215000 0 100000 CELGENE CORP COM 151020104 54894 928200 SH DEFINED 1 570200 0 358000 CEPHALON INC COM 156708109 15430 250000 SH CALL DEFINED 1 250000 0 0 CEPHALON INC COM 156708109 1870 30300 SH DEFINED 1 30300 0 0 CIGNA CORP COM 125509109 17128 467200 SH DEFINED 1 250200 0 217000 CLINICAL DATA INC NEW COM 18725U109 1990 125100 SH DEFINED 1 112400 0 12700 COMPLETE GENOMICS INC COM 20454K104 31047 4156270 SH SOLE 4156270 0 0 COVANCE INC COM 222816100 2468 48000 SH SOLE 0 0 48000 COVIDIEN PLC SHS G2554F105 5936 130000 SH SOLE 0 0 130000 CUBIST PHARMACEUTICALS INC COM 229678107 10099 471900 SH DEFINED 1 471900 0 0 CUBIST PHARMACEUTICALS INC NOTE 2.500%11/0 229678AD9 4838 5000000 PRN SOLE 3000000 0 2000000 CYNOSURE INC CL A 232577205 1840 179900 SH DEFINED 1 139600 0 40300 CYTOKINETICS INC COM 23282W100 2829 1353500 SH DEFINED 1 1353500 0 0 DENDREON CORP NOTE 4.750% 6/1 24823QAB3 3500 1000000 PRN SOLE 1000000 0 0 DENDREON CORP COM 24823Q107 47198 1351600 SH DEFINED 1 1143500 0 208100 ELAN PLC ADR 284131208 43453 7583500 SH DEFINED 1 6583500 0 1000000 ENDO PHARMACEUTICALS HLDGS I COM 29264F205 59725 1672500 SH DEFINED 1 1371400 0 301100 EXPRESS SCRIPTS INC COM 302182100 2703 50000 SH SOLE 0 0 50000 GENZYME CORP COM 372917104 17800 250000 SH CALL DEFINED 1 250000 0 0 GENZYME CORP COM 372917104 134127 1883800 SH DEFINED 1 1616800 0 267000 GILEAD SCIENCES INC COM 375558103 121089 3341300 SH DEFINED 1 2462300 0 879000 GIVEN IMAGING ORD SHS M52020100 20379 1392000 SH DEFINED 1 1149000 0 243000 HOLOGIC INC COM 436440101 4705 250000 SH SOLE 0 0 250000 HOSPIRA INC COM 441060100 61409 1102700 SH DEFINED 1 912700 0 190000 HUMAN GENOME SCIENCES INC COM 444903108 48279 2020900 SH DEFINED 1 1684000 0 336900 HUMANA INC COM 444859102 15327 280000 SH DEFINED 1 280000 0 0 ILLUMINA INC COM 452327109 65316 1031200 SH DEFINED 1 866200 0 165000 ILLUMINA INC COM 452327109 12668 200000 SH PUT DEFINED 1 200000 0 0 INCYTE CORP COM 45337C102 19658 1187100 SH DEFINED 1 1015100 0 172000 INHIBITEX INC COM 45719T103 8320 3200000 SH SOLE 3200000 0 0 INSULET CORP COM 45784P101 22611 1458803 SH SOLE 1458803 0 0 INTERMUNE INC COM 45884X103 1900 52200 SH DEFINED 1 52200 0 0 JOHNSON & JOHNSON COM 478160104 35935 581000 SH SOLE 425000 0 156000 LIFE TECHNOLOGIES CORP COM 53217V109 5828 105000 SH SOLE 0 0 105000 MAP PHARMACEUTICALS INC COM 56509R108 25421 1518600 SH DEFINED 1 1008600 0 510000 MCKESSON CORP COM 58155Q103 2815 40000 SH SOLE 0 0 40000 MEDIVATION INC COM 58501N101 1138 75000 SH CALL DEFINED 1 75000 0 0 MEDTRONIC INC COM 585055106 17803 480000 SH SOLE 0 0 480000 MERCK & CO INC NEW COM 58933Y105 118806 3296500 SH DEFINED 1 2761500 0 535000 MOMENTA PHARMACEUTICALS INC COM 60877T100 32347 2160800 SH DEFINED 1 1910800 0 250000 NPS PHARMACEUTICALS INC COM 62936P103 681 86200 SH CALL DEFINED 1 86200 0 0 NPS PHARMACEUTICALS INC COM 62936P103 22971 2907700 SH DEFINED 1 2907700 0 0 NPS PHARMACEUTICALS INC COM 62936P103 905 114500 SH PUT DEFINED 1 114500 0 0 NXSTAGE MEDICAL INC COM 67072V103 66939 2690476 SH SOLE 2690476 0 0 ORASURE TECHNOLOGIES INC COM 68554V108 10091 1755000 SH DEFINED 1 1129700 0 625300 OREXIGEN THERAPEUTICS INC COM 686164104 808 100000 SH CALL DEFINED 1 100000 0 0 OREXIGEN THERAPEUTICS INC COM 686164104 808 100000 SH PUT DEFINED 1 100000 0 0 PACIFIC BIOSCIENCES CALIF IN COM 69404D108 2546 160000 SH SOLE 160000 0 0 PERRIGO CO COM 714290103 33248 525000 SH DEFINED 1 525000 0 0 PFIZER INC COM 717081103 108860 6217000 SH DEFINED 1 4767000 0 1450000 PHARMACYCLICS INC COM 716933106 1520 250000 SH CALL DEFINED 1 250000 0 0 PHARMACYCLICS INC COM 716933106 32306 5313500 SH DEFINED 1 4063500 0 1250000 PHARMASSET INC COM 71715N106 22098 507300 SH DEFINED 1 355300 0 152000 SEATTLE GENETICS INC COM 812578102 3582 239600 SH DEFINED 1 239600 0 0 SEQUENOM INC COM NEW 817337405 16575 2064100 SH DEFINED 1 2064100 0 0 SHIRE PLC SPONSORED ADR 82481R106 90895 1255800 SH DEFINED 1 1101700 0 154100 SOLTA MED INC COM 83438K103 1503 492900 SH DEFINED 1 320000 0 172900 STRYKER CORP COM 863667101 20240 376900 SH DEFINED 1 244500 0 132400 SYNERON MEDICAL LTD ORD SHS M87245102 3713 364400 SH DEFINED 1 225400 0 139000 TEVA PHARMACEUTICAL INDS LTD ADR 881624209 9128 175100 SH DEFINED 1 175100 0 0 THERMO FISHER SCIENTIFIC INC COM 883556102 84363 1523900 SH DEFINED 1 1154900 0 369000 TOMOTHERAPY INC COM 890088107 4249 1177100 SH DEFINED 1 888100 0 289000 UNITED THERAPEUTICS CORP DEL COM 91307C102 1979 31300 SH DEFINED 1 31300 0 0 UNITEDHEALTH GROUP INC COM 91324P102 53836 1490900 SH DEFINED 1 1050900 0 440000 UROPLASTY INC COM NEW 917277204 1530 379600 SH DEFINED 1 379600 0 0 VERTEX PHARMACEUTICALS INC COM 92532F100 58059 1657400 SH DEFINED 1 1426700 0 230700 VERTEX PHARMACEUTICALS INC NOTE 3.350%10/0 92532FAN0 4040 4000000 PRN SOLE 4000000 0 0 VOLCANO CORPORATION COM 928645100 6213 227500 SH CALL DEFINED 1 227500 0 0 VOLCANO CORPORATION NOTE 2.875% 9/0 928645AA8 1718 1500000 PRN SOLE 1500000 0 0 VOLCANO CORPORATION COM 928645100 3960 145000 SH DEFINED 1 145000 0 0 WARNER CHILCOTT PLC IRELAND SHS A G94368100 70595 3129200 SH DEFINED 1 2729200 0 400000 WARNER CHILCOTT PLC IRELAND SHS A G94368100 5866 260000 SH CALL DEFINED 1 260000 0 0 WATERS CORP COM 941848103 7771 100000 SH SOLE 0 0 100000 WATSON PHARMACEUTICALS INC COM 942683103 41682 807000 SH DEFINED 1 657000 0 150000 WELLPOINT INC COM 94973V107 58139 1022500 SH DEFINED 1 702500 0 320000 YM BIOSCIENCES INC COM 984238105 4208 1805800 SH DEFINED 1 1197300 0 608500 ZIMMER HLDGS INC COM 98956P102 23404 436000 SH DEFINED 1 334500 0 101500
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