0001172661-13-000738.txt : 20130417 0001172661-13-000738.hdr.sgml : 20130417 20130417162707 ACCESSION NUMBER: 0001172661-13-000738 CONFORMED SUBMISSION TYPE: 13F-HR/A PUBLIC DOCUMENT COUNT: 1 CONFORMED PERIOD OF REPORT: 20121231 FILED AS OF DATE: 20130417 DATE AS OF CHANGE: 20130417 EFFECTIVENESS DATE: 20130417 FILER: COMPANY DATA: COMPANY CONFORMED NAME: ORBIMED ADVISORS LLC CENTRAL INDEX KEY: 0001055951 IRS NUMBER: 133976876 STATE OF INCORPORATION: DE FILING VALUES: FORM TYPE: 13F-HR/A SEC ACT: 1934 Act SEC FILE NUMBER: 028-06774 FILM NUMBER: 13767153 BUSINESS ADDRESS: STREET 1: 601 LEXINGTON AVENUE STREET 2: 54TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10022 BUSINESS PHONE: (212) 739-6400 MAIL ADDRESS: STREET 1: 601 LEXINGTON AVENUE STREET 2: 54TH FLOOR CITY: NEW YORK STATE: NY ZIP: 10022 13F-HR/A 1 orbimedadvisors4q12a2.txt FORM 13F AMENDMENT FILING UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Form 13F Form 13F COVER PAGE Report for the Calendar Year or Quarter Ended: December 31, 2012 Check here if Amendment [ X]; Amendment Number: 2 This Amendment (Check only one.): [ X] is a restatement. [ ] adds new holdings entries. Institutional Investment Manager Filing this Report: Name: OrbiMed Advisors LLC Address: 601 Lexington Avenue 54th Floor New York, NY 10022 13F File Number: 028-06774 The institutional investment manager filing this report and the person by whom it is signed hereby represent that the person signing the report is authorized to submit it, that all information contained herein is true, correct and complete, and that it is understood that all required items, statements, schedules, lists, and tables, are considered integral parts of this form. Person Signing this Report on Behalf of Reporting Manager: Name: Samuel D. Isaly Title: Managing Member Phone: (212) 739-6400 Signature, Place, and Date of Signing: /s/ Samuel D. Isaly New York, NY April 17, 2013 Report Type (Check only one.): [ X] 13F HOLDINGS REPORT. [ ] 13F NOTICE. [ ] 13F COMBINATION REPORT. FORM 13F SUMMARY PAGE Report Summary: Number of Other Included Managers: 1 Form 13F Information Table Entry Total: 114 Form 13F Information Table Value Total: $3,322,844 (thousands) List of Other Included Managers: Provide a numbered list of the name(s) and Form 13F file number(s) of all institutional managers with respect to which this report is filed, other than the manager filing this report. No. 13F File Number Name 1 028-10410 OrbiMed Capital LLC FORM 13F INFORMATION TABLE VALUE SHARES/ SH/ PUT/ INVSTMT OTHER VOTING AUTHORITY NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DSCRETN MANAGERS SOLE SHARED NONE ------------------------------ ---------------- --------- -------- -------- --- ---- ------- ------------ -------- -------- -------- 3SBIO INC SPONSORED ADR 88575Y105 28484 2088300 SH DEFINED 1 673600 0 1414700 ABBOTT LABS COM 002824100 7835 250000 SH CALL DEFINED 1 61500 0 188500 ABBOTT LABS COM 002824100 85151 2717000 SH DEFINED 1 238000 0 2479000 ACADIA PHARMACEUTICALS INC COM 004225108 5245 1128000 SH DEFINED 1 418000 0 710000 ACHILLION PHARMACEUTICALS IN COM 00448Q201 4157 519000 SH DEFINED 1 177000 0 342000 ACORDA THERAPEUTICS INC COM 00484M106 8925 359000 SH DEFINED 1 0 0 359000 ACTAVIS INC COM 00507K103 82990 965000 SH DEFINED 1 181000 0 784000 AETNA INC NEW COM 00817Y108 19728 426000 SH DEFINED 1 0 0 426000 AFFYMAX INC COM 00826A109 48937 2577000 SH DEFINED 1 453000 0 2124000 AFFYMETRIX INC COM 00826T108 21654 6831000 SH DEFINED 1 1715500 0 5115500 AFFYMETRIX INC NOTE 4.000% 7/0 00826TAH1 3409 4100000 PRN DEFINED 1 0 0 4100000 AGILENT TECHNOLOGIES INC COM 00846U101 6428 157000 SH DEFINED 1 0 0 157000 ALEXION PHARMACEUTICALS INC COM 015351109 24766 264200 SH DEFINED 1 0 0 264200 ALLERGAN INC COM 018490102 9173 100000 SH PUT DEFINED 1 23500 0 76500 ALLERGAN INC COM 018490102 35683 389000 SH DEFINED 1 0 0 389000 AMARIN CORP PLC SPONS ADR NEW 023111206 4854 600000 SH SOLE 600000 0 0 AMGEN INC COM 031162100 71770 832600 SH DEFINED 1 61300 0 771300 ANTARES PHARMA INC COM 036642106 30232 7934800 SH DEFINED 1 2604800 0 5330000 ARRAY BIOPHARMA INC COM 04269X105 16108 4330100 SH DEFINED 1 1342600 0 2987500 AUXILIUM PHARMACEUTICALS INC COM 05334D107 1112 60000 SH DEFINED 1 0 0 60000 BAXTER INTL INC COM 071813109 34930 524000 SH DEFINED 1 0 0 524000 BIODEL INC COM NEW 09064M204 3279 1395510 SH SOLE 1395510 0 0 BIOGEN IDEC INC COM 09062X103 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DEFINED 1 255000 0 1549170 FLUIDIGM CORP DEL COM 34385P108 19593 1369200 SH DEFINED 1 173100 0 1196100 FOREST LABS INC COM 345838106 4238 120000 SH DEFINED 1 0 0 120000 GILEAD SCIENCES INC COM 375558103 89025 2424100 SH DEFINED 1 294000 0 2130100 GIVEN IMAGING ORD SHS M52020100 14937 855000 SH DEFINED 1 0 0 855000 HCA HOLDINGS INC COM 40412C101 79649 2640000 SH DEFINED 1 295000 0 2345000 HI-TECH PHARMACAL INC COM 42840B101 11659 333300 SH DEFINED 1 110100 0 223200 HOLOGIC INC COM 436440101 5003 250000 SH DEFINED 1 0 0 250000 HUMANA INC COM 444859102 39874 581000 SH DEFINED 1 80000 0 501000 ILLUMINA INC COM 452327109 5559 100000 SH CALL DEFINED 1 23500 0 76500 ILLUMINA INC COM 452327109 92713 1667800 SH DEFINED 1 287000 0 1380800 IMPAX LABORATORIES INC COM 45256B101 44424 2168100 SH DEFINED 1 329100 0 1839000 INCYTE CORP COM 45337C102 66420 3998800 SH DEFINED 1 586600 0 3412200 INCYTE CORP NOTE 4.750%10/0 45337CAJ1 17315 8679000 PRN DEFINED 1 1857000 0 6822000 INFINITY PHARMACEUTICALS INC COM 45665G303 7000 200000 SH CALL DEFINED 1 47100 0 152900 INFINITY PHARMACEUTICALS INC COM 45665G303 111251 3178600 SH DEFINED 1 631000 0 2547600 INTERCEPT PHARMACEUTICALS IN COM 45845P108 73638 2150634 SH SOLE 2150634 0 0 JOHNSON & JOHNSON COM 478160104 31608 450900 SH DEFINED 1 0 0 450900 LIFE TECHNOLOGIES CORP COM 53217V109 93378 1904500 SH DEFINED 1 257000 0 1647500 MAKO SURGICAL CORP COM 560879108 15202 1183000 SH DEFINED 1 0 0 1183000 MAP PHARMACEUTICALS INC COM 56509R108 44274 2829000 SH DEFINED 1 930000 0 1899000 MCKESSON CORP COM 58155Q103 7369 76000 SH DEFINED 1 0 0 76000 MEDIVATION INC COM 58501N101 72811 1423200 SH DEFINED 1 264000 0 1159200 MEDTRONIC INC COM 585055106 7888 192300 SH DEFINED 1 0 0 192300 MERCK & CO INC NEW COM 58933Y105 6141 150000 SH CALL DEFINED 1 35500 0 114500 MERCK & CO INC NEW COM 58933Y105 113445 2771000 SH DEFINED 1 0 0 2771000 MOLINA HEALTHCARE INC COM 60855R100 4627 171000 SH DEFINED 1 58000 0 113000 MYLAN INC COM 628530107 83366 3037000 SH 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SH DEFINED 1 56300 0 163500 REPROS THERAPEUTICS INC COM NEW 76028H209 9308 591000 SH DEFINED 1 290000 0 301000 SALIX PHARMACEUTICALS INC COM 795435106 13400 331100 SH DEFINED 1 95100 0 236000 SEQUENOM INC COM NEW 817337405 31500 6688000 SH DEFINED 1 1131000 0 5557000 SINOVAC BIOTECH LTD SHS P8696W104 716 228000 SH SOLE 228000 0 0 SOLTA MED INC COM 83438K103 1220 456800 SH DEFINED 1 131100 0 325700 SPDR S&P 500 ETF TR TR UNIT 78462F103 21362 150000 US PUT DEFINED 1 35300 0 114700 ST JUDE MED INC COM 790849103 5240 145000 SH DEFINED 1 0 0 145000 STRYKER CORP COM 863667101 6293 114800 SH DEFINED 1 0 0 114800 SUPERNUS PHARMACEUTICALS INC COM 868459108 23677 3302183 SH SOLE 3302183 0 0 SYNERON MEDICAL LTD ORD SHS M87245102 3035 350000 SH DEFINED 1 121000 0 229000 THERMO FISHER SCIENTIFIC INC COM 883556102 63652 998000 SH DEFINED 1 199400 0 798600 UNITEDHEALTH GROUP INC COM 91324P102 67420 1243000 SH DEFINED 1 141000 0 1102000 UROPLASTY INC COM NEW 917277204 5689 1750500 SH DEFINED 1 867600 0 882900 VALEANT PHARMACEUTICALS INTL COM 91911K102 8248 138000 SH DEFINED 1 0 0 138000 VERTEX PHARMACEUTICALS INC COM 92532F100 3645 87000 SH DEFINED 1 0 0 87000 VIVUS INC COM 928551100 12361 921100 SH DEFINED 1 163200 0 757900 VOCERA COMMUNICATIONS INC COM 92857F107 9413 375000 SH DEFINED 1 0 0 375000 VOLCANO CORPORATION NOTE 1.750%12/0 928645AB6 3033 3000000 PRN DEFINED 1 900000 0 2100000 WARNER CHILCOTT PLC IRELAND SHS A G94368100 4515 375000 SH CALL DEFINED 1 88400 0 286600 WARNER CHILCOTT PLC IRELAND SHS A G94368100 45787 3802900 SH DEFINED 1 1027000 0 2775900 WELLCARE HEALTH PLANS INC COM 94946T106 8862 182000 SH DEFINED 1 67000 0 115000 WELLPOINT INC COM 94973V107 54584 896000 SH DEFINED 1 137000 0 759000 XENOPORT INC COM 98411C100 17801 2291000 SH DEFINED 1 720700 0 1570300 XOMA CORP DEL COM 98419J107 5807 2419727 SH DEFINED 1 688500 0 1731227 ZIMMER HLDGS INC COM 98956P102 34483 517300 SH DEFINED 1 0 0 517300