The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
|
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
|
||||||||||||||||
| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ABBOTT LABS | COM | 002824100 | 9,499 | 211,000 | SH | DFND | 1 | 53,000 | 0 | 158,000 | |
| ABBVIE INC | COM | 00287Y109 | 348,867 | 5,331,100 | SH | DFND | 1 | 2,316,100 | 0 | 3,015,000 | |
| ACHILLION PHARMACEUTICALS IN | COM | 00448Q201 | 1,936 | 158,000 | SH | DFND | 1 | 0 | 0 | 158,000 | |
| ACTAVIS PLC | SHS | G0083B108 | 383,078 | 1,488,200 | SH | DFND | 1 | 645,300 | 0 | 842,900 | |
| AEGERION PHARMACEUTICALS INC | COM | 00767E102 | 8,376 | 400,000 | SH | Call | DFND | 1 | 158,700 | 0 | 241,300 |
| AETNA INC NEW | COM | 00817Y108 | 8,350 | 94,000 | SH | DFND | 1 | 24,000 | 0 | 70,000 | |
| AFFIMED N V | COM | N01045108 | 36,051 | 5,814,630 | SH | SOLE | 5,814,630 | 0 | 0 | ||
| AFFYMETRIX INC | COM | 00826T108 | 64,826 | 6,568,000 | SH | DFND | 1 | 1,560,000 | 0 | 5,008,000 | |
| AGENUS INC | COM NEW | 00847G705 | 9,693 | 2,441,500 | SH | DFND | 1 | 1,090,300 | 0 | 1,351,200 | |
| AGILENT TECHNOLOGIES INC | COM | 00846U101 | 165,848 | 4,051,000 | SH | DFND | 1 | 1,719,300 | 0 | 2,331,700 | |
| ALEXION PHARMACEUTICALS INC | COM | 015351109 | 61,430 | 332,000 | SH | DFND | 1 | 34,000 | 0 | 298,000 | |
| ALIMERA SCIENCES INC | COM | 016259103 | 8,310 | 1,500,000 | SH | DFND | 1 | 670,000 | 0 | 830,000 | |
| ALLERGAN INC | COM | 018490102 | 157,593 | 741,300 | SH | DFND | 1 | 322,600 | 0 | 418,700 | |
| ALLERGAN INC | COM | 018490102 | 53,148 | 250,000 | SH | Call | DFND | 1 | 99,200 | 0 | 150,800 |
| AMAG PHARMACEUTICALS INC | COM | 00163U106 | 19,989 | 469,000 | SH | DFND | 1 | 0 | 0 | 469,000 | |
| AMARIN CORP PLC | SPONS ADR NEW | 023111206 | 392 | 400,000 | SH | SOLE | 400,000 | 0 | 0 | ||
| AMGEN INC | COM | 031162100 | 431,357 | 2,708,000 | SH | DFND | 1 | 992,000 | 0 | 1,716,000 | |
| ANTHEM INC | COM | 036752103 | 17,443 | 138,800 | SH | DFND | 1 | 35,000 | 0 | 103,800 | |
| ARQULE INC | COM | 04269E107 | 6,956 | 5,702,000 | SH | DFND | 1 | 1,623,100 | 0 | 4,078,900 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 34,282 | 7,247,700 | SH | DFND | 1 | 2,633,400 | 0 | 4,614,300 | |
| AUSPEX PHARMACEUTICALS INC | COM | 05211J102 | 4,912 | 93,600 | SH | DFND | 1 | 0 | 0 | 93,600 | |
| BACTERIN INTL HLDGS INC | COM NEW | 05644R200 | 1,441 | 475,439 | SH | SOLE | 475,439 | 0 | 0 | ||
| BIODEL INC | COM NEW | 09064M204 | 279 | 209,700 | SH | SOLE | 209,700 | 0 | 0 | ||
| BIOGEN IDEC INC | COM | 09062X103 | 507,376 | 1,494,700 | SH | DFND | 1 | 542,600 | 0 | 952,100 | |
| BIOLINERX LTD | SPONSORED ADR | 09071M106 | 1,839 | 1,135,000 | SH | SOLE | 1,135,000 | 0 | 0 | ||
| BIOMARIN PHARMACEUTICAL INC | NOTE 0.750%10/1 | 09061GAE1 | 593 | 500,000 | PRN | DFND | 1 | 215,000 | 0 | 285,000 | |
| BIOMARIN PHARMACEUTICAL INC | NOTE 1.500%10/1 | 09061GAF8 | 611 | 500,000 | PRN | DFND | 1 | 215,000 | 0 | 285,000 | |
| BOSTON SCIENTIFIC CORP | COM | 101137107 | 4,240 | 320,000 | SH | DFND | 1 | 83,000 | 0 | 237,000 | |
| BRISTOL MYERS SQUIBB CO | COM | 110122108 | 453,864 | 7,688,700 | SH | DFND | 1 | 3,294,400 | 0 | 4,394,300 | |
| BRISTOL MYERS SQUIBB CO | COM | 110122108 | 14,758 | 250,000 | SH | Call | DFND | 1 | 99,200 | 0 | 150,800 |
| CARDINAL HEALTH INC | COM | 14149Y108 | 26,237 | 325,000 | SH | DFND | 1 | 82,000 | 0 | 243,000 | |
| CELGENE CORP | COM | 151020104 | 409,139 | 3,657,600 | SH | DFND | 1 | 1,248,700 | 0 | 2,408,900 | |
| CELLDEX THERAPEUTICS INC NEW | COM | 15117B103 | 37,635 | 2,062,200 | SH | DFND | 1 | 885,200 | 0 | 1,177,000 | |
| CEMPRA INC | COM | 15130J109 | 1,176 | 50,000 | SH | DFND | 1 | 0 | 0 | 50,000 | |
| CERUS CORP | COM | 157085101 | 43,898 | 7,035,000 | SH | DFND | 1 | 2,635,000 | 0 | 4,400,000 | |
| CLOVIS ONCOLOGY INC | COM | 189464100 | 39,990 | 714,100 | SH | DFND | 1 | 281,200 | 0 | 432,900 | |
| CONNECTURE INC | COM | 20786J106 | 2,724 | 302,300 | SH | DFND | 1 | 138,200 | 0 | 164,100 | |
| COOPER COS INC | COM NEW | 216648402 | 197,847 | 1,220,600 | SH | DFND | 1 | 559,200 | 0 | 661,400 | |
| COVIDIEN PLC | SHS | G2554F113 | 25,570 | 250,000 | SH | Call | DFND | 1 | 86,700 | 0 | 163,300 |
| COVIDIEN PLC | SHS | G2554F113 | 21,602 | 211,200 | SH | DFND | 1 | 52,000 | 0 | 159,200 | |
| CURIS INC | COM | 231269101 | 2,925 | 1,950,100 | SH | DFND | 1 | 0 | 0 | 1,950,100 | |
| DAVITA HEALTHCARE PARTNERS I | COM | 23918K108 | 5,756 | 76,000 | SH | DFND | 1 | 19,000 | 0 | 57,000 | |
| DERMA SCIENCES INC | COM PAR $.01 | 249827502 | 2,793 | 300,000 | SH | DFND | 1 | 134,300 | 0 | 165,700 | |
| ENDOLOGIX INC | NOTE 2.250%12/1 | 29266SAA4 | 980 | 1,000,000 | PRN | DFND | 1 | 0 | 0 | 1,000,000 | |
| EXACT SCIENCES CORP | COM | 30063P105 | 48,788 | 1,778,000 | SH | DFND | 1 | 824,000 | 0 | 954,000 | |
| EXPRESS SCRIPTS HLDG CO | COM | 30219G108 | 195,334 | 2,307,000 | SH | DFND | 1 | 961,000 | 0 | 1,346,000 | |
| FATE THERAPEUTICS INC | COM | 31189P102 | 3,485 | 692,900 | SH | DFND | 1 | 296,100 | 0 | 396,800 | |
| FLUIDIGM CORP DEL | COM | 34385P108 | 72,054 | 2,136,200 | SH | DFND | 1 | 878,000 | 0 | 1,258,200 | |
| FLUIDIGM CORP DEL | NOTE 2.750% 2/0 | 34385PAA6 | 19,851 | 21,935,000 | PRN | DFND | 1 | 5,330,000 | 0 | 16,605,000 | |
| FORWARD PHARMA A/S | SPONSORED ADR | 34986J105 | 20,009 | 960,600 | SH | DFND | 1 | 389,100 | 0 | 571,500 | |
| GILEAD SCIENCES INC | COM | 375558103 | 400,558 | 4,249,500 | SH | DFND | 1 | 1,519,200 | 0 | 2,730,300 | |
| HCA HOLDINGS INC | COM | 40412C101 | 316,164 | 4,308,000 | SH | DFND | 1 | 1,871,000 | 0 | 2,437,000 | |
| HEALTH NET INC | COM | 42222G108 | 198,671 | 3,711,400 | SH | DFND | 1 | 1,576,000 | 0 | 2,135,400 | |
| HORIZON PHARMA PLC | SHS | G4617B105 | 13,857 | 1,075,000 | SH | DFND | 1 | 0 | 0 | 1,075,000 | |
| ILLUMINA INC | COM | 452327109 | 272,551 | 1,476,600 | SH | DFND | 1 | 582,500 | 0 | 894,100 | |
| IMPAX LABORATORIES INC | COM | 45256B101 | 211,559 | 6,678,000 | SH | DFND | 1 | 2,592,300 | 0 | 4,085,700 | |
| IMPAX LABORATORIES INC | COM | 45256B101 | 4,752 | 150,000 | SH | Call | DFND | 1 | 59,500 | 0 | 90,500 |
| INCYTE CORP | COM | 45337C102 | 230,245 | 3,149,300 | SH | DFND | 1 | 1,463,900 | 0 | 1,685,400 | |
| INCYTE CORP | NOTE 4.750%10/0 | 45337CAJ1 | 35,309 | 4,242,000 | PRN | DFND | 1 | 0 | 0 | 4,242,000 | |
| INCYTE CORP | NOTE 0.375%11/1 | 45337CAM4 | 6,425 | 4,250,000 | PRN | DFND | 1 | 1,816,000 | 0 | 2,434,000 | |
| INCYTE CORP | NOTE 1.250%11/1 | 45337CAN2 | 6,558 | 4,250,000 | PRN | DFND | 1 | 1,816,000 | 0 | 2,434,000 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 80,006 | 4,736,900 | SH | DFND | 1 | 1,766,600 | 0 | 2,970,300 | |
| INSPIREMD INC | COM NEW | 45779A309 | 2,449 | 3,150,000 | SH | SOLE | 3,150,000 | 0 | 0 | ||
| INSULET CORP | COM | 45784P101 | 91,982 | 1,997,000 | SH | DFND | 1 | 948,800 | 0 | 1,048,200 | |
| INSYS THERAPEUTICS INC NEW | COM NEW | 45824V209 | 52,413 | 1,243,200 | SH | DFND | 1 | 449,500 | 0 | 793,700 | |
| INTERCEPT PHARMACEUTICALS IN | COM | 45845P108 | 231,660 | 1,485,000 | SH | SOLE | 1,485,000 | 0 | 0 | ||
| INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 232,734 | 440,000 | SH | DFND | 1 | 212,500 | 0 | 227,500 | |
| IRONWOOD PHARMACEUTICALS INC | COM CL A | 46333X108 | 184,025 | 12,012,100 | SH | DFND | 1 | 4,781,300 | 0 | 7,230,800 | |
| JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 18,829 | 115,000 | SH | DFND | 1 | 0 | 0 | 115,000 | |
| JOHNSON & JOHNSON | COM | 478160104 | 51,762 | 495,000 | SH | DFND | 1 | 123,000 | 0 | 372,000 | |
| KYTHERA BIOPHARMACEUTICALS I | COM | 501570105 | 25,070 | 722,900 | SH | DFND | 1 | 285,800 | 0 | 437,100 | |
| LOXO ONCOLOGY INC | COM | 548862101 | 25,566 | 2,175,857 | SH | SOLE | 2,175,857 | 0 | 0 | ||
| MAGELLAN HEALTH INC | COM NEW | 559079207 | 72,516 | 1,208,000 | SH | DFND | 1 | 447,000 | 0 | 761,000 | |
| MALLINCKRODT PUB LTD CO | SHS | G5785G107 | 56,150 | 567,001 | SH | DFND | 1 | 227,001 | 0 | 340,000 | |
| MCKESSON CORP | COM | 58155Q103 | 154,024 | 742,000 | SH | DFND | 1 | 299,000 | 0 | 443,000 | |
| MEDIVATION INC | COM | 58501N101 | 226,005 | 2,268,900 | SH | DFND | 1 | 878,000 | 0 | 1,390,900 | |
| MEDTRONIC INC | COM | 585055106 | 35,652 | 493,800 | SH | DFND | 1 | 121,000 | 0 | 372,800 | |
| MEI PHARMA INC | COM NEW | 55279B202 | 10,353 | 2,424,500 | SH | DFND | 1 | 1,087,800 | 0 | 1,336,700 | |
| MERCK & CO INC NEW | COM | 58933Y105 | 165,560 | 2,915,300 | SH | DFND | 1 | 1,242,000 | 0 | 1,673,300 | |
| MERGE HEALTHCARE INC | COM | 589499102 | 16,477 | 4,628,500 | SH | DFND | 1 | 1,621,000 | 0 | 3,007,500 | |
| MIMEDX GROUP INC | COM | 602496101 | 9,648 | 836,800 | SH | DFND | 1 | 315,000 | 0 | 521,800 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 21,613 | 1,167,000 | SH | SOLE | 1,167,000 | 0 | 0 | ||
| MOLINA HEALTHCARE INC | COM | 60855R100 | 191,739 | 3,581,900 | SH | DFND | 1 | 1,552,000 | 0 | 2,029,900 | |
| NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 133,339 | 5,968,600 | SH | DFND | 1 | 2,255,700 | 0 | 3,712,900 | |
| NEWLINK GENETICS CORP | COM | 651511107 | 3,975 | 100,000 | SH | Call | DFND | 1 | 35,200 | 0 | 64,800 |
| NPS PHARMACEUTICALS INC | COM | 62936P103 | 105,697 | 2,954,900 | SH | DFND | 1 | 1,179,200 | 0 | 1,775,700 | |
| NUVASIVE INC | COM | 670704105 | 50,556 | 1,072,000 | SH | DFND | 1 | 589,000 | 0 | 483,000 | |
| OPHTHOTECH CORP | COM | 683745103 | 38,669 | 861,800 | SH | DFND | 1 | 348,300 | 0 | 513,500 | |
| ORASURE TECHNOLOGIES INC | COM | 68554V108 | 20,062 | 1,978,500 | SH | DFND | 1 | 728,500 | 0 | 1,250,000 | |
| OREXIGEN THERAPEUTICS INC | NOTE 2.750%12/0 | 686164AB0 | 7,538 | 7,500,000 | PRN | DFND | 1 | 2,210,000 | 0 | 5,290,000 | |
| OTONOMY INC | COM | 68906L105 | 75,206 | 2,256,398 | SH | SOLE | 2,256,398 | 0 | 0 | ||
| PACIRA PHARMACEUTICALS INC | COM | 695127100 | 15,604 | 176,000 | SH | DFND | 1 | 0 | 0 | 176,000 | |
| PERNIX THERAPEUTICS HLDGS IN | COM | 71426V108 | 10,075 | 1,073,000 | SH | DFND | 1 | 485,000 | 0 | 588,000 | |
| PERRIGO CO PLC | SHS | G97822103 | 208,582 | 1,247,800 | SH | DFND | 1 | 543,000 | 0 | 704,800 | |
| PFIZER INC | COM | 717081103 | 85,943 | 2,759,000 | SH | DFND | 1 | 541,000 | 0 | 2,218,000 | |
| PORTOLA PHARMACEUTICALS INC | COM | 737010108 | 24,092 | 850,700 | SH | DFND | 1 | 475,700 | 0 | 375,000 | |
| PROQR THRAPEUTICS N V | SHS EURO | N71542109 | 39,643 | 1,829,400 | SH | DFND | 1 | 833,600 | 0 | 995,800 | |
| PUMA BIOTECHNOLOGY INC | COM | 74587V107 | 47,488 | 250,900 | SH | DFND | 1 | 99,800 | 0 | 151,100 | |
| RECEPTOS INC | COM | 756207106 | 19,124 | 156,100 | SH | DFND | 1 | 0 | 0 | 156,100 | |
| REDHILL BIOPHARMA LTD | SPONSORED ADS | 757468103 | 8,075 | 605,800 | SH | SOLE | 605,800 | 0 | 0 | ||
| REGENERON PHARMACEUTICALS | COM | 75886F107 | 160,080 | 390,200 | SH | DFND | 1 | 159,000 | 0 | 231,200 | |
| REGULUS THERAPEUTICS INC | COM | 75915K101 | 6,416 | 400,000 | SH | DFND | 1 | 0 | 0 | 400,000 | |
| RELYPSA INC | COM | 759531106 | 272,813 | 8,857,551 | SH | SOLE | 8,857,551 | 0 | 0 | ||
| ROKA BIOSCIENCE INC | COM | 775431109 | 14,202 | 3,220,429 | SH | SOLE | 3,220,429 | 0 | 0 | ||
| SAGE THERAPEUTICS INC | COM | 78667J108 | 15,091 | 412,335 | SH | SOLE | 412,335 | 0 | 0 | ||
| SALIX PHARMACEUTICALS INC | COM | 795435106 | 9,425 | 82,000 | SH | DFND | 1 | 0 | 0 | 82,000 | |
| SANGAMO BIOSCIENCES INC | COM | 800677106 | 1,521 | 100,000 | SH | Call | DFND | 1 | 39,700 | 0 | 60,300 |
| SEATTLE GENETICS INC | COM | 812578102 | 3,213 | 100,000 | SH | Put | DFND | 1 | 39,700 | 0 | 60,300 |
| SHIRE PLC | SPONSORED ADR | 82481R106 | 248,672 | 1,170,000 | SH | DFND | 1 | 501,000 | 0 | 669,000 | |
| SHIRE PLC | SPONSORED ADR | 82481R106 | 10,627 | 50,000 | SH | Call | DFND | 1 | 18,500 | 0 | 31,500 |
| SIENTRA INC | COM | 82621J105 | 53,481 | 3,185,308 | SH | SOLE | 3,185,308 | 0 | 0 | ||
| SINOVAC BIOTECH LTD | SHS | P8696W104 | 14,756 | 2,821,500 | SH | DFND | 1 | 1,373,500 | 0 | 1,448,000 | |
| SPDR S&P 500 ETF TR | TR UNIT | 78462F103 | 41,108 | 200,000 | SH | Put | DFND | 1 | 79,400 | 0 | 120,600 |
| ST JUDE MED INC | COM | 790849103 | 11,250 | 173,000 | SH | DFND | 1 | 43,000 | 0 | 130,000 | |
| STRYKER CORP | COM | 863667101 | 97,311 | 1,031,600 | SH | DFND | 1 | 367,600 | 0 | 664,000 | |
| SUPERNUS PHARMACEUTICALS INC | COM | 868459108 | 4,814 | 580,000 | SH | DFND | 1 | 0 | 0 | 580,000 | |
| SYNAGEVA BIOPHARMA CORP | COM | 87159A103 | 7,219 | 77,800 | SH | DFND | 1 | 34,300 | 0 | 43,500 | |
| TESARO INC | COM | 881569107 | 49,463 | 1,330,000 | SH | DFND | 1 | 524,000 | 0 | 806,000 | |
| TEVA PHARMACEUTICAL INDS LTD | ADR | 881624209 | 23,004 | 400,000 | SH | DFND | 1 | 103,000 | 0 | 297,000 | |
| THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 199,925 | 1,595,700 | SH | DFND | 1 | 695,700 | 0 | 900,000 | |
| TORNIER N V | SHS | N87237108 | 122,528 | 4,805,000 | SH | DFND | 1 | 2,100,000 | 0 | 2,705,000 | |
| UNITEDHEALTH GROUP INC | COM | 91324P102 | 23,756 | 235,000 | SH | DFND | 1 | 60,000 | 0 | 175,000 | |
| UROPLASTY INC | COM NEW | 917277204 | 2,809 | 1,363,500 | SH | DFND | 1 | 600,600 | 0 | 762,900 | |
| VALEANT PHARMACEUTICALS INTL | COM | 91911K102 | 23,184 | 162,000 | SH | DFND | 1 | 41,000 | 0 | 121,000 | |
| VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 205,667 | 1,731,200 | SH | DFND | 1 | 594,000 | 0 | 1,137,200 | |
| VOLCANO CORPORATION | NOTE 1.750%12/0 | 928645AB6 | 14,865 | 15,000,000 | PRN | DFND | 1 | 4,683,000 | 0 | 10,317,000 | |
| WRIGHT MED GROUP INC | COM | 98235T107 | 67,900 | 2,527,000 | SH | DFND | 1 | 1,122,000 | 0 | 1,405,000 | |
| XENCOR INC | COM | 98401F105 | 16,778 | 1,046,000 | SH | DFND | 1 | 0 | 0 | 1,046,000 | |
| XENOPORT INC | COM | 98411C100 | 48,639 | 5,546,100 | SH | DFND | 1 | 2,098,700 | 0 | 3,447,400 | |
| XOMA CORP DEL | COM | 98419J107 | 7,180 | 2,000,000 | SH | DFND | 1 | 526,700 | 0 | 1,473,300 | |
| ZIMMER HLDGS INC | COM | 98956P102 | 145,484 | 1,282,700 | SH | DFND | 1 | 493,700 | 0 | 789,000 | |