The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ACHAOGEN INC | COM | 004449104 | 1,783 | 136,600 | SH | DFND | 1 | 0 | 136,600 | 0 | |
| ANTHERA PHARMACEUTICALS INC | COM NEW | 03674U201 | 884 | 559,624 | SH | DFND | 1 | 0 | 559,624 | 0 | |
| APTOSE BIOSCIENCES INC | COM NEW | 03835T200 | 986 | 166,664 | SH | DFND | 1 | 0 | 166,664 | 0 | |
| ARQULE INC | COM | 04269E107 | 5,763 | 4,723,811 | SH | DFND | 1 | 0 | 4,723,811 | 0 | |
| ARRAY BIOPHARMA INC | NOTE 3.000% 06/0 | 04269XAA3 | 8,477 | 9,000,000 | PRN | DFND | 1 | 0 | 9,000,000 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 55,683 | 11,772,335 | SH | DFND | 1 | 0 | 11,772,335 | 0 | |
| BIOLINERX LTD | SPONSORED ADR | 09071M106 | 2,432 | 1,501,000 | SH | DFND | 1 | 0 | 1,501,000 | 0 | |
| BIOTA PHARMACEUTIALS INC | COM | 090694100 | 976 | 435,900 | SH | DFND | 1 | 0 | 435,900 | 0 | |
| CHEMOCENTRYX INC | COM | 16383L106 | 58,716 | 8,596,772 | SH | DFND | 1 | 0 | 8,596,772 | 0 | |
| CONCERT PHARMACEUTICALS INC | COM | 206022105 | 16,070 | 1,206,459 | SH | DFND | 1 | 0 | 1,206,459 | 0 | |
| CYTOKINETICS INC | COM NEW | 23282W605 | 19,569 | 2,443,100 | SH | DFND | 1 | 0 | 2,443,100 | 0 | |
| EXELIXIS INC | NOTE 4.250% 8/1 | 30161QAC8 | 18,093 | 31,239,000 | PRN | DFND | 1 | 0 | 31,239,000 | 0 | |
| EXELIXIS INC | COM | 30161Q104 | 6,041 | 4,195,352 | SH | DFND | 1 | 0 | 4,195,352 | 0 | |
| FIVE PRIME THERAPEUTICS INC | COM | 33830X104 | 22,311 | 826,332 | SH | DFND | 1 | 0 | 826,332 | 0 | |
| FORWARD PHARMA A/S | SPONSORED ADR | 34986J105 | 21,921 | 1,052,381 | SH | DFND | 1 | 0 | 1,052,381 | 0 | |
| GTX INC DEL | COM | 40052B108 | 8,111 | 11,111,111 | SH | DFND | 1 | 0 | 11,111,111 | 0 | |
| IRONWOOD PHARMACEUTICALS INC | COM CL A | 46333X108 | 78,037 | 5,093,810 | SH | DFND | 1 | 0 | 5,093,810 | 0 | |
| KALOBIOS PHARMACEUTICALS INC | COM | 48344T100 | 2,010 | 1,162,000 | SH | DFND | 1 | 0 | 1,162,000 | 0 | |
| LIGAND PHARMACEUTICALS INC | COM NEW | 53220K504 | 45,764 | 860,063 | SH | DFND | 1 | 0 | 860,063 | 0 | |
| LOXO ONCOLOGY INC | COM | 548862101 | 13,991 | 1,190,702 | SH | DFND | 1 | 0 | 1,190,702 | 0 | |
| MAST THERAPEUTICS INC | COM | 576314108 | 4,083 | 7,291,600 | SH | DFND | 1 | 0 | 7,291,600 | 0 | |
| ONCOGENEX PHARMACEUTICALS IN | COM | 68230A106 | 3,134 | 1,368,500 | SH | DFND | 1 | 0 | 1,368,500 | 0 | |
| ONCOMED PHARMACEUTICALS INC | COM | 68234X102 | 29,916 | 1,374,815 | SH | DFND | 1 | 0 | 1,374,815 | 0 | |
| ONCOTHYREON INC | COM | 682324108 | 26,148 | 13,762,260 | SH | DFND | 1 | 0 | 13,762,260 | 0 | |
| QLT INC | COM | 746927102 | 10,629 | 2,650,563 | SH | DFND | 1 | 0 | 2,650,563 | 0 | |
| REGADO BIOSCIENCES INC | COM | 75874Q107 | 1,719 | 1,882,521 | SH | DFND | 1 | 0 | 1,882,521 | 0 | |
| SOPHIRIS BIO INC | COM NEW | 83578Q209 | 573 | 1,060,283 | SH | DFND | 1 | 0 | 1,060,283 | 0 | |
| SUNESIS PHARMACEUTICALS INC | COM NEW | 867328601 | 7,997 | 3,136,000 | SH | DFND | 1 | 0 | 3,136,000 | 0 | |
| TARGACEPT INC | COM | 87611R306 | 17,503 | 6,655,128 | SH | DFND | 1 | 0 | 6,655,128 | 0 | |
| VITAE PHARMACEUTICALS INC | COM | 92847N103 | 12,545 | 753,935 | SH | DFND | 1 | 0 | 753,935 | 0 | |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 12,210 | 618,224 | SH | DFND | 1 | 0 | 618,224 | 0 | |