The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERATE DIAGNOSTICS INC COM 00430H102 215 10,000 SH   SOLE 0 10,000 0 0
ADURO BIOTECH INC COM 00739L101 294 10,436 SH   SOLE 0 10,436 0 0
ALLERGAN PLC SHS G0177J108 21,487 68,758 SH   SOLE 0 68,758 0 0
AMICUS THERAPEUTICS INC COM 03152W109 99,722 10,280,620 SH   SOLE 0 10,280,620 0 0
ARRAY BIOPHARMA INC COM 04269X105 75,330 17,850,650 SH   SOLE 0 17,850,650 0 0
ARRAY BIOPHARMA INC NOTE 3.000% 6/0 04269XAA3 3,702 4,000,000 PRN   SOLE 0 4,000,000 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 40,538 1,534,962 SH   SOLE 0 1,534,962 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 41 16,610 SH   SOLE 0 16,610 0 0
AVALANCHE BIOTECHNOLOGIES IN COM 05337G107 231 24,236 SH   SOLE 0 24,236 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 7,288 276,687 SH   SOLE 0 276,687 0 0
BOSTON SCIENTIFIC CORP COM 101137107 41,509 2,251,020 SH   SOLE 0 2,251,020 0 0
CASTLIGHT HEALTH INC CL B 14862Q100 44 10,229 SH   SOLE 0 10,229 0 0
CELGENE CORP COM 151020104 1,204 10,055 SH   SOLE 0 10,055 0 0
CENTENE CORP DEL COM 15135B101 26,850 408,000 SH   SOLE 0 408,000 0 0
CHARLES RIV LABS INTL INC COM 159864107 9,840 122,400 SH   SOLE 0 122,400 0 0
CHEMOCENTRYX INC COM 16383L106 512 63,189 SH   SOLE 0 63,189 0 0
CLOVIS ONCOLOGY INC COM 189464100 62,858 1,795,936 SH   SOLE 0 1,795,936 0 0
CONFORMIS INC COM 20717E101 2,174 125,709 SH   SOLE 0 125,709 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 14,405 738,356 SH   SOLE 0 738,356 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 290 7,994 SH   SOLE 0 7,994 0 0
DIPLOMAT PHARMACY INC COM 25456K101 38,186 1,115,902 SH   SOLE 0 1,115,902 0 0
DURECT CORP COM 266605104 5,809 2,628,416 SH   SOLE 0 2,628,416 0 0
ELEVEN BIOTHERAPEUTICS INC COM 286221106 2,636 875,857 SH   SOLE 0 875,857 0 0
ENDOLOGIX INC COM 29266S106 9,971 1,007,177 SH   SOLE 0 1,007,177 0 0
FATE THERAPEUTICS INC COM 31189P102 7,990 2,371,001 SH   SOLE 0 2,371,001 0 0
FLUIDIGM CORP DEL COM 34385P108 352 32,561 SH   SOLE 0 32,561 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 7,071 218,718 SH   SOLE 0 218,718 0 0
HEALTH NET INC COM 42222G108 12,393 181,029 SH   SOLE 0 181,029 0 0
INCYTE CORP COM 45337C102 38,816 357,912 SH   SOLE 0 357,912 0 0
INSMED INC COM PAR $.01 457669307 25,261 1,391,813 SH   SOLE 0 1,391,813 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 65,824 1,223,717 SH   SOLE 0 1,223,717 0 0
INVITAE CORP COM 46185L103 5,420 660,129 SH   SOLE 0 660,129 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 42,551 3,671,344 SH   SOLE 0 3,671,344 0 0
ISHARES TR US HLTHCR PR ETF 464288828 562 4,520 SH   SOLE 0 4,520 0 0
MEDIVATION INC COM 58501N101 77,315 1,599,393 SH   SOLE 0 1,599,393 0 0
MODEL N INC COM 607525102 20,849 1,868,159 SH   SOLE 0 1,868,159 0 0
NANOSTRING TECHNOLOGIES INC COM 63009R109 19,972 1,357,692 SH   SOLE 0 1,357,692 0 0
NEURODERM LTD ORD SHS M74231107 27,097 1,589,261 SH   SOLE 0 1,589,261 0 0
NEVRO CORP COM 64157F103 28,030 415,198 SH   SOLE 0 415,198 0 0
ONCOTHYREON INC COM 682324108 5,175 2,331,300 SH   SOLE 0 2,331,300 0 0
OXFORD IMMUNOTEC GLOBAL PLC ORD SHS G6855A103 9,893 860,288 SH   SOLE 0 860,288 0 0
PENUMBRA INC COM 70975L107 76,213 1,537,570 SH   SOLE 0 1,537,570 0 0
PFIZER INC COM 717081103 3,996 123,800 SH   SOLE 0 123,800 0 0
PFIZER INC CALL 717081903 40,686 1,260,400 SH Call SOLE 0 1,260,400 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 49,297 958,155 SH   SOLE 0 958,155 0 0
PRESS GANEY HLDGS INC COM 74113L102 7,560 239,616 SH   SOLE 0 239,616 0 0
PRONAI THERAPEUTICS INC COM 74346L101 373 24,787 SH   SOLE 0 24,787 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 4,836 557,193 SH   SOLE 0 557,193 0 0
SAGE THERAPEUTICS INC COM 78667J108 55,873 958,374 SH   SOLE 0 958,374 0 0
SEATTLE GENETICS INC COM 812578102 61,597 1,372,492 SH   SOLE 0 1,372,492 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 317 4,530 SH   SOLE 0 4,530 0 0
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 61,579 938,139 SH   SOLE 0 938,139 0 0
TRIVASCULAR TECHNOLOGIES INC COM 89685A102 9,727 1,462,762 SH   SOLE 0 1,462,762 0 0
UNITEDHEALTH GROUP INC COM 91324P102 22,003 187,034 SH   SOLE 0 187,034 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 18,326 1,213,627 SH   SOLE 0 1,213,627 0 0
WELLCARE HEALTH PLANS INC COM 94946T106 44,022 562,873 SH   SOLE 0 562,873 0 0
ZELTIQ AESTHETICS INC COM 98933Q108 20,240 709,426 SH   SOLE 0 709,426 0 0