The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABIOMED INC COM 003654100 262,233 2,827,005 SH   SOLE 0 2,827,005 0 0
ACELRX PHARMACEUTICALS INC COM 00444T100 5,053 1,656,644 SH   SOLE 0 1,656,644 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 8,244 325,599 SH   SOLE 0 325,599 0 0
ALCOBRA LTD SHS M2239P109 1,535 254,188 SH   SOLE 0 254,188 0 0
ALIGN TECHNOLOGY INC COM 016255101 1,575 27,757 SH   SOLE 0 27,757 0 0
ALIMERA SCIENCES INC COM 016259103 6,660 3,013,793 SH   SOLE 0 3,013,793 0 0
AMAG PHARMACEUTICALS INC COM 00163U106 110,346 2,777,392 SH   SOLE 0 2,777,392 0 0
AMICUS THERAPEUTICS INC COM 03152W109 27,622 1,974,376 SH   SOLE 0 1,974,376 0 0
ANACOR PHARMACEUTICALS INC COM 032420101 303,592 2,579,154 SH   SOLE 0 2,579,154 0 0
ARIAD PHARMACEUTICALS INC COM 04033A100 13,033 2,231,717 SH   SOLE 0 2,231,717 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 175,515 1,666,492 SH   SOLE 0 1,666,492 0 0
BIOSPECIFICS TECHNOLOGIES CO COM 090931106 1,274 29,257 SH   SOLE 0 29,257 0 0
CELGENE CORP COM 151020104 29,292 270,800 SH   SOLE 0 270,800 0 0
CLOVIS ONCOLOGY INC COM 189464100 285,886 3,108,808 SH   SOLE 0 3,108,808 0 0
CYTOKINETICS INC COM NEW 23282W605 827 123,686 SH   SOLE 0 123,686 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 2,199 267,890 SH   SOLE 0 267,890 0 0
ENDO INTL PLC SHS G30401106 55,509 801,230 SH   SOLE 0 801,230 0 0
EPIZYME INC COM 29428V104 27,207 2,115,638 SH   SOLE 0 2,115,638 0 0
EXACT SCIENCES CORP COM 30063P105 7,064 392,676 SH   SOLE 0 392,676 0 0
GILEAD SCIENCES INC COM 375558103 31,116 316,900 SH   SOLE 0 316,900 0 0
HEARTWARE INTL INC COM 422368100 12,757 243,868 SH   SOLE 0 243,868 0 0
HISTOGENICS CORP COM 43358V109 1,811 454,545 SH   SOLE 0 454,545 0 0
IDERA PHARMACEUTICALS INC COM NEW 45168K306 4,213 1,257,748 SH   SOLE 0 1,257,748 0 0
INSMED INC COM PAR $.01 457669307 88,557 4,768,800 SH   SOLE 0 4,768,800 0 0
INTREXON CORP COM 46122T102 1,498 47,100 SH   SOLE 0 47,100 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 13,374 29,100 SH   SOLE 0 29,100 0 0
KARYOPHARM THERAPEUTICS INC COM 48576U106 32,493 3,085,745 SH   SOLE 0 3,085,745 0 0
KYTHERA BIOPHARMACEUTICALS I COM 501570105 84,395 1,125,564 SH   SOLE 0 1,125,564 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 492 59,017 SH   SOLE 0 59,017 0 0
MEDIVATION INC COM 58501N101 21,669 509,862 SH   SOLE 0 509,862 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 23,879 1,455,176 SH   SOLE 0 1,455,176 0 0
OREXIGEN THERAPEUTICS INC COM 686164104 4,075 1,931,324 SH   SOLE 0 1,931,324 0 0
PROTHENA CORP PLC SHS G72800108 31,553 695,918 SH   SOLE 0 695,918 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 12,786 5,176,319 SH   SOLE 0 5,176,319 0 0
SEQUENOM INC COM NEW 817337405 17,542 10,023,842 SH   SOLE 0 10,023,842 0 0
SHIRE PLC SPONSORED ADR 82481R106 21,488 104,700 SH   SOLE 0 104,700 0 0
SOPHIRIS BIO INC COM NEW 83578Q209 163 191,600 SH   SOLE 0 191,600 0 0
STAAR SURGICAL CO COM PAR $0.01 852312305 20,509 2,642,922 SH   SOLE 0 2,642,922 0 0
SUNESIS PHARMACEUTICALS INC COM NEW 867328601 5,650 6,974,854 SH   SOLE 0 6,974,854 0 0
THORATEC CORP COM NEW 885175307 17,008 268,861 SH   SOLE 0 268,861 0 0
UNIQURE NV SHS N90064101 418 20,453 SH   SOLE 0 20,453 0 0
UNITED THERAPEUTICS CORP DEL COM 91307C102 200,043 1,524,254 SH   SOLE 0 1,524,254 0 0
VANDA PHARMACEUTICALS INC COM 921659108 45,087 3,997,108 SH   SOLE 0 3,997,108 0 0
WRIGHT MED GROUP INC COM 98235T107 43,222 2,056,251 SH   SOLE 0 2,056,251 0 0
XOMA CORP DEL COM 98419J107 601 799,000 SH   SOLE 0 799,000 0 0
ZELTIQ AESTHETICS INC COM 98933Q108 18,207 568,436 SH   SOLE 0 568,436 0 0
ZOGENIX INC COM NEW 98978L204 375 27,800 SH   SOLE 0 27,800 0 0