The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8

COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aclaris therapeutics Common 00461U105 107,342 4,191,397 SH   SOLE   0 0 4,191,397
Advanced Accelerator Applications S.A. Common 00790T100 17,357 455,798 SH   SOLE   0 0 455,798
Agile Therapeutics, Inc. Common 00847L100 14,099 2,019,955 SH   SOLE   0 0 2,019,955
Aimmune Therapeutics, Inc. Common 00900T107 11,445 763,009 SH   SOLE   0 0 763,009
Akari Therapeutics Plc ADR 00972G108 4,492 527,842 SH   SOLE   0 0 527,842
Ascendis Pharma ADR 04351P101 35,513 1,766,832 SH   SOLE   0 0 1,766,832
Capnia, Inc. Common 14066L105 6,711 7,456,984 SH   SOLE   7,456,984 0 0
Capnia, Inc. Warrant 14066L113 198 943,858 SH   SOLE   943,858 0 0
Carbylan Therapeutics Common 141384107 1,934 4,204,562 SH   SOLE   0 0 4,204,562
CoLucid Pharmaceuticals, Inc. Common 19716T101 8,584 225,000 SH   SOLE   0 0 0
Codexis, Inc. Common 192005106 23,509 5,294,825 SH   SOLE   0 0 5,294,825
Dynavax Technologies Corporation Common 268158201 3,775 359,828 SH   SOLE   0 0 359,828
Eiger BioPharmaceuticals Common 28249U105 23,929 1,787,091 SH   SOLE   1,599,591 0 0
Foamix Pharmaceuticals Ltd. Common M46135105 7,917 855,000 SH   SOLE   0 0 855,000
Nabriva Therapeutics AG ADR 62957M104 22,219 3,151,700 SH   SOLE   3,151,700 0 0
Ocera Therapeutics, Inc. Common 67552A108 405 153,331 SH   SOLE   0 0 153,331
Palatin Technologies, Inc. Common 696077403 148 234,909 SH   SOLE   0 0 234,909
ProNAi Therapeutics, Inc. Common 74346L101 4,438 2,438,270 SH   SOLE   0 0 2,438,270
Regenxbio Inc. Common 75901B107 13,876 990,449 SH   SOLE   0 0 990,449
ReVance Therapeutics, Inc. Common 761330109 1,254 77,373 SH   SOLE   0 0 77,373
Trevena, Inc. Common 89532E109 11,664 1,728,000 SH   SOLE   0 0 1,728,000
Zosano Pharma Corp Common 98979H103 78 98,515 SH   SOLE   0 0 98,515