The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| ADURO BIOTECH INC | COM | 00739L101 | 6,229 | 501,155 | SH | DFND | 1 | 0 | 501,155 | 0 | |
| ARQULE INC | COM | 04269E107 | 13,246 | 7,400,128 | SH | DFND | 1 | 0 | 7,400,128 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 43,613 | 6,461,186 | SH | DFND | 1 | 0 | 6,461,186 | 0 | |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 82,123 | 2,765,080 | SH | DFND | 1 | 0 | 2,765,080 | 0 | |
| CASCADIAN THERAPEUTICS INC | COM | 14740B101 | 30,831 | 18,799,368 | SH | DFND | 1 | 0 | 18,799,368 | 0 | |
| CATALYST BIOSCIENCES INC | COM | 14888D109 | 1,048 | 865,773 | SH | DFND | 1 | 0 | 865,773 | 0 | |
| CHEMOCENTRYX INC | COM | 16383L106 | 48,707 | 8,064,019 | SH | DFND | 1 | 0 | 8,064,019 | 0 | |
| COLUCID PHARMACEUTICALS INC | COM | 19716T101 | 29,120 | 763,300 | SH | DFND | 1 | 0 | 763,300 | 0 | |
| CONCERT PHARMACEUTICALS INC | COM | 206022105 | 27,532 | 2,723,210 | SH | DFND | 1 | 0 | 2,723,210 | 0 | |
| CTI BIOPHARMA CORP | COM | 12648L106 | 16,767 | 44,796,940 | SH | DFND | 1 | 0 | 44,796,940 | 0 | |
| CYTOKINETICS INC | COM NEW | 23282W605 | 45,873 | 4,997,071 | SH | DFND | 1 | 0 | 4,997,071 | 0 | |
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 9,280 | 591,813 | SH | DFND | 1 | 0 | 591,813 | 0 | |
| ESPERION THERAPEUTICS INC NE | COM | 29664W105 | 6,840 | 493,872 | SH | DFND | 1 | 0 | 493,872 | 0 | |
| FORWARD PHARMA A/S | SPONSORED ADR | 34986J105 | 29,145 | 1,387,853 | SH | DFND | 1 | 0 | 1,387,853 | 0 | |
| GLOBEIMMUNE INC | COM | 37957B100 | 822 | 657,653 | SH | DFND | 1 | 0 | 657,653 | 0 | |
| GLYCOMIMETICS INC | COM | 38000Q102 | 17,348 | 2,426,282 | SH | DFND | 1 | 0 | 2,426,282 | 0 | |
| GTX INC DEL | COM | 40052B108 | 9,014 | 11,512,000 | SH | DFND | 1 | 0 | 11,512,000 | 0 | |
| IMMUNE DESIGN CORP | COM | 45252L103 | 9,096 | 1,200,000 | SH | DFND | 1 | 0 | 1,200,000 | 0 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 8,033 | 5,149,644 | SH | DFND | 1 | 0 | 5,149,644 | 0 | |
| NIVALIS THERAPEUTICS INC | COM | 65481J109 | 13,900 | 1,709,673 | SH | DFND | 1 | 0 | 1,709,673 | 0 | |
| ONCOMED PHARMACEUTICALS INC | COM | 68234X102 | 20,711 | 1,812,005 | SH | DFND | 1 | 0 | 1,812,005 | 0 | |
| OREXIGEN THERAPEUTICS INC | COM NEW | 686164302 | 2,440 | 734,976 | SH | DFND | 1 | 0 | 734,976 | 0 | |
| OREXIGEN THERAPEUTICS INC | NOTE 2.750%12/0 | 686164AB0 | 2,650 | 10,000,000 | PRN | DFND | 1 | 0 | 10,000,000 | 0 | |
| PAIN THERAPEUTICS INC | COM | 69562K100 | 2,278 | 2,278,552 | SH | DFND | 1 | 0 | 2,278,552 | 0 | |
| PIERIS PHARMACEUTICALS INC | COM | 720795103 | 1,858 | 1,016,593 | SH | DFND | 1 | 0 | 1,016,593 | 0 | |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 7,924 | 375,000 | SH | DFND | 1 | 0 | 375,000 | 0 | |
| SUNESIS PHARMACEUTICALS INC | COM PAR | 867328700 | 3,192 | 730,361 | SH | DFND | 1 | 0 | 730,361 | 0 | |
| TOBIRA THERAPEUTICS INC | COM | 88883P101 | 15,873 | 399,433 | SH | DFND | 1 | 0 | 399,433 | 0 | |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 25,182 | 3,108,905 | SH | DFND | 1 | 0 | 3,108,905 | 0 | |