The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACCELERON PHARMA INC COM 00434H108 2,552 100,000 SH   DFND 1,2 100,000 0 0
ACHAOGEN INC COM 004449104 6,697 514,342 SH   DFND 1,2 514,342 0 0
ADAMAS PHARMACEUTICALS INC COM 00548A106 4,563 270,000 SH   DFND 1,2 270,000 0 0
ADVANCE AUTO PARTS INC COM 00751Y106 2,716 16,059 SH   DFND   16,059 0 0
AEVI GENOMIC MEDICINE INC COM 00835P105 2,331 450,000 SH   DFND 1,2 450,000 0 0
AIR PRODS & CHEMS INC COM 009158106 3,044 21,165 SH   DFND   21,165 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 1,971 368,500 SH   DFND 1,2 368,500 0 0
ALEXION PHARMACEUTICALS INC COM 015351109 13,826 113,000 SH   DFND 1,2 113,000 0 0
ALPHABET INC CAP STK CL A 02079K305 4,555 5,748 SH   DFND   5,748 0 0
AMICUS THERAPEUTICS INC COM 03152W109 3,628 730,000 SH   DFND 1,2 730,000 0 0
ARBUTUS BIOPHARMA CORP COM 03879J100 54 22,000 SH   DFND 1,2 22,000 0 0
ARDELYX INC COM 039697107 2,156 151,813 SH   DFND 1,2 151,813 0 0
ARRAY BIOPHARMA INC COM 04269X105 7,911 900,000 SH   DFND 1,2 900,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 6,611 326,622 SH   DFND 1,2 326,622 0 0
ASTRAZENECA PLC SPONSORED ADR 046353108 1,366 50,000 SH   DFND 1,2 50,000 0 0
AVEXIS INC COM 05366U100 2,148 45,000 SH   DFND 1,2 45,000 0 0
AXOVANT SCIENCES LTD COM G0750W104 1,242 100,000 SH   DFND 1,2 100,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 3,728 45,000 SH   DFND 1,2 45,000 0 0
BOEING CO COM 097023105 1,306 8,392 SH   DFND   8,392 0 0
CABLE ONE INC COM 12685J105 311 500 SH   DFND   500 0 0
CATABASIS PHARMACEUTICALS IN COM 14875P107 1,400 387,943 SH   DFND 1,2 387,943 0 0
CELGENE CORP COM 151020104 20,835 180,000 SH   DFND 1,2 180,000 0 0
CHARTER COMMUNICATIONS INC N CL A 16119P108 4,654 16,165 SH   DFND   16,165 0 0
CLEARSIDE BIOMEDICAL INC COM 185063104 2,682 300,000 SH   DFND 1,2 300,000 0 0
COGNIZANT TECHNOLOGY SOLUTIO CL A 192446102 1,562 27,875 SH   DFND   27,875 0 0
COLUCID PHARMACEUTICALS INC COM 19716T101 13,031 358,000 SH   DFND 1,2 358,000 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 4,579 320,229 SH   DFND 1,2 320,229 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 2,777 79,058 SH   DFND 1,2 79,058 0 0
EDGE THERAPEUTICS INC COM 279870109 1,875 150,000 SH   DFND 1,2 150,000 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 4,489 385,301 SH   DFND 1,2 385,301 0 0
FACEBOOK INC CL A 30303M102 1,503 13,062 SH   DFND   13,062 0 0
FIBROGEN INC COM 31572Q808 3,332 155,700 SH   DFND 1,2 155,700 0 0
FIDELITY NATL INFORMATION SV COM 31620M106 3,291 43,503 SH   DFND   43,503 0 0
FIVE PRIME THERAPEUTICS INC COM 33830X104 2,004 40,000 SH   DFND 1,2 40,000 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 3,796 342,000 SH   DFND 1,2 342,000 0 0
FORWARD PHARMA A/S SPONSORED ADR 34986J105 1,824 121,500 SH   DFND 1,2 121,500 0 0
GENOCEA BIOSCIENCES INC COM 372427104 2,869 696,273 SH   DFND 1,2 696,273 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 1,806 125,000 SH   DFND 1,2 125,000 0 0
GLYCOMIMETICS INC COM 38000Q102 4,549 745,796 SH   DFND 1,2 745,796 0 0
HORIZON PHARMA PLC CALL G4617B905 293 18,100 SH Call DFND 1,2 0 0 0
HORIZON PHARMA PLC SHS G4617B105 4,854 300,000 SH   DFND 1,2 300,000 0 0
IGNYTA INC COM 451731103 117 22,065 SH   DFND 1,2 22,065 0 0
IMMUNE DESIGN CORP COM 45252L103 567 103,000 SH   DFND 1,2 103,000 0 0
IMMUNOMEDICS INC COM 452907108 3,854 1,050,000 SH   DFND 1,2 1,050,000 0 0
INOTEK PHARMACEUTICALS CORP COM 45780V102 2,451 401,764 SH   DFND 1,2 401,764 0 0
ISHARES TR PUT 464287958 2,682 12,000 SH Put DFND   12,000 0 0
ISHARES TR PUT 464287955 13,485 100,000 SH Put DFND   100,000 0 0
ISHARES TR CALL 464287903 13,485 100,000 SH Call DFND   0 0 0
ITURAN LOCATION AND CONTROL SHS M6158M104 8,126 306,633 SH   DFND   306,633 0 0
KITE PHARMA INC COM 49803L109 2,242 50,000 SH   DFND 1,2 50,000 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 888 50,677 SH   DFND 1,2 50,677 0 0
LOWES COS INC COM 548661107 185 2,600 SH   DFND   2,600 0 0
MACROGENICS INC COM 556099109 1,660 81,200 SH   DFND 1,2 81,200 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 1,354 1,340,588 SH   DFND 1,2 1,340,588 0 0
MASTERCARD INCORPORATED CL A 57636Q104 1,118 10,825 SH   DFND   10,825 0 0
MERCK & CO INC COM 58933Y105 26,492 450,000 SH   DFND 1,2 450,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 383 80,528 SH   DFND 1,2 80,528 0 0
MOHAWK INDS INC COM 608190104 220 1,100 SH   DFND   1,100 0 0
MYOKARDIA INC COM 62857M105 1,078 83,240 SH   DFND 1,2 83,240 0 0
NEURODERM LTD ORD SHS M74231107 3,906 175,951 SH   DFND 1,2 175,951 0 0
NICE LTD SPONSORED ADR 653656108 2,635 38,323 SH   DFND   38,323 0 0
ONCOBIOLOGICS INC COM 68235M105 525 174,477 SH   DFND 1,2 174,477 0 0
ORBOTECH LTD ORD M75253100 1,511 45,221 SH   DFND   45,221 0 0
PACIRA PHARMACEUTICALS INC COM 695127100 1,615 50,000 SH   DFND 1,2 50,000 0 0
PALATIN TECHNOLOGIES INC COM PAR $ .01 696077403 1,481 2,906,037 SH   DFND 1,2 2,906,037 0 0
PALO ALTO NETWORKS INC COM 697435105 882 7,052 SH   DFND   7,052 0 0
PARATEK PHARMACEUTICALS INC COM 699374302 2,156 140,000 SH   DFND 1,2 140,000 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 1,134 810,000 SH   DFND 1,2 810,000 0 0
PORTOLA PHARMACEUTICALS INC COM 737010108 2,244 100,000 SH   DFND 1,2 100,000 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 980 200,000 SH   DFND 1,2 200,000 0 0
PROSHARES TR PSHS ULTSH 20YRS 74347B201 761 18,650 SH   DFND   18,650 0 0
PTC THERAPEUTICS INC COM 69366J200 1,637 150,000 SH   DFND 1,2 150,000 0 0
RA PHARMACEUTICALS INC COM 74933V108 911 60,000 SH   DFND 1,2 60,000 0 0
REPROS THERAPEUTICS INC COM NEW 76028H209 1,292 978,800 SH   DFND 1,2 978,800 0 0
RETROPHIN INC COM 761299106 2,725 143,974 SH   DFND 1,2 143,974 0 0
SAGE THERAPEUTICS INC COM 78667J108 4,595 90,000 SH   DFND 1,2 90,000 0 0
SAPIENS INTL CORP N V SHS NEW N7716A151 1,568 109,322 SH   DFND   109,322 0 0
SAREPTA THERAPEUTICS INC COM 803607100 10,918 398,047 SH   DFND 1,2 398,047 0 0
SCHLUMBERGER LTD COM 806857108 2,885 34,361 SH   DFND   34,361 0 0
SEALED AIR CORP NEW COM 81211K100 159 3,500 SH   DFND   3,500 0 0
SELECTA BIOSCIENCES INC COM 816212104 4,605 268,534 SH   DFND 1,2 268,534 0 0
SHIRE PLC SPONSORED ADR 82481R106 5,537 32,500 SH   DFND 1,2 32,500 0 0
SITEONE LANDSCAPE SUPPLY INC COM 82982L103 306 8,820 SH   DFND   8,820 0 0
SNAP ON INC COM 833034101 1,879 10,972 SH   DFND   10,972 0 0
SOLAREDGE TECHNOLOGIES INC COM 83417M104 325 26,203 SH   DFND   26,203 0 0
SPDR SERIES TRUST PUT 78464A950 32,555 550,000 SH Put DFND 1,2 550,000 0 0
STARBUCKS CORP COM 855244109 2,533 45,631 SH   DFND   45,631 0 0
SUMMIT THERAPEUTICS PLC SPONS ADS 86627R102 1,262 147,450 SH   DFND 1,2 147,450 0 0
SUNESIS PHARMACEUTICALS INC COM PAR 867328700 453 125,000 SH   DFND 1,2 125,000 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 1,192 166,310 SH   DFND 1,2 166,310 0 0
TESARO INC COM 881569107 2,690 20,000 SH   DFND 1,2 20,000 0 0
TEVA PHARMACEUTICAL FIN LLC DBCV 0.250% 2/0 88163VAE9 4,247 6,585 SH   DFND   6,585 0 0
TEVA PHARMACEUTICAL INDS LTD ADR 881624209 18,923 522,000 SH   DFND 1,2 522,000 0 0
TEVA PHARMACEUTICAL INDS LTD CALL 881624909 7,794 215,000 SH Call DFND   0 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 898 6,363 SH   DFND   6,363 0 0
TOWER SEMICONDUCTOR LTD SHS NEW M87915274 1,597 83,940 SH   DFND   83,940 0 0
UNION PAC CORP COM 907818108 3,740 36,076 SH   DFND   36,076 0 0
UNITEDHEALTH GROUP INC COM 91324P102 272 1,700 SH   DFND   1,700 0 0
VERSARTIS INC COM 92529L102 3,725 250,000 SH   DFND 1,2 250,000 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 3,315 45,000 SH   DFND 1,2 45,000 0 0
VISA INC COM CL A 92826C839 4,053 51,951 SH   DFND   51,951 0 0
VISTAGEN THERAPEUTICS INC COM NEW 92840H202 2,029 544,100 SH   DFND 1,2 544,100 0 0
VTV THERAPEUTICS INC CL A 918385105 966 200,000 SH   DFND 1,2 200,000 0 0
XENON PHARMACEUTICALS INC COM 98420N105 2,526 328,029 SH   DFND 1,2 328,029 0 0