The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8

COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aclaris therapeutics Common 00461U105 89,116 3,283,569 SH   SOLE   0 0 3,283,569
Advanced Accelerator Applications S.A. Common 00790T100 12,197 455,798 SH   SOLE   0 0 455,798
Agile Therapeutics, Inc. Common 00847L100 8,630 1,513,975 SH   SOLE   0 0 1,513,975
Aimmune Therapeutics, Inc. Common 00900T107 15,604 763,009 SH   SOLE   0 0 763,009
Akari Therapeutics Plc ADR 00972G108 3,716 527,842 SH   SOLE   0 0 527,842
Ascendis Pharma ADR 04351P101 35,761 1,766,832 SH   SOLE   0 0 1,766,832
BioPharmX Corporation Common 09072X101 4,793 12,814,286 SH   SOLE   0 0 12,814,286
Capnia, Inc. Common 14066L105 6,040 7,456,984 SH   SOLE   7,456,984 0 0
Capnia, Inc. Warrant 14066L113 76 943,858 SH   SOLE   943,858 0 0
KalVista Pharmaceuticals, Inc. Common 483497103 2,123 300,325 SH   SOLE   300,325 0 0
CoLucid Pharmaceuticals, Inc. Common 19716T101 8,190 225,000 SH   SOLE   0 0 225,000
Codexis, Inc. Common 192005106 24,356 5,294,825 SH   SOLE   0 0 5,294,825
Dynavax Technologies Corporation Common 268158201 1,421 359,828 SH   SOLE   0 0 359,828
Eiger BioPharmaceuticals Common 28249U105 20,820 1,787,091 SH   SOLE   1,787,091 0 0
Foamix Pharmaceuticals Ltd. Common M46135105 9,491 855,000 SH   SOLE   0 0 855,000
Nabriva Therapeutics AG ADR 62957M104 23,968 4,021,559 SH   SOLE   0 0 4,021,559
Ocera Therapeutics, Inc. Common 67552A108 322 153,331 SH   SOLE   0 0 153,331
ProNAi Therapeutics, Inc. Common 74346L101 3,633 2,438,270 SH   SOLE   0 0 2,438,270
Regenxbio Inc. Common 75901B107 9,328 502,863 SH   SOLE   0 0 502,863
ReVance Therapeutics, Inc. Common 761330109 1,602 77,373 SH   SOLE   0 0 77,373
Strongbridge Biopharma plc Ordinary Shares G85347105 7,200 3,000,000 SH   SOLE   0 0 3,000,000
Sunesis Pharmaceuticals, Inc. Common 867328700 1,810 500,000 SH   SOLE   0 0 500,000
Trevena, Inc. Common 89532E109 10,161 1,728,000 SH   SOLE   0 0 1,728,000
Zosano Pharma Corp Common 98979H103 77 98,515 SH   SOLE   0 0 98,515
CRISPR Therapeutics AG Common H17182108 3,016 148,878 SH   SOLE   0 0 148,878