The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBVIE INC COM 00287Y109 135,533 2,080,000 SH   DFND 1 907,100 0 1,172,900
ACADIA PHARMACEUTICALS INC COM 004225108 40,190 1,169,000 SH   DFND 1 479,500 0 689,500
ACHILLION PHARMACEUTICALS IN COM 00448Q201 55,181 13,107,200 SH   DFND 1 5,140,500 0 7,966,700
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 10,550 1,914,660 SH   SOLE   1,914,660 0 0
AEGERION PHARMACEUTICALS INC NOTE 2.000% 8/1 00767EAB8 12,317 15,000,000 PRN   DFND 1 6,995,000 0 8,005,000
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 10,948 1,469,524 SH   SOLE   1,469,524 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 67,844 1,496,000 SH   DFND 1 501,700 0 994,300
AETNA INC NEW COM 00817Y108 167,397 1,312,400 SH   DFND 1 465,100 0 847,300
AFFIMED N V COM N01045108 4,643 2,018,900 SH   SOLE   2,018,900 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 191,913 3,629,900 SH   DFND 1 1,590,200 0 2,039,700
ALEXION PHARMACEUTICALS INC COM 015351109 449,920 3,710,986 SH   DFND 1 1,286,600 0 2,424,386
ALEXION PHARMACEUTICALS INC COM 015351109 6,062 50,000 SH Call DFND 1 23,000 0 27,000
ALIMERA SCIENCES INC COM 016259103 350 250,000 SH   DFND 1 98,300 0 151,700
ALKERMES PLC SHS G01767105 8,483 145,000 SH   SOLE   0 0 145,000
ALLERGAN PLC SHS G0177J108 114,058 477,390 SH   DFND 1 190,200 0 287,190
ALLERGAN PLC PFD CONV SER A G0177J116 74,832 88,200 SH   DFND 1 30,300 0 57,900
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 4,213 82,200 SH   SOLE   0 0 82,200
AMARIN CORP PLC SPONS ADR NEW 023111206 1,120 350,000 SH   SOLE   350,000 0 0
AMGEN INC COM 031162100 235,982 1,438,300 SH   DFND 1 456,100 0 982,200
ANTHEM INC COM 036752103 142,657 862,600 SH   DFND 1 311,600 0 551,000
ARRAY BIOPHARMA INC COM 04269X105 126,795 14,182,900 SH   DFND 1 5,004,900 0 9,178,000
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 76,085 2,717,315 SH   SOLE   2,717,315 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 32,049 1,257,300 SH   DFND 1 589,900 0 667,400
AUDENTES THERAPEUTICS INC COM 05070R104 81,820 4,801,638 SH   SOLE   4,801,638 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 13,193 1,797,400 SH   SOLE   0 0 1,797,400
BARD C R INC COM 067383109 14,415 58,000 SH   DFND 1 26,300 0 31,700
BEIGENE LTD SPONSORED ADR 07725L102 33,084 903,700 SH   DFND 1 381,600 0 522,100
BIOGEN INC COM 09062X103 392,877 1,436,900 SH   DFND 1 432,700 0 1,004,200
BIOLINERX LTD SPONSORED ADR 09071M106 998 1,038,600 SH   SOLE   1,038,600 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 111,840 1,274,100 SH   DFND 1 428,400 0 845,700
BIOMARIN PHARMACEUTICAL INC NOTE 0.750%10/1 09061GAE1 567 500,000 PRN   DFND 1 215,000 0 285,000
BIOMARIN PHARMACEUTICAL INC NOTE 1.500%10/1 09061GAF8 593 500,000 PRN   DFND 1 215,000 0 285,000
BLUEBIRD BIO INC COM 09609G100 25,797 283,800 SH   DFND 1 113,900 0 169,900
BOSTON SCIENTIFIC CORP COM 101137107 380,795 15,311,400 SH   DFND 1 5,673,800 0 9,637,600
BRISTOL MYERS SQUIBB CO COM 110122108 10,876 200,000 SH Put DFND 1 93,500 0 106,500
BRISTOL MYERS SQUIBB CO COM 110122108 103,920 1,911,000 SH   DFND 1 705,100 0 1,205,900
BRISTOL MYERS SQUIBB CO COM 110122108 5,438 100,000 SH Call DFND 1 47,000 0 53,000
CELGENE CORP COM 151020104 389,737 3,132,177 SH   DFND 1 1,071,600 0 2,060,577
CELLECTIS S A SPONSORED ADS 15117K103 8,400 350,000 SH   DFND 1 162,100 0 187,900
CENTENE CORP DEL COM 15135B101 117,985 1,655,700 SH   DFND 1 655,400 0 1,000,300
CLEARSIDE BIOMEDICAL INC COM 185063104 2,382 300,000 SH   SOLE   0 0 300,000
COHERUS BIOSCIENCES INC COM 19249H103 22,935 1,084,400 SH   DFND 1 139,300 0 945,100
COOPER COS INC COM NEW 216648402 38,139 190,800 SH   DFND 1 83,500 0 107,300
CORVUS PHARMACEUTICALS INC COM 221015100 111,729 5,379,349 SH   SOLE   5,379,349 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 8,103 372,191 SH   DFND 1 171,207 0 200,984
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 18,064 512,900 SH   SOLE   0 0 512,900
DERMIRA INC COM 24983L104 34,917 1,023,673 SH   DFND 1 270,670 0 753,003
DIMENSION THERAPEUTICS INC COM 25433V105 9,446 5,397,698 SH   SOLE   5,397,698 0 0
EAGLE PHARMACEUTICALS INC COM 269796108 55,653 671,000 SH   DFND 1 306,300 0 364,700
EDWARDS LIFESCIENCES CORP COM 28176E108 173,023 1,839,300 SH   DFND 1 630,000 0 1,209,300
EHEALTH INC COM 28238P109 21,913 1,820,000 SH   DFND 1 836,200 0 983,800
EXACT SCIENCES CORP COM 30063P105 14,240 602,900 SH   SOLE   0 0 602,900
FLUIDIGM CORP DEL COM 34385P108 9,935 1,746,100 SH   DFND 1 215,500 0 1,530,600
FLUIDIGM CORP DEL NOTE 2.750% 2/0 34385PAA6 6,815 10,000,000 PRN   DFND 1 4,466,000 0 5,534,000
GALAPAGOS NV SPON ADR 36315X101 24,435 283,500 SH   DFND 1 82,400 0 201,100
GILEAD SCIENCES INC COM 375558103 54,397 800,900 SH   DFND 1 269,000 0 531,900
GLAUKOS CORP COM 377322102 89,349 1,741,700 SH   SOLE   1,741,700 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 39,964 1,084,500 SH   DFND 1 489,100 0 595,400
GW PHARMACEUTICALS PLC ADS 36197T103 57,555 475,900 SH   DFND 1 166,000 0 309,900
HCA HOLDINGS INC COM 40412C101 155,288 1,745,000 SH   DFND 1 527,700 0 1,217,300
HERON THERAPEUTICS INC COM 427746102 9,750 650,000 SH   DFND 1 311,000 0 339,000
HUMANA INC COM 444859102 153,018 742,300 SH   DFND 1 257,400 0 484,900
ILLUMINA INC COM 452327109 54,929 321,900 SH   DFND 1 38,800 0 283,100
IMMUNOGEN INC COM 45253H101 23,590 6,095,647 SH   DFND 1 1,919,480 0 4,176,167
IMMUNOMEDICS INC COM 452907108 7,972 1,232,100 SH   DFND 1 684,100 0 548,000
IMMUNOMEDICS INC NOTE 4.750% 2/1 452907AK4 42,261 30,000,000 PRN   DFND 1 16,014,000 0 13,986,000
INCYTE CORP COM 45337C102 263,811 1,973,597 SH   DFND 1 537,211 0 1,436,386
INFINITY PHARMACEUTICALS INC COM 45665G303 10,498 3,250,300 SH   DFND 1 1,064,000 0 2,186,300
INOTEK PHARMACEUTICALS CORP NOTE 5.750% 8/0 45780VAB8 4,433 7,000,000 PRN   DFND 1 3,200,000 0 3,800,000
INSMED INC COM PAR $.01 457669307 84,239 4,810,905 SH   DFND 1 2,193,760 0 2,617,145
INSYS THERAPEUTICS INC NEW COM NEW 45824V209 63,811 6,071,440 SH   DFND 1 2,538,600 0 3,532,840
INTELLIA THERAPEUTICS INC COM 45826J105 37,510 2,662,180 SH   SOLE   2,662,180 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 117,285 1,037,000 SH   SOLE   1,037,000 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 38,630 50,400 SH   SOLE   0 0 50,400
INVITAE CORP COM 46185L103 5,051 456,666 SH   SOLE   456,666 0 0
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 123,537 7,241,300 SH   DFND 1 2,524,000 0 4,717,300
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 53,901 371,400 SH   DFND 1 140,100 0 231,300
JOHNSON & JOHNSON COM 478160104 110,177 884,600 SH   DFND 1 370,700 0 513,900
LILLY ELI & CO COM 532457108 280,103 3,330,200 SH   DFND 1 1,087,100 0 2,243,100
LION BIOTECHNOLOGIES INC COM 53619R102 25,203 3,382,900 SH   DFND 1 1,446,500 0 1,936,400
LOXO ONCOLOGY INC COM 548862101 72,714 1,728,000 SH   SOLE   1,728,000 0 0
MAGELLAN HEALTH INC COM NEW 559079207 75,177 1,088,727 SH   DFND 1 479,900 0 608,827
MALLINCKRODT PUB LTD CO SHS G5785G107 65,638 1,472,700 SH   DFND 1 659,200 0 813,500
MARINUS PHARMACEUTICALS INC COM 56854Q101 1,005 567,600 SH   SOLE   567,600 0 0
MEDIGUS LTD SPONSORD ADR NEW 58471G201 185 60,000 SH   SOLE   60,000 0 0
MEDTRONIC PLC SHS G5960L103 61,757 766,600 SH   DFND 1 322,100 0 444,500
MERCK & CO INC COM 58933Y105 363,125 5,714,900 SH   DFND 1 2,038,200 0 3,676,700
MINERVA NEUROSCIENCES INC COM 603380106 5,705 704,300 SH   SOLE   0 0 704,300
MOMENTA PHARMACEUTICALS INC COM 60877T100 28,156 2,109,068 SH   DFND 1 613,300 0 1,495,768
MYLAN N V SHS EURO N59465109 50,687 1,300,000 SH   DFND 1 607,300 0 692,700
NABRIVA THERAPEUTICS AG SPONSORED ADR 62957M104 20,135 1,677,940 SH   SOLE   1,677,940 0 0
NATERA INC COM 632307104 11,320 1,276,190 SH   SOLE   1,276,190 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 19,110 441,341 SH   DFND 1 200,000 0 241,341
NEVRO CORP COM 64157F103 7,290 77,800 SH   DFND 1 18,100 0 59,700
NEWLINK GENETICS CORP COM 651511107 4,820 200,000 SH Call DFND 1 93,500 0 106,500
NEWLINK GENETICS CORP COM 651511107 48,000 1,991,700 SH   DFND 1 740,300 0 1,251,400
NOVELION THERAPEUTICS INC COM NEW 67001K202 1,074 100,000 SH   DFND 1 40,120 0 59,880
NUVASIVE INC COM 670704105 9,223 123,500 SH   SOLE   0 0 123,500
OBSEVA SA COM H5861P103 27,124 2,605,531 SH   SOLE   2,605,531 0 0
OREXIGEN THERAPEUTICS INC NOTE 2.750%12/0 686164AC8 2,591 5,210,000 PRN   DFND 1 2,210,000 0 3,000,000
OTONOMY INC COM 68906L105 22,664 1,850,094 SH   SOLE   1,850,094 0 0
PFIZER INC COM 717081103 184,943 5,406,100 SH   DFND 1 2,212,500 0 3,193,600
PIERIS PHARMACEUTICALS INC COM 720795103 18,875 7,259,620 SH   SOLE   7,259,620 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 11,527 2,305,446 SH   DFND 1 973,446 0 1,332,000
PUMA BIOTECHNOLOGY INC COM 74587V107 83,548 2,245,925 SH   DFND 1 856,800 0 1,389,125
RADIUS HEALTH INC COM NEW 750469207 27,213 704,100 SH   DFND 1 243,000 0 461,100
REDHILL BIOPHARMA LTD SPONSORED ADS 757468103 5,417 564,900 SH   SOLE   564,900 0 0
REGENERON PHARMACEUTICALS COM 75886F107 146,545 378,170 SH   DFND 1 89,400 0 288,770
ROKA BIOSCIENCE INC COM NEW 775431208 3,181 893,470 SH   SOLE   893,470 0 0
SAREPTA THERAPEUTICS INC COM 803607100 31,207 1,054,300 SH   DFND 1 423,600 0 630,700
SELECT MED HLDGS CORP COM 81619Q105 27,852 2,086,300 SH   DFND 1 945,400 0 1,140,900
SELECTA BIOSCIENCES INC COM 816212104 26,389 1,842,797 SH   SOLE   1,842,797 0 0
SHIRE PLC SPONSORED ADR 82481R106 156,363 897,451 SH   DFND 1 330,000 0 567,451
SIENTRA INC COM 82621J105 4,397 522,257 SH   SOLE   522,257 0 0
SIERRA ONCOLOGY INC COM 82640U107 5,667 3,703,704 SH   SOLE   3,703,704 0 0
SINOVAC BIOTECH LTD SHS P8696W104 15,285 2,667,500 SH   DFND 1 1,219,500 0 1,448,000
STEADYMED LTD SHS M84920103 17,819 3,072,196 SH   SOLE   3,072,196 0 0
STRYKER CORP COM 863667101 41,641 316,300 SH   DFND 1 77,000 0 239,300
SYNDAX PHARMACEUTICALS INC COM 87164F105 6,651 484,800 SH   SOLE   484,800 0 0
SYNERGY PHARMACEUTICALS DEL COM NEW 871639308 98,575 21,153,343 SH   DFND 1 9,710,743 0 11,442,600
TENET HEALTHCARE CORP COM NEW 88033G407 94,784 5,352,000 SH   DFND 1 2,108,500 0 3,243,500
TESARO INC COM 881569107 7,263 47,200 SH   SOLE   0 0 47,200
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADR 881624209 13,240 412,600 SH   DFND 1 123,400 0 289,200
THERMO FISHER SCIENTIFIC INC COM 883556102 82,053 534,200 SH   DFND 1 197,600 0 336,600
UNITEDHEALTH GROUP INC COM 91324P102 48,613 296,400 SH   DFND 1 59,900 0 236,500
VALEANT PHARMACEUTICALS INTL COM 91911K102 2,150 194,900 SH   DFND 1 76,800 0 118,100
VANDA PHARMACEUTICALS INC COM 921659108 703 50,200 SH   DFND 1 22,900 0 27,300
VERTEX PHARMACEUTICALS INC COM 92532F100 237,202 2,169,200 SH   DFND 1 706,700 0 1,462,500
VIEWRAY INC COM 92672L107 80,492 9,458,567 SH   SOLE   9,458,567 0 0
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 278,407 8,946,234 SH   DFND 1 3,008,050 0 5,938,184
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 7,780 250,000 SH Call DFND 1 117,000 0 133,000
WRIGHT MED GROUP N V RIGHT 03/01/2019 N96617126 10,558 6,900,000 SH   SOLE   0 0 6,900,000
XENCOR INC COM 98401F105 20,098 840,237 SH   SOLE   0 0 840,237
XENON PHARMACEUTICALS INC COM 98420N105 2,539 634,812 SH   SOLE   634,812 0 0
XTANT MED HLDGS INC COM 98420P100 296 475,439 SH   SOLE   475,439 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 5,983 49,000 SH   DFND 1 20,600 0 28,400