The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aclaris therapeutics Common 00461U105 77,524 2,858,569 SH   SOLE   0 0 2,858,569
Advanced Accelerator Applications S.A. Common 00790T100 14,007 358,786 SH   SOLE   0 0 358,786
Agile Therapeutics, Inc. Common 00847L100 5,677 1,513,975 SH   SOLE   0 0 1,513,975
Aimmune Therapeutics, Inc. Common 00900T107 15,971 776,813 SH   SOLE   0 0 776,813
Akari Therapeutics Plc ADR 00972G108 2,433 527,842 SH   SOLE   0 0 527,842
Ascendis Pharma ADR 04351P101 49,047 1,766,832 SH   SOLE   0 0 1,766,832
Aurinia Pharmaceuticals Inc. Common 05156V102 6,211 1,013,149 SH   SOLE   0 0 1,013,149
Biohaven Pharmaceutical Holding Company Ltd Common 0G1196105 49,420 1,976,818 SH   SOLE   0 0 1,976,818
BioPharmX Corporation Common 09072X101 6,752 14,096,338 SH   SOLE   0 0 14,096,338
Capnia, Inc. Common 14066L105 7,362 14,695,264 SH   SOLE   14,695,264 0 0
Capnia, Inc. Warrant 14066L113 159 943,858 SH   SOLE   943,858 0 0
KalVista Pharmaceuticals, Inc. Common 048349710 2,210 300,325 SH   SOLE   0 0 300,325
Codexis, Inc. Common 192005106 28,857 5,294,825 SH   SOLE   0 0 5,294,825
CRISPR Therapeutics AG Common H17182108 2,385 148,878 SH   SOLE   0 0 148,878
Dynavax Technologies Corporation Common 268158201 3,472 359,827 SH   SOLE   0 0 359,827
Eiger BioPharmaceuticals Common 28249U105 14,118 1,787,091 SH   SOLE   1,787,091 0 0
Foamix Pharmaceuticals Ltd. Common M46135105 3,967 855,000 SH   SOLE   0 0 855,000
Nabriva Therapeutics AG ADR 62957M104 42,146 4,021,559 SH   SOLE   0 0 4,021,559
Sierra Oncology, Inc. Common 74346L101 2,853 2,438,270 SH   SOLE   0 0 2,438,270
Regenxbio Inc. Common 75901B107 3,247 164,403 SH   SOLE   0 0 164,403
ReVance Therapeutics, Inc. Common 761330109 2,043 77,373 SH   SOLE   0 0 77,373
Selecta Biosciences, Inc. Common 816212104 22,227 1,119,189 SH   SOLE   0 0 1,119,189
Strongbridge Biopharma plc Ordinary Shares G85347105 21,450 3,000,000 SH   SOLE   0 0 3,000,000
Sunesis Pharmaceuticals, Inc. Common 867328700 1,350 500,000 SH   SOLE   0 0 500,000
Trevena, Inc. Common 89532E109 3,974 1,728,000 SH   SOLE   0 0 1,728,000
Verona Pharma Plc ADS 925050106 8,208 704,225 SH   SOLE   704,225 0 0