The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
Abeona Therapeutics Inc. | COM | 00289Y107 | 10,780 | 1,684,364 | SH | SOLE | 1,684,364 | 0 | 0 | ||
ACADIA Pharmaceuticals Inc. | COM | 004225108 | 720,113 | 25,819,768 | SH | SOLE | 25,819,768 | 0 | 0 | ||
Acceleron Pharma Inc. | COM | 00434H108 | 874 | 28,765 | SH | SOLE | 28,765 | 0 | 0 | ||
Achaogen, Inc. | COM | 004449104 | 104,404 | 4,804,604 | SH | SOLE | 4,804,604 | 0 | 0 | ||
Achillion Pharmaceuticals, Inc. | COM | 00448Q201 | 8,522 | 1,856,637 | SH | SOLE | 1,856,637 | 0 | 0 | ||
Adamas Pharmaceuticals, Inc. | COM | 00548A106 | 3,019 | 172,630 | SH | SOLE | 172,630 | 0 | 0 | ||
Adaptimmune Therapeutics plc | SPONSORED ADR | 00653A107 | 449 | 100,000 | SH | SOLE | 600,000 | 0 | 0 | ||
Advanced Accelerator Applications S.A. | SPONSORED ADS | 00790T100 | 86,735 | 2,221,706 | SH | SOLE | 4,443,412 | 0 | 0 | ||
Aeglea BioTherapeutics, Inc. | COM | 00773J103 | 4,381 | 1,137,872 | SH | SOLE | 1,137,872 | 0 | 0 | ||
Aerie Pharmaceuticals, Inc. | COM | 00771V108 | 15,731 | 299,356 | SH | SOLE | 299,356 | 0 | 0 | ||
Aevi Genomic Medicine, Inc. | COM | 00835P105 | 2,152 | 1,618,089 | SH | SOLE | 1,618,089 | 0 | 0 | ||
Affimed N.V. | COM | N01045108 | 820 | 400,000 | SH | SOLE | 400,000 | 0 | 0 | ||
Agios Pharmaceuticals, Inc. | COM | 00847X104 | 6,620 | 128,666 | SH | SOLE | 128,666 | 0 | 0 | ||
Aimmune Therapeutics, Inc. | COM | 00900T107 | 13,856 | 673,908 | SH | SOLE | 673,908 | 0 | 0 | ||
Akari Therapeutics plc | SPONSORED ADR | 00972G108 | 2,291 | 496,901 | SH | SOLE | 49,690,100 | 0 | 0 | ||
Albireo Pharma, Inc. | COM | 01345P106 | 4,120 | 200,000 | SH | SOLE | 200,000 | 0 | 0 | ||
Alder BioPharmaceuticals, Inc. | COM | 014339105 | 2,488 | 217,328 | SH | SOLE | 217,328 | 0 | 0 | ||
Alexion Pharmaceuticals, Inc. | COM | 015351109 | 1,040,749 | 8,553,864 | SH | SOLE | 8,553,864 | 0 | 0 | ||
Alkermes plc | SHS | G01767105 | 8,710 | 150,251 | SH | SOLE | 150,251 | 0 | 0 | ||
Amarin Corporation plc | SPONSORED ADR NEW | 023111206 | 91,358 | 22,669,509 | SH | SOLE | 22,669,509 | 0 | 0 | ||
AnaptysBio, Inc. | COM | 032724106 | 2,805 | 117,211 | SH | SOLE | 117,211 | 0 | 0 | ||
Aquinox Pharmaceuticals, Inc. | COM | 03842B101 | 153,844 | 10,934,154 | SH | SOLE | 10,934,154 | 0 | 0 | ||
Arbutus Biopharma Corporation | COM | 03879J100 | 650 | 180,582 | SH | SOLE | 180,582 | 0 | 0 | ||
argenx SE | SPONSORED ADR ADDED | 04016X101 | 2,121 | 100,000 | SH | SOLE | 100,000 | 0 | 0 | ||
Array BioPharma Inc. | COM | 04269X105 | 13,274 | 1,585,913 | SH | SOLE | 1,585,913 | 0 | 0 | ||
Ascendis Pharma A/S | SPONSORED ADR | 04351P101 | 48,621 | 1,751,463 | SH | SOLE | 1,751,463 | 0 | 0 | ||
Assembly Biosciences, Inc. | COM | 045396108 | 5,163 | 250,000 | SH | SOLE | 250,000 | 0 | 0 | ||
AveXis, Inc. | COM | 05366U100 | 51,350 | 625,000 | SH | SOLE | 625,000 | 0 | 0 | ||
BeiGene, Ltd. | SPONSORED ADR | 07725L102 | 165,293 | 3,673,175 | SH | SOLE | 47,751,275 | 0 | 0 | ||
Bellicum Pharmaceuticals, Inc. | COM | 079481107 | 58,777 | 5,032,313 | SH | SOLE | 5,032,313 | 0 | 0 | ||
BioCryst Pharmaceuticals, Inc. | COM | 09058V103 | 65,145 | 11,716,784 | SH | SOLE | 11,716,784 | 0 | 0 | ||
BioDelivery Sciences International, Inc. | COM | 09060J106 | 588 | 210,021 | SH | SOLE | 210,021 | 0 | 0 | ||
BioMarin Pharmaceutical Inc. | COM | 09061G101 | 536,353 | 5,905,673 | SH | SOLE | 5,905,673 | 0 | 0 | ||
BioPharmX Corporation | COM | 09072X101 | 287 | 598,758 | SH | SOLE | 598,758 | 0 | 0 | ||
BioTime, Inc. | *W EXP 10/1/201 | 09066L162 | 7 | 20,084 | SH | SOLE | 20,084 | 0 | 0 | ||
Bioverativ Inc. | COM | 09075E100 | 496 | 8,249 | SH | SOLE | 8,249 | 0 | 0 | ||
bluebird bio, Inc. | COM | 09609G100 | 31,666 | 301,441 | SH | SOLE | 301,441 | 0 | 0 | ||
Catalyst Pharmaceuticals, Inc. | COM | 14888U101 | 14,082 | 5,102,153 | SH | SOLE | 5,102,153 | 0 | 0 | ||
Cellectis S.A. | SPONSORED ADS | 15117K103 | 1,291 | 50,000 | SH | SOLE | 50,000 | 0 | 0 | ||
Cerus Corporation | COM | 157085101 | 25,707 | 10,241,943 | SH | SOLE | 10,241,943 | 0 | 0 | ||
ChemoCentryx, Inc. | COM | 16383L106 | 459 | 49,064 | SH | SOLE | 49,064 | 0 | 0 | ||
Chimerix, Inc. | COM | 16934W106 | 628 | 115,216 | SH | SOLE | 115,216 | 0 | 0 | ||
ContraFect Corporation | COM | 212326102 | 5,867 | 4,045,876 | SH | SOLE | 4,045,876 | 0 | 0 | ||
Corbus Pharmaceuticals Holdings, Inc. | COM | 21833P103 | 820 | 130,129 | SH | SOLE | 130,129 | 0 | 0 | ||
Cyclacel Pharmaceuticals, Inc. | PFD CONV EX 6% | 23254L207 | 82 | 13,253 | SH | SOLE | 13,253 | 0 | 0 | ||
CymaBay Therapeutics, Inc. | COM | 23257D103 | 7,441 | 1,291,775 | SH | SOLE | 1,291,775 | 0 | 0 | ||
DBV Technologies S.A. | SPONSORED ADR | 23306J101 | 196,746 | 5,509,560 | SH | SOLE | 2,754,780 | 0 | 0 | ||
Dimension Therapeutics, Inc. | COM | 25433V105 | 1,815 | 1,251,881 | SH | SOLE | 1,251,881 | 0 | 0 | ||
Dynavax Technologies Corporation | COM NEW | 268158201 | 724 | 75,000 | SH | SOLE | 75,000 | 0 | 0 | ||
Epizyme, Inc. | COM | 29428V104 | 3,510 | 232,481 | SH | SOLE | 232,481 | 0 | 0 | ||
Exelixis, Inc. | COM | 30161Q104 | 51,280 | 2,082,012 | SH | SOLE | 2,082,012 | 0 | 0 | ||
Five Prime Therapeutics, Inc. | COM | 33830X104 | 580 | 19,247 | SH | SOLE | 19,247 | 0 | 0 | ||
Foamix Pharmaceuticals Ltd. | SHS | M46135105 | 11,445 | 2,466,702 | SH | SOLE | 2,466,702 | 0 | 0 | ||
Fulgent Genetics, Inc. | COM | 359664109 | 799 | 125,000 | SH | SOLE | 125,000 | 0 | 0 | ||
Galapagos NV | SPONSORED ADR | 36315X101 | 19,887 | 259,894 | SH | SOLE | 259,894 | 0 | 0 | ||
Genomic Health, Inc. | COM | 37244C101 | 448,535 | 13,779,866 | SH | SOLE | 13,779,866 | 0 | 0 | ||
GlycoMimetics, Inc. | COM | 38000Q102 | 6,287 | 563,312 | SH | SOLE | 563,312 | 0 | 0 | ||
Halozyme Therapeutics, Inc. | COM | 40637H109 | 20,274 | 1,581,424 | SH | SOLE | 1,581,424 | 0 | 0 | ||
Heron Therapeutics, Inc. | COM | 427746102 | 38,552 | 2,783,569 | SH | SOLE | 2,783,569 | 0 | 0 | ||
Idera Pharmaceuticals, Inc. | COM NEW | 45168K306 | 17,707 | 10,294,970 | SH | SOLE | 10,294,970 | 0 | 0 | ||
Ignyta, Inc. | COM | 451731103 | 9,274 | 896,000 | SH | SOLE | 896,000 | 0 | 0 | ||
Immune Design Corp. | COM | 45252L103 | 1,452 | 148,937 | SH | SOLE | 148,937 | 0 | 0 | ||
ImmunoGen, Inc. | COM | 45253H101 | 21,439 | 3,015,353 | SH | SOLE | 3,015,353 | 0 | 0 | ||
Incyte Corporation | COM | 45337C102 | 4,297,329 | 34,130,161 | SH | SOLE | 34,130,161 | 0 | 0 | ||
Infinity Pharmaceuticals, Inc. | COM | 45665G303 | 911 | 580,400 | SH | SOLE | 580,400 | 0 | 0 | ||
Insmed Incorporated | COM PAR $.01 | 457669307 | 6,864 | 400,000 | SH | SOLE | 400,000 | 0 | 0 | ||
Intellia Therapeutics, Inc. | COM | 45826J105 | 16,994 | 1,062,120 | SH | SOLE | 1,062,120 | 0 | 0 | ||
Intra-Cellular Therapies, Inc. | COM | 46116X101 | 7,566 | 609,166 | SH | SOLE | 609,166 | 0 | 0 | ||
Invitae Corporation | COM | 46185L103 | 69,676 | 7,288,300 | SH | SOLE | 7,288,300 | 0 | 0 | ||
InVivo Therapeutics Holdings Corp. | COM NEW | 46186M209 | 1,080 | 400,000 | SH | SOLE | 400,000 | 0 | 0 | ||
Jounce Therapeutics, Inc. | COM | 481116101 | 1,403 | 100,000 | SH | SOLE | 100,000 | 0 | 0 | ||
Juno Therapeutics, Inc. | COM | 48205A109 | 1,495 | 50,000 | SH | SOLE | 50,000 | 0 | 0 | ||
Karyopharm Therapeutics Inc. | COM | 48576U106 | 1,964 | 216,990 | SH | SOLE | 216,990 | 0 | 0 | ||
La Jolla Pharmaceutical Company | COM PAR $.0001 2 | 503459604 | 15,026 | 504,732 | SH | SOLE | 504,732 | 0 | 0 | ||
Ligand Pharmaceuticals Incorporated | COM NEW | 53220K504 | 8,909 | 73,386 | SH | SOLE | 73,386 | 0 | 0 | ||
Loxo Oncology, Inc. | COM | 548862101 | 11,091 | 138,312 | SH | SOLE | 138,312 | 0 | 0 | ||
MacroGenics, Inc. | COM | 556099109 | 6,368 | 363,676 | SH | SOLE | 363,676 | 0 | 0 | ||
Madrigal Pharmaceuticals, Inc. | COM | 558868105 | 939 | 57,762 | SH | SOLE | 57,762 | 0 | 0 | ||
MediWound Ltd. | ORD SHS | M68830104 | 1,537 | 226,000 | SH | SOLE | 226,000 | 0 | 0 | ||
Merus N.V. | COM | N5749R100 | 18,386 | 1,160,014 | SH | SOLE | 1,160,014 | 0 | 0 | ||
Mirati Therapeutics, Inc. | COM | 60468T105 | 8,283 | 2,269,198 | SH | SOLE | 2,269,198 | 0 | 0 | ||
MyoKardia, Inc. | COM | 62857M105 | 1,310 | 100,000 | SH | SOLE | 100,000 | 0 | 0 | ||
Nabriva Therapeutics plc | SHS ADDED | G63637105 | 3,668 | 350,000 | SH | SOLE | 350,000 | 0 | 0 | ||
Natera, Inc. | COM | 632307104 | 2,483 | 228,676 | SH | SOLE | 228,676 | 0 | 0 | ||
Neurocrine Biosciences, Inc. | COM | 64125C109 | 28,367 | 616,682 | SH | SOLE | 616,682 | 0 | 0 | ||
NeuroDerm Ltd. | ORD SHS | M74231107 | 17,093 | 571,667 | SH | SOLE | 571,667 | 0 | 0 | ||
NewLink Genetics Corporation | COM | 651511107 | 3,675 | 500,000 | SH | SOLE | 500,000 | 0 | 0 | ||
Novavax, Inc. | COM | 670002104 | 2,300 | 2,000,000 | SH | SOLE | 2,000,000 | 0 | 0 | ||
Ovid Therapeutics Inc. | COM ADDED | 690469101 | 3,497 | 333,333 | SH | SOLE | 333,333 | 0 | 0 | ||
Palatin Technologies, Inc. | COM PAR $.01 | 696077403 | 882 | 2,050,000 | SH | SOLE | 2,050,000 | 0 | 0 | ||
Progenics Pharmaceuticals, Inc. | COM | 743187106 | 21,394 | 3,150,808 | SH | SOLE | 3,150,808 | 0 | 0 | ||
Proteon Therapeutics, Inc. | COM | 74371L109 | 455 | 298,591 | SH | SOLE | 298,591 | 0 | 0 | ||
Ra Pharmaceuticals, Inc. | COM | 74933V108 | 3,335 | 177,952 | SH | SOLE | 177,952 | 0 | 0 | ||
Rigel Pharmaceuticals, Inc. | COM NEW | 766559603 | 6,877 | 2,518,882 | SH | SOLE | 2,518,882 | 0 | 0 | ||
Ritter Pharmaceuticals, Inc. | COM | 767836109 | 220 | 400,000 | SH | SOLE | 400,000 | 0 | 0 | ||
Sage Therapeutics, Inc. | COM | 78667J108 | 16,591 | 208,328 | SH | SOLE | 208,328 | 0 | 0 | ||
Sangamo Therapeutics, Inc. | COM | 800677106 | 36,198 | 4,113,376 | SH | SOLE | 4,113,376 | 0 | 0 | ||
Seattle Genetics, Inc. | COM | 812578102 | 2,365,840 | 45,725,556 | SH | SOLE | 45,725,556 | 0 | 0 | ||
Selecta Biosciences, Inc. | COM | 816212104 | 5,756 | 289,809 | SH | SOLE | 289,809 | 0 | 0 | ||
Seres Therapeutics, Inc. | COM | 81750R102 | 1,413 | 125,000 | SH | SOLE | 125,000 | 0 | 0 | ||
Spark Therapeutics, Inc. | COM | 84652J103 | 78,758 | 1,318,341 | SH | SOLE | 1,318,341 | 0 | 0 | ||
Spring Bank Pharmaceuticals, Inc. | COM | 849431101 | 5,052 | 373,144 | SH | SOLE | 373,144 | 0 | 0 | ||
Stemline Therapeutics, Inc. | COM | 85858C107 | 5,828 | 633,497 | SH | SOLE | 633,497 | 0 | 0 | ||
Sunesis Pharmaceuticals, Inc. | COM PAR | 867328700 | 2,002 | 741,665 | SH | SOLE | 741,665 | 0 | 0 | ||
Syros Pharmaceuticals, Inc. | COM | 87184Q107 | 9,249 | 574,835 | SH | SOLE | 574,835 | 0 | 0 | ||
Tenax Therapeutics, Inc. | COM | 88032L100 | 98 | 132,974 | SH | SOLE | 132,974 | 0 | 0 | ||
Tonix Pharmaceuticals Holding Corp. | COM | 890260409 | 2,212 | 510,922 | SH | SOLE | 510,922 | 0 | 0 | ||
Trevena, Inc. | COM | 89532E109 | 2,185 | 950,000 | SH | SOLE | 950,000 | 0 | 0 | ||
Trillium Therapeutics Inc. | COM NEW | 89620X506 | 1,820 | 413,697 | SH | SOLE | 413,697 | 0 | 0 | ||
Ultragenyx Pharmaceutical Inc. | COM | 90400D108 | 1,553 | 25,000 | SH | SOLE | 25,000 | 0 | 0 | ||
Versartis, Inc. | COM | 92529L102 | 28,977 | 1,660,593 | SH | SOLE | 1,660,593 | 0 | 0 | ||
Xencor, Inc. | COM | 98401F105 | 18,409 | 872,072 | SH | SOLE | 872,072 | 0 | 0 | ||
Zogenix, Inc. | COM NEW | 98978L204 | 2,687 | 185,290 | SH | SOLE | 185,290 | 0 | 0 | ||
Acorda Therapeutics, Inc. | NOTE 1.75% 6/15/2021 | 00484MAA4 | 29,985 | 35,083,000 | PRN | SOLE | 35,083,000 | 0 | 0 | ||
Aegerion Pharmaceuticals, Inc. | NOTE 2.0% 8/15/2019 | 00767EAB8 | 11,549 | 14,517,000 | PRN | SOLE | 14,517,000 | 0 | 0 | ||
Array BioPharma Inc. | NOTE 3.0% 6/1/2020 | 04269XAA3 | 4,066 | 3,000,000 | PRN | SOLE | 3,000,000 | 0 | 0 | ||
BioMarin Pharmaceutical Inc. | NOTE 0.75% 10/15/2018 | 09061GAE1 | 13,547 | 12,228,000 | PRN | SOLE | 12,228,000 | 0 | 0 | ||
Inotek Pharmaceuticals Corporation | NOTE 5.75% 8/1/2021 | 45780VAB8 | 2,978 | 5,000,000 | PRN | SOLE | 5,000,000 | 0 | 0 | ||
Novavax, Inc. | NOTE 3.75% 2/1/2023 | 670002AB0 | 46,429 | 108,500,000 | PRN | SOLE | 108,500,000 | 0 | 0 | ||
Protalix BioTherapeutics, Inc. | NOTE 4.5% 9/15/2018 | 74365AAB7 | 2,572 | 3,423,000 | PRN | SOLE | 3,423,000 | 0 | 0 |