The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aclaris Therapeutics Common 00461U105 73,780 2,858,569 SH   SOLE   2,858,569 0 0
Advanced Accelerator Applications S.A. ADS 00790T100 16,854 249,241 SH   SOLE   249,241 0 0
Agile Therapeutics, Inc. Common 00847L100 6,752 1,513,975 SH   SOLE   1,513,975 0 0
Aimmune Therapeutics, Inc. Common 00900T107 19,257 776,813 SH   SOLE   776,813 0 0
Akari Therapeutics Plc ADR 00972G108 2,124 345,850 SH   SOLE   345,850 0 0
Amyris Common 03236M200 9,045 2,826,711 SH   SOLE   2,826,711 0 0
Ascendis Pharma ADR 04351P101 64,048 1,766,832 SH   SOLE   1,766,832 0 0
Aurinia Pharmaceuticals Inc. Common 05156V102 7,607 1,213,290 SH   SOLE   1,213,290 0 0
Biohaven Pharmaceutical Holding Company Ltd Common G11196105 73,893 1,976,818 SH   SOLE   1,976,818 0 0
BioPharmX Corporation Common 09072X101 4,032 14,096,338 SH   SOLE   14,096,338 0 0
Codexis, Inc. Common 192005106 20,315 3,054,825 SH   SOLE   3,054,825 0 0
CRISPR Therapeutics AG NAMEN AKT H17182108 2,660 148,878 SH   SOLE   148,878 0 0
Eiger BioPharmaceuticals Common 28249U105 19,658 1,787,091 SH   SOLE   1,787,091 0 0
Foamix Pharmaceuticals Ltd. SHS M46135105 4,745 855,000 SH   SOLE   855,000 0 0
Kadmon Holdings, Inc. Common 48283N106 11,167 3,333,333 SH   SOLE   3,333,333 0 0
Kala Pharmaceuticals Inc. Common 483119103 26,470 1,158,911 SH   SOLE   1,158,911 0 0
KalVista Pharmaceuticals, Inc. Common 483497103 2,021 300,325 SH   SOLE   300,325 0 0
Nabriva Therapeutics PLC SHS G63637105 33,368 4,074,190 SH   SOLE   4,074,190 0 0
Regenxbio Inc. Common 75901B107 5,417 164,403 SH   SOLE   164,403 0 0
ReVance Therapeutics, Inc. Common 761330109 2,132 77,373 SH   SOLE   77,373 0 0
Selecta Biosciences, Inc. Common 816212104 20,425 1,119,189 SH   SOLE   1,119,189 0 0
Sierra Oncology, Inc Common 82640U107 3,779 2,438,270 SH   SOLE   2,438,270 0 0
Soleno Therapeutics, Inc. Common 834203101 7,642 14,695,264 SH   SOLE   14,695,264 0 0
Soleno Therapeutics, Inc. (W) Warrant 834203119 112 943,858 SH   SOLE   943,858 0 0
Strongbridge Biopharma plc Ordinary Shares G85347105 20,442 2,962,645 SH   SOLE   2,962,645 0 0
Sunesis Pharmaceuticals, Inc. Common 867328700 970 500,000 SH   SOLE   500,000 0 0
Trevena, Inc. Common 89532E109 4,406 1,728,000 SH   SOLE   1,728,000 0 0
Verona Pharma Plc ADS 925050106 22,917 1,492,951 SH   SOLE   1,492,951 0 0
Zai Lab ADR 98887Q104 8,775 325,000 SH   SOLE   325,000 0 0