The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aclaris Therapeutics Common 00461U105 40,620 1,647,214 SH   SOLE   1,647,214 0 0
Advanced Accelerator Applications S.A. ADS 00790T100 20,343 249,241 SH   SOLE   249,241 0 0
Agile Therapeutics, Inc. Common 00847L100 4,073 1,513,975 SH   SOLE   1,513,975 0 0
Aimmune Therapeutics, Inc. Common 00900T107 24,342 643,626 SH   SOLE   643,626 0 0
Akari Therapeutics Plc ADR 00972G108 1,498 345,850 SH   SOLE   345,850 0 0
Amyris, Inc. Common 03236M200 10,600 2,826,711 SH   SOLE   2,826,711 0 0
Apellis Pharmaceuticals, Inc. Common 03753U106 31,635 1,457,834 SH   SOLE   1,457,834 0 0
Ascendis Pharma ADR 04351P101 70,779 1,766,832 SH   SOLE   1,766,832 0 0
Aurinia Pharmaceuticals Inc. Common 05156V102 5,496 1,213,290 SH   SOLE   1,213,290 0 0
Biohaven Pharmaceutical Holding Company Ltd Common G11196105 53,335 1,976,818 SH   SOLE   1,976,818 0 0
BioPharmX Corporation Common 09072X101 1,521 13,799,944 SH   SOLE   13,799,944 0 0
Codexis, Inc. Common 192005106 25,508 3,054,825 SH   SOLE   3,054,825 0 0
CRISPR Therapeutics AG NAMEN AKT H17182108 2,313 98,511 SH   SOLE   98,511 0 0
Eiger BioPharmaceuticals Common 28249U105 24,988 1,791,257 SH   SOLE   1,791,257 0 0
Foamix Pharmaceuticals Ltd. SHS M46135105 5,139 855,000 SH   SOLE   855,000 0 0
Kadmon Holdings, Inc. Common 48283N106 12,067 3,333,333 SH   SOLE   3,333,333 0 0
Kala Pharmaceuticals, Inc. Common 483119103 21,428 1,158,911 SH   SOLE   1,158,911 0 0
KalVista Pharmaceuticals, Inc. Common 483497103 2,928 300,325 SH   SOLE   300,325 0 0
Nabriva Therapeutics Plc SHS G63637105 24,364 4,074,190 SH   SOLE   4,074,190 0 0
Regenxbio Inc. Common 75901B107 5,466 164,403 SH   SOLE   164,403 0 0
Selecta Biosciences, Inc. Common 816212104 10,979 1,119,189 SH   SOLE   1,119,189 0 0
Sierra Oncology, Inc Common 82640U107 9,095 2,438,270 SH   SOLE   2,438,270 0 0
Soleno Therapeutics, Inc. Common 834203200 7,260 4,033,534 SH   SOLE   4,033,534 0 0
Soleno Therapeutics, Inc. Warrant 834203135 27 188,772 SH   SOLE   188,772 0 0
Strongbridge Biopharma Plc Ordinary Shares G85347105 17,780 2,452,397 SH   SOLE   2,452,397 0 0
Sunesis Pharmaceuticals, Inc. Common Par 867328700 1,845 500,000 SH   SOLE   500,000 0 0
Trevena, Inc. Common 89532E109 2,765 1,728,000 SH   SOLE   1,728,000 0 0
Verona Pharma Plc ADS 925050106 17,723 1,492,951 SH   SOLE   1,492,951 0 0
Zai Lab LTD ADR 98887Q104 6,742 317,567 SH   SOLE   317,567 0 0
Zogenix, Inc. Common 98978L204 4,205 105,000 SH   SOLE   105,000 0 0