The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
ABEONA THERAPEUTICS INC | COM | 00289Y107 | 4,233 | 295,000 | SH | DFND | 1,2 | 295,000 | 0 | 0 | |
ADAMAS PHARMACEUTICALS INC | COM | 00548A106 | 8,018 | 335,500 | SH | DFND | 1,2 | 335,500 | 0 | 0 | |
ADVANCE AUTO PARTS INC | COM | 00751Y106 | 633 | 5,336 | SH | DFND | 5,336 | 0 | 0 | ||
ALDEYRA THERAPEUTICS INC | COM | 01438T106 | 7,568 | 1,009,131 | SH | DFND | 1,2 | 1,009,131 | 0 | 0 | |
ALEXION PHARMACEUTICALS INC | COM | 015351109 | 9,140 | 82,000 | SH | DFND | 1,2 | 82,000 | 0 | 0 | |
ALLENA PHARMACEUTICALS INC | COM | 018119107 | 4,520 | 410,199 | SH | DFND | 1,2 | 410,199 | 0 | 0 | |
ALLERGAN PLC | SHS | G0177J108 | 10,097 | 60,000 | SH | DFND | 1,2 | 60,000 | 0 | 0 | |
ALPHABET INC | CAP STK CL A | 02079K305 | 4,970 | 4,792 | SH | DFND | 4,792 | 0 | 0 | ||
AMICUS THERAPEUTICS INC | COM | 03152W109 | 27,759 | 1,845,704 | SH | DFND | 1,2 | 1,845,704 | 0 | 0 | |
AQUINOX PHARMACEUTICALS INC | COM | 03842B101 | 1,064 | 75,535 | SH | DFND | 1,2 | 75,535 | 0 | 0 | |
ARQULE INC | COM | 04269E107 | 5,075 | 1,762,000 | SH | DFND | 1,2 | 1,762,000 | 0 | 0 | |
ARQULE INC | COM | 04269E107 | 1,446 | 502,136 | SH | DFND | 1,2 | 502,136 | 0 | 0 | |
ARRAY BIOPHARMA INC | COM | 04269X105 | 6,610 | 405,000 | SH | DFND | 1,2 | 405,000 | 0 | 0 | |
ARSANIS INC | COM | 042873109 | 2,632 | 114,972 | SH | DFND | 1,2 | 114,972 | 0 | 0 | |
ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 6,244 | 95,474 | SH | DFND | 1,2 | 95,474 | 0 | 0 | |
ATHERSYS INC | COM | 04744L106 | 1 | 773 | SH | DFND | 1,2 | 773 | 0 | 0 | |
AUDENTES THERAPEUTICS INC | COM | 05070R104 | 2,855 | 95,000 | SH | DFND | 1,2 | 95,000 | 0 | 0 | |
BIOGEN INC | COM | 09062X103 | 17,798 | 65,000 | SH | DFND | 1,2 | 65,000 | 0 | 0 | |
BIOHAVEN PHARMACTL HLDG CO L | COM | G11196105 | 3,377 | 131,100 | SH | DFND | 1,2 | 131,100 | 0 | 0 | |
CAESARSTONE LTD | ORD SHS | M20598104 | 240 | 12,195 | SH | DFND | 12,195 | 0 | 0 | ||
CELGENE CORP | COM | 151020104 | 28,458 | 319,000 | SH | DFND | 1,2 | 319,000 | 0 | 0 | |
CELLECTIS S A | SPONSORED ADS | 15117K103 | 10,693 | 339,367 | SH | DFND | 1,2 | 339,367 | 0 | 0 | |
CHARTER COMMUNICATIONS INC N | CL A | 16119P108 | 1,036 | 3,329 | SH | DFND | 3,329 | 0 | 0 | ||
CLEARSIDE BIOMEDICAL INC | COM | 185063104 | 11,052 | 1,030,000 | SH | DFND | 1,2 | 1,030,000 | 0 | 0 | |
CLEMENTIA PHARMACEUTICALS IN | COM | 185575107 | 3,030 | 200,000 | SH | DFND | 1,2 | 200,000 | 0 | 0 | |
CLOVIS ONCOLOGY INC | COM | 189464100 | 8,870 | 168,000 | SH | DFND | 1,2 | 168,000 | 0 | 0 | |
COHERUS BIOSCIENCES INC | COM | 19249H103 | 2,984 | 270,000 | SH | DFND | 1,2 | 270,000 | 0 | 0 | |
COMCAST CORP NEW | CL A | 20030N101 | 342 | 10,000 | SH | DFND | 10,000 | 0 | 0 | ||
CORVUS PHARMACEUTICALS INC | COM | 221015100 | 3,706 | 321,430 | SH | DFND | 1,2 | 321,430 | 0 | 0 | |
CTI BIOPHARMA CORP | COM NEW | 12648L601 | 3,251 | 833,633 | SH | DFND | 1,2 | 833,633 | 0 | 0 | |
CYTOMX THERAPEUTICS INC | COM | 23284F105 | 5,121 | 180,000 | SH | DFND | 1,2 | 180,000 | 0 | 0 | |
DECIPHERA PHARMACEUTICALS IN | COM | 24344T101 | 819 | 40,846 | SH | DFND | 1,2 | 40,846 | 0 | 0 | |
DELEK US HLDGS INC NEW | COM | 24665A103 | 4,977 | 122,284 | SH | DFND | 122,284 | 0 | 0 | ||
DENTSPLY SIRONA INC | COM | 24906P109 | 126 | 2,500 | SH | DFND | 2,500 | 0 | 0 | ||
EIGER BIOPHARMACEUTICALS INC | COM | 28249U105 | 4,679 | 475,000 | SH | DFND | 1,2 | 475,000 | 0 | 0 | |
ENDO INTL PLC | SHS | G30401106 | 3,267 | 550,000 | SH | DFND | 1,2 | 550,000 | 0 | 0 | |
ERYTECH PHARMA | SPONSORED ADR | 29604W108 | 2,520 | 120,000 | SH | DFND | 1,2 | 120,000 | 0 | 0 | |
EVOKE PHARMA INC | COM | 30049G104 | 819 | 393,852 | SH | DFND | 1,2 | 393,852 | 0 | 0 | |
EXPEDIA GROUP INC | COM NEW | 30212P303 | 2,087 | 18,900 | SH | DFND | 18,900 | 0 | 0 | ||
FACEBOOK INC | CL A | 30303M102 | 974 | 6,097 | SH | DFND | 6,097 | 0 | 0 | ||
FIBROGEN INC | COM | 31572Q808 | 1,838 | 39,779 | SH | DFND | 1,2 | 39,779 | 0 | 0 | |
FLEX LTD | ORD | Y2573F102 | 5,027 | 307,839 | SH | DFND | 307,839 | 0 | 0 | ||
GCI LIBERTY INC | COM CLASS A | 36164V305 | 159 | 3,000 | SH | DFND | 3,000 | 0 | 0 | ||
GEMPHIRE THERAPEUTICS INC | COM | 36870A108 | 3,132 | 481,046 | SH | DFND | 1,2 | 481,046 | 0 | 0 | |
GILAT SATELLITE NETWORKS LTD | SHS NEW | M51474118 | 985 | 111,646 | SH | DFND | 111,646 | 0 | 0 | ||
GLAXOSMITHKLINE PLC | SPONSORED ADR | 37733W105 | 19,535 | 500,000 | SH | DFND | 1,2 | 500,000 | 0 | 0 | |
GLYCOMIMETICS INC | COM | 38000Q102 | 2,435 | 150,000 | SH | DFND | 1,2 | 150,000 | 0 | 0 | |
HOMOLOGY MEDICINES INC | COM | 438083107 | 2,487 | 133,000 | SH | DFND | 1,2 | 133,000 | 0 | 0 | |
IMMUNOMEDICS INC | COM | 452907108 | 7,013 | 480,000 | SH | DFND | 1,2 | 480,000 | 0 | 0 | |
INNOVATE BIOPHARMACEUTICLS I | COM PAR | 45782F105 | 12,256 | 980,502 | SH | DFND | 1,2 | 980,502 | 0 | 0 | |
INTELLIA THERAPEUTICS INC | COM | 45826J105 | 3,374 | 160,000 | SH | DFND | 1,2 | 160,000 | 0 | 0 | |
KADMON HLDGS INC | COM | 48283N106 | 6,333 | 1,490,000 | SH | DFND | 1,2 | 1,490,000 | 0 | 0 | |
KURA ONCOLOGY INC | COM | 50127T109 | 6,188 | 330,000 | SH | DFND | 1,2 | 330,000 | 0 | 0 | |
LA JOLLA PHARMACEUTICAL CO | COM PAR $.0001 2 | 503459604 | 7,743 | 260,000 | SH | DFND | 1,2 | 260,000 | 0 | 0 | |
LAM RESEARCH CORP | COM | 512807108 | 2,713 | 13,356 | SH | DFND | 13,356 | 0 | 0 | ||
LEAP THERAPEUTICS INC | COM | 52187K101 | 3,545 | 427,086 | SH | DFND | 1,2 | 427,086 | 0 | 0 | |
LIVEPERSON INC | COM | 538146101 | 2 | 136 | SH | DFND | 136 | 0 | 0 | ||
MACROGENICS INC | COM | 556099109 | 3,397 | 135,000 | SH | DFND | 1,2 | 135,000 | 0 | 0 | |
MASTERCARD INCORPORATED | CL A | 57636Q104 | 2,895 | 16,525 | SH | DFND | 16,525 | 0 | 0 | ||
MEDICINOVA INC | COM NEW | 58468P206 | 6,447 | 630,838 | SH | DFND | 1,2 | 630,838 | 0 | 0 | |
MELINTA THERAPEUTICS INC | COM | 58549G100 | 1,805 | 243,896 | SH | DFND | 1,2 | 243,896 | 0 | 0 | |
MELLANOX TECHNOLOGIES LTD | SHS | M51363113 | 7,305 | 100,279 | SH | DFND | 100,279 | 0 | 0 | ||
MERCK & CO INC | COM | 58933Y105 | 31,593 | 580,000 | SH | DFND | 1,2 | 580,000 | 0 | 0 | |
MICROSOFT CORP | COM | 594918104 | 6,101 | 66,850 | SH | DFND | 66,850 | 0 | 0 | ||
MINERVA NEUROSCIENCES INC | COM | 603380106 | 4,844 | 775,000 | SH | DFND | 1,2 | 775,000 | 0 | 0 | |
MOHAWK INDS INC | COM | 608190104 | 255 | 1,100 | SH | DFND | 1,100 | 0 | 0 | ||
MYLAN N V | SHS EURO | N59465109 | 23,632 | 574,000 | SH | DFND | 1,2 | 574,000 | 0 | 0 | |
NEOS THERAPEUTICS INC | COM | 64052L106 | 2,662 | 320,692 | SH | DFND | 1,2 | 320,692 | 0 | 0 | |
NICE LTD | SPONSORED ADR | 653656108 | 6,365 | 67,758 | SH | DFND | 67,758 | 0 | 0 | ||
O REILLY AUTOMOTIVE INC NEW | COM | 67103H107 | 2,683 | 10,844 | SH | DFND | 10,844 | 0 | 0 | ||
OBSEVA SA | COM | H5861P103 | 10,053 | 745,197 | SH | DFND | 1,2 | 745,197 | 0 | 0 | |
PERRIGO CO PLC | SHS | G97822103 | 1,600 | 19,221 | SH | DFND | 19,221 | 0 | 0 | ||
PFIZER INC | COM | 717081103 | 20,939 | 590,000 | SH | DFND | 1,2 | 590,000 | 0 | 0 | |
PIERIS PHARMACEUTICALS INC | COM | 720795103 | 5,456 | 800,000 | SH | DFND | 1,2 | 800,000 | 0 | 0 | |
PORTOLA PHARMACEUTICALS INC | COM | 737010108 | 6,532 | 200,000 | SH | Call | DFND | 1,2 | 0 | 0 | 0 |
POWERSHARES QQQ TRUST | UNIT SER 1 | 73935A104 | 12,810 | 80,000 | SH | Put | DFND | 80,000 | 0 | 0 | |
PROQR THRAPEUTICS N V | SHS EURO | N71542109 | 2,025 | 658,500 | SH | DFND | 1,2 | 658,500 | 0 | 0 | |
PUMA BIOTECHNOLOGY INC | COM | 74587V107 | 4,083 | 60,000 | SH | DFND | 1,2 | 60,000 | 0 | 0 | |
RADCOM LTD | SHS NEW | M81865111 | 1,207 | 65,760 | SH | DFND | 65,760 | 0 | 0 | ||
RADWARE LTD | ORD | M81873107 | 389 | 18,230 | SH | DFND | 18,230 | 0 | 0 | ||
REATA PHARMACEUTICALS INC | CL A | 75615P103 | 4,615 | 225,000 | SH | DFND | 1,2 | 225,000 | 0 | 0 | |
RECRO PHARMA INC | COM | 75629F109 | 4,010 | 364,197 | SH | DFND | 1,2 | 364,197 | 0 | 0 | |
REGENERON PHARMACEUTICALS | COM | 75886F107 | 14,291 | 41,500 | SH | DFND | 1,2 | 41,500 | 0 | 0 | |
REGENXBIO INC | COM | 75901B107 | 2,985 | 100,000 | SH | DFND | 1,2 | 100,000 | 0 | 0 | |
RETROPHIN INC | COM | 761299106 | 4,919 | 220,000 | SH | DFND | 1,2 | 220,000 | 0 | 0 | |
ROCKET PHARMACEUTICALS INC | COM | 77313F106 | 5,668 | 302,275 | SH | DFND | 1,2 | 302,275 | 0 | 0 | |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 18,448 | 248,997 | SH | DFND | 1,2 | 248,997 | 0 | 0 | |
SEALED AIR CORP NEW | COM | 81211K100 | 193 | 4,500 | SH | DFND | 4,500 | 0 | 0 | ||
SERVICEMASTER GLOBAL HLDGS I | COM | 81761R109 | 483 | 9,500 | SH | DFND | 9,500 | 0 | 0 | ||
SHIRE PLC | SPONSORED ADR | 82481R106 | 29,355 | 196,500 | SH | DFND | 1,2 | 196,500 | 0 | 0 | |
SIERRA ONCOLOGY INC | COM | 82640U107 | 2,070 | 1,000,000 | SH | DFND | 1,2 | 1,000,000 | 0 | 0 | |
SITEONE LANDSCAPE SUPPLY INC | COM | 82982L103 | 231 | 3,000 | SH | DFND | 3,000 | 0 | 0 | ||
SNAP ON INC | COM | 833034101 | 202 | 1,366 | SH | DFND | 1,366 | 0 | 0 | ||
SOLAREDGE TECHNOLOGIES INC | COM | 83417M104 | 904 | 17,190 | SH | DFND | 17,190 | 0 | 0 | ||
SPDR SERIES TRUST | S&P BIOTECH | 78464A870 | 65,798 | 750,000 | SH | Put | DFND | 1,2 | 750,000 | 0 | 0 |
SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 4,247 | 298,472 | SH | DFND | 1,2 | 298,472 | 0 | 0 | |
TESARO INC | COM | 881569107 | 6,067 | 106,175 | SH | DFND | 1,2 | 106,175 | 0 | 0 | |
TEVA PHARMACEUTICAL FIN LLC | DBCV 0.250% 2/0 | 88163VAE9 | 703 | 2,135 | SH | DFND | 2,135 | 0 | 0 | ||
ULTIMATE SOFTWARE GROUP INC | COM | 90385D107 | 195 | 800 | SH | DFND | 800 | 0 | 0 | ||
UNIQURE NV | SHS | N90064101 | 2,999 | 127,600 | SH | DFND | 1,2 | 127,600 | 0 | 0 | |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 428 | 2,000 | SH | DFND | 2,000 | 0 | 0 | ||
VBI VACCINES INC | COM NEW | 91822J103 | 2,332 | 666,284 | SH | DFND | 1,2 | 666,284 | 0 | 0 | |
VIKING THERAPEUTICS INC | COM | 92686J106 | 6,959 | 1,592,416 | SH | DFND | 1,2 | 1,592,416 | 0 | 0 | |
VISA INC | COM CL A | 92826C839 | 4,833 | 40,401 | SH | DFND | 40,401 | 0 | 0 | ||
VISTA OUTDOOR INC | COM | 928377100 | 98 | 6,000 | SH | DFND | 6,000 | 0 | 0 | ||
VISTAGEN THERAPEUTICS INC | COM NEW | 92840H202 | 1,157 | 1,247,251 | SH | DFND | 1,2 | 1,247,251 | 0 | 0 | |
VTV THERAPEUTICS INC | CL A | 918385105 | 1,146 | 281,679 | SH | DFND | 1,2 | 281,679 | 0 | 0 | |
WATSCO INC | COM | 942622200 | 380 | 2,100 | SH | DFND | 2,100 | 0 | 0 |