The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aclaris Therapeutics Common 00461U105 32,895 1,647,214 SH   SOLE   1,647,214 0 0
Agile Therapeutics, Inc. Common 00847L100 742 1,513,975 SH   SOLE   1,513,975 0 0
Akari Therapeutics Plc ADR 00972G108 674 345,850 SH   SOLE   345,850 0 0
Amyris, Inc. Common 03236M200 18,063 2,826,711 SH   SOLE   2,826,711 0 0
Apellis Pharmaceuticals, Inc. Common 03753U106 32,043 1,456,499 SH   SOLE   1,456,499 0 0
Arrowhead Pharmaceuticals In Common 04280A100 25,840 1,900,000 SH   SOLE   1,900,000 0 0
Ascendis Pharma ADR 04351P101 144,138 2,166,832 SH   SOLE   2,166,832 0 0
Aurinia Pharmaceuticals Inc. Common 05156V102 6,831 1,213,290 SH   SOLE   1,213,290 0 0
Biohaven Pharmaceutical Holding Company Ltd Common G11196105 80,998 2,049,545 SH   SOLE   2,049,545 0 0
BioPharmX Corporation Common 09072X101 3,561 16,128,515 SH   SOLE   16,128,515 0 0
Codexis, Inc. Common 192005106 43,989 3,054,825 SH   SOLE   3,054,825 0 0
Cymabay Therapeutics inc Common 23257D103 12,158 906,000 SH   SOLE   906,000 0 0
Deciphera Pharmaceuticals In Common 24344T101 9,953 252,942 SH   SOLE   252,942 0 0
Eiger BioPharmaceuticals Common 28249U105 21,853 1,791,257 SH   SOLE   1,791,257 0 0
Foamix Pharmaceuticals Ltd. SHS M46135105 4,284 855,000 SH   SOLE   855,000 0 0
Galmed Pharmaceuticals Ltd SHS M47238106 9,433 792,707 SH   SOLE   792,707 0 0
Genocea Biosciences Inc(NMS) Common 372427104 7,000 8,180,000 SH   SOLE   8,180,000 0 0
Homology Medicines, Inc. Common 438083107 28,759 1,409,742 SH   SOLE   1,409,742 0 0
Kadmon Holdings (KDMN) Common 48283N106 68,919 10,454,545 SH   SOLE   10,454,545 0 0
Kala Pharmaceuticals, Inc. Common 483119103 14,321 1,043,020 SH   SOLE   1,043,020 0 0
KalVista Pharmaceuticals, Inc. Common 483497103 2,439 300,325 SH   SOLE   300,325 0 0
Kiniksa Pharmaceuticals-A Common G5269C101 3,228 186,073 SH   SOLE   186,073 0 0
Madrigal Pharmaceuticals Inc Common 558868105 17,402 62,220 SH   SOLE   62,220 0 0
MEI Pharma Inc (NAS) Common 55279B202 26,007 6,600,660 SH   SOLE   6,600,660 0 0
Menlo Therapeutics Common 586858102 32,571 4,011,236 SH   SOLE   4,011,236 0 0
Nabriva Therapeutics Plc SHS G63637105 14,178 4,074,190 SH   SOLE   4,074,190 0 0
Obseva SA Common H5861P103 14,005 925,000 SH   SOLE   925,000 0 0
Regenxbio Inc. Common 75901B107 5,912 82,403 SH   SOLE   82,403 0 0
Selecta Biosciences, Inc. Common 816212104 10,343 780,601 SH   SOLE   780,601 0 0
Sierra Oncology, Inc Common 82640U107 7,217 2,438,270 SH   SOLE   2,438,270 0 0
Soleno Therapeutics, Inc. Common 834203200 10,202 4,359,683 SH   SOLE   4,359,683 0 0
Soleno Therapeutics, Inc. Warrant 834203135 79 188,772 SH   SOLE   188,772 0 0
Strongbridge Biopharma plc SHS USD G85347105 11,509 1,918,132 SH   SOLE   1,918,132 0 0
Sunesis Pharmaceuticals, Inc. Common Par 867328700 414 195,474 SH   SOLE   195,474 0 0
Trevena, Inc. Common 89532E109 2,488 1,728,000 SH   SOLE   1,728,000 0 0
Tricida, Inc. Common 89610F101 29,652 991,711 SH   SOLE   991,711 0 0
Verona Pharma Plc ADS 925050106 2,792 1,492,951 SH   SOLE   1,492,951 0 0
Zai Lab LTD ADR 98887Q104 5,371 231,010 SH   SOLE   231,010 0 0
Zogenix, Inc. Common 98978L204 4,641 105,000 SH   SOLE   105,000 0 0
Zymeworks Inc Common 98985W102 9,166 620,134 SH   SOLE   620,134 0 0