The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Acer Therapeutics Inc Common 00444P108 17,442 565,579 SH   SOLE   565,579 0 0
Aclaris Therapeutics Common 00461U105 23,918 1,647,214 SH   SOLE   1,647,214 0 0
Agile Therapeutics, Inc. Common 00847L100 555 1,513,975 SH   SOLE   1,513,975 0 0
Akari Therapeutics Plc ADR 00972G108 885 345,850 SH   SOLE   345,850 0 0
Amyris, Inc. Common 03236M200 44,266 5,575,118 SH   SOLE   5,575,118 0 0
Apellis Pharmaceuticals, Inc. Common 03753U106 24,084 1,354,554 SH   SOLE   1,354,554 0 0
Arrowhead Pharmaceuticals In Common 04280A100 44,637 2,328,475 SH   SOLE   2,328,475 0 0
Arvinas Holding Co LLC Common 04335A105 5,061 300,000 SH   SOLE   300,000 0 0
Ascendis Pharma ADR 04351P101 153,542 2,166,832 SH   SOLE   2,166,832 0 0
Aurinia Pharmaceuticals Inc. Common 05156V102 8,056 1,213,290 SH   SOLE   1,213,290 0 0
Biohaven Pharmaceutical Holding Company Ltd Common G11196105 76,960 2,049,545 SH   SOLE   2,049,545 0 0
BioPharmX Corporation Common 09072X101 3,064 16,128,515 SH   SOLE   16,128,515 0 0
Codexis, Inc. Common 192005106 47,151 2,749,343 SH   SOLE   2,749,343 0 0
Crinetics Pharmaceuticals Inc Common 22663K107 108,646 3,792,169 SH   SOLE   3,792,169 0 0
Cymabay Therapeutics inc Common 23257D103 10,038 906,000 SH   SOLE   906,000 0 0
Deciphera Pharmaceuticals In Common 24344T101 8,234 212,648 SH   SOLE   212,648 0 0
Eiger BioPharmaceuticals Common 28249U105 21,495 1,791,257 SH   SOLE   1,791,257 0 0
Foamix Pharmaceuticals Ltd. SHS M46135105 2,450 427,500 SH   SOLE   427,500 0 0
Galmed Pharmaceuticals Ltd SHS M47238106 11,563 851,492 SH   SOLE   851,492 0 0
Genocea Biosciences Inc(NMS) Common 372427104 6,378 8,180,000 SH   SOLE   8,180,000 0 0
GTX Inc Common 40052B207 165 105,043 SH   SOLE   105,043 0 0
Homology Medicines, Inc. Common 438083107 26,512 1,159,742 SH   SOLE   1,159,742 0 0
Kadmon Holdings (KDMN) Common 48283N106 34,918 10,454,545 SH   SOLE   10,454,545 0 0
Kala Pharmaceuticals, Inc. Common 483119103 10,295 1,043,020 SH   SOLE   1,043,020 0 0
KalVista Pharmaceuticals, Inc. Common 483497103 30,051 1,359,149 SH   SOLE   1,359,149 0 0
Kiniksa Pharmaceuticals-A Common G5269C101 6,754 264,878 SH   SOLE   264,878 0 0
MEI Pharma Inc (NAS) Common 55279B202 24,904 5,778,106 SH   SOLE   5,778,106 0 0
Menlo Therapeutics Common 586858102 39,511 4,011,236 SH   SOLE   4,011,236 0 0
Nabriva Therapeutics Plc SHS G63637105 17,872 6,619,190 SH   SOLE   6,619,190 0 0
Obseva SA Common H5861P103 16,897 937,147 SH   SOLE   937,147 0 0
Selecta Biosciences, Inc. Common 816212104 11,837 761,253 SH   SOLE   761,253 0 0
Sierra Oncology, Inc Common 82640U107 4,145 2,438,270 SH   SOLE   2,438,270 0 0
Sinovac Biotech Ltd SHS P8696W104 44,958 5,900,000 SH   SOLE   5,900,000 0 0
Soleno Therapeutics, Inc. Common 834203200 9,417 4,359,683 SH   SOLE   4,359,683 0 0
Soleno Therapeutics, Inc. Warrant 834203135 23 188,772 SH   SOLE   188,772 0 0
Strongbridge Biopharma plc SHS USD G85347105 4,453 918,132 SH   SOLE   918,132 0 0
Sunesis Pharmaceuticals, Inc. Common Par 867328700 391 195,474 SH   SOLE   195,474 0 0
Trevena, Inc. Common 89532E109 3,663 1,728,000 SH   SOLE   1,728,000 0 0
Tricida, Inc. Common 89610F101 30,297 991,711 SH   SOLE   991,711 0 0
Verona Pharma Plc ADS 925050106 18,677 1,492,951 SH   SOLE   1,492,951 0 0
Xenon Pharmaceuticals Inc Common 98420N105 18,552 1,405,476 SH   SOLE   1,405,476 0 0
Zai Lab LTD ADR 98887Q104 4,500 231,010 SH   SOLE   231,010 0 0
Zogenix, Inc. Common 98978L204 5,208 105,000 SH   SOLE   105,000 0 0
Zymeworks Inc Common 98985W102 9,736 620,134 SH   SOLE   620,134 0 0