The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
111 INC ADS 68247Q102 6,760 500,000 SH   SOLE   0 0 500,000
ABBOTT LABS COM 002824100 28,911 394,100 SH   DFND 1 250,000 0 144,100
AC IMMUNE SA SHS H00263105 11,520 1,440,000 SH   SOLE   0 0 1,440,000
ADAMAS PHARMACEUTICALS INC COM 00548A106 2,002 100,000 SH   DFND 1 20,500 0 79,500
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 9,039 666,593 SH   SOLE   666,593 0 0
AEGERION PHARMACEUTICALS INC NOTE 2.000% 8/1 00767EAB8 1,551 2,000,000 PRN   DFND 1 419,600 0 1,580,400
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 20,724 2,165,524 SH   SOLE   2,165,524 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 75,081 1,219,830 SH   DFND 1 200,300 0 1,019,530
AERPIO PHARMACEUTICALS INC COM 00810B105 16,049 5,193,946 SH   SOLE   5,193,946 0 0
AETNA INC NEW COM 00817Y108 19,920 98,200 SH   DFND 1 18,700 0 79,500
AFFIMED N V COM N01045108 1,421 326,650 SH   SOLE   326,650 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 76,543 1,085,100 SH   DFND 1 167,200 0 917,900
ALEXION PHARMACEUTICALS INC COM 015351109 400,502 2,881,103 SH   DFND 1 457,200 0 2,423,903
ALIMERA SCIENCES INC COM 016259103 245 250,000 SH   DFND 1 25,000 0 225,000
ALKERMES PLC SHS G01767105 6,154 145,000 SH   SOLE   0 0 145,000
ALLAKOS INC COM 01671P100 8,998 200,000 SH   DFND 1 36,600 0 163,400
ALLERGAN PLC SHS G0177J108 219,129 1,150,405 SH   DFND 1 258,431 0 891,974
ALPINE IMMUNE SCIENCES INC COM 02083G100 20,880 3,298,516 SH   SOLE   3,298,516 0 0
AMGEN INC COM 031162100 31,425 151,600 SH   SOLE   0 0 151,600
AMICUS THERAPEUTICS INC COM 03152W109 21,318 1,763,277 SH   DFND 1 276,785 0 1,486,492
ANAPTYSBIO INC COM 032724106 1,995 20,000 SH Put DFND 1 4,000 0 16,000
ANTHEM INC COM 036752103 129,900 474,000 SH   DFND 1 103,300 0 370,700
ARGENX SE SPONSORED ADR 04016X101 54,514 718,800 SH   SOLE   0 0 718,800
ARRAY BIOPHARMA INC COM 04269X105 73,065 4,806,900 SH   DFND 1 777,600 0 4,029,300
ARSANIS INC COM 042873109 3,028 1,868,966 SH   SOLE   1,868,966 0 0
ARVINAS INC COM 04335A105 44,636 2,645,865 SH   DFND 1 1,916,310 0 729,555
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 294,486 4,155,891 SH   DFND 1 3,572,373 0 583,518
ASSEMBLY BIOSCIENCES INC COM 045396108 45,807 1,233,371 SH   SOLE   0 0 1,233,371
ATHENEX INC COM 04685N103 6,682 430,000 SH   SOLE   0 0 430,000
AUDENTES THERAPEUTICS INC COM 05070R104 86,306 2,180,000 SH   SOLE   2,180,000 0 0
AVROBIO INC COM 05455M100 12,968 250,000 SH   SOLE   0 0 250,000
BAUSCH HEALTH COS INC COM 071734107 48,873 1,903,900 SH   DFND 1 335,800 0 1,568,100
BEIGENE LTD SPONSORED ADR 07725L102 48,652 282,500 SH   DFND 1 55,200 0 227,300
BIOGEN INC COM 09062X103 321,618 910,300 SH   DFND 1 146,465 0 763,835
BIOLINERX LTD SPONSORED ADR 09071M106 1,111 1,038,600 SH   SOLE   1,038,600 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 7,418 76,500 SH   SOLE   0 0 76,500
BIOMARIN PHARMACEUTICAL INC NOTE 0.750%10/1 09061GAE1 517 500,000 PRN   SOLE   0 0 500,000
BIOMARIN PHARMACEUTICAL INC NOTE 1.500%10/1 09061GAF8 602 500,000 PRN   SOLE   0 0 500,000
BLUEBIRD BIO INC COM 09609G100 67,043 459,200 SH   DFND 1 76,200 0 383,000
BOSTON SCIENTIFIC CORP COM 101137107 302,764 7,863,995 SH   DFND 1 1,500,700 0 6,363,295
BRISTOL MYERS SQUIBB CO COM 110122108 125,762 2,025,800 SH   DFND 1 349,900 0 1,675,900
CATALYST PHARMACEUTICALS INC COM 14888U101 4,166 1,102,000 SH   SOLE   0 0 1,102,000
CELGENE CORP COM 151020104 220,490 2,463,850 SH   DFND 1 387,100 0 2,076,750
CENTENE CORP DEL COM 15135B101 48,849 337,400 SH   DFND 1 68,500 0 268,900
CIGNA CORPORATION COM 125509109 132,010 633,900 SH   DFND 1 144,500 0 489,400
CLEMENTIA PHARMACEUTICALS IN COM 185575107 116,241 10,425,225 SH   SOLE   10,425,225 0 0
CLOVIS ONCOLOGY INC COM 189464100 65,629 2,234,570 SH   DFND 1 418,500 0 1,816,070
COHERUS BIOSCIENCES INC COM 19249H103 28,420 1,722,400 SH   SOLE   0 0 1,722,400
CONSTELLATION PHARMCETICLS I COM 210373106 5,625 835,842 SH   SOLE   835,842 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 51,202 5,967,584 SH   SOLE   5,967,584 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 54,844 1,914,282 SH   SOLE   1,914,282 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 22,006 496,200 SH   DFND 1 106,100 0 390,100
CTI BIOPHARMA CORP COM NEW 12648L601 10,800 5,000,000 SH   SOLE   5,000,000 0 0
DAVITA INC COM 23918K108 103,555 1,445,700 SH   DFND 1 289,900 0 1,155,800
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 14,940 665,200 SH   SOLE   0 0 665,200
DECIPHERA PHARMACEUTICALS IN COM 24344T101 75,640 1,953,500 SH   DFND 1 234,800 0 1,718,700
DENTSPLY SIRONA INC COM 24906P109 71,298 1,889,200 SH   DFND 1 390,500 0 1,498,700
DERMIRA INC COM 24983L104 11,244 1,031,596 SH   SOLE   0 0 1,031,596
EDWARDS LIFESCIENCES CORP COM 28176E108 172,463 990,600 SH   DFND 1 191,200 0 799,400
EHEALTH INC COM 28238P109 45,533 1,611,200 SH   SOLE   0 0 1,611,200
ELECTROCORE INC COM 28531P103 5,570 397,826 SH   DFND 1 198,913 0 198,913
EXELIXIS INC COM 30161Q104 49,650 2,801,900 SH   DFND 1 410,200 0 2,391,700
FLUIDIGM CORP DEL COM 34385P108 8,073 1,077,801 SH   DFND 1 26,200 0 1,051,601
FLUIDIGM CORP DEL NOTE 2.750% 2/0 34385PAA6 8,625 10,000,000 PRN   SOLE   0 0 10,000,000
FOAMIX PHARMACEUTICALS LTD SHS M46135105 29,769 5,195,330 SH   SOLE   0 0 5,195,330
GALAPAGOS NV SPON ADR 36315X101 44,031 391,631 SH   DFND 1 58,400 0 333,231
GILEAD SCIENCES INC COM 375558103 28,151 364,600 SH   SOLE   0 0 364,600
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 11,761 309,500 SH   SOLE   0 0 309,500
GW PHARMACEUTICALS PLC ADS 36197T103 3,628 21,000 SH   SOLE   0 0 21,000
HCA HEALTHCARE INC COM 40412C101 10,559 75,900 SH   DFND 1 41,900 0 34,000
HERON THERAPEUTICS INC COM 427746102 47,934 1,514,500 SH   SOLE   0 0 1,514,500
HUMANA INC COM 444859102 133,038 393,000 SH   DFND 1 92,800 0 300,200
ILLUMINA INC COM 452327109 98,189 267,500 SH   DFND 1 53,600 0 213,900
IMMUNOGEN INC COM 45253H101 13,913 1,469,189 SH   DFND 1 179,200 0 1,289,989
IMMUNOMEDICS INC COM 452907108 90,164 4,328,573 SH   DFND 1 958,903 0 3,369,670
INOTEK PHARMACEUTICALS CORP NOTE 5.750% 8/0 45780VAB8 7,788 7,000,000 PRN   SOLE   0 0 7,000,000
INSMED INC COM PAR $.01 457669307 36,988 1,829,300 SH   DFND 1 278,377 0 1,550,923
INSMED INC NOTE 1.750% 1/1 457669AA7 22,611 26,500,000 PRN   DFND 1 7,456,000 0 19,044,000
INSPIRE MED SYS INC COM 457730109 102,853 2,444,221 SH   SOLE   2,444,221 0 0
INSYS THERAPEUTICS INC NEW COM NEW 45824V209 30,526 3,028,354 SH   DFND 1 651,900 0 2,376,454
INTELLIA THERAPEUTICS INC COM 45826J105 21,310 744,600 SH   SOLE   744,600 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 52,923 92,200 SH   DFND 1 33,700 0 58,500
INVITAE CORP COM 46185L103 21,323 1,274,549 SH   SOLE   1,274,549 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 62,419 5,548,326 SH   DFND 1 1,337,800 0 4,210,526
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 54,074 2,929,250 SH   DFND 1 667,500 0 2,261,750
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 2,769 150,000 SH Call DFND 1 30,500 0 119,500
JAZZ PHARMACEUTICALS PLC SHS USD G50871105 148,627 884,000 SH   DFND 1 166,000 0 718,000
JOHNSON & JOHNSON COM 478160104 57,216 414,100 SH   DFND 1 209,100 0 205,000
KALA PHARMACEUTICALS INC COM 483119103 34,030 3,447,840 SH   SOLE   3,447,840 0 0
LOXO ONCOLOGY INC COM 548862101 56,374 330,000 SH   SOLE   330,000 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 5,676 567,600 SH   SOLE   567,600 0 0
MCKESSON CORP COM 58155Q103 6,633 50,000 SH Call DFND 1 10,000 0 40,000
MCKESSON CORP COM 58155Q103 9,829 74,100 SH   DFND 1 14,100 0 60,000
MEDIGUS LTD SPONSORED ADS 58471G300 51 15,000 SH   SOLE   15,000 0 0
MEDNAX INC COM 58502B106 68,558 1,469,300 SH   DFND 1 362,200 0 1,107,100
MEIRAGTX HOLDINGS PLC COM G59665102 3,443 253,183 SH   SOLE   0 0 253,183
MENLO THERAPEUTICS INC COM 586858102 4,656 472,729 SH   SOLE   0 0 472,729
MERCK & CO INC COM 58933Y105 251,440 3,544,400 SH   DFND 1 718,400 0 2,826,000
MOLINA HEALTHCARE INC COM 60855R100 72,682 488,781 SH   DFND 1 99,600 0 389,181
MYLAN N V SHS EURO N59465109 174,933 4,779,600 SH   DFND 1 887,600 0 3,892,000
NABRIVA THERAPEUTICS PLC SHS G63637105 12,540 4,644,600 SH   SOLE   4,644,600 0 0
NATERA INC COM 632307104 16,377 684,086 SH   SOLE   684,086 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 16,943 137,800 SH   SOLE   0 0 137,800
NEURONETICS INC COM 64131A105 4,809 150,000 SH   DFND 1 51,400 0 98,600
NEVRO CORP COM 64157F103 77,388 1,357,691 SH   DFND 1 272,700 0 1,084,991
NOVO-NORDISK A S ADR 670100205 15,556 330,000 SH   SOLE   0 0 330,000
NOVUS THERAPEUTICS INC COM 67011N105 11,848 2,537,110 SH   SOLE   2,537,110 0 0
NUVECTRA CORP COM 67075N108 7,693 350,000 SH   SOLE   0 0 350,000
OBSEVA SA COM H5861P103 46,978 2,605,531 SH   SOLE   2,605,531 0 0
PFIZER INC COM 717081103 29,470 668,700 SH   SOLE   668,700 0 0
PIERIS PHARMACEUTICALS INC COM 720795103 13,753 2,455,900 SH   SOLE   2,455,900 0 0
PRINCIPIA BIOPHARMA INC COM 74257L108 76,139 2,605,713 SH   SOLE   2,605,713 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 39,433 2,037,875 SH   DFND 1 337,731 0 1,700,144
PTC THERAPEUTICS INC COM 69366J200 59,925 1,275,000 SH   DFND 1 202,000 0 1,073,000
PUMA BIOTECHNOLOGY INC COM 74587V107 124,033 2,705,181 SH   DFND 1 535,046 0 2,170,135
RA MED SYS INC COM 74933X104 5,460 300,000 SH   DFND 1 62,100 0 237,900
RADIUS HEALTH INC COM NEW 750469207 13,580 762,900 SH   DFND 1 59,700 0 703,200
REALM THERAPEUTICS PLC SPONSORED ADS 75606L103 3,051 1,021,484 SH   SOLE   1,021,484 0 0
RECRO PHARMA INC COM 75629F109 763 107,357 SH   SOLE   107,357 0 0
REDHILL BIOPHARMA LTD SPONSORED ADS 757468103 2,516 284,900 SH   SOLE   284,900 0 0
REGENERON PHARMACEUTICALS COM 75886F107 159,353 394,400 SH   DFND 1 66,600 0 327,800
RESTORBIO INC COM 76133L103 73,132 4,830,387 SH   SOLE   4,830,387 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 30,376 1,041,353 SH   SOLE   1,041,353 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 19,081 775,000 SH   SOLE   0 0 775,000
SAREPTA THERAPEUTICS INC COM 803607100 137,994 854,400 SH   DFND 1 122,400 0 732,000
SCPHARMACEUTICALS INC COM 810648105 20,016 3,409,865 SH   SOLE   3,409,865 0 0
SELECT MED HLDGS CORP COM 81619Q105 19,039 1,034,711 SH   DFND 1 190,500 0 844,211
SELECTA BIOSCIENCES INC COM 816212104 26,323 1,692,797 SH   SOLE   1,692,797 0 0
SIERRA ONCOLOGY INC COM 82640U107 1,304 767,104 SH   SOLE   767,104 0 0
SINOVAC BIOTECH LTD SHS P8696W104 21,637 2,839,500 SH   SOLE   0 0 2,839,500
SPECTRUM PHARMACEUTICALS INC COM 84763A108 38,060 2,265,500 SH   DFND 1 342,800 0 1,922,700
STRYKER CORP COM 863667101 23,134 130,200 SH   DFND 1 54,000 0 76,200
SYNDAX PHARMACEUTICALS INC COM 87164F105 3,531 437,000 SH   SOLE   437,000 0 0
SYNLOGIC INC COM 87166L100 28,846 2,029,996 SH   SOLE   2,029,996 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 30,609 714,500 SH   DFND 1 104,400 0 610,100
TELEFLEX INC COM 879369106 41,856 157,300 SH   DFND 1 35,700 0 121,600
TESARO INC COM 881569107 2,625 67,281 SH   DFND 1 17,934 0 49,347
THERMO FISHER SCIENTIFIC INC COM 883556102 163,045 668,000 SH   DFND 1 121,300 0 546,700
TRICIDA INC COM 89610F101 332,668 10,889,280 SH   SOLE   10,889,280 0 0
UNITEDHEALTH GROUP INC COM 91324P102 49,616 186,500 SH   DFND 1 84,500 0 102,000
VERONA PHARMA PLC SPONSORED ADS 925050106 15,642 1,250,396 SH   SOLE   1,250,396 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 24,046 1,479,733 SH   SOLE   1,479,733 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 308,480 1,600,500 SH   DFND 1 223,300 0 1,377,200
VERTEX PHARMACEUTICALS INC COM 92532F100 19,274 100,000 SH Call DFND 1 20,500 0 79,500
VIEWRAY INC COM 92672L107 53,691 5,736,267 SH   SOLE   5,736,267 0 0
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 186,876 6,439,568 SH   DFND 1 1,089,649 0 5,349,919
WRIGHT MED GROUP N V RIGHT 03/01/2019 N96617126 12,245 8,746,583 SH   SOLE   0 0 8,746,583
XENON PHARMACEUTICALS INC COM 98420N105 8,380 634,812 SH   SOLE   634,812 0 0
XTANT MED HLDGS INC COM NEW 98420P308 35,447 9,207,012 SH   SOLE   9,207,012 0 0
ZAI LAB LTD ADR 98887Q104 34,159 1,753,538 SH   SOLE   1,753,538 0 0