The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Adamas Pharmaceuticals Inc COMM 00548A106 754 29,192 SH   SOLE   29,192 0 0
Aduro Biotech Inc COMM 00739L101 174 24,857 SH   SOLE   24,857 0 0
Aimmune Therapeutics Inc COMM 00900T107 1,036 38,528 SH   SOLE   38,528 0 0
Alexion Pharmaceuticals Inc COMM 015351109 1,800 14,498 SH   SOLE   14,498 0 0
Allergan plc COMM G0177J108 1,916 11,490 SH   SOLE   11,490 0 0
AMAG Pharmaceuticals Inc COMM 00163U106 287 14,695 SH   SOLE 1 14,695 0 0
AstraZeneca PLC ADR 046353108 1,193 33,981 SH   SOLE   33,981 0 0
bluebird bio Inc COMM 09609G100 896 5,707 SH   SOLE   5,707 0 0
Blueprint Medicines Corp COMM 09627Y109 603 9,499 SH   SOLE   9,499 0 0
Calithera Biosciences Inc COMM 13089P101 153 30,622 SH   SOLE   30,622 0 0
Catalyst Pharmaceuticals Inc COMM 14888U101 503 161,089 SH   SOLE   161,089 0 0
Celgene Corp COMM 151020104 1,510 19,014 SH   SOLE   19,014 0 0
ChemoCentryx Inc COMM 16383L106 90 6,836 SH   SOLE   6,836 0 0
Clearside Biomedical Inc COMM 185063104 477 44,620 SH   SOLE   44,620 0 0
Conatus Pharmaceuticals Inc COMM 20600T108 380 88,742 SH   SOLE   88,742 0 0
CRISPR Therapeutics AG COMM H17182108 1,210 20,600 SH Put SOLE   20,600 0 0
Dermira Inc COMM 24983L104 345 37,543 SH   SOLE   37,543 0 0
Esperion Therapeutics Inc COMM 29664W105 610 15,571 SH   SOLE   15,571 0 0
Foamix Pharmaceuticals Ltd COMM M46135105 361 72,017 SH   SOLE   72,017 0 0
Forty Seven Inc COMM 34983P104 39 2,442 SH   SOLE   2,442 0 0
GW Pharmaceuticals PLC ADR 36197T103 907 6,497 SH   SOLE   6,497 0 0
Heron Therapeutics Inc COMM 427746102 1,035 26,644 SH   SOLE   26,644 0 0
Innate Pharma SA COMM F5277D100 62 11,418 SH   SOLE   11,418 0 0
Intercept Pharmaceuticals Inc COMM 45845P108 923 11,005 SH   SOLE   11,005 0 0
Kadmon Holdings Inc COMM 48283N106 552 138,249 SH   SOLE   138,249 0 0
Kadmon Holdings Inc Warrant 48283N106 38 59,909 SH   SOLE   59,909 0 0
Kala Pharmaceuticals Inc COMM 483119103 443 32,248 SH   SOLE   32,248 0 0
Kura Oncology Inc COMM 50127T109 315 17,295 SH   SOLE   17,295 0 0
OncoMed Pharmaceuticals Inc COMM 68234X102 159 68,899 SH   SOLE   68,899 0 0
Otonomy Inc COMM 68906L105 385 99,874 SH   SOLE   99,874 0 0
PTC Therapeutics Inc COMM 69366J200 442 13,104 SH   SOLE   13,104 0 0
Puma Biotechnology Inc COMM 74587V107 378 6,384 SH   SOLE   6,384 0 0
Reata Pharmaceuticals Inc COMM 75615P103 325 9,307 SH   SOLE   9,307 0 0
Rhythm Pharmaceuticals Inc COMM 76243J105 452 14,452 SH   SOLE   14,452 0 0
Rigel Pharmaceuticals Inc COMM 766559603 663 234,107 SH   SOLE   234,107 0 0
Sarepta Therapeutics Inc COMM 803607100 659 4,986 SH   SOLE   4,986 0 0
Savara Inc COMM 805111101 299 26,441 SH   SOLE   26,441 0 0
Spectrum Pharmaceuticals Inc COMM 84763A108 367 17,488 SH   SOLE   17,488 0 0
Syndax Pharmaceuticals Inc COMM 87164F105 87 12,354 SH   SOLE   12,354 0 0
AMAG Pharmaceuticals Inc COMM 00163U106 814 41,727 SH   OTR   41,727 0 0
Adamas Pharmaceuticals Inc COMM 00548A106 2,142 82,912 SH   OTR 1 82,912 0 0
Aduro Biotech Inc COMM 00739L101 494 70,601 SH   OTR 1 70,601 0 0
Aimmune Therapeutics Inc COMM 00900T107 2,944 109,496 SH   OTR 1 109,496 0 0
Alexion Pharmaceuticals Inc COMM 015351109 5,112 41,179 SH   OTR 1 41,179 0 0
Allergan plc COMM G0177J108 5,441 32,635 SH   OTR 1 32,635 0 0
AstraZeneca PLC ADR 046353108 3,387 96,478 SH   OTR 1 96,478 0 0
Blueprint Medicines Corp COMM 09627Y109 1,713 26,979 SH   OTR 1 26,979 0 0
CRISPR Therapeutics AG COMM H17182108 3,437 58,500 SH Put OTR 1 58,500 0 0
Calithera Biosciences Inc COMM 13089P101 435 86,939 SH   OTR 1 86,939 0 0
Catalyst Pharmaceuticals Inc COMM 14888U101 1,523 488,243 SH   OTR 1 488,243 0 0
Celgene Corp COMM 151020104 4,288 53,991 SH   OTR 1 53,991 0 0
ChemoCentryx Inc COMM 16383L106 257 19,514 SH   OTR 1 19,514 0 0
Clearside Biomedical Inc COMM 185063104 1,354 126,652 SH   OTR 1 126,652 0 0
Conatus Pharmaceuticals Inc COMM 20600T108 1,082 252,723 SH   OTR 1 252,723 0 0
Dermira Inc COMM 24983L104 981 106,593 SH   OTR 1 106,593 0 0
Esperion Therapeutics Inc COMM 29664W105 1,733 44,224 SH   OTR 1 44,224 0 0
Foamix Pharmaceuticals Ltd COMM M46135105 1,091 217,670 SH   OTR 1 217,670 0 0
Forty Seven Inc COMM 34983P104 111 6,935 SH   OTR 1 6,935 0 0
GW Pharmaceuticals PLC ADR 36197T103 2,575 18,452 SH   OTR 1 18,452 0 0
Heron Therapeutics Inc COMM 427746102 2,939 75,645 SH   OTR 1 75,645 0 0
Innate Pharma SA COMM F5277D100 177 32,422 SH   OTR 1 32,422 0 0
Intercept Pharmaceuticals Inc COMM 45845P108 2,622 31,248 SH   OTR 1 31,248 0 0
Kadmon Holdings Inc COMM 48283N106 1,570 393,476 SH   OTR 1 393,476 0 0
Kadmon Holdings Inc Warrant 48283N106 154 240,091 SH   OTR 1 240,091 0 0
Kala Pharmaceuticals Inc COMM 483119103 1,259 91,662 SH   OTR 1 91,662 0 0
Kura Oncology Inc COMM 50127T109 894 49,121 SH   OTR 1 49,121 0 0
OncoMed Pharmaceuticals Inc COMM 68234X102 483 209,088 SH   OTR 1 209,088 0 0
Otonomy Inc COMM 68906L105 1,146 297,559 SH   OTR 1 297,559 0 0
PTC Therapeutics Inc COMM 69366J200 1,255 37,203 SH   OTR 1 37,203 0 0
Puma Biotechnology Inc COMM 74587V107 1,073 18,132 SH   OTR 1 18,132 0 0
Reata Pharmaceuticals Inc COMM 75615P103 925 26,439 SH   OTR 1 26,439 0 0
Rhythm Pharmaceuticals Inc COMM 76243J105 1,283 41,047 SH   OTR 1 41,047 0 0
Rigel Pharmaceuticals Inc COMM 766559603 1,882 664,917 SH   OTR 1 664,917 0 0
Sarepta Therapeutics Inc COMM 803607100 1,872 14,160 SH   OTR 1 14,160 0 0
Savara Inc COMM 805111101 850 75,099 SH   OTR 1 75,099 0 0
Spectrum Pharmaceuticals Inc COMM 84763A108 1,043 49,743 SH   OTR 1 49,743 0 0
Syndax Pharmaceuticals Inc COMM 87164F105 246 35,027 SH   OTR 1 35,027 0 0
bluebird bio Inc COMM 09609G100 2,544 16,209 SH   OTR 1 16,209 0 0
AMAG Pharmaceuticals Inc COMM 00163U106 1,679 86,089 SH   OTR 2 86,089 0 0
Adamas Pharmaceuticals Inc COMM 00548A106 4,425 171,294 SH   OTR 2 171,294 0 0
Aduro Biotech Inc COMM 00739L101 1,021 145,860 SH   OTR 2 145,860 0 0
Aimmune Therapeutics Inc COMM 00900T107 6,105 227,020 SH   OTR 2 227,020 0 0
Alexion Pharmaceuticals Inc COMM 015351109 10,562 85,075 SH   OTR 2 85,075 0 0
Allergan plc COMM G0177J108 11,241 67,425 SH   OTR 2 67,425 0 0
AstraZeneca PLC ADR 046353108 6,999 199,341 SH   OTR 2 199,341 0 0
Blueprint Medicines Corp COMM 09627Y109 3,537 55,722 SH   OTR 2 55,722 0 0
CRISPR Therapeutics AG COMM H17182108 7,104 120,900 SH Put OTR 2 120,900 0 0
Calithera Biosciences Inc COMM 13089P101 898 179,662 SH   OTR 2 179,662 0 0
Catalyst Pharmaceuticals Inc COMM 14888U101 2,498 800,625 SH   OTR 2 800,625 0 0
Celgene Corp COMM 151020104 8,847 111,394 SH   OTR 2 111,394 0 0
ChemoCentryx Inc COMM 16383L106 552 41,908 SH   OTR 2 41,908 0 0
Clearside Biomedical Inc COMM 185063104 2,797 261,632 SH   OTR 2 261,632 0 0
Conatus Pharmaceuticals Inc COMM 20600T108 2,214 517,385 SH   OTR 2 517,385 0 0
Dermira Inc COMM 24983L104 2,026 220,204 SH   OTR 2 220,204 0 0
Esperion Therapeutics Inc COMM 29664W105 3,581 91,366 SH   OTR 2 91,366 0 0
Foamix Pharmaceuticals Ltd COMM M46135105 1,967 392,712 SH   OTR 2 392,712 0 0
Forty Seven Inc COMM 34983P104 229 14,323 SH   OTR 2 14,323 0 0
GW Pharmaceuticals PLC ADR 36197T103 5,319 38,121 SH   OTR 2 38,121 0 0
Heron Therapeutics Inc COMM 427746102 6,072 156,296 SH   OTR 2 156,296 0 0
Innate Pharma SA COMM F5277D100 365 66,948 SH   OTR 2 66,948 0 0
Intercept Pharmaceuticals Inc COMM 45845P108 5,418 64,564 SH   OTR 2 64,564 0 0
Kadmon Holdings Inc COMM 48283N106 3,742 937,858 SH   OTR 2 937,858 0 0
Kala Pharmaceuticals Inc COMM 483119103 2,464 179,466 SH   OTR 2 179,466 0 0
Kura Oncology Inc COMM 50127T109 1,847 101,484 SH   OTR 2 101,484 0 0
OncoMed Pharmaceuticals Inc COMM 68234X102 273 118,257 SH   OTR 2 118,257 0 0
Otonomy Inc COMM 68906L105 2,243 582,545 SH   OTR 2 582,545 0 0
PTC Therapeutics Inc COMM 69366J200 2,590 76,772 SH   OTR 2 76,772 0 0
Puma Biotechnology Inc COMM 74587V107 2,213 37,420 SH   OTR 2 37,420 0 0
Reata Pharmaceuticals Inc COMM 75615P103 1,894 54,163 SH   OTR 2 54,163 0 0
Rhythm Pharmaceuticals Inc COMM 76243J105 2,651 84,801 SH   OTR 2 84,801 0 0
Rigel Pharmaceuticals Inc COMM 766559603 3,888 1,373,703 SH   OTR 2 1,373,703 0 0
Sarepta Therapeutics Inc COMM 803607100 3,867 29,254 SH   OTR 2 29,254 0 0
Savara Inc COMM 805111101 1,756 155,152 SH   OTR 2 155,152 0 0
Spectrum Pharmaceuticals Inc COMM 84763A108 2,153 102,734 SH   OTR 2 102,734 0 0
Syndax Pharmaceuticals Inc COMM 87164F105 360 51,232 SH   OTR 2 51,232 0 0
bluebird bio Inc COMM 09609G100 5,251 33,455 SH   OTR 2 33,455 0 0
Aclaris Therapeutics Common Shares 00461U105 30,743 1,539,480 SH   SOLE   1,539,480 0 0
Amarin American Depositary Shares 023111206 10,264 3,321,587 SH   SOLE   3,321,587 0 0
Amarin Ordinary Shares 023111206 0 1 SH   SOLE   1 0 0
Amarin Series A Preferred Stock 023111PR2 12,010 3,886,718 SH   SOLE   3,886,718 0 0
Apellis Pharmaceuticals, Inc Common Shares 03753U106 13,548 615,802 SH   SOLE   615,802 0 0
Ascendis Pharma A/S American Depositary Shares 04351P101 66,423 998,538 SH   SOLE   998,538 0 0
Ascendis Pharma A/S Ordinary Shares 04351P101 98,515 1,480,976 SH   SOLE   1,480,976 0 0
Audentes Therapeutics Common Shares 05070R104 35,674 933,640 SH   SOLE   933,640 0 0
Auris Medical Holding AG (frmlyAuris Medical) Warrant(s) H0381L104 0 140,000 SH   SOLE   140,000 0 0
Chiasma Common Shares 16706W102 2,445 1,630,221 SH   SOLE   1,630,221 0 0
Chiasma Warrant(s) 16706W102 0 136,881 SH   SOLE   136,881 0 0
Coherus BioSciences (frmly Intekrin) Common Shares 19249H103 40,505 2,893,221 SH   SOLE   2,893,221 0 0
Edge Therapeutics Common Shares 279870109 2,938 2,852,711 SH   SOLE   2,852,711 0 0
Histogenics Common Shares 43358V109 5,193 2,077,040 SH   SOLE   2,077,040 0 0
Iterum Therapeutics Common Shares G6333L101 18,802 1,726,514 SH   SOLE   1,726,514 0 0
Kiniksa Pharmaceuticals, Ltd Common Stock Class A G5269C101 16,009 922,700 SH   SOLE   922,700 0 0
Merus N.V. Common Shares N5749R100 44,633 1,961,039 SH   SOLE   1,961,039 0 0
Natera Common Shares 632307104 58,353 3,100,560 SH   SOLE   3,100,560 0 0
Nucana Biomed American Depositary Shares 67022C106 12,667 666,666 SH   SOLE   666,666 0 0
Nucana Biomed Ordinary Shares GB00BYWYV 76,000 4,000,000 SH   SOLE   4,000,000 0 0
ObsEva SA Common Shares H5861P103 71,909 4,749,623 SH   SOLE   4,749,623 0 0
Spark Therapeutics Common Shares 84652J103 39,830 481,270 SH   SOLE   481,270 0 0
Synlogic Inc. (fmrly Mirna) Common Shares 87166L100 5,652 574,972 SH   SOLE   574,972 0 0