The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABEONA THERAPEUTICS INC W EXP12/24/201 00289Y115 1,267 659,636 SH   SOLE   659,636 0 0
ABEONA THERAPEUTICS INC COM 00289Y107 1,269 180,797 SH   SOLE   180,797 0 0
ACASTI PHARMA INC CL A NEW 00430K402 1,480 1,779,882 SH   SOLE   1,779,882 0 0
ACCELERON PHARMA INC COM 00434H108 39,938 905,017 SH   SOLE   905,017 0 0
ADMA BIOLOGICS INC COM 000899104 14,542 6,521,102 SH   SOLE   6,521,102 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 960 300,000 SH   SOLE   300,000 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 9,182 1,703,440 SH   SOLE   1,703,440 0 0
ALBIREO PHARMA INC COM 01345P106 39,506 1,704,330 SH   SOLE   1,704,330 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 24,684 3,085,458 SH   SOLE   3,085,458 0 0
ALLENA PHARMACEUTICALS INC COM 018119107 704 132,300 SH   SOLE   132,300 0 0
ALLIQUA BIOMEDICAL INC COM PAR 019621309 214 114,730 SH   SOLE   114,730 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 41,574 1,543,790 SH   SOLE   1,543,790 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 18,462 262,241 SH   SOLE   262,241 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 64,553 4,875,600 SH   SOLE   4,875,600 0 0
AMEDISYS INC COM 023436108 422 3,672 SH   SOLE   3,672 0 0
AMICUS THERAPEUTICS INC COM 03152W109 191,701 20,724,424 SH   SOLE   20,724,424 0 0
ANI PHARMACEUTICALS INC NOTE 3.000%12/0 00182CAA1 7,383 7,500,000 PRN   SOLE   7,500,000 0 0
AQUESTIVE THERAPEUTICS INC COM 3843E1047 13,314 2,113,400 SH   SOLE   2,113,400 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 55,605 1,430,171 SH   SOLE   1,430,171 0 0
ARGENX SE SPONSORED ADR 04016X101 53,889 560,941 SH   SOLE   560,941 0 0
ARROWHEAD PHARMACEUTICALS INC COM 04280A100 3,582 300,000 SH   SOLE   300,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 63,043 1,052,647 SH   SOLE   1,052,647 0 0
ATHENEX INC COM 04685N103 32,550 5,096,022 SH   SOLE   5,096,022 0 0
AXONICS MODULATION TECH INC COM 05465P101 10,935 751,000 SH   SOLE   751,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 43,484 857,326 SH   SOLE   857,326 0 0
CAREDX INC COM 14167L103 1,037 44,128 SH   SOLE   44,128 0 0
CLEMENTIA PHARMACEUTICALS INC COM 185575107 17,640 1,500,000 SH   SOLE   1,500,000 0 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 7,374 445,000 SH   SOLE   445,000 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 22,823 1,873,779 SH   SOLE   1,873,779 0 0
CRINETICS PHARMACEUTICALS INC COM 22663K107 77,612 2,587,953 SH   SOLE   2,587,953 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 19,382 2,462,821 SH   SOLE   2,462,821 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 43,588 2,911,715 SH   SOLE   2,911,715 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 5,309 826,960 SH   SOLE   826,960 0 0
DEXCOM INC COM 252131107 442 3,733 SH   SOLE   3,733 0 0
DOVA PHARMACEUTICALS INC COM 25985T102 23,693 3,125,851 SH   SOLE   3,125,851 0 0
EDIOS THERAPEUTICS INC COM 28249H104 9,452 686,922 SH   SOLE   686,922 0 0
EHEALTH INC COM 28238P109 2,113 55,021 SH   SOLE   55,021 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 1,421 139,890 SH   SOLE   139,890 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 15,878 614,242 SH   SOLE   614,242 0 0
FERRARI N.V. COM N3167Y103 610 6,200 SH   SOLE   6,200 0 0
FIAT CHRYSLER AUTOMOBILES N. SHS N31738102 894 62,000 SH   SOLE   62,000 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 15,850 4,661,824 SH   SOLE   4,661,824 0 0
GLAUKOS CORP COM 377322102 417 7,466 SH   SOLE   7,466 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 222,726 5,425,726 SH   SOLE   5,425,726 0 0
IMMUNOMEDICS INC COM 452907108 10,500 700,000 SH   SOLE   700,000 0 0
IMMUNOMEDICS INC COM 452907108 308 200,000 SH Call SOLE   200,000 0 0
INVACARE CORP COM 461203101 860 200,000 SH   SOLE   200,000 0 0
INVITAE CORP COM 46185L103 20,609 1,863,406 SH   SOLE   1,863,406 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 108,333 12,241,111 SH   SOLE   12,241,111 0 0
KADMON HLDGS INC COM 48283N106 27,384 13,165,746 SH   SOLE   13,165,746 0 0
KODIAK SCIENCES INC COM 50015M109 22,259 3,135,199 SH   SOLE   3,135,199 0 0
LA JOLLA PHARMACEUTICAL CO COM PAR $.0001 2 503459604 41,022 4,313,611 SH   SOLE   4,313,611 0 0
MARKER THERAPEUTICS INC COM 57055L107 11,100 2,000,000 SH   SOLE   2,000,000 0 0
MEI PHARMA INC COM NEW 55279B202 11,617 4,400,440 SH   SOLE   4,400,440 0 0
MEIRAGTX HOLDINGS PLC COM G59665102 45,340 4,703,398 SH   SOLE   4,703,398 0 0
MERIT MEDICAL SYSTEMS INC COM 589889104 52,177 949,198 SH   SOLE   949,198 0 0
MIRATI THERAPEUTICS INC COM 60468T105 5,250 125,875 SH   SOLE   125,875 0 0
MOLECULAR TEMPLATES INC COM 608550109 7,107 1,974,133 SH   SOLE   1,974,133 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 31,132 2,825,000 SH   SOLE   2,825,000 0 0
MOTUS GI HOLDINGS INC COM 62014P108 9,984 3,210,542 SH   SOLE   3,210,542 0 0
MYOKARDIA INC COM 62857M105 53,503 1,075,216 SH   SOLE   1,075,216 0 0
NEPTUNE WELLNESS SOLUTIONS I COM 64079L105 17,849 8,891,452 SH   SOLE   8,891,452 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 315,363 4,608,554 SH   SOLE   4,608,554 0 0
ONCOMED PHARMACEUTICALS INC COM 68234X102 1,284 1,719,111 SH   SOLE   1,719,111 0 0
ONCOSEC MEDICAL INC COM 68234L207 32 50,000 SH   SOLE   50,000 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 8,207 521,800 SH   SOLE   521,800 0 0
OUTLOOK THERAPEUTICS INC *W EXP 02/18/201 69012T115 72 420,875 SH   SOLE   420,875 0 0
PENUMBRA INC COM 70975L107 2,037 16,338 SH   SOLE   16,338 0 0
PERNIX THERAPEUTICS HLDGS IN DBCV 4,250% 4/0 71426VAK4 642 1,000,000 PRN   SOLE   1,000,000 0 0
PROQR THERAPEUTICS N.V. SHS EURO N71542109 11,250 722,523 SH   SOLE   722,523 0 0
PROTAGONIST THERAPEUTICS INC COM 4366E1029 9,190 1,365,579 SH   SOLE   1,365,579 0 0
QUOTIENT LTD COM G73268107 66,029 10,789,054 SH   SOLE   10,789,054 0 0
REGENXBIO INC COM 75901B107 26,894 645,726 SH   SOLE   645,726 0 0
RETROPHIN INC COM 761299106 49,782 3,342,038 SH   SOLE   3,342,038 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 13,763 509,186 SH   SOLE   509,186 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 3,495 240,173 SH   SOLE   240,173 0 0
SAGE THERAPEUTICS INC COM 78667J108 13,110 147,315 SH   SOLE   147,315 0 0
SI-BONE INC COM 825704109 307 15,000 SH   SOLE   15,000 0 0
SIERRA ONCOLOGY INC COM 82640U107 3,413 2,666,190 SH   SOLE   2,666,190 0 0
SOLID BIOSCIENCES INC COM 83422E105 14 1,835 SH Call SOLE   1,835 0 0
SOLID BIOSCIENCES INC COM 83422E105 105,249 3,927,222 SH   SOLE   3,927,222 0 0
STAAR SURGICAL CO COM PAR $ 0.01 852312305 405 12,953 SH   SOLE   12,953 0 0
SYNLOGIC INC COM 87166L100 6,049 867,852 SH   SOLE   867,852 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 479 12,844 SH   SOLE   12,844 0 0
TELADOC HEALTH INC COM 87918A105 2,974 60,000 SH   SOLE   60,000 0 0
THERAPEUTICSMD INC COM 88338N107 5,715 1,500,000 SH   SOLE   1,500,000 0 0
TRANSLATE BIO INC COM 89374L104 3,167 435,000 SH   SOLE   435,000 0 0
UNIQURE NV SHS N90064101 5,946 220,707 SH   SOLE   220,707 0 0
UROVANT SCIENCES LTD SHS G9381B108 3,915 625,359 SH   SOLE   625,359 0 0
VACCINEX INC COM 918640103 190 50,000 SH   SOLE   50,000 0 0
VAPOTHERM INC COM 922107107 24,464 1,226,315 SH   SOLE   1,226,315 0 0
VBI VACCINES INC COM NEW 91822J103 38,322 23,951,556 SH   SOLE   23,951,556 0 0
VERICEL CORP COM 92346J108 488 28,090 SH   SOLE   28,090 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 27,794 3,410,412 SH   SOLE   3,410,412 0 0
VERU INC COM 92536C103 1,853 1,425,000 SH   SOLE   1,425,000 0 0
VIEWRAY INC COM 92672L107 21,715 3,905,650 SH   SOLE   3,905,650 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 2,501 59,498 SH   SOLE   59,498 0 0
XENCOR INC COM 98401F105 6,833 196,810 SH   SOLE   196,810 0 0
ZOGENIX INC COM 98978L204 138,191 3,790,216 SH   SOLE   3,790,216 0 0
ZOGENIX INC COM 98978L204 410 200,000 SH Put SOLE   200,000 0 0
ZYMEWORKS INC COM 98985W102 7,196 573,890 SH   SOLE   573,890 0 0