The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
111 INC ADS 68247Q102 3,070 500,000 SH   SOLE   0 0 500,000
ABBOTT LABS COM 002824100 32,433 448,400 SH   DFND 1 250,000 0 198,400
AC IMMUNE SA SHS H00263105 13,608 1,440,000 SH   SOLE   0 0 1,440,000
ADAMAS PHARMACEUTICALS INC COM 00548A106 854 100,000 SH Call DFND 1 19,000 0 81,000
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 7,766 1,350,655 SH   SOLE   1,350,655 0 0
AEGERION PHARMACEUTICALS INC NOTE 2.000% 8/1 00767EAB8 1,676 2,000,000 PRN   DFND 1 419,600 0 1,580,400
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 16,220 2,165,524 SH   SOLE   2,165,524 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 31,483 872,100 SH   DFND 1 200,300 0 671,800
AERPIO PHARMACEUTICALS INC COM 00810B105 8,830 5,193,946 SH   SOLE   5,193,946 0 0
AFFIMED N V COM N01045108 1,016 326,650 SH   SOLE   326,650 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 50,797 753,000 SH   DFND 1 164,500 0 588,500
ALEXION PHARMACEUTICALS INC COM 015351109 199,335 2,047,400 SH   DFND 1 426,600 0 1,620,800
ALIMERA SCIENCES INC COM 016259103 180 250,000 SH   DFND 1 25,000 0 225,000
ALLAKOS INC COM 01671P100 9,147 175,000 SH   DFND 1 32,300 0 142,700
ALLERGAN PLC SHS G0177J108 127,913 957,000 SH   DFND 1 228,500 0 728,500
ALPINE IMMUNE SCIENCES INC COM 02083G100 12,139 3,298,516 SH   SOLE   3,298,516 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 1,102 81,000 SH   SOLE   0 0 81,000
AMGEN INC COM 031162100 23,769 122,100 SH   SOLE   0 0 122,100
AMICUS THERAPEUTICS INC COM 03152W109 3,094 323,009 SH   SOLE   0 0 323,009
ANTHEM INC COM 036752103 80,207 305,400 SH   DFND 1 74,400 0 231,000
APELLIS PHARMACEUTICALS INC COM 03753U106 4,313 327,000 SH   SOLE   0 0 327,000
ARGENX SE SPONSORED ADR 04016X101 62,215 647,600 SH   SOLE   0 0 647,600
ARSANIS INC COM 042873109 4,336 1,868,966 SH   SOLE   1,868,966 0 0
ARVINAS INC COM 04335A105 34,423 2,678,810 SH   DFND 1 1,916,310 0 762,500
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 256,074 4,087,373 SH   DFND 1 3,572,373 0 515,000
ASSEMBLY BIOSCIENCES INC COM 045396108 22,532 996,123 SH   SOLE   0 0 996,123
ATHENEX INC COM 04685N103 5,457 430,000 SH   SOLE   0 0 430,000
AUDENTES THERAPEUTICS INC COM 05070R104 40,369 1,893,500 SH   SOLE   1,893,500 0 0
AVROBIO INC COM 05455M100 4,161 249,900 SH   SOLE   0 0 249,900
BAUSCH HEALTH COS INC COM 071734107 66,498 3,600,300 SH   DFND 1 733,000 0 2,867,300
BEIGENE LTD SPONSORED ADR 07725L102 39,623 282,500 SH   DFND 1 55,200 0 227,300
BIOGEN INC COM 09062X103 251,343 835,249 SH   DFND 1 160,565 0 674,684
BIOLINERX LTD SPONSORED ADS 09071M106 454 1,038,600 SH   SOLE   1,038,600 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 6,514 76,500 SH   SOLE   0 0 76,500
BLUEBIRD BIO INC COM 09609G100 38,410 387,200 SH   DFND 1 76,200 0 311,000
BOSTON SCIENTIFIC CORP COM 101137107 204,633 5,790,400 SH   DFND 1 1,500,700 0 4,289,700
BOSTON SCIENTIFIC CORP COM 101137107 8,835 250,000 SH Call DFND 1 48,000 0 202,000
BRISTOL MYERS SQUIBB CO COM 110122108 26,297 505,900 SH   DFND 1 175,000 0 330,900
CELGENE CORP COM 151020104 6,409 100,000 SH Call DFND 1 19,500 0 80,500
CELGENE CORP COM 151020104 208,722 3,256,700 SH   DFND 1 567,700 0 2,689,000
CENTENE CORP DEL COM 15135B101 48,126 417,400 SH   DFND 1 103,800 0 313,600
CIGNA CORP NEW COM 125523100 91,674 482,700 SH   DFND 1 144,500 0 338,200
CLEMENTIA PHARMACEUTICALS IN COM 185575107 122,601 10,425,225 SH   SOLE   10,425,225 0 0
CLOVIS ONCOLOGY INC COM 189464100 49,430 2,752,200 SH   DFND 1 452,300 0 2,299,900
CONSTELLATION PHARMCETICLS I COM 210373106 3,352 835,842 SH   SOLE   835,842 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 21,901 5,967,584 SH   SOLE   5,967,584 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 57,409 1,914,282 SH   SOLE   1,914,282 0 0
CTI BIOPHARMA CORP COM NEW 12648L601 3,668 5,000,000 SH   SOLE   5,000,000 0 0
CVS HEALTH CORP COM 126650100 52,010 793,800 SH   DFND 1 184,000 0 609,800
DAVITA INC COM 23918K108 27,480 534,000 SH   DFND 1 148,000 0 386,000
DECIPHERA PHARMACEUTICALS IN COM 24344T101 51,262 2,442,200 SH   DFND 1 348,300 0 2,093,900
DERMIRA INC COM 24983L104 7,417 1,031,596 SH   SOLE   0 0 1,031,596
DEXCOM INC COM 252131107 16,616 138,700 SH   DFND 1 34,300 0 104,400
EDWARDS LIFESCIENCES CORP COM 28176E108 71,316 465,600 SH   DFND 1 109,700 0 355,900
EHEALTH INC COM 28238P109 42,262 1,100,000 SH   SOLE   0 0 1,100,000
ELECTROCORE INC COM 28531P103 2,490 397,826 SH   DFND 1 198,913 0 198,913
EXELIXIS INC COM 30161Q104 55,113 2,801,900 SH   DFND 1 410,200 0 2,391,700
FOAMIX PHARMACEUTICALS LTD SHS M46135105 18,651 5,195,330 SH   SOLE   0 0 5,195,330
GILEAD SCIENCES INC COM 375558103 27,760 443,800 SH   SOLE   0 0 443,800
GUARDANT HEALTH INC COM 40131M109 57,681 1,534,464 SH   SOLE   1,534,464 0 0
HCA HEALTHCARE INC COM 40412C101 9,446 75,900 SH   DFND 1 41,900 0 34,000
HERON THERAPEUTICS INC COM 427746102 36,324 1,400,300 SH   SOLE   0 0 1,400,300
HUMANA INC COM 444859102 59,158 206,500 SH   DFND 1 59,100 0 147,400
ILLUMINA INC COM 452327109 73,753 245,900 SH   DFND 1 53,600 0 192,300
IMMUNOMEDICS INC COM 452907108 1,427 100,000 SH Call DFND 1 19,000 0 81,000
IMMUNOMEDICS INC COM 452907108 70,885 4,967,403 SH   DFND 1 958,903 0 4,008,500
INSMED INC NOTE 1.750% 1/1 457669AA7 12,006 16,952,000 PRN   DFND 1 7,456,000 0 9,496,000
INSPIRE MED SYS INC COM 457730109 77,294 1,829,449 SH   SOLE   1,829,449 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 5,154 377,600 SH   SOLE   377,600 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 4,818 47,800 SH   SOLE   0 0 53,500
INTERCEPT PHARMACEUTICALS IN COM 45845P108 6,652 66,000 SH Call DFND 1 12,500 0 47,800
INTUITIVE SURGICAL INC COM NEW 46120E602 81,656 170,500 SH   DFND 1 41,200 0 129,300
INVITAE CORP COM 46185L103 9,120 824,549 SH   SOLE   824,549 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 49,103 5,548,326 SH   DFND 1 1,337,800 0 4,210,526
IRONWOOD PHARMACEUTICALS INC COM CL A 46333X108 29,816 2,878,000 SH   DFND 1 698,000 0 2,180,000
KALA PHARMACEUTICALS INC COM 483119103 16,860 3,447,840 SH   SOLE   3,447,840 0 0
LOGICBIO THERAPEUTICS INC COM 54142F102 67,255 6,466,783 SH   SOLE   6,466,783 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 1,430 498,101 SH   SOLE   498,101 0 0
MEDICINES CO COM 584688105 1,045 54,600 SH   SOLE   0 0 54,600
MEDIGUS LTD SPONSORED ADS 58471G300 39 15,000 SH   SOLE   15,000 0 0
MEIRAGTX HOLDINGS PLC COM G59665102 4,530 469,953 SH   SOLE   0 0 469,953
MERCK & CO INC COM 58933Y105 190,643 2,495,000 SH   DFND 1 648,300 0 1,846,700
MOLINA HEALTHCARE INC COM 60855R100 35,447 305,000 SH   DFND 1 63,100 0 241,900
MYLAN N V SHS EURO N59465109 109,222 3,986,200 SH   DFND 1 887,600 0 3,098,600
MYOKARDIA INC COM 62857M105 16,373 335,100 SH   DFND 1 68,700 0 266,400
NABRIVA THERAPEUTICS PLC SHS G63637105 6,781 4,644,600 SH   SOLE   4,644,600 0 0
NATERA INC COM 632307104 9,550 684,086 SH   SOLE   684,086 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 35,291 494,200 SH   DFND 1 59,300 0 434,900
NOVO-NORDISK A S ADR 670100205 15,203 330,000 SH   SOLE   0 0 330,000
NOVUS THERAPEUTICS INC COM 67011N105 4,059 2,537,110 SH   SOLE   2,537,110 0 0
NUVECTRA CORP COM 67075N108 5,719 350,000 SH   SOLE   0 0 350,000
OBSEVA SA COM H5861P103 32,986 2,605,531 SH   SOLE   2,605,531 0 0
PFIZER INC COM 717081103 26,286 602,200 SH   SOLE   602,200 0 0
PRINCIPIA BIOPHARMA INC COM 74257L108 71,370 2,605,713 SH   SOLE   2,605,713 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 22,687 1,437,731 SH   DFND 1 337,731 0 1,100,000
PTC THERAPEUTICS INC COM 69366J200 52,156 1,519,700 SH   DFND 1 281,000 0 1,238,700
PUMA BIOTECHNOLOGY INC COM 74587V107 52,887 2,598,883 SH   DFND 1 535,046 0 2,063,837
RA MED SYS INC COM 74933X104 2,783 350,000 SH   DFND 1 72,400 0 277,600
REALM THERAPEUTICS PLC SPONSORED ADS 75606L103 1,890 1,021,484 SH   SOLE   1,021,484 0 0
RECRO PHARMA INC COM 75629F109 762 107,357 SH   SOLE   107,357 0 0
REDHILL BIOPHARMA LTD SPONSORED ADS 757468103 303 54,600 SH   SOLE   54,600 0 0
REGENERON PHARMACEUTICALS COM 75886F107 82,954 222,100 SH   DFND 1 53,200 0 168,900
RESTORBIO INC COM 76133L103 41,638 4,830,387 SH   SOLE   4,830,387 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 24,958 928,500 SH   SOLE   928,500 0 0
SAGE THERAPEUTICS INC COM 78667J108 3,477 36,300 SH   SOLE   0 0 36,300
SAREPTA THERAPEUTICS INC COM 803607100 85,231 781,000 SH   DFND 1 115,800 0 665,200
SCPHARMACEUTICALS INC COM 810648105 12,821 3,409,865 SH   SOLE   3,409,865 0 0
SELECTA BIOSCIENCES INC COM 816212104 4,200 1,579,064 SH   SOLE   1,579,064 0 0
SHIRE PLC SPONSORED ADR 82481R106 26,106 150,000 SH Call DFND 1 28,500 0 121,500
SI BONE INC COM 825704109 20,584 985,368 SH   SOLE   985,368 0 0
SIERRA ONCOLOGY INC COM 82640U107 551 417,104 SH   SOLE   417,104 0 0
SINOVAC BIOTECH LTD SHS P8696W104 19,706 2,839,500 SH   SOLE   0 0 2,839,500
SPECTRUM PHARMACEUTICALS INC COM 84763A108 19,823 2,265,500 SH   DFND 1 342,800 0 1,922,700
STRYKER CORP COM 863667101 20,409 130,200 SH   DFND 1 54,000 0 76,200
SYNDAX PHARMACEUTICALS INC COM 87164F105 943 212,000 SH   SOLE   212,000 0 0
SYNLOGIC INC COM 87166L100 14,230 2,029,996 SH   SOLE   2,029,996 0 0
SYNTHORX INC COM 87167A103 92,398 5,316,355 SH   SOLE   5,316,355 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 35,996 948,000 SH   DFND 1 169,400 0 778,600
TENET HEALTHCARE CORP COM NEW 88033G407 9,646 562,785 SH   DFND 1 144,800 0 417,985
THERMO FISHER SCIENTIFIC INC COM 883556102 97,908 437,500 SH   DFND 1 98,600 0 338,900
TRICIDA INC COM 89610F101 256,769 10,889,280 SH   SOLE   10,889,280 0 0
UNITEDHEALTH GROUP INC COM 91324P102 46,461 186,500 SH   DFND 1 84,500 0 102,000
VERONA PHARMA PLC SPONSORED ADS 925050106 12,066 1,250,396 SH   SOLE   1,250,396 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 12,060 1,479,733 SH   SOLE   1,479,733 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 187,783 1,133,200 SH   DFND 1 180,300 0 952,900
VIEWRAY INC COM 92672L107 31,255 5,149,019 SH   SOLE   5,149,019 0 0
WRIGHT MED GROUP N V ORD SHS 0.03 PAR N96617118 133,539 4,905,899 SH   DFND 1 1,089,649 0 3,816,250
WRIGHT MED GROUP N V RIGHT 03/01/2019 N96617126 109 8,746,583 SH   SOLE   0 0 8,746,583
XENON PHARMACEUTICALS INC COM 98420N105 4,006 634,812 SH   SOLE   634,812 0 0
XTANT MED HLDGS INC COM NEW 98420P308 14,823 9,207,012 SH   SOLE   9,207,012 0 0
ZAI LAB LTD ADR 98887Q104 40,717 1,753,538 SH   SOLE   1,753,538 0 0