The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||
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UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| AC IMMUNE SA | SHS | H00263105 | 37,650 | 7,455,534 | SH | DFND | 1 | 0 | 7,455,534 | 0 | |
| ALBIREO PHARMA INC | COM | 01345P106 | 6,458 | 200,500 | SH | DFND | 1 | 0 | 200,500 | 0 | |
| ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 8,244 | 1,201,717 | SH | DFND | 1 | 0 | 1,201,717 | 0 | |
| ANAPTYSBIO INC | COM | 032724106 | 16,090 | 220,265 | SH | DFND | 1 | 0 | 220,265 | 0 | |
| ARCUS BIOSCIENCES INC | COM | 03969F109 | 35,100 | 2,810,223 | SH | DFND | 1 | 0 | 2,810,223 | 0 | |
| ARGENX SE | SPONSORED ADR | 04016X101 | 10,096 | 80,868 | SH | DFND | 1 | 0 | 80,868 | 0 | |
| ARQULE INC | COM | 04269E107 | 30,219 | 6,308,746 | SH | DFND | 1 | 0 | 6,308,746 | 0 | |
| ARRAY BIOPHARMA INC | COM | 04269X105 | 83,393 | 3,420,562 | SH | DFND | 1 | 0 | 3,420,562 | 0 | |
| BIOLINERX LTD | SPONSORED ADS | 09071M106 | 11,178 | 25,995,575 | SH | DFND | 1 | 0 | 25,995,575 | 0 | |
| BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 45,225 | 564,965 | SH | DFND | 1 | 0 | 564,965 | 0 | |
| CALITHERA BIOSCIENCES INC | COM | 13089P101 | 20,378 | 3,023,482 | SH | DFND | 1 | 0 | 3,023,482 | 0 | |
| CHEMOCENTRYX INC | COM | 16383L106 | 20,342 | 1,464,515 | SH | DFND | 1 | 0 | 1,464,515 | 0 | |
| CIDARA THERAPEUTICS INC | COM | 171757107 | 4,533 | 1,710,684 | SH | DFND | 1 | 0 | 1,710,684 | 0 | |
| CONCERT PHARMACEUTICALS INC | COM | 206022105 | 16,723 | 1,385,487 | SH | DFND | 1 | 0 | 1,385,487 | 0 | |
| CONTRAFECT CORP | COM | 212326102 | 755 | 1,898,990 | SH | DFND | 1 | 0 | 1,898,990 | 0 | |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | 8,480 | 2,109,342 | SH | DFND | 1 | 0 | 2,109,342 | 0 | |
| CTI BIOPHARMA CORP | COM NEW | 12648L601 | 6,723 | 6,929,690 | SH | DFND | 1 | 0 | 6,929,690 | 0 | |
| CYTOKINETICS INC | COM NEW | 23282W605 | 30,757 | 3,801,817 | SH | DFND | 1 | 0 | 3,801,817 | 0 | |
| CYTOMX THERAPEUTICS INC | COM | 23284F105 | 12,879 | 1,198,000 | SH | DFND | 1 | 0 | 1,198,000 | 0 | |
| DICERNA PHARMACEUTICALS INC | COM | 253031108 | 20,524 | 1,400,956 | SH | DFND | 1 | 0 | 1,400,956 | 0 | |
| EIGER BIOPHARMACEUTICALS INC | COM | 28249U105 | 9,437 | 675,000 | SH | DFND | 1 | 0 | 675,000 | 0 | |
| ERYTECH PHARMA | SPONSORED ADR | 29604W108 | 4,750 | 625,000 | SH | DFND | 1 | 0 | 625,000 | 0 | |
| ESSA PHARMA INC | COM NEW | 29668H708 | 1,991 | 580,368 | SH | DFND | 1 | 0 | 580,368 | 0 | |
| FIVE PRIME THERAPEUTICS INC | COM | 33830X104 | 41,062 | 3,064,346 | SH | DFND | 1 | 0 | 3,064,346 | 0 | |
| FORWARD PHARMA A/S | SPONSORED ADR | 34986J105 | 10,006 | 8,480,079 | SH | DFND | 1 | 0 | 8,480,079 | 0 | |
| GALMED PHARMACEUTICALS LTD | SHS | M47238106 | 15,347 | 1,878,508 | SH | DFND | 1 | 0 | 1,878,508 | 0 | |
| GENOCEA BIOSCIENCES INC | COM | 372427104 | 4,619 | 7,828,243 | SH | DFND | 1 | 0 | 7,828,243 | 0 | |
| INFINITY PHARMACEUTICALS INC | COM | 45665G303 | 32,763 | 17,426,968 | SH | DFND | 1 | 0 | 17,426,968 | 0 | |
| KURA ONCOLOGY INC | COM | 50127T109 | 41,395 | 2,495,156 | SH | DFND | 1 | 0 | 2,495,156 | 0 | |
| MEI PHARMA INC | COM NEW | 55279B202 | 8,285 | 2,698,755 | SH | DFND | 1 | 0 | 2,698,755 | 0 | |
| MERSANA THERAPEUTICS INC | COM | 59045L106 | 13,150 | 2,500,000 | SH | DFND | 1 | 0 | 2,500,000 | 0 | |
| MERUS N V | COM | N5749R100 | 67,055 | 4,539,913 | SH | DFND | 1 | 0 | 4,539,913 | 0 | |
| MIRATI THERAPEUTICS INC | COM | 60468T105 | 31,644 | 431,700 | SH | DFND | 1 | 0 | 431,700 | 0 | |
| MOLECULAR TEMPLATES INC | COM | 608550109 | 20,795 | 3,579,140 | SH | DFND | 1 | 0 | 3,579,140 | 0 | |
| ONCOMED PHARMACEUTICALS INC | COM | 68234X102 | 4,273 | 4,108,815 | SH | DFND | 1 | 0 | 4,108,815 | 0 | |
| OVID THERAPEUTICS INC | COM | 690469101 | 5,829 | 3,293,000 | SH | DFND | 1 | 0 | 3,293,000 | 0 | |
| PIERIS PHARMACEUTICALS INC | COM | 720795103 | 13,596 | 4,058,385 | SH | DFND | 1 | 0 | 4,058,385 | 0 | |
| PROTAGONIST THERAPEUTICS INC | COM | 74366E102 | 14,119 | 1,123,255 | SH | DFND | 1 | 0 | 1,123,255 | 0 | |
| REALM THERAPEUTICS PLC | SPONSORED ADS | 75606L103 | 2,409 | 612,889 | SH | DFND | 1 | 0 | 612,889 | 0 | |
| REGULUS THERAPEUTICS INC | COM NEW | 75915K200 | 1,073 | 1,051,940 | SH | DFND | 1 | 0 | 1,051,940 | 0 | |
| REPLIMUNE GROUP INC | COM | 76029N106 | 24,456 | 1,606,817 | SH | DFND | 1 | 0 | 1,606,817 | 0 | |
| SPERO THERAPEUTICS INC | COM | 84833T103 | 5,902 | 460,706 | SH | DFND | 1 | 0 | 460,706 | 0 | |
| SPRING BK PHARMACEUTICALS INC | COM | 849431101 | 9,983 | 951,701 | SH | DFND | 1 | 0 | 951,701 | 0 | |
| SUNESIS PHARMACEUTICALS INC | COM PAR | 867328700 | 2,780 | 2,287,860 | SH | DFND | 1 | 0 | 2,287,860 | 0 | |
| SURFACE ONCOLOGY INC | COM | 86877M209 | 2,155 | 451,850 | SH | DFND | 1 | 0 | 451,850 | 0 | |
| SYNDAX PHARMACEUTICALS INC | COM | 87164F105 | 10,435 | 1,987,669 | SH | DFND | 1 | 0 | 1,987,669 | 0 | |
| VBI VACCINES INC | COM NEW | 91822J103 | 8,831 | 4,722,572 | SH | DFND | 1 | 0 | 4,722,572 | 0 | |
| VERASTEM INC | COM | 92337C104 | 10,401 | 3,513,994 | SH | DFND | 1 | 0 | 3,513,994 | 0 | |
| VICAL INC | COM NEW | 925602203 | 2,735 | 2,279,059 | SH | DFND | 1 | 0 | 2,279,059 | 0 | |
| VOYAGER THERAPEUTICS INC | COM | 92915B106 | 5,939 | 310,299 | SH | DFND | 1 | 0 | 310,299 | 0 | |
| XENCOR INC | COM | 98401F105 | 28 | 904 | SH | DFND | 1 | 0 | 904 | 0 | |
| XENON PHARMACEUTICALS INC | COM | 98420N105 | 18,174 | 1,788,774 | SH | DFND | 1 | 0 | 1,788,774 | 0 | |
| XOMA CORP DEL | COM NEW | 98419J206 | 21,901 | 1,769,029 | SH | DFND | 1 | 0 | 1,769,029 | 0 | |