The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 49,195 615,400 SH   DFND 1 250,000 0 365,400
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 5,808 1,350,655 SH   SOLE   1,350,655 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 6,514 1,243,200 SH   SOLE   0 0 1,243,200
AEGERION PHARMACEUTICALS INC NOTE 2.000% 8/1 00767EAB8 1,381 2,000,000 PRN   DFND 1 419,600 0 1,580,400
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 17,432 2,165,524 SH   SOLE   2,165,524 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 2,755 58,000 SH   SOLE   0 0 58,000
AERPIO PHARMACEUTICALS INC COM 00810B105 4,680 5,193,946 SH   SOLE   5,193,946 0 0
AGILENT TECHNOLOGIES INC COM 00846U101 64,200 798,700 SH   DFND 1 210,200 0 588,500
ALECTOR INC COM 014442107 246,773 13,182,329 SH   DFND 1 12,890,829 0 291,500
ALEXION PHARMACEUTICALS INC COM 015351109 264,574 1,957,200 SH   DFND 1 398,400 0 1,558,800
ALPINE IMMUNE SCIENCES INC COM 02083G100 25,183 3,670,955 SH   SOLE   3,670,955 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 7,266 350,000 SH Call DFND 1 79,000 0 271,000
AMARIN CORP PLC SPONS ADR NEW 023111206 9,707 467,600 SH   SOLE   0 0 467,600
AMGEN INC COM 031162100 23,197 122,100 SH   SOLE   0 0 122,100
AMICUS THERAPEUTICS INC COM 03152W109 7,049 518,309 SH   SOLE   0 0 518,309
ANTHEM INC COM 036752103 93,326 325,200 SH   DFND 1 88,300 0 236,900
APELLIS PHARMACEUTICALS INC COM 03753U106 1,463 75,000 SH Call DFND 1 17,000 0 58,000
APELLIS PHARMACEUTICALS INC COM 03753U106 34,365 1,762,300 SH   SOLE   0 0 1,762,300
ARGENX SE SPONSORED ADR 04016X101 45,105 361,300 SH   SOLE   0 0 361,300
ARVINAS INC COM 04335A105 39,539 2,678,810 SH   DFND 1 1,916,310 0 762,500
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 467,348 3,970,673 SH   DFND 1 3,397,673 0 573,000
ASSEMBLY BIOSCIENCES INC COM 045396108 19,614 996,123 SH   SOLE   0 0 996,123
ATHENEX INC COM 04685N103 5,268 430,000 SH   SOLE   0 0 430,000
AUDENTES THERAPEUTICS INC COM 05070R104 70,821 1,815,000 SH   SOLE   1,815,000 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 20,474 3,149,810 SH   SOLE   0 0 3,149,810
AVEDRO INC COM 05355N109 52,026 4,240,128 SH   SOLE   4,240,128 0 0
AVROBIO INC COM 05455M100 4,379 198,583 SH   SOLE   0 0 198,583
BAUSCH HEALTH COS INC COM 071734107 92,395 3,740,700 SH   DFND 1 873,400 0 2,867,300
BEIGENE LTD SPONSORED ADR 07725L102 37,290 282,500 SH   DFND 1 55,200 0 227,300
BIOGEN INC COM 09062X103 20,731 87,700 SH   SOLE   0 0 87,700
BIOLINERX LTD SPONSORED ADS 09071M106 447 1,038,600 SH   SOLE   1,038,600 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 22,208 250,000 SH Put DFND 1 58,000 0 192,000
BIOMARIN PHARMACEUTICAL INC COM 09061G101 6,795 76,500 SH   SOLE   0 0 76,500
BOSTON SCIENTIFIC CORP COM 101137107 222,236 5,790,400 SH   DFND 1 1,500,700 0 4,289,700
BRISTOL MYERS SQUIBB CO COM 110122108 57,013 1,195,000 SH   DFND 1 423,400 0 771,600
CAREDX INC COM 14167L103 26,086 827,600 SH   DFND 1 189,700 0 637,900
CELGENE CORP COM 151020104 27,830 295,000 SH   SOLE   0 0 295,000
CIGNA CORP NEW COM 125523100 40,623 252,600 SH   DFND 1 91,000 0 161,600
CLEMENTIA PHARMACEUTICALS IN COM 185575107 272,098 10,425,225 SH   SOLE   10,425,225 0 0
CLOVIS ONCOLOGY INC COM 189464100 70,298 2,832,300 SH   DFND 1 490,000 0 2,342,300
CONSTELLATION PHARMCETICLS I COM 210373106 11,326 835,842 SH   SOLE   835,842 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 23,990 5,967,584 SH   SOLE   5,967,584 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 43,569 1,914,282 SH   SOLE   1,914,282 0 0
CTI BIOPHARMA CORP COM NEW 12648L601 4,851 5,000,000 SH   SOLE   5,000,000 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 24,899 1,874,955 SH   SOLE   0 0 1,874,955
DECIPHERA PHARMACEUTICALS IN COM 24344T101 83,978 3,618,171 SH   DFND 1 548,800 0 3,069,371
DEXCOM INC COM 252131107 16,519 138,700 SH   DFND 1 34,300 0 104,400
EDWARDS LIFESCIENCES CORP COM 28176E108 136,801 715,000 SH   DFND 1 163,800 0 551,200
EHEALTH INC COM 28238P109 73,637 1,181,214 SH   DFND 1 150,000 0 1,031,214
ENANTA PHARMACEUTICALS INC COM 29251M106 22,266 233,100 SH   SOLE   0 0 233,100
ENDO INTL PLC SHS G30401106 49,509 6,165,464 SH   DFND 1 1,125,200 0 5,040,264
EXELIXIS INC COM 30161Q104 66,685 2,801,900 SH   DFND 1 410,200 0 2,391,700
FOAMIX PHARMACEUTICALS LTD SHS M46135105 19,482 5,195,330 SH   SOLE   0 0 5,195,330
GENFIT S A ADS 372279109 29,528 1,230,314 SH   DFND 1 290,000 0 940,314
GILEAD SCIENCES INC COM 375558103 28,851 443,800 SH   SOLE   0 0 443,800
GUARDANT HEALTH INC COM 40131M109 117,693 1,534,464 SH   SOLE   1,534,464 0 0
HARPOON THERAPEUTICS INC COM 41358P106 23,167 2,446,409 SH   DFND 1 1,360,704 0 1,085,705
HERON THERAPEUTICS INC COM 427746102 26,126 1,069,000 SH   SOLE   0 0 1,069,000
HUMANA INC COM 444859102 55,940 210,300 SH   DFND 1 58,000 0 152,300
ILLUMINA INC COM 452327109 70,620 227,300 SH   DFND 1 53,600 0 173,700
IMMUNOMEDICS INC COM 452907108 82,034 4,270,403 SH   DFND 1 958,903 0 3,311,500
INSPIRE MED SYS INC COM 457730109 83,523 1,471,000 SH   SOLE   1,471,000 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 6,449 377,600 SH   SOLE   377,600 0 0
INTUITIVE SURGICAL INC COM NEW 46120E602 119,993 210,300 SH   DFND 1 51,400 0 158,900
INVITAE CORP COM 46185L103 5,200 222,017 SH   SOLE   222,017 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 52,765 5,548,326 SH   DFND 1 1,337,800 0 4,210,526
KALA PHARMACEUTICALS INC COM 483119103 28,514 3,447,840 SH   SOLE   3,447,840 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 2,590 90,500 SH   SOLE   0 0 90,500
KRYSTAL BIOTECH INC COM 501147102 1,948 59,210 SH   SOLE   0 0 59,210
LOGICBIO THERAPEUTICS INC COM 54142F102 63,892 6,466,783 SH   SOLE   6,466,783 0 0
MARINUS PHARMACEUTICALS INC COM 56854Q101 1,664 398,101 SH   SOLE   398,101 0 0
MEDIGUS LTD SPONSORED ADS 58471G300 44 15,000 SH   SOLE   15,000 0 0
MEIRAGTX HOLDINGS PLC COM G59665102 42,390 2,460,251 SH   SOLE   0 0 2,460,251
MENLO THERAPEUTICS INC COM 586858102 4,976 633,920 SH   SOLE   0 0 633,920
MERCK & CO INC COM 58933Y105 213,755 2,570,100 SH   DFND 1 723,400 0 1,846,700
MERSANA THERAPEUTICS INC COM 59045L106 9,947 1,891,119 SH   SOLE   0 0 1,891,119
MYLAN N V SHS EURO N59465109 137,783 4,861,800 SH   DFND 1 1,028,600 0 3,833,200
MYOKARDIA INC COM 62857M105 47,134 906,600 SH   DFND 1 176,600 0 730,000
NABRIVA THERAPEUTICS PLC SHS G63637105 11,333 4,644,600 SH   SOLE   4,644,600 0 0
NATERA INC COM 632307104 22,220 1,077,586 SH   DFND 1 684,086 0 393,500
NEUROCRINE BIOSCIENCES INC COM 64125C109 161,505 1,833,200 SH   DFND 1 322,500 0 1,510,700
NOVO-NORDISK A S ADR 670100205 17,262 330,000 SH   SOLE   0 0 330,000
NOVUS THERAPEUTICS INC COM 67011N105 10,199 2,537,110 SH   SOLE   2,537,110 0 0
NUVECTRA CORP COM 67075N108 3,854 350,000 SH   SOLE   0 0 350,000
OBSEVA SA COM H5861P103 33,325 2,605,531 SH   SOLE   2,605,531 0 0
PRINCIPIA BIOPHARMA INC COM 74257L108 88,594 2,605,713 SH   SOLE   2,605,713 0 0
PROQR THRAPEUTICS N V SHS EURO N71542109 27,491 1,982,031 SH   DFND 1 337,731 0 1,644,300
PROTHENA CORP PLC SHS G72800108 29,540 2,435,278 SH   DFND 1 479,300 0 1,955,978
PTC THERAPEUTICS INC COM 69366J200 57,202 1,519,700 SH   DFND 1 281,000 0 1,238,700
PUMA BIOTECHNOLOGY INC COM 74587V107 72,925 1,880,000 SH   DFND 1 364,600 0 1,515,400
REALM THERAPEUTICS PLC SPONSORED ADS 75606L103 3,933 1,021,484 SH   SOLE   1,021,484 0 0
RECRO PHARMA INC COM 75629F109 255 43,499 SH   SOLE   43,499 0 0
REGENERON PHARMACEUTICALS COM 75886F107 88,201 214,800 SH   DFND 1 41,700 0 173,100
RESTORBIO INC COM 76133L103 32,943 4,830,387 SH   SOLE   4,830,387 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 21,580 787,300 SH   SOLE   787,300 0 0
SAREPTA THERAPEUTICS INC COM 803607100 98,737 828,400 SH   DFND 1 129,400 0 699,000
SCPHARMACEUTICALS INC COM 810648105 10,230 3,409,865 SH   SOLE   3,409,865 0 0
SELECTA BIOSCIENCES INC COM 816212104 6,823 2,879,064 SH   SOLE   2,879,064 0 0
SI BONE INC COM 825704109 18,564 985,368 SH   SOLE   985,368 0 0
SIERRA ONCOLOGY INC COM 82640U107 542 317,104 SH   SOLE   317,104 0 0
SINOVAC BIOTECH LTD SHS P8696W104 18,372 2,839,500 SH   SOLE   0 0 2,839,500
SPDR S&P 500 ETF TR TR UNIT 78462F103 14,124 50,000 SH Put DFND 1 11,000 0 39,000
SPERO THERAPEUTICS INC COM 84833T103 6,501 507,471 SH   SOLE   0 0 507,471
STRYKER CORP COM 863667101 10,666 54,000 SH   SOLE   54,000 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 1,113 212,000 SH   SOLE   212,000 0 0
SYNLOGIC INC COM 87166L100 15,408 2,029,996 SH   SOLE   2,029,996 0 0
SYNTHORX INC COM 87167A103 108,294 5,316,355 SH   SOLE   5,316,355 0 0
TAKEDA PHARMACEUTICAL CO LTD SPONSORED ADS 874060205 15,278 750,000 SH   DFND 1 172,000 0 578,000
TAKEDA PHARMACEUTICAL CO LTD SPONSORED ADS 874060205 20,370 1,000,000 SH Call DFND 1 70,000 0 930,000
TANDEM DIABETES CARE INC COM NEW 875372203 40,088 631,300 SH   DFND 1 148,300 0 483,000
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS 881624209 63,959 4,079,000 SH   DFND 1 867,600 0 3,211,400
THERMO FISHER SCIENTIFIC INC COM 883556102 122,435 447,300 SH   DFND 1 108,400 0 338,900
TRICIDA INC COM 89610F101 420,544 10,889,280 SH   SOLE   10,889,280 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 8,128 1,250,396 SH   SOLE   1,250,396 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 15,996 1,479,733 SH   SOLE   1,479,733 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 175,727 955,300 SH   DFND 1 156,900 0 798,400
VIEWRAY INC COM 92672L107 38,051 5,149,019 SH   SOLE   5,149,019 0 0
WAVE LIFE SCIENCES LTD SHS Y95308105 6,993 180,000 SH Put DFND 1 40,500 0 139,500
WRIGHT MED GROUP N V ORD SHS N96617118 131,706 4,187,799 SH   DFND 1 967,749 0 3,220,050
WRIGHT MED GROUP N V ORD SHS N96617118 7,863 250,000 SH Call DFND 1 57,500 0 192,500
X4 PHARMACEUTICALS INC COM 98420X103 5,423 311,493 SH   SOLE   311,493 0 0
XENON PHARMACEUTICALS INC COM 98420N105 6,450 634,812 SH   SOLE   634,812 0 0
XTANT MED HLDGS INC COM NEW 98420P308 28,081 9,207,012 SH   SOLE   9,207,012 0 0
ZAI LAB LTD ADR 98887Q104 41,353 1,401,318 SH   SOLE   1,401,318 0 0