The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABEONA THERAPEUTICS INC *W EXP 12/24/201 00289Y115 1,906 659,636 SH   SOLE   659,636 0 0
ABEONA THERAPEUTICS INC COM 00289Y107 1,331 180,797 SH   SOLE   180,797 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 400 14,897 SH   SOLE   14,897 0 0
ACASTI PHARMA INC CL A NEW 00430K402 1,815 1,779,882 SH   SOLE   1,779,882 0 0
ADMA BIOLOGICS INC COM 000899104 24,715 6,521,102 SH   SOLE   6,521,102 0 0
AGILE THERAPEUTICS INC COM 00847L100 12,724 8,426,750 SH   SOLE   8,426,750 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 140 200,000 SH Call SOLE   200,000 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 13,951 1,703,440 SH   SOLE   1,703,440 0 0
ALBIREO PHARMA INC COM 01345P106 54,896 1,704,330 SH   SOLE   1,704,330 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 27,862 3,085,458 SH   SOLE   3,085,458 0 0
ALECTOR INC COM 014442107 9,579 511,731 SH   SOLE   511,731 0 0
ALLENA PHARMACEUTICALS INC COM 018119107 929 132,300 SH   SOLE   132,300 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 44,630 1,543,790 SH   SOLE   1,543,790 0 0
AMARIN CORPORATION PLC SPONS ADR NEW 023111206 135,790 6,540,957 SH   SOLE   6,540,957 0 0
AMICUS THERAPEUTICS INC COM 03152W109 294,297 21,639,486 SH   SOLE   21,639,486 0 0
ANI PHARMACEUTICALS INC NOTE 3.000%12/0 00182CAA1 8,239 7,500,000 PRN   SOLE   7,500,000 0 0
AQUESTIVE THERAPEUTICS INC COM 3843E1047 14,603 2,113,400 SH   SOLE   2,113,400 0 0
ARENA PHARMACEUTICALS INC COM 040047607 62,770 1,400,171 SH   SOLE   1,400,171 0 0
ARRAY BIOPHARMA INC COM 04269X105 103,101 4,228,900 SH   SOLE   4,228,900 0 0
ARROWHEAD PHARMACEUTICALS INC COM 04280A100 6,069 330,738 SH   SOLE   330,738 0 0
ASCENDIS PHARMA A S COM 04351P101 25 200,000 SH Put SOLE   200,000 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 131,039 1,113,328 SH   SOLE   1,113,328 0 0
ATHENEX INC COM 04685N103 62,426 5,096,022 SH   SOLE   5,096,022 0 0
AVEDRO INC COM 05355N109 1,227 100,000 SH   SOLE   100,000 0 0
AXONICS MODULATION TECHNOLOGIES INC COM 05465P101 16,424 685,756 SH   SOLE   685,756 0 0
AXSOME THERAPEUTICS INC COM 05464T104 767 53,879 SH   SOLE   53,879 0 0
BAUSCH HEALTH COS INC COM 071734107 14,820 600,000 SH   SOLE   600,000 0 0
BIOGEN INC COM 09062X103 620 400,000 SH Call SOLE   400,000 0 0
BIOTELEMETRY INC COM 090672106 399 6,369 SH   SOLE   6,369 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 101,748 1,271,054 SH   SOLE   1,271,054 0 0
CLOVIS ONCOLOGY INC COM 189464100 125 200,000 SH Call SOLE   200,000 0 0
CLOVIS ONCOLOGY INC COM 189464100 660 200,000 SH Put SOLE   200,000 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 26,610 2,204,641 SH   SOLE   2,204,641 0 0
CRINETICS PHARMACEUTICALS INC COM 22663K107 58,901 2,587,953 SH   SOLE   2,587,953 0 0
CRYOLIFE INC COM 228903100 1,459 50,000 SH   SOLE   50,000 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 55,946 4,212,821 SH   SOLE   4,212,821 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 34,120 3,173,923 SH   SOLE   3,173,923 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 8,700 1,128,524 SH   SOLE   1,128,524 0 0
DOVA PHARMACEUTICALS INC COM 25985T102 27,788 3,125,851 SH   SOLE   3,125,851 0 0
EHEALTH INC COM 28238P109 18,070 289,857 SH   SOLE   289,857 0 0
EIDOS THERAPEUTICS INC COM 28249H104 16,109 686,992 SH   SOLE   686,992 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 1,955 139,890 SH   SOLE   139,890 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 14,766 614,242 SH   SOLE   614,242 0 0
EVOLUS INC COM 30052C107 344 15,232 SH   SOLE   15,232 0 0
FERRARI N.V. COM N3167Y103 830 6,200 SH   SOLE   6,200 0 0
FIBROGEN INC COM 31572Q808 506 9,306 SH   SOLE   9,306 0 0
FIAT CHRYSLER AUTOMOBILES N SHS N31739102 920 62,000 SH   SOLE   62,000 0 0
FLUIDIGM CORP COM 34385P108 612 46,030 SH   SOLE   46,030 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 17,482 4,661,824 SH   SOLE   4,661,824 0 0
GLOBAL BLOOD THERAPEUTICS INC COM 37890U108 292,476 5,525,726 SH   SOLE   5,525,726 0 0
HUMANA INC COM 444859102 9,310 35,000 SH   SOLE   35,000 0 0
IMMUNOGEN INC COM 45253H101 15 600,000 SH Call SOLE   600,000 0 0
IMMUNOMEDICS INC COM 452907108 125 200,000 SH Call SOLE   200,000 0 0
INTERSECT ENT INC COM 46071F103 2,251 70,000 SH   SOLE   70,000 0 0
INVITAE CORP COM 46185L103 50,866 2,171,918 SH   SOLE   2,171,918 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 116,362 12,235,811 SH   SOLE   12,235,811 0 0
IRHYTHM TECHNOLOGIES INC COM 450056106 14,992 200,000 SH   SOLE   200,000 0 0
KADMON HOLDINGS INC COM 48283N106 34,757 13,165,746 SH   SOLE   13,165,746 0 0
KODIAK SCIENCES INC COM 50015M109 20,472 3,135,199 SH   SOLE   3,135,199 0 0
LIVANOVA PLC SHS G5509L101 3,890 40,000 SH   SOLE   40,000 0 0
MARKER THERAPEUTICS INC COM 57055L107 13,200 2,000,000 SH   SOLE   2,000,000 0 0
MEI PHARMA INC COM NEW 55279B202 13,509 4,400,440 SH   SOLE   4,400,440 0 0
MEIRAGTX HOLDINGS PLC COM G59665102 103,513 6,007,746 SH   SOLE   6,007,746 0 0
MERIT MEDICAL SYSTEMS INC COM 589889104 65,113 1,053,098 SH   SOLE   1,053,098 0 0
MIRATI THERAPEUTICS INC COM 60468T105 85,349 1,164,382 SH   SOLE   1,164,382 0 0
MOLECULAR TEMPLATES INC COM 608550109 11,470 1,974,133 SH   SOLE   1,974,133 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 41,774 2,875,000 SH   SOLE   2,875,000 0 0
MOTUS GI HLDGS INC COM 62014P108 12,521 3,210,542 SH   SOLE   3,210,542 0 0
MYOKARDIA INC COM 62857M105 51,393 988,511 SH   SOLE   988,511 0 0
NEPTUNE WELLNESS SOLUTIONS INC COM 64079L105 28,363 8,891,452 SH   SOLE   8,891,452 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 331,138 3,758,662 SH   SOLE   3,758,662 0 0
NEVRO CORP COM 64157F103 26,063 416,949 SH   SOLE   416,949 0 0
ONCOMED PHARMACEUTICALS INC COM 68234X102 1,787 1,719,111 SH   SOLE   1,719,111 0 0
ONCOSEC MEDICAL INC COM 68234L207 17 30,000 SH   SOLE   30,000 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 9,329 521,800 SH   SOLE   521,800 0 0
OUTLOOK THERAPEUTICS INC *W EXP 02/18/202 69012T115 159 420,875 SH   SOLE   420,875 0 0
PROQR THERAPEUTICS N.V. SHS EURO N71542109 10,021 722,523 SH   SOLE   722,523 0 0
PROTAGONIST THERAPEUTICS INC COM 4366E1029 26,036 2,071,297 SH   SOLE   2,071,297 0 0
QUOTIENT LTD SHS G73268107 97,209 10,789,054 SH   SOLE   10,789,054 0 0
REGENXBIO INC COM 75901B107 65,662 1,145,726 SH   SOLE   1,145,726 0 0
RETROPHIN INC COM 761299106 69,128 3,054,707 SH   SOLE   3,054,707 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 13,786 502,970 SH   SOLE   502,970 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 8,036 458,173 SH   SOLE   458,173 0 0
SAREPTA THERAPEUTICS INC COM 803607100 421 100,000 SH Call SOLE   100,000 0 0
SHOCKWAVE MEDICAL INC COM 82489T104 5,021 150,000 SH   SOLE   150,000 0 0
SIERRA ONCOLOGY INC COM 82640U107 4,559 2,666,190 SH   SOLE   2,666,190 0 0
SOLID BIOSCIENCES INC COM 3422E1055 29 10,000 SH Call SOLE   10,000 0 0
SOLID BIOSCIENCES INC COM 3422E1055 36,130 3,927,222 SH   SOLE   3,927,222 0 0
SYNLOGIC INC COM 87166L100 6,587 867,852 SH   SOLE   867,852 0 0
TANDEM DIABETES CARE INC COM 875372203 816 12,844 SH   SOLE   12,844 0 0
TELADOC HEALTH INC COM 87918A105 27,522 495,000 SH   SOLE   495,000 0 0
TRANSLATE BIO INC COM 89374L104 4,433 435,000 SH   SOLE   435,000 0 0
ULTRAGENYX PHARMACEUTICAL INC COM 90400D108 3,468 50,000 SH   SOLE   50,000 0 0
UNIQURE NV. SHS N90064101 13,828 231,820 SH   SOLE   231,820 0 0
UROVANT SCIENCES LTD COM G9381B108 8,697 865,359 SH   SOLE   865,359 0 0
VAPOTHERM INC COM 922107107 24,490 1,246,315 SH   SOLE   1,246,315 0 0
VBI VACCINES INC COM 91822J103 42,633 23,951,556 SH   SOLE   23,951,556 0 0
VERACYTE INC COM 92337F107 789 31,521 SH   SOLE   31,521 0 0
VERICEL CORP COM 92346J108 492 28,090 SH   SOLE   28,090 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 38,537 3,410,412 SH   SOLE   3,410,412 0 0
VERU INC COM 92536C103 2,081 1,425,000 SH   SOLE   1,425,000 0 0
VIEWRAY INC COM 92672L107 35,514 4,805,650 SH   SOLE   4,805,650 0 0
VOCERA COMMUNICATIONS INC COM 92857F107 1,582 50,000 SH   SOLE   50,000 0 0
ZOGENIX INC COM 98978L204 212,860 3,869,491 SH   SOLE   3,869,491 0 0
ZYMEWORKS INC COM 98985W102 8,529 573,890 SH   SOLE   573,890 0 0