The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Aclaris Therapeutics, Inc. Common 00461U105 3,607 1,647,214 SH   SOLE   1,647,214 0 0
Agile Therapeutics, Inc. Common 00847L100 2,210 1,513,975 SH   SOLE   1,513,975 0 0
Akari Therapeutics Plc ADR 00972G108 699 345,850 SH   SOLE   345,850 0 0
Amyris, Inc Common 03236M200 23,106 6,490,557 SH   SOLE   6,490,557 0 0
Apellis Pharmaceuticals, Inc. Common 03753U106 9,719 383,538 SH   SOLE   383,538 0 0
Arrowhead Pharmaceuticals Inc Common 04280A100 73,277 2,765,153 SH   SOLE   2,765,153 0 0
Ascendis Pharma A/S ADR 04351P101 237,225 2,060,135 SH   SOLE   2,060,135 0 0
Aurinia Pharmaceuticals Inc. Common 05156V102 12,592 1,913,623 SH   SOLE   1,913,623 0 0
BioPharmX Corporation Common 09072X309 189 317,270 SH   SOLE   317,270 0 0
Chiasma Inc Common 16706W102 17,758 2,377,213 SH   SOLE   2,377,213 0 0
Codexis, Inc Common 192005106 48,184 2,614,458 SH   SOLE   2,614,458 0 0
Crinetics Pharmaceuticals Inc Common 22663K107 84,379 3,375,169 SH   SOLE   3,375,169 0 0
Cymabay Therapeutics Inc Common 23257D103 15,429 2,154,934 SH   SOLE   2,154,934 0 0
DBV Technologies S.A. ADR 23306J101 2,219 269,995 SH   SOLE   269,995 0 0
Dermira Inc Common 24983L104 6,692 700,000 SH   SOLE   700,000 0 0
Eiger BioPharmaceuticals Inc Common 28249U105 18,987 1,791,257 SH   SOLE   1,791,257 0 0
Galmed Pharmaceuticals Ltd SHS M47238106 7,139 971,337 SH   SOLE   971,337 0 0
Genocea Biosciences Inc Common 372427401 2,455 626,401 SH   SOLE   626,401 0 0
Homology Medicines, Inc. Common 438083107 22,696 1,159,742 SH   SOLE   1,159,742 0 0
Insmed Inc Common Par 457669307 44,753 1,748,174 SH   SOLE   1,748,174 0 0
Iovance Biotherapeutics, Inc. Common 462260100 39,232 1,600,000 SH   SOLE   1,600,000 0 0
Kadmon Holdings Inc Common 48283N106 25,970 12,606,605 SH   SOLE   12,606,605 0 0
Kala Pharmaceuticals, Inc. Common 483119103 6,654 1,043,020 SH   SOLE   1,043,020 0 0
KalVista Pharmaceuticals Inc. Common 483497103 30,105 1,359,149 SH   SOLE   1,359,149 0 0
Karuna Therapeutics Inc Common 48576A100 6,507 325,000 SH   SOLE   325,000 0 0
Kiniksa Pharmaceuticals Common G5269C101 11,421 843,478 SH   SOLE   843,478 0 0
Matinas Biopharma Hldgs Inc Common 576810105 5,840 6,818,181 SH   SOLE   6,818,181 0 0
MEI Pharma Inc Common 55279B202 14,203 5,681,397 SH   SOLE   5,681,397 0 0
Menlo Therapeutics Inc. Common 586858102 24,027 4,011,236 SH   SOLE   4,011,236 0 0
Mirati Therapeutics Inc. Common 60468T105 24,004 233,045 SH   SOLE   233,045 0 0
Nabriva Therapeutics AG SHS G63637105 9,815 4,039,139 SH   SOLE   4,039,139 0 0
Obseva SA Common H5861P103 10,599 937,147 SH   SOLE   937,147 0 0
Orchard Therapeutics plc ADS 68570P101 18,356 1,312,084 SH   SOLE   1,312,084 0 0
Precision Biosciences Inc Common 74019P108 3,717 280,511 SH   SOLE   280,511 0 0
Rocket Pharmaceuticals Inc Common 77313F106 11,801 786,712 SH   SOLE   786,712 0 0
Selecta Biosciences Inc Common 816212104 977 546,054 SH   SOLE   546,054 0 0
Sierra Oncology, Inc Common 82640U107 1,365 2,438,270 SH   SOLE   2,438,270 0 0
Sinovac Biotech Ltd. SHS P8696W104 38,173 5,900,000 SH   SOLE   5,900,000 0 0
Soleno Therapeutics, Inc. Common 834203200 11,953 4,268,959 SH   SOLE   4,268,959 0 0
Soleno Therapeutics, Inc. - Warrant Warrant 834203135 19 188,772 SH   SOLE   188,772 0 0
The Medicines Company Common 584688105 24,399 669,012 SH   SOLE   669,012 0 0
Tricida, Inc. Common 89610F101 56,212 1,424,525 SH   SOLE   1,424,525 0 0
Verona Pharma PLC ADS 925050106 7,614 1,492,951 SH   SOLE   1,492,951 0 0
Xenon Pharmaceuticals Inc Common 98420N105 13,858 1,405,476 SH   SOLE   1,405,476 0 0
Zogenix Inc Common 98978L204 5,017 105,000 SH   SOLE   105,000 0 0
Zymeworks Inc Common 98985W102 31,976 1,453,467 SH   SOLE   1,453,467 0 0