The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABEONA THERAPEUTICS INC *W EXP 12/24/201 00289Y115 620 659,636 SH   SOLE   659,636 0 0
ACASTI PHARMA INC CL A NEW 00430K402 2,029 1,779,882 SH   SOLE   1,779,882 0 0
ACORDA THERAPEUTICS INC COM 00484M106 8,647 1,127,318 SH   SOLE   1,127,318 0 0
ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 13,766 285,000 SH   SOLE   285,000 0 0
ADMA BIOLOGICS INC COM 000899104 44,586 11,521,102 SH   SOLE   11,521,102 0 0
AGILE THERAPEUTICS INC COM 00847L100 10,443 8,426,750 SH   SOLE   8,426,750 0 0
ALBIREO PHARMA INC COM 01345P106 54,948 1,704,330 SH   SOLE   1,704,330 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 18,512 3,085,458 SH   SOLE   3,085,458 0 0
ALECTOR INC COM 014442107 9,325 511,731 SH   SOLE   511,731 0 0
ALLENA PHARMACEUTICALS INC COM 018119107 538 132,300 SH   SOLE   132,300 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 41,450 1,543,790 SH   SOLE   1,543,790 0 0
AMARIN CORPORATION PLC SPONS ADR NEW 023111206 120,242 6,201,269 SH   SOLE   6,201,269 0 0
AMICUS THERAPEUTICS INC COM 03152W109 268,438 21,509,486 SH   SOLE   21,509,486 0 0
ANI PHARMACEUTICALS INC NOTE 3.000% 12/0 00182CAA1 8,992 7,500,000 PRN   SOLE   7,500,000 0 0
AQUESTIVE THERAPEUTICS INC COM 3843E1047 8,876 2,113,400 SH   SOLE   2,113,400 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 80,919 1,380,171 SH   SOLE   1,380,171 0 0
ARRAY BIOPHARMA INC COM 04269X105 48,109 1,038,390 SH   SOLE   1,038,390 0 0
ARROWHEAD PHARMACEUTICALS INC COM 04280A100 8,765 330,738 SH   SOLE   330,738 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 54,521 473,475 SH   SOLE   473,475 0 0
ATHENEX INC COM 04685N103 187,636 9,822,118 SH   SOLE   9,822,118 0 0
AXONICS MODULATION TECHNOLOGIES INC COM 05465P101 11,697 285,502 SH   SOLE   285,502 0 0
AXSOME THERAPEUTICS INC COM 05464T104 1,387 53,879 SH   SOLE   53,879 0 0
BAUSCH HEALTH COS INC COM 071734107 15,132 600,000 SH   SOLE   600,000 0 0
BIOGEN INC COM 09062X103 65 200,000 SH Call SOLE   200,000 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 114,397 1,212,731 SH   SOLE   1,212,731 0 0
BRIDGEBIO PHARMA INC COM 10806X102 180,868 6,706,268 SH   SOLE   6,706,268 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 26,456 2,204,641 SH   SOLE   2,204,641 0 0
CONFORMIS INC COM 0717E1010 436 100,000 SH   SOLE   100,000 0 0
CRINETICS PHARMACEUTICALS INC COM 22663K107 64,698 2,587,953 SH   SOLE   2,587,953 0 0
CRYOLIFE INC COM 228903100 1,497 50,000 SH   SOLE   50,000 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 27,657 3,862,821 SH   SOLE   3,862,821 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 35,387 3,153,923 SH   SOLE   3,153,923 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 29,666 3,609,084 SH   SOLE   3,609,084 0 0
DEXCOM INC COM 252131107 8,990 60,000 SH   SOLE   60,000 0 0
DOVA PHARMACEUTICALS INC COM 25985T102 50,098 3,553,060 SH   SOLE   3,553,060 0 0
EHEALTH INC COM 28238P109 33,233 385,982 SH   SOLE   385,982 0 0
EIDOS THERAPEUTICS INC COM 28249H104 21,349 686,992 SH   SOLE   686,992 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 1,482 139,890 SH   SOLE   139,890 0 0
ESTABLISHMENT LABS HLDGS INC COM G31249108 27,719 1,260,528 SH   SOLE   1,260,528 0 0
FERRARI N.V. COM N3167Y103 1,001 6,200 SH   SOLE   6,200 0 0
FIAT CHRYSLER AUTOMOBILES N SHS N31739102 10,008 62,000 SH   SOLE   62,000 0 0
FLUIDIGM CORP COM 34385P108 567 46,030 SH   SOLE   46,030 0 0
FOAMIX PHARMACEUTICALS LTD SHS M46135105 11,095 4,661,824 SH   SOLE   4,661,824 0 0
GLOBAL BLOOD THERAPEUTICS INC COM 37890U108 303,803 5,775,726 SH   SOLE   5,775,726 0 0
GUARDANT HEALTH INC COM 40131M109 571 6,617 SH   SOLE   6,617 0 0
HEALTH SCIENCES ACQUISITIONS CORP UNIT 04/01/2024 42227C201 4,241 400,000 SH   SOLE   400,000 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 11,369 1,141,484 SH   SOLE   1,141,484 0 0
INTERCEPT PHARMACEUTICALS INC COM 45845P108 7,766 97,600 SH   SOLE   97,600 0 0
INVITAE CORP COM 46185L103 31,572 1,343,491 SH   SOLE   1,343,491 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 292,158 11,915,127 SH   SOLE   11,915,127 0 0
KADMON HOLDINGS INC COM 48283N106 27,121 13,165,746 SH   SOLE   13,165,746 0 0
KODIAK SCIENCES INC COM 50015M109 36,681 3,135,199 SH   SOLE   3,135,199 0 0
MARKER THERAPEUTICS INC COM 57055L107 15,840 2,000,000 SH   SOLE   2,000,000 0 0
MEDICINES CO COM 584688105 712 19,532 SH   SOLE   19,532 0 0
MEI PHARMA INC COM NEW 55279B202 11,001 4,400,440 SH   SOLE   4,400,440 0 0
MEIRAGTX HOLDINGS PLC COM G59665102 155,766 6,007,746 SH   SOLE   6,007,746 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 452 179,419 SH   SOLE   179,419 0 0
MERIT MEDICAL SYSTEMS INC COM 589889104 48,673 817,209 SH   SOLE   817,209 0 0
MIRATI THERAPEUTICS INC COM 60468T105 298,659 2,899,606 SH   SOLE   2,899,606 0 0
MOLECULAR TEMPLATES INC COM 608550109 16,484 1,974,133 SH   SOLE   1,974,133 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 36,167 2,905,000 SH   SOLE   2,905,000 0 0
MORPHIC HOLDING INC COM 61775R105 12,883 650,000 SH   SOLE   650,000 0 0
MOTUS GI HLDGS INC COM 62014P108 12,757 4,210,542 SH   SOLE   4,210,542 0 0
MYOKARDIA INC COM 62857M105 55,180 1,100,511 SH   SOLE   1,100,511 0 0
NATERA INC COM 632307104 401 14,549 SH   SOLE   14,549 0 0
NEPTUNE WELLNESS SOLUTIONS INC COM 64079L105 29,978 8,891,452 SH   SOLE   8,891,452 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 339,734 4,023,862 SH   SOLE   4,023,862 0 0
NEVRO CORP COM 64157F103 73,761 1,137,765 SH   SOLE   1,137,765 0 0
ORCHARD THERAPEUTICS PLC ADS 68570P101 7,299 521,800 SH   SOLE   521,800 0 0
OUTLOOK THERAPEUTICS INC *W EXP 02/18/202 69012T115 46 420,875 SH   SOLE   420,875 0 0
PROTAGONIST THERAPEUTICS INC COM 4366E1029 25,083 2,071,297 SH   SOLE   2,071,297 0 0
QUOTIENT LTD SHS G73268107 100,877 10,789,054 SH   SOLE   10,789,054 0 0
REGENXBIO INC COM 75901B107 49,880 970,997 SH   SOLE   970,997 0 0
RETROPHIN INC COM 761299106 75,791 3,772,582 SH   SOLE   3,772,582 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 5,785 262,970 SH   SOLE   262,970 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 29,661 1,977,412 SH   SOLE   1,977,412 0 0
ROCKWELL MEDICAL INC COM 774374102 4,515 1,500,000 SH   SOLE   1,500,000 0 0
SERES THERAPEUTICS INC COM 81750R102 8,050 2,500,000 SH   SOLE   2,500,000 0 0
SHOCKWAVE MEDICAL INC COM 82489T104 8,564 150,000 SH   SOLE   150,000 0 0
SIERRA ONCOLOGY INC COM 82640U107 1,493 2,666,190 SH   SOLE   2,666,190 0 0
SOLID BIOSCIENCES INC COM 83422E105 23 200 SH Call SOLE   200 0 0
SOLID BIOSCIENCES INC COM 83422E105 22,581 3,927,222 SH   SOLE   3,927,222 0 0
SPARK THERAPEUTICS INC COM 84652J103 35,833 350,000 SH   SOLE   350,000 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 70 200,000 SH Put SOLE   200,000 0 0
STOKE THERAPEUTICS INC COM 86150R107 19,601 671,978 SH   SOLE   671,978 0 0
SYNLOGIC INC COM 87166L100 7,897 867,852 SH   SOLE   867,852 0 0
TANDEM DIABETES CARE INC COM 875372203 414 6,422 SH   SOLE   6,422 0 0
TELADOC HEALTH INC COM 87918A105 20,389 307,021 SH   SOLE   307,021 0 0
TENET HEALTHCARE CORP COM 88033G407 6,211 300,633 SH   SOLE   300,633 0 0
TRANSLATE BIO INC COM 89374L104 5,494 435,000 SH   SOLE   435,000 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 17,296 424,968 SH   SOLE   424,968 0 0
TWIST BIOSCIENCE CORP COM 90184D100 3,216 110,856 SH   SOLE   110,856 0 0
UNIQURE N.V COM N90064101 22,024 281,820 SH   SOLE   281,820 0 0
UROVANT SCIENCES LTD COM G9381B108 14,835 1,875,426 SH   SOLE   1,875,426 0 0
VAPOTHERM INC COM 922107107 32,302 1,404,470 SH   SOLE   1,404,470 0 0
VBI VACCINES INC COM 91822J103 24,607 25,951,556 SH   SOLE   25,951,556 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 39,628 3,410,412 SH   SOLE   3,410,412 0 0
VERU INC COM 92536C103 3,078 1,445,000 SH   SOLE   1,445,000 0 0
VIEWRAY INC COM 92672L107 48,061 5,455,243 SH   SOLE   5,455,243 0 0
VOCERA COMMUNICATIONS INC COM 92857F107 6,205 194,400 SH   SOLE   194,400 0 0
VOYAGER THERAPEUTICS INC COM 92915B106 996 36,573 SH   SOLE   36,573 0 0
ZIOPHARM ONCOLOGY INC COM 98973P101 528 90,498 SH   SOLE   90,498 0 0
ZOGENIX INC COM 98978L204 167,575 3,507,223 SH   SOLE   3,507,223 0 0
ZYMEWORKS INC COM 98985W102 52,115 2,368,890 SH   SOLE   2,368,890 0 0