The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ABBOTT LABS COM 002824100 68,810 822,400 SH   DFND 1 194,000 0 628,400
ACADIA PHARMACEUTICALS INC COM 004225108 3,460 96,143 SH   SOLE   0 0 96,143
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 2,039 1,350,655 SH   SOLE   1,350,655 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 21,871 4,012,969 SH   DFND 1 341,300 0 3,671,669
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 22,036 2,865,524 SH   SOLE   2,865,524 0 0
AERPIO PHARMACEUTICALS INC COM 00810B105 3,531 5,193,946 SH   SOLE   5,193,946 0 0
ALCON INC ORD SHS H01301128 20,493 351,380 SH   DFND 1 125,800 0 225,580
ALDER BIOPHARMACEUTICALS INC COM 014339105 6,601 350,000 SH Put DFND 1 66,500 0 283,500
ALECTOR INC COM 014442107 180,716 12,532,329 SH   DFND 1 12,240,829 0 291,500
ALEXION PHARMACEUTICALS INC COM 015351109 162,902 1,663,285 SH   DFND 1 270,000 0 1,393,285
ALPINE IMMUNE SCIENCES INC COM 02083G100 14,537 3,670,955 SH   SOLE   3,670,955 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 3,352 221,100 SH   SOLE   0 0 221,100
AMGEN INC COM 031162100 23,628 122,100 SH   SOLE   0 0 122,100
ANTHEM INC COM 036752103 61,129 254,600 SH   DFND 1 39,000 0 215,600
APELLIS PHARMACEUTICALS INC COM 03753U106 15,029 623,859 SH   SOLE   0 0 623,859
ARENA PHARMACEUTICALS INC COM NEW 040047607 5,035 110,000 SH   SOLE   0 0 110,000
ARGENX SE SPONSORED ADR 04016X101 35,373 310,400 SH   SOLE   0 0 310,400
ARQULE INC COM 04269E107 26,538 3,701,273 SH   DFND 1 261,200 0 3,440,073
ARVINAS INC COM 04335A105 45,153 2,095,283 SH   DFND 1 1,517,183 0 578,100
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 358,231 3,719,173 SH   DFND 1 3,397,673 0 321,500
ATHENEX INC COM 04685N103 40,253 3,308,920 SH   SOLE   0 0 3,308,920
AUDENTES THERAPEUTICS INC COM 05070R104 44,609 1,588,069 SH   SOLE   1,588,069 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 18,856 3,531,002 SH   SOLE   0 0 3,531,002
AVEDRO INC COM 05355N109 96,251 4,240,128 SH   SOLE   4,240,128 0 0
AVROBIO INC COM 05455M100 8,058 570,700 SH   SOLE   0 0 570,700
BAUSCH HEALTH COS INC COM 071734107 72,374 3,312,300 SH   DFND 1 675,000 0 2,637,300
BELLUS HEALTH INC NEW COM NEW 07987C204 45,129 7,025,832 SH   DFND 1 4,943,416 0 2,082,416
BIOGEN INC COM 09062X103 8,428 36,200 SH   SOLE   0 0 36,200
BIOLINERX LTD SPONSORED ADS 09071M205 183 69,240 SH   SOLE   69,240 0 0
BOSTON SCIENTIFIC CORP COM 101137107 214,383 5,268,700 SH   DFND 1 1,017,800 0 4,250,900
CEL SCI CORP COM PAR NEW 150837607 1,118 125,000 SH Put DFND 1 24,000 0 101,000
CIGNA CORP NEW COM 125523100 44,262 291,600 SH   DFND 1 73,000 0 218,600
CONSTELLATION PHARMCETICLS I COM 210373106 5,400 835,842 SH   SOLE   835,842 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 20,370 6,767,584 SH   SOLE   6,767,584 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 30,671 2,039,282 SH   SOLE   2,039,282 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 21,167 516,400 SH   DFND 1 27,400 0 489,000
CTI BIOPHARMA CORP COM 12648L601 4,185 5,000,000 SH   SOLE   5,000,000 0 0
CURIS INC COM NEW 231269200 2,781 1,241,494 SH   SOLE   0 0 1,241,494
DECIPHERA PHARMACEUTICALS IN COM 24344T101 83,512 2,460,571 SH   DFND 1 384,800 0 2,075,771
DEXCOM INC COM 252131107 57,308 384,000 SH   DFND 1 61,000 0 323,000
EDWARDS LIFESCIENCES CORP COM 28176E108 111,670 507,800 SH   DFND 1 77,000 0 430,800
EHEALTH INC COM 28238P109 6,679 100,000 SH Call DFND 1 19,000 0 81,000
EHEALTH INC COM 28238P109 74,632 1,117,414 SH   DFND 1 124,800 0 992,614
ESSA PHARMA INC COM NEW 29668H708 4,960 1,471,853 SH   SOLE   1,471,853 0 0
EXELIXIS INC COM 30161Q104 69,200 3,912,900 SH   DFND 1 555,200 0 3,357,700
FOAMIX PHARMACEUTICALS LTD SHS M46135105 14,558 4,788,896 SH   SOLE   0 0 4,788,896
GILEAD SCIENCES INC COM 375558103 20,668 326,100 SH   SOLE   0 0 326,100
HARPOON THERAPEUTICS INC COM 41358P106 33,418 2,446,409 SH   DFND 1 1,360,704 0 1,085,705
HEALTH CATALYST INC COM 42225T107 5,682 179,598 SH   SOLE   179,598 0 0
HUMANA INC COM 444859102 46,481 181,800 SH   DFND 1 32,000 0 149,800
INSMED INC COM PAR $.01 457669307 9,919 562,300 SH   SOLE   0 0 562,300
INSPIRE MED SYS INC COM 457730109 89,760 1,471,000 SH   SOLE   1,471,000 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 4,373 327,600 SH   SOLE   327,600 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 2,137 32,200 SH   SOLE   0 0 32,200
INTUITIVE SURGICAL INC COM NEW 46120E602 111,010 205,600 SH   DFND 1 32,000 0 173,600
IOVANCE BIOTHERAPEUTICS INC COM 462260100 100,980 5,548,326 SH   DFND 1 1,337,800 0 4,210,526
IQVIA HLDGS INC COM 46266C105 26,142 175,000 SH   SOLE   0 0 175,000
ISHARES TR NASDAQ BIOTECH 464287556 19,900 200,000 SH Put DFND 1 38,000 0 162,000
KALA PHARMACEUTICALS INC COM 483119103 13,119 3,447,840 SH   SOLE   3,447,840 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 449 38,733 SH   SOLE   0 0 38,733
KARYOPHARM THERAPEUTICS INC COM 48576U106 10,254 1,065,900 SH   SOLE   0 0 1,065,900
KRYSTAL BIOTECH INC COM 501147102 20,903 601,950 SH   SOLE   0 0 601,950
LOGICBIO THERAPEUTICS INC COM 54142F102 69,906 6,466,783 SH   SOLE   6,466,783 0 0
MEDIGUS LTD SPONSORED ADS 58471G300 26 15,000 SH   SOLE   15,000 0 0
MEIRAGTX HOLDINGS PLC COM G59665102 53,418 3,349,060 SH   SOLE   0 0 3,349,060
MENLO THERAPEUTICS INC COM 586858102 2,968 662,600 SH   SOLE   0 0 662,600
MERCK & CO INC COM 58933Y105 164,496 1,954,100 SH   DFND 1 290,000 0 1,664,100
MERSANA THERAPEUTICS INC COM 59045L106 2,988 1,891,119 SH   SOLE   0 0 1,891,119
MIRATI THERAPEUTICS INC COM 60468T105 41,693 535,143 SH   DFND 1 65,400 0 469,743
MYOKARDIA INC COM 62857M105 40,835 783,032 SH   DFND 1 140,400 0 642,632
NABRIVA THERAPEUTICS PLC SHS G63637105 9,289 4,644,600 SH   SOLE   4,644,600 0 0
NATERA INC COM 632307104 98,404 3,000,128 SH   DFND 1 978,786 0 2,021,342
NEUROCRINE BIOSCIENCES INC COM 64125C109 141,939 1,575,170 SH   DFND 1 235,170 0 1,340,000
NEXTCURE INC COM 65343E108 83,635 2,711,013 SH   SOLE   2,711,013 0 0
NOVO-NORDISK A S ADR 670100205 17,061 330,000 SH   SOLE   0 0 330,000
NOVUS THERAPEUTICS INC COM 67011N105 1,974 3,183,314 SH   SOLE   3,183,314 0 0
OBSEVA SA COM H5861P103 21,704 2,605,531 SH   SOLE   2,605,531 0 0
PERSONALIS INC COM 71535D106 7,100 483,842 SH   SOLE   0 0 483,842
PREVAIL THERAPEUTICS INC COM 74140Y101 169,740 13,822,463 SH   SOLE   13,822,463 0 0
PRINCIPIA BIOPHARMA INC COM 74257L108 45,345 1,605,713 SH   SOLE   1,605,713 0 0
PROTHENA CORP PLC SHS G72800108 23,693 3,022,117 SH   DFND 1 613,800 0 2,408,317
PTC THERAPEUTICS INC COM 69366J200 66,250 1,958,900 SH   DFND 1 302,600 0 1,656,300
PUMA BIOTECHNOLOGY INC COM 74587V107 6,853 636,600 SH   SOLE   0 0 636,600
PUMA BIOTECHNOLOGY INC COM 74587V107 1,615 150,000 SH Call DFND 1 28,500 0 121,500
RA PHARMACEUTICALS INC COM 74933V108 8,914 376,894 SH   SOLE   0 0 376,894
REATA PHARMACEUTICALS INC CL A 75615P103 12,044 150,000 SH Put DFND 1 28,500 0 121,500
REGENERON PHARMACEUTICALS COM 75886F107 63,275 228,100 SH   DFND 1 54,000 0 174,100
RESTORBIO INC COM 76133L103 42,701 4,830,387 SH   SOLE   4,830,387 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 785 100,000 SH Put DFND 1 39,000 0 61,000
SAREPTA THERAPEUTICS INC COM 803607100 63,069 837,349 SH   DFND 1 134,800 0 702,549
SAREPTA THERAPEUTICS INC COM 803607100 3,766 50,000 SH Call DFND 1 9,500 0 40,500
SCPHARMACEUTICALS INC COM 810648105 20,016 3,409,865 SH   SOLE   3,409,865 0 0
SELECTA BIOSCIENCES INC COM 816212104 5,038 2,879,064 SH   SOLE   2,879,064 0 0
SI BONE INC COM 825704109 7,457 422,000 SH   SOLE   422,000 0 0
SINOVAC BIOTECH LTD SHS P8696W104 16,611 2,839,500 SH   SOLE   0 0 2,839,500
SPARK THERAPEUTICS INC COM 84652J103 23,750 244,900 SH   DFND 1 38,500 0 206,400
SPERO THERAPEUTICS INC COM 84833T103 1,492 140,709 SH   SOLE   0 0 140,709
SPRINGWORKS THERAPEUTICS INC COM 85205L107 160,569 7,406,307 SH   SOLE   7,406,307 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 1,584 212,000 SH   SOLE   212,000 0 0
SYNLOGIC INC COM 87166L100 4,649 2,029,996 SH   SOLE   2,029,996 0 0
SYNTHORX INC COM 87167A103 86,497 5,316,355 SH   SOLE   5,316,355 0 0
TAKEDA PHARMACEUTICAL CO LTD SPONSORED ADS 874060205 12,900 750,000 SH   DFND 1 172,000 0 578,000
TANDEM DIABETES CARE INC COM NEW 875372203 39,186 664,390 SH   DFND 1 134,200 0 530,190
THERMO FISHER SCIENTIFIC INC COM 883556102 102,498 351,900 SH   DFND 1 68,000 0 283,900
TRICIDA INC COM 89610F101 343,098 11,114,280 SH   SOLE   11,114,280 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 103,224 2,745,327 SH   DFND 1 2,027,550 0 717,777
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 35,692 834,313 SH   DFND 1 136,100 0 698,213
UNIQURE NV SHS N90064101 33,047 839,600 SH   DFND 1 137,300 0 702,300
VERONA PHARMA PLC SPONSORED ADS 925050106 5,714 1,250,396 SH   SOLE   1,250,396 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 21,841 1,479,733 SH   SOLE   1,479,733 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 143,397 846,400 SH   DFND 1 113,100 0 733,300
WRIGHT MED GROUP N V ORD SHS N96617118 79,162 3,837,250 SH   DFND 1 745,000 0 3,092,250
X4 PHARMACEUTICALS INC COM 98420X103 11,903 936,493 SH   SOLE   936,493 0 0
XENON PHARMACEUTICALS INC COM 98420N105 5,720 634,812 SH   SOLE   634,812 0 0
XTANT MED HLDGS INC COM NEW 98420P308 26,148 9,207,012 SH   SOLE   9,207,012 0 0
ZAI LAB LTD ADR 98887Q104 16,628 514,000 SH   SOLE   514,000 0 0