The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
Abeona Therapeutics Inc. COM 00289Y107 7,483 2,288,235 SH   SOLE   2,288,235 0 0
ACADIA Pharmaceuticals Inc. COM 004225108 1,747,759 40,854,586 SH   SOLE   40,854,586 0 0
Adamas Pharmaceuticals, Inc. COM 00548A106 654 172,630 SH   SOLE   172,630 0 0
Adaptive Biotechnologies Corporation COM 00650F109 33,373 1,115,411 SH   SOLE   1,115,411 0 0
Aeglea BioTherapeutics, Inc. COM 00773J103 13,092 1,713,604 SH   SOLE   1,713,604 0 0
Affimed N.V. COM N01045108 548 200,000 SH   SOLE   200,000 0 0
Aimmune Therapeutics, Inc. COM 00900T107 22,556 673,908 SH   SOLE   673,908 0 0
Albireo Pharma, Inc. COM 01345P106 6,355 250,000 SH   SOLE   250,000 0 0
Alexion Pharmaceuticals, Inc. COM 015351109 893,110 8,258,068 SH   SOLE   8,258,068 0 0
Alkermes plc SHS G01767105 16,180 793,130 SH   SOLE   793,130 0 0
Allakos Inc. COM 01671P100 32,393 339,690 SH   SOLE   339,690 0 0
Amarin Corporation plc SPONSORED ADR 023111206 739,609 34,496,685 SH   SOLE   34,496,685 0 0
AnaptysBio, Inc. COM 032724106 1,838 113,086 SH   SOLE   113,086 0 0
Apellis Pharmaceuticals, Inc. COM 03753U106 15,217 496,969 SH   SOLE   496,969 0 0
Aravive, Inc. COM 03890D108 5,924 433,333 SH   SOLE   433,333 0 0
Arcus Biosciences, Inc. COM 03969F109 1,227 121,534 SH   SOLE   121,534 0 0
argenx SE SPONSORED ADR 04016X101 163,659 1,019,557 SH   SOLE   1,019,557 0 0
Ascendis Pharma A/S SPONSORED ADR 04351P101 471,654 3,390,270 SH   SOLE   3,390,270 0 0
Assembly Biosciences, Inc. COM 045396108 31,542 1,541,618 SH   SOLE   1,541,618 0 0
Atreca, Inc. CL A Common 04965G109 54,652 3,532,760 SH   SOLE   3,532,760 0 0
Audentes Therapeutics, Inc. COM 05070R104 48,154 804,720 SH   SOLE   804,720 0 0
Aurinia Pharmaceuticals Inc. COM 05156V102 34,481 1,701,929 SH   SOLE   1,701,929 0 0
Autolus Therapeutics plc SPONSORED ADS 05280R100 2,069 156,773 SH   SOLE   156,773 0 0
Axsome Therapeutics, Inc. COM 05464T104 85,764 829,757 SH   SOLE   829,757 0 0
BeiGene, Ltd. SPONSORED ADR 07725L102 1,952,203 11,777,285 SH   SOLE   11,777,285 0 0
Bellicum Pharmaceuticals, Inc. COM 079481107 3,454 2,677,818 SH   SOLE   2,677,818 0 0
BioCryst Pharmaceuticals, Inc. COM 09058V103 37,764 10,946,166 SH   SOLE   10,946,166 0 0
BioMarin Pharmaceutical Inc. COM 09061G101 641,675 7,589,294 SH   SOLE   7,589,294 0 0
bluebird bio, Inc. COM 09609G100 3,510 40,000 SH   SOLE   40,000 0 0
Cabaletta Bio, Inc. COM 12674W109 8,890 636,363 SH   SOLE   636,363 0 0
Catalyst Pharmaceuticals, Inc. COM 14888U101 5,032 1,341,902 SH   SOLE   1,341,902 0 0
Cerus Corporation COM 157085101 45,365 10,749,937 SH   SOLE   10,749,937 0 0
ChemoCentryx, Inc. COM 16383L106 29,228 739,016 SH   SOLE   739,016 0 0
Constellation Pharmaceuticals, Inc. COM 210373106 6,281 133,333 SH   SOLE   133,333 0 0
Crinetics Pharmaceuticals, Inc. COM 22663K107 4,391 175,000 SH   SOLE   175,000 0 0
CytomX Therapeutics, Inc. COM 23284F105 1,615 194,377 SH   SOLE   194,377 0 0
DBV Technologies S.A. SPONSORED ADR 23306J101 156,373 14,614,264 SH   SOLE   14,614,264 0 0
Dynavax Technologies Corporation COM 268158201 429 75,000 SH   SOLE   75,000 0 0
Evofem Biosciences, Inc. COM 30048L104 4,670 756,813 SH   SOLE   756,813 0 0
Exact Sciences Corporation COM 30063P105 239,134 2,585,791 SH   SOLE   2,585,791 0 0
Frequency Therapeutics, Inc. COM 35803L108 21,587 1,231,433 SH   SOLE   1,231,433 0 0
Fulgent Genetics, Inc. COM 359664109 7,346 569,444 SH   SOLE   569,444 0 0
G1 Therapeutics, Inc. COM 3621LQ109 3,363 127,236 SH   SOLE   127,236 0 0
Galapagos NV SPONSORED ADR 36315X101 2,704 13,072 SH   SOLE   13,072 0 0
Galmed Pharmaceuticals Ltd. SHS M47238106 1,246 215,594 SH   SOLE   215,594 0 0
GW Pharmaceuticals plc ADS 36197T103 38,776 370,845 SH   SOLE   370,845 0 0
Harpoon Therapeutics, Inc. COM 41358P106 3,169 214,285 SH   SOLE   214,285 0 0
Heron Therapeutics, Inc. COM 427746102 141,425 6,018,104 SH   SOLE   6,018,104 0 0
HOOKIPA Pharma Inc. COM 43906K100 10,920 892,857 SH   SOLE   892,857 0 0
IDEAYA Biosciences, Inc. COM 45166A102 1,500 200,000 SH   SOLE   200,000 0 0
Idera Pharmaceuticals, Inc. COM PAR 45168K405 8,388 4,608,786 SH   SOLE   4,608,786 0 0
IGM Biosciences, Inc. COM 449585108 119,975 3,144,000 SH   SOLE   3,144,000 0 0
Incyte Corporation COM 45337C102 2,792,221 31,976,873 SH   SOLE   31,976,873 0 0
Infinity Pharmaceuticals, Inc. COM 45665G303 557 580,400 SH   SOLE   580,400 0 0
Inflarx N.V. COM N44821101 7,043 1,778,415 SH   SOLE   1,778,415 0 0
Insmed Incorporated COM PAR $.01 457669307 58,393 2,445,265 SH   SOLE   2,445,265 0 0
Intellia Therapeutics, Inc. COM 45826J105 1,886 128,538 SH   SOLE   128,538 0 0
Invitae Corporation COM 46185L103 146,737 9,097,165 SH   SOLE   9,097,165 0 0
IVERIC bio, Inc. COM 46583P102 1,216 141,750 SH   SOLE   141,750 0 0
Kiniksa Pharmaceuticals, Ltd. COM CL A G5269C101 30,963 2,799,577 SH   SOLE   2,799,577 0 0
Kodiak Sciences Inc. COM 50015M109 794,852 11,047,289 SH   SOLE   11,047,289 0 0
Krystal Biotech, Inc. COM 501147102 57,300 1,034,674 SH   SOLE   1,034,674 0 0
Leap Therapeutics, Inc. COM 52187K101 1,096 978,454 SH   SOLE   978,454 0 0
Madrigal Pharmaceuticals, Inc. COM 558868105 106,533 1,169,278 SH   SOLE   1,169,278 0 0
Marker Therapeutics, Inc. COM 57055L107 4,320 1,500,000 SH   SOLE   1,500,000 0 0
Matinas BioPharma Holdings, Inc. COM 576810105 5,975 2,632,348 SH   SOLE   2,632,348 0 0
Menlo Therapeutics Inc. COM 586858102 3,248 700,000 SH   SOLE   700,000 0 0
Merus N.V. COM N5749R100 28,688 2,037,469 SH   SOLE   2,037,469 0 0
Millendo Therapeutics, Inc. COM 60040X103 5,617 833,333 SH   SOLE   833,333 0 0
Mirati Therapeutics, Inc. COM 60468T105 168,448 1,307,220 SH   SOLE   1,307,220 0 0
Mirum Pharmaceuticals, Inc. COM 604749101 8,173 333,333 SH   SOLE   333,333 0 0
Molecular Templates, Inc. COM 608550109 4,429 316,730 SH   SOLE   316,730 0 0
MyoKardia, Inc. COM 62857M105 129,315 1,774,234 SH   SOLE   1,774,234 0 0
Neoleukin Therapeutics, Inc. COM 64049K104 41,860 3,397,740 SH   SOLE   3,397,740 0 0
Neurocrine Biosciences, Inc. COM 64125C109 134,819 1,254,243 SH   SOLE   1,254,243 0 0
NextCure, Inc. COM 65343E108 8,450 150,000 SH   SOLE   150,000 0 0
NGM Biopharmaceuticals, Inc. COM 62921N105 4,623 250,000 SH   SOLE   250,000 0 0
Orchard Therapeutics plc ADS 68570P101 5,578 405,702 SH   SOLE   405,702 0 0
Principia Biopharma Inc. COM 74257L108 97,944 1,787,957 SH   SOLE   1,787,957 0 0
Protagonist Therapeutics, Inc. COM 74366E102 8,279 1,174,282 SH   SOLE   1,174,282 0 0
Ra Pharmaceuticals, Inc. COM 74933V108 98,264 2,093,839 SH   SOLE   2,093,839 0 0
Reata Pharmaceuticals, Inc. CL A 75615P103 8,378 40,983 SH   SOLE   40,983 0 0
Rhythm Pharmaceuticals, Inc. COM 76243J105 62,180 2,708,200 SH   SOLE   2,708,200 0 0
Sangamo Therapeutics, Inc. COM 800677106 8,369 999,823 SH   SOLE   999,823 0 0
Seattle Genetics, Inc. COM 812578102 5,719,544 50,057,277 SH   SOLE   50,057,277 0 0
Spring Bank Pharmaceuticals, Inc. COM 849431101 969 613,144 SH   SOLE   613,144 0 0
Sunesis Pharmaceuticals, Inc. COM 867328700 188 556,665 SH   SOLE   556,665 0 0
Syros Pharmaceuticals, Inc. COM 87184Q107 4,769 690,167 SH   SOLE   690,167 0 0
Tricida, Inc. COM 89610F101 74,344 1,969,905 SH   SOLE   1,969,905 0 0
Trillium Therapeutics Inc. COM 89620X506 1,133 1,100,000 SH   SOLE   1,100,000 0 0
uniQure N.V. SHS N90064101 37,098 517,700 SH   SOLE   517,700 0 0
UroGen Pharma Ltd. COM M96088105 27,747 831,488 SH   SOLE   831,488 0 0
Urovant Sciences Ltd. SHS G9381B108 15,510 1,000,000 SH   SOLE   1,000,000 0 0
Viking Therapeutics, Inc. COM 92686J106 3,409 425,000 SH   SOLE   425,000 0 0
Xencor, Inc. COM 98401F105 14,723 428,120 SH   SOLE   428,120 0 0
Y-mAbs Therapeutics, Inc. COM 984241109 4,329 138,514 SH   SOLE   138,514 0 0
Zymeworks Inc. COM 98985W102 77,667 1,708,472 SH   SOLE   1,708,472 0 0
BioMarin Pharmaceutical Inc. NOTE 0.599% 8/1/2024 09061GAH4 15,841 15,000,000 PRN   SOLE   15,000,000 0 0
Neurocrine Biosciences, Inc. NOTE 2.25% 5/15/2024 64125CAD1 47,123 30,770,000 PRN   SOLE   30,770,000 0 0