The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 105,277 4,004,442 SH   SOLE   4,004,442 0 0
ABBOTT LABS COM 002824100 62,114 715,100 SH   DFND 1 194,000 0 521,100
ACADIA PHARMACEUTICALS INC COM 004225108 4,113 96,143 SH   SOLE   0 0 96,143
ACCELERON PHARMA INC COM 00434H108 5,700 107,500 SH   SOLE   0 0 107,500
ADAPTIMMUNE THERAPEUTICS PLC SPONDS ADR 00653A107 1,621 1,350,655 SH   SOLE   1,350,655 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 50,022 4,342,190 SH   DFND 1 398,100 0 3,944,090
AEGLEA BIOTHERAPEUTICS INC COM 00773J103 21,893 2,865,524 SH   SOLE   2,865,524 0 0
AERPIO PHARMACEUTICALS INC COM 00810B105 3,238 5,193,946 SH   SOLE   5,193,946 0 0
ALCON INC ORD SHS H01301128 19,925 351,380 SH   DFND 1 125,800 0 225,580
ALECTOR INC COM 014442107 189,322 10,987,944 SH   DFND 1 10,930,344 0 57,600
ALEXION PHARMACEUTICALS INC COM 015351109 179,809 1,662,585 SH   DFND 1 285,200 0 1,377,385
ALPINE IMMUNE SCIENCES INC COM 02083G100 14,096 3,670,955 SH   SOLE   3,670,955 0 0
AMARIN CORP PLC SPONS ADR NEW 023111206 5,351 249,600 SH   SOLE   0 0 249,600
AMGEN INC COM 031162100 29,435 122,100 SH   SOLE   0 0 122,100
ANAPTYSBIO INC COM 032724106 6,107 375,800 SH   DFND 1 35,200 0 340,600
ANTHEM INC COM 036752103 32,196 106,600 SH   DFND 1 19,000 0 87,600
APPLIED THERAPEUTICS INC COM 03828A101 26,930 987,186 SH   DFND 1 137,932 0 849,254
APTINYX INC COM 03836N103 489 143,000 SH   SOLE   143,000 0 0
APTOSE BIOSCIENCES INC COM NEW 03835T200 6,521 1,150,000 SH   DFND 1 283,000 0 867,000
ARENA PHARMACEUTICALS INC COM NEW 040047607 4,996 110,000 SH   SOLE   0 0 110,000
ARGENX SE SPONSORED ADR 04016X101 41,141 256,300 SH   SOLE   0 0 256,300
ARQULE INC COM 04269E107 99,800 5,000,000 SH   DFND 1 584,600 0 4,415,400
ARVINAS INC COM 04335A105 78,022 1,898,800 SH   DFND 1 910,000 0 988,800
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 465,092 3,343,100 SH   DFND 1 3,056,000 0 287,100
ASTRAZENECA PLC SPONSORED ADR 046353108 3,470 69,600 SH   SOLE   69,600 0 0
ATHENEX INC COM 04685N103 42,332 2,772,221 SH   SOLE   0 0 2,772,221
ATRICURE INC COM 04963C209 5,482 168,621 SH   DFND 1 27,000 0 141,621
AURINIA PHARMACEUTICALS INC COM 05156V102 47,519 2,345,447 SH   SOLE   0 0 2,345,447
AVANTOR INC COM 05352A100 18,382 1,012,800 SH   DFND 1 133,700 0 879,100
AVROBIO INC COM 05455M100 12,777 634,700 SH   DFND 1 64,000 0 570,700
BAUSCH HEALTH COS INC COM 071734107 95,238 3,183,100 SH   DFND 1 675,000 0 2,508,100
BELLUS HEALTH INC NEW COM NEW 07987C204 53,137 7,025,832 SH   DFND 1 4,943,416 0 2,082,416
BIOGEN INC COM 09062X103 19,139 64,500 SH   SOLE   0 0 64,500
BIOLINERX LTD SPONSORED ADS 09071M205 156 69,240 SH   SOLE   69,240 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 2,934 34,700 SH   SOLE   0 0 34,700
BIOMX INC COM 09090D103 22,406 2,313,489 SH   SOLE   2,313,489 0 0
BOSTON SCIENTIFIC CORP COM 101137107 211,394 4,674,800 SH   DFND 1 888,500 0 3,786,300
BRISTOL MYERS SQUIBB CO COM 110122108 109,123 1,700,000 SH   DFND 1 290,500 0 1,409,500
BRISTOL MYERS SQUIBB CO RIGHT 99/99/9999 110122157 1,054 350,000 SH   DFND 1 120,140 0 229,860
CIGNA CORP NEW COM 125523100 100,139 489,700 SH   DFND 1 95,000 0 394,700
CORVUS PHARMACEUTICALS INC COM 221015100 36,816 6,767,584 SH   SOLE   6,767,584 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 51,166 2,039,282 SH   SOLE   2,039,282 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 46,676 766,378 SH   DFND 1 60,000 0 706,378
CTI BIOPHARMA CORP COM 12648L601 7,900 5,000,000 SH   SOLE   5,000,000 0 0
CURIS INC COM NEW 231269200 2,309 1,358,363 SH   DFND 1 116,869 0 1,241,494
DANAHER CORPORATION COM 235851102 98,058 638,900 SH   DFND 1 101,200 0 537,700
DECIPHERA PHARMACEUTICALS IN COM 24344T101 94,242 1,514,171 SH   DFND 1 257,800 0 1,256,371
DERMIRA INC COM 24983L104 3,790 250,000 SH Call DFND 1 84,000 0 166,000
DEXCOM INC COM 252131107 51,382 234,900 SH   DFND 1 48,500 0 186,400
EDWARDS LIFESCIENCES CORP COM 28176E108 101,458 434,900 SH   DFND 1 68,300 0 366,600
EHEALTH INC COM 28238P109 106,833 1,111,914 SH   DFND 1 134,200 0 977,714
ESSA PHARMA INC COM NEW 29668H708 8,095 1,471,853 SH   SOLE   1,471,853 0 0
EXELIXIS INC COM 30161Q104 66,140 3,753,700 SH   DFND 1 555,200 0 3,198,500
FLEXION THERAPEUTICS INC COM 33938J106 2,753 133,000 SH   SOLE   0 0 133,000
FOAMIX PHARMACEUTICALS LTD SHS M46135105 8,585 2,577,982 SH   SOLE   0 0 2,577,982
GILEAD SCIENCES INC COM 375558103 21,190 326,100 SH   SOLE   0 0 326,100
GLAUKOS CORP COM 377322102 84,300 1,547,646 SH   SOLE   1,547,646 0 0
HARPOON THERAPEUTICS INC COM 41358P106 36,182 2,446,409 SH   DFND 1 1,360,704 0 1,085,705
HCA HEALTHCARE INC COM 40412C101 28,084 190,000 SH   DFND 1 40,000 0 150,000
HEALTH CATALYST INC COM 42225T107 6,232 179,598 SH   SOLE   179,598 0 0
HORIZON THERAPEUTICS PUB LTD SHS G46188101 57,279 1,582,300 SH   DFND 1 229,600 0 1,352,700
HUMANA INC COM 444859102 143,639 391,900 SH   DFND 1 63,900 0 328,000
IMMUNOGEN INC COM 45253H101 1,464 286,800 SH   SOLE   286,800 0 0
INCYTE CORP COM 45337C102 5,196 59,500 SH   SOLE   0 0 59,500
INSMED INC COM PAR $.01 457669307 1,409 59,000 SH   SOLE   0 0 59,000
INSPIRE MED SYS INC COM 457730109 99,961 1,347,000 SH   SOLE   1,347,000 0 0
INTELLIA THERAPEUTICS INC COM 45826J105 3,845 262,100 SH   SOLE   262,100 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 2,825 22,800 SH   SOLE   0 0 22,800
INTUITIVE SURGICAL INC COM NEW 46120E602 99,195 167,800 SH   DFND 1 26,400 0 141,400
IONIS PHARMACEUTICALS INC COM 462222100 6,458 106,900 SH   SOLE   0 0 106,900
IOVANCE BIOTHERAPEUTICS INC COM 462260100 153,578 5,548,326 SH   DFND 1 1,337,800 0 4,210,526
IQVIA HLDGS INC COM 46266C105 27,039 175,000 SH   SOLE   0 0 175,000
IVERIC BIO INC COM 46583P102 8,580 1,000,000 SH   DFND 1 250,000 0 750,000
KALA PHARMACEUTICALS INC COM 483119103 12,723 3,447,840 SH   SOLE   3,447,840 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 2,859 160,541 SH   DFND 1 6,900 0 153,641
KARYOPHARM THERAPEUTICS INC COM 48576U106 11,922 621,900 SH   SOLE   0 0 621,900
KRYSTAL BIOTECH INC COM 501147102 55,092 994,808 SH   DFND 1 61,300 0 933,508
LOGICBIO THERAPEUTICS INC COM 54142F102 46,561 6,466,783 SH   SOLE   6,466,783 0 0
MEDIGUS LTD SPONSORED ADS 58471G300 26 15,000 SH   SOLE   15,000 0 0
MEIRAGTX HOLDINGS PLC COM G59665102 69,129 3,453,020 SH   DFND 1 4,200 0 3,448,820
MERCK & CO INC COM 58933Y105 177,725 1,954,100 SH   DFND 1 290,000 0 1,664,100
MERSANA THERAPEUTICS INC COM 59045L106 11,880 2,073,319 SH   DFND 1 182,200 0 1,891,119
MILESTONE PHARMACEUTICALS IN COM 59935V107 5,831 364,206 SH   DFND 1 19,700 0 344,506
MIRATI THERAPEUTICS INC COM 60468T105 172,750 1,340,600 SH   DFND 1 170,400 0 1,170,200
MIRUM PHARMACEUTICALS INC COM 604749101 1,748 71,300 SH   SOLE   71,300 0 0
MUSTANG BIO INC COM 62818Q104 1,027 251,685 SH   SOLE   251,685 0 0
MYOKARDIA INC COM 62857M105 2,033 27,900 SH   SOLE   0 0 27,900
NABRIVA THERAPEUTICS PLC SHS G63637105 6,131 4,644,600 SH   SOLE   4,644,600 0 0
NATERA INC COM 632307104 82,224 2,440,613 SH   DFND 1 866,844 0 1,573,769
NEOLEUKIN THERAPEUTICS INC COM 64049K104 11,088 900,000 SH   DFND 1 137,200 0 762,800
NEUROCRINE BIOSCIENCES INC COM 64125C109 100,607 935,970 SH   DFND 1 101,170 0 834,800
NEXTCURE INC COM 65343E108 152,711 2,711,013 SH   SOLE   2,711,013 0 0
NOVO-NORDISK A S ADR 670100205 19,100 330,000 SH   SOLE   0 0 330,000
NOVUS THERAPEUTICS INC COM 67011N105 1,846 3,183,314 SH   SOLE   3,183,314 0 0
OBSEVA SA COM H5861P103 9,953 2,605,531 SH   SOLE   2,605,531 0 0
OTONOMY INC COM 68906L105 1,343 350,700 SH   SOLE   350,700 0 0
PERSONALIS INC COM 71535D106 5,274 483,842 SH   SOLE   0 0 483,842
PFENEX INC COM 717071104 6,751 614,868 SH   DFND 1 43,168 0 571,700
PREVAIL THERAPEUTICS INC COM 74140Y101 218,810 13,822,463 SH   SOLE   13,822,463 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 1,348 191,209 SH   DFND 1 32,600 0 158,609
PROTHENA CORP PLC SHS G72800108 45,942 2,902,239 SH   DFND 1 613,800 0 2,288,439
PTC THERAPEUTICS INC COM 69366J200 83,053 1,729,200 SH   DFND 1 253,400 0 1,475,800
REGENERON PHARMACEUTICALS COM 75886F107 78,588 209,300 SH   DFND 1 54,000 0 155,300
REGENXBIO INC COM 75901B107 1,098 26,800 SH   SOLE   0 0 26,800
RESTORBIO INC COM 76133L103 7,197 4,830,387 SH   SOLE   4,830,387 0 0
RUBIUS THERAPEUTICS INC COM 78116T103 950 100,000 SH Put DFND 1 39,000 0 61,000
SANOFI SPONSORED ADR 80105N105 3,434 68,400 SH   SOLE   68,400 0 0
SAREPTA THERAPEUTICS INC COM 803607100 98,851 766,049 SH   DFND 1 134,800 0 631,249
SCPHARMACEUTICALS INC COM 810648105 19,300 3,409,865 SH   SOLE   3,409,865 0 0
SELECT SECTOR SPDR TR SBI HEALTHCARE 81369Y209 11,531 113,200 SH   SOLE   113,200 0 0
SELECTA BIOSCIENCES INC COM 816212104 6,852 2,879,064 SH   SOLE   2,879,064 0 0
SINOVAC BIOTECH LTD SHS P8696W104 17,151 2,839,500 SH   SOLE   0 0 2,839,500
SPDR SERIES TRUST S&P BIOTECH 78464A870 12,098 127,200 SH   SOLE   127,200 0 0
SPDR SERIES TRUST S&P BIOTECH 78464A870 10,462 110,000 SH Call SOLE   110,000 0 0
SPERO THERAPEUTICS INC COM 84833T103 1,266 131,653 SH   SOLE   0 0 131,653
SPRINGWORKS THERAPEUTICS INC COM 85205L107 285,069 7,406,307 SH   SOLE   7,406,307 0 0
SUTRO BIOPHARMA INC COM 869367102 1,153 104,800 SH   SOLE   104,800 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 1,861 212,000 SH   SOLE   212,000 0 0
SYNLOGIC INC COM 87166L100 5,237 2,029,996 SH   SOLE   2,029,996 0 0
SYNTHORX INC COM 87167A103 371,560 5,316,355 SH   SOLE   5,316,355 0 0
TANDEM DIABETES CARE INC COM NEW 875372203 68,038 1,141,390 SH   DFND 1 174,200 0 967,190
TELA BIO INC COM 872381108 39,207 3,027,542 SH   SOLE   3,027,542 0 0
THERMO FISHER SCIENTIFIC INC COM 883556102 71,634 220,500 SH   DFND 1 33,600 0 186,900
TRICIDA INC COM 89610F101 362,843 9,614,280 SH   SOLE   9,614,280 0 0
TURNING POINT THERAPEUTICS I COM 90041T108 171,006 2,745,327 SH   DFND 1 2,027,550 0 717,777
UNIQURE NV SHS N90064101 77,519 1,081,765 SH   DFND 1 171,300 0 910,465
VERONA PHARMA PLC SPONSORED ADS 925050106 7,190 1,250,396 SH   SOLE   1,250,396 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 23,513 1,479,733 SH   SOLE   1,479,733 0 0
VERTEX PHARMACEUTICALS INC COM 92532F100 171,460 783,100 SH   DFND 1 113,100 0 670,000
X4 PHARMACEUTICALS INC COM 98420X103 11,625 1,086,493 SH   SOLE   1,086,493 0 0
XENON PHARMACEUTICALS INC COM 98420N105 8,322 634,812 SH   SOLE   634,812 0 0
XTANT MED HLDGS INC COM NEW 98420P308 14,731 9,207,012 SH   SOLE   9,207,012 0 0
ZAFGEN INC COM 98885E103 911 821,000 SH   SOLE   821,000 0 0
ZAI LAB LTD ADR 98887Q104 21,377 514,000 SH   SOLE   514,000 0 0
ZIMMER BIOMET HLDGS INC COM 98956P102 26,748 178,700 SH   DFND 1 38,200 0 140,500
ZOGENIX INC COM NEW 98978L204 6,516 125,000 SH Call DFND 1 42,000 0 83,000