The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
10X GENOMICS INC CLASS A COM 88025U109 13,816 220,000 SH   SOLE   220,000 0 0
1LIFE HEALTHCARE INC COM 68269G107 3,310 185,000 SH   SOLE   185,000 0 0
ABEONA THERAPEUTICS INC COM 00289Y107 3,060 1,500,000 SH   SOLE   1,500,000 0 0
ACCELERON PHARMA INC COM 00434H108 583 6,813 SH   SOLE   6,813 0 0
ADAPTIVE BIOTECHNOLOGIES CORP COM 00650F109 13,424 495,000 SH   SOLE   495,000 0 0
ADMA BIOLOGICS INC COM 000899104 47,764 16,584,802 SH   SOLE   16,584,802 0 0
AGILE THERAPEUTICS INC COM 00847L100 29,611 15,919,325 SH   SOLE   15,919,325 0 0
AGIOS PHARMACEUTICALS INC COM 00847X104 31,860 900,000 SH   SOLE   900,000 0 0
ALBIREO PHARMA INC COM 01345P106 31,931 1,960,139 SH   SOLE   1,960,139 0 0
ALDEYRA THERAPEUTICS INC COM 01438T106 7,621 3,085,458 SH   SOLE   3,085,458 0 0
ALECTOR INC COM 014442107 12,348 511,731 SH   SOLE   511,731 0 0
ALLOGENE THERAPEUTICS INC COM 019770106 30,011 1,543,790 SH   SOLE   1,543,790 0 0
ALPHATEC HOLDINGS INC COM 02081G201 2,021 561,574 SH   SOLE   561,574 0 0
AMICUS THERAPEUTICS INC COM 03152W109 232,685 25,182,364 SH   SOLE   25,182,364 0 0
ANAPTYSBIO INC COM 032724106 7,070 500,000 SH   SOLE   500,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 327 11,418 SH   SOLE   11,418 0 0
AQUESTIVE THERAPEUTICS INC COM 3843E1047 3,833 1,750,000 SH   SOLE   1,750,000 0 0
ARENA PHARMACEUTICALS INC COM 040047607 28,356 675,129 SH   SOLE   675,129 0 0
ARTARA THERAPEUTICS INC COM 04300J107 184 8,543 SH   SOLE   8,543 0 0
ATHENEX INC COM 04685N103 89,261 11,532,467 SH   SOLE   11,532,467 0 0
ATRICURE INC COM 04963C209 10,152 302,227 SH   SOLE   302,227 0 0
AVADEL PHARMACEUTICALS PLC ADR 05337M104 76 8,681 SH   SOLE   8,681 0 0
AXONICS MODULATION TECHNOLOGIES INC COM 05465P101 1,188 50,000 SH   SOLE   50,000 0 0
BIO-RAD LABORATORIES INC COM 090572207 1,218 3,489 SH   SOLE   3,489 0 0
BLACK DIAMOND THERAPEUTICS INC COM 09203E105 27,561 1,104,656 SH   SOLE   1,104,656 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 40,271 688,624 SH   SOLE   688,624 0 0
BRIDGEBIO PHARMA INC COM 10806X102 194,481 6,706,268 SH   SOLE   6,706,268 0 0
CERNER CORP COM 156782104 6,745 105,000 SH   SOLE   105,000 0 0
CHEMOCENTRYX INC COM 16383L106 406 10,252 SH   SOLE   10,252 0 0
COLLEGIUM PHARMACEUTICAL INC COM 19459J104 25,339 1,551,722 SH   SOLE   1,551,722 0 0
CONCERT PHARMACEUTICALS INC COM 206022105 19,549 2,150,641 SH   SOLE   2,150,641 0 0
CRINETICS PHARMACEUTICALS INC COM 22663K107 38,042 2,587,953 SH   SOLE   2,587,953 0 0
CUE BIOPHARMA INC COM 22978P106 362 26,371 SH   SOLE   26,371 0 0
CYTOMX THERAPEUTICS INC COM 23284F105 24,958 3,253,923 SH   SOLE   3,253,923 0 0
DBV TECHNOLOGIES SA SPONSORED ADR 23306J101 28,685 7,317,809 SH   SOLE   7,317,809 0 0
DENALI THERAPEUTICS INC COM 24823R105 14,884 850,000 SH   SOLE   850,000 0 0
DERMTECH INC COM 24984K105 3,215 285,856 SH   SOLE   285,856 0 0
EIDOS THERAPEUTICS INC COM 28249H104 33,652 686,922 SH   SOLE   686,922 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 951 139,890 SH   SOLE   139,890 0 0
ESTABLISHMENT LABS HOLDINGS INC COM G31249108 13,332 922,633 SH   SOLE   922,633 0 0
FERRARI N.V. COM N3167Y103 957 6,200 SH   SOLE   6,200 0 0
FREQUENCY THERAPEUTICS INC COM 35803L108 54,040 3,034,296 SH   SOLE   3,034,296 0 0
FULCRUM THERAPEUTICS INC COM 359616109 7,164 600,000 SH   SOLE   600,000 0 0
GALERA THERAPEUTICS INC COM 36338D108 3,088 325,000 SH   SOLE   325,000 0 0
GILEAD SCIENCES INC COM 375558103 11,214 1,500,000 SH   SOLE   1,500,000 0 0
GLOBAL BLOOD THERAPEUTICS INC COM 37890U108 309,897 6,065,726 SH   SOLE   6,065,726 0 0
HEALTH CATALYST INC COM 42225T107 8,375 328,698 SH   SOLE   328,698 0 0
IDEAYA BIOSCIENCES INC COM 45166A102 4,702 1,141,484 SH   SOLE   1,141,484 0 0
IMMUNOVANT INC UNIT 12/18/2024 45258J201 7,356 400,000 SH   SOLE   400,000 0 0
INSULET CORP COM 45784P101 13,708 82,733 SH   SOLE   82,733 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 349,343 11,670,057 SH   SOLE   11,670,057 0 0
IVERIC BIO INC COM 46583P102 4,738 1,377,289 SH   SOLE   1,377,289 0 0
KADMON HOLDINGS INC COM 48283N106 65,830 15,711,334 SH   SOLE   15,711,334 0 0
KARUNA THERAPEUTICS INC COM 48576A100 497 6,944 SH   SOLE   6,944 0 0
KODIAK SCIENCES INC COM 50015M109 174,752 3,663,557 SH   SOLE   3,663,557 0 0
LEAP THERAPEUTICS INC COM 52187K101 10,627 6,726,496 SH   SOLE   6,726,496 0 0
LIFESCI ACQUISITION CORP UNIT 3/31/2025 53228P208 2,940 300,000 SH   SOLE   300,000 0 0
LUMINEX CORP COM 5027E1029 500 18,926 SH   SOLE   18,926 0 0
MEI PHARMA INC COM NEW 55279B202 4,879 3,030,440 SH   SOLE   3,030,440 0 0
MEIRAGTX HOLDINGS PLC COM G59665102 86,463 6,433,277 SH   SOLE   6,433,277 0 0
MENLO THERAPEUTICS INC COM 586858102 17,456 6,637,179 SH   SOLE   6,637,179 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 187 179,419 SH   SOLE   179,419 0 0
MIRATI THERAPEUTICS INC COM 60468T105 149 100,000 SH Put SOLE   100,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 255,167 3,319,450 SH   SOLE   3,319,450 0 0
MOLECULAR TEMPLATES INC COM 608550109 32,882 2,474,133 SH   SOLE   2,474,133 0 0
MOMENTA PHARMACEUTICALS INC COM 60877T100 881 30,637 SH   SOLE   30,637 0 0
MORPHIC HOLDING INC COM 61775R105 9,542 650,000 SH   SOLE   650,000 0 0
MOTUS GI HLDGS INC COM 62014P108 2,837 4,210,542 SH   SOLE   4,210,542 0 0
MYLAN N.V. SHS EURO N59465109 6,028 400,000 SH   SOLE   400,000 0 0
MYOKARDIA INC COM 62857M105 61,611 1,314,209 SH   SOLE   1,314,209 0 0
NEOLEUKIN THERAPEUTICS INC COM 64049K104 5,535 500,000 SH   SOLE   500,000 0 0
NEPTUNE WELLNESS SOLUTIONS INC COM 64079L105 15,721 13,436,906 SH   SOLE   13,436,906 0 0
NEUROCRINE BIOSCIENCES INC COM 64125C109 265,126 3,063,263 SH   SOLE   3,063,263 0 0
NEVRO CORP COM 64157F103 107,449 1,092,068 SH   SOLE   1,092,068 0 0
OUTLOOK THERAPEUTICS INC W EXP 02/18/202 69012T115 46 420,875 SH   SOLE   420,875 0 0
PHREESIA INC COM 71944F106 1,424 70,000 SH   SOLE   70,000 0 0
PROVENTION BIO INC COM 74374N102 27,707 3,011,574 SH   SOLE   3,011,574 0 0
QUOTIENT LTD COM G73268107 52,491 13,289,054 SH   SOLE   13,289,054 0 0
REGENERON PHARMACEUTICALS INC COM 75886F107 39,063 80,000 SH   SOLE   80,000 0 0
REGENXBIO INC COM 75901B107 17,145 508,000 SH   SOLE   508,000 0 0
REPRO MED SYS INC COM 759910102 537 74,813 SH   SOLE   74,813 0 0
RESTORBIO INC COM 76133L103 10 9,306 SH   SOLE   9,306 0 0
RETROPHIN INC NOTE 2.500% 9/1 761299AB2 35,016 45,000,000 PRN   SOLE   45,000,000 0 0
RETROPHIN INC COM 761299106 42,173 2,890,608 SH   SOLE   2,890,608 0 0
REVANCE THERAPEUTICS INC COM 761330109 13,690 925,000 SH   SOLE   925,000 0 0
REVOLUTION MEDICINES INC COM 76155X100 7,816 350,000 SH   SOLE   350,000 0 0
RHYTHM PHARMACEUTICALS INC COM 76243J105 2,600 170,859 SH   SOLE   170,859 0 0
ROCKET PHARMACEUTICALS INC COM 77313F106 30,537 2,189,010 SH   SOLE   2,189,010 0 0
SC HEALTH CORP UNIT 99/99/9999 G78516302 10,000 1,000,000 SH   SOLE   1,000,000 0 0
SCHRODINGER INC COM 80810D103 10,545 250,000 SH   SOLE   250,000 0 0
SIERRA ONCOLOGY INC COM 82640U404 664 66,654 SH   SOLE   66,654 0 0
SILK ROAD MEDICAL INC COM 82710M100 6,639 204,600 SH   SOLE   204,600 0 0
SOLID BIOSCIENCES INC COM 3422E1055 16,132 6,749,803 SH   SOLE   6,749,803 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 159 325,000 SH Call SOLE   325,000 0 0
SPRINGWORKS THERAPEUTICS INC COM 85205L107 94,078 3,484,358 SH   SOLE   3,484,358 0 0
STOKE THERAPEUTICS INC COM 86150R107 15,388 671,978 SH   SOLE   671,978 0 0
THERAPEUTICSMD INC COM 88338N107 1,173 1,096,101 SH   SOLE   1,096,101 0 0
THERAVANCE BIOPHARMA INC COM G8807B106 23,110 1,000,000 SH   SOLE   1,000,000 0 0
TRANSLATE BIO INC COM 89374L104 4,994 435,000 SH   SOLE   435,000 0 0
TURNING POINT THERAPEUTICS INC COM 90041T108 15,441 349,890 SH   SOLE   349,890 0 0
TWIST BIOSCIENCE CORP COM 90184D100 10,380 322,356 SH   SOLE   322,356 0 0
UROVANT SCIENCES LTD COM G9381B108 21,823 2,366,831 SH   SOLE   2,366,831 0 0
VAPOTHERM INC COM 922107107 31,447 1,670,067 SH   SOLE   1,670,067 0 0
VBI VACCINES INC COM 91822J103 43,653 45,951,556 SH   SOLE   45,951,556 0 0
VERRICA PHARMACEUTICALS INC COM 92511W108 37,275 3,410,412 SH   SOLE   3,410,412 0 0
VERU INC REGISTERED SHS COM 92536C103 5,396 1,650,000 SH   SOLE   1,650,000 0 0
VIEWRAY INC COM 92672L107 5,713 2,451,748 SH   SOLE   2,451,748 0 0
VOCERA COMMUNICATIONS INC COM 92857F107 10,298 470,000 SH   SOLE   470,000 0 0
Y-MABS THERAPEUTICS INC COM 984241109 12,085 522,480 SH   SOLE   522,480 0 0
ZIMMER BIOMET HOLDINGS INC COM 98956P102 4,914 50,000 SH   SOLE   50,000 0 0
ZOGENIX INC COM 98978L204 85,390 3,452,921 SH   SOLE   3,452,921 0 0
ZOGENIX INC COM 98978L204 724 300,000 SH Put SOLE   300,000 0 0
ZYMEWORKS INC COM 98985W102 126,092 3,560,999 SH   SOLE   3,560,999 0 0