The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACADIA PHARMACEUTICALS INC COM 004225108 2,230 46,008 SH   SOLE   46,008 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 9,694 200,000 SH Put SOLE   200,000 0 0
ACCELERON PHARMA INC COM 00434H108 17,882 187,700 SH Call SOLE   187,700 0 0
ACCELERON PHARMA INC COM 00434H108 3,287 34,500 SH Put SOLE   34,500 0 0
ACHIEVE LIFE SCIENCE INC COM NEW 004468203 1,452 3,658,537 SH   SOLE   3,658,537 0 0
ADMA BIOLOGICS INC COM 000899104 1,109 378,574 SH   SOLE   378,574 0 0
ADURO BIOTECH INC COM 00739L101 7,785 3,369,976 SH   SOLE   3,369,976 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 7,490 358,700 SH Call SOLE   358,700 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 1,979 94,800 SH Put SOLE   94,800 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 477 22,840 SH   SOLE   22,840 0 0
AETERNA ZENTARIS INC COM 007975402 94 117,443 SH   SOLE   117,443 0 0
ALBIREO PHARMA INC COM 01345P106 2,662 100,500 SH Call SOLE   100,500 0 0
ALLAKOS INC COM 01671P100 3,057 42,536 SH   SOLE   42,536 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 46 4,739 SH   SOLE   4,739 0 0
ALTIMMUNE INC COM NEW 02155H200 1,767 165,000 SH   SOLE   165,000 0 0
AMERICAN CAMPUS CMNTYS INC COM 024835100 19,228 550,000 SH Put SOLE   550,000 0 0
ANAPTYSBIO INC COM 032724106 102 4,581 SH   SOLE   4,581 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 69 2,126 SH   SOLE   2,126 0 0
APPLIED GENETIC TECHNOLOGIES COM 03820J100 3,024 545,884 SH   SOLE   545,884 0 0
APTINYX INC COM 03836N103 2,464 591,000 SH   SOLE   591,000 0 0
ARDELYX INC COM 039697107 9,637 1,392,565 SH   SOLE   1,392,565 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 315 5,000 SH   SOLE   5,000 0 0
ARGENX SE SPONSORED ADR 04016X101 394 1,750 SH   SOLE   1,750 0 0
ARGENX SE SPONSORED ADR 04016X101 28,334 125,800 SH Put SOLE   125,800 0 0
ARVINAS INC COM 04335A105 5,165 154,000 SH Put SOLE   154,000 0 0
ARVINAS INC COM 04335A105 3,559 106,100 SH Call SOLE   106,100 0 0
ASCENDIS PHARMA A S SPONSORED ADR 04351P101 21,446 145,000 SH Call SOLE   145,000 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 3,672 157,468 SH   SOLE   157,468 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 5,326 327,771 SH   SOLE   327,771 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 3,936 487,143 SH   SOLE   487,143 0 0
AXOVANT GENE THERAPIES COM G0750W203 533 188,884 SH   SOLE   188,884 0 0
AXSOME THERAPEUTICS INC COM 05464T104 1,506 18,300 SH Call SOLE   18,300 0 0
BAUDAX BIO INC COM 07160F107 415 100,000 SH   SOLE   100,000 0 0
BIOGEN INC COM 09062X103 213 795 SH   SOLE   795 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 3,656 50,000 SH Call SOLE   50,000 0 0
BIOMARIN PHARMACEUTICAL INC COM 09061G101 4,650 37,700 SH Call SOLE   37,700 0 0
BIOXCEL THERAPEUTICS INC COM 09075P105 14,250 268,818 SH   SOLE   268,818 0 0
BIOXCEL THERAPEUTICS INC COM 09075P105 7,888 148,800 SH Call SOLE   148,800 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 7,485 177,544 SH   SOLE   177,544 0 0
BLUEBIRD BIO INC COM 09609G100 2,136 35,000 SH Call SOLE   35,000 0 0
BLUEBIRD BIO INC COM 09609G100 6,402 104,874 SH   SOLE   104,874 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 15,730 201,662 SH   SOLE   201,662 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 10,015 128,400 SH Call SOLE   128,400 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 31,200 400,000 SH Put SOLE   400,000 0 0
BRIDGEBIO PHARMA INC COM 10806X102 1,027 31,500 SH Call SOLE   31,500 0 0
BRISTOL-MYERS SQUIBB CO RIGHT 99/99/9999 110122157 3,938 1,100,000 SH   SOLE   1,100,000 0 0
CARA THERAPEUTICS INC COM 140755109 335 19,600 SH Call SOLE   19,600 0 0
CARA THERAPEUTICS INC COM 140755109 4,677 273,524 SH   SOLE   273,524 0 0
CASI PHARMACEUTICALS INC COM 14757U109 2,600 1,039,910 SH   SOLE   1,039,910 0 0
CEL SCI CORP COM PAR NEW 150837607 9,514 637,700 SH Put SOLE   637,700 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 3,569 274,500 SH Call SOLE   274,500 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 21,417 1,647,439 SH   SOLE   1,647,439 0 0
CELLECTIS S A SPON ADS 15117K103 1,301 73,067 SH   SOLE   73,067 0 0
CERECOR INC COM 15671L109 1,047 402,865 SH   SOLE   402,865 0 0
CHARDAN HEALTHCR ACQSTN 2 CO UNIT 99/99/9999 15957T206 4,200 400,000 SH   SOLE   400,000 0 0
CHEMOCENTRYX INC COM 16383L106 28,770 500,000 SH Put SOLE   500,000 0 0
CHIASMA INC COM 16706W102 7,691 1,429,633 SH   SOLE   1,429,633 0 0
CLOVIS ONCOLOGY INC COM 189464100 3,219 476,900 SH Call SOLE   476,900 0 0
CLOVIS ONCOLOGY INC COM 189464100 101 14,918 SH   SOLE   14,918 0 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 11,327 1,350,000 SH Put SOLE   1,350,000 0 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 8,390 1,000,000 SH Call SOLE   1,000,000 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 13,162 179,100 SH Put SOLE   179,100 0 0
CYMABAY THERAPEUTICS INC COM 23257D103 5,339 1,529,830 SH   SOLE   1,529,830 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 723 164,730 SH   SOLE   164,730 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 5,972 100,000 SH Put SOLE   100,000 0 0
DELCATH SYS INC COM NEW 24661P807 964 94,000 SH   SOLE   94,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 254 10,000 SH Put SOLE   10,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 648 25,500 SH Call SOLE   25,500 0 0
EIDOS THERAPEUTICS INC COM 28249H104 4,767 100,000 SH   SOLE   100,000 0 0
FATE THERAPEUTICS INC COM 31189P102 1,719 50,100 SH Put SOLE   50,100 0 0
FATE THERAPEUTICS INC COM 31189P102 1,719 50,100 SH Call SOLE   50,100 0 0
FIBROGEN INC COM 31572Q808 8,106 200,000 SH Call SOLE   200,000 0 0
FIBROGEN INC COM 31572Q808 3,242 80,000 SH Put SOLE   80,000 0 0
GENFIT S A ADS 372279109 353 64,027 SH   SOLE   99,750 0 0
GILEAD SCIENCES INC COM 375558103 478 6,218 SH   SOLE   6,218 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 14,520 230,000 SH Call SOLE   230,000 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 6,446 102,100 SH Put SOLE   102,100 0 0
GOSSAMER BIO INC COM 38341P102 9,152 703,999 SH   SOLE   703,999 0 0
HORIZON THERAPEUTICS PUB LTD SHS USD G16411810 2,092 37,641 SH   SOLE   37,641 0 0
HORIZON THERAPEUTICS PUB LTD SHS USD G16411810 13,700 246,500 SH Call SOLE   246,500 0 0
ICAD INC COM NEW 44934S206 3,120 312,268 SH   SOLE   312,268 0 0
IMMUNOMEDICS INC COM 452907108 571 16,100 SH Call SOLE   16,100 0 0
IMMUNOVANT INC COM 45258J102 6,871 282,163 SH   SOLE   282,163 0 0
INCYTE CORP COM 45337C102 15,596 150,000 SH Call SOLE   150,000 0 0
INCYTE CORP COM 45337C102 385 3,700 SH   SOLE   3,700 0 0
INFLARX NV COM N44821101 700 152,600 SH   SOLE   152,600 0 0
INSMED INC COM PAR $.01 457669307 80 2,919 SH   SOLE   2,919 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 1,701 35,500 SH Put SOLE   35,500 0 0
INTERCEPT PHARMACEUTICALS IN COM 45845P108 7,187 150,000 SH Call SOLE   150,000 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 185 7,202 SH   SOLE   7,202 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 11,790 459,300 SH Call SOLE   459,300 0 0
INVESCO QQQ TR UNIT SER 1 46090E103 30,950 125,000 SH Call SOLE   125,000 0 0
ISHARES TR CHINA LG-CAP ETF 464287184 23,820 600,000 SH Put SOLE   600,000 0 0
ISHARES TR RUSSELL 2000 ETF 464287655 165 1,154 SH   SOLE   1,154 0 0
KADMON HLDGS INC COM 48283N106 5,023 981,070 SH   SOLE   981,070 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 13,472 1,113,395 SH   SOLE   1,113,395 0 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 720 28,274 SH   SOLE   28,274 0 0
KURA ONCOLOGY INC COM 50127T109 7,590 465,619 SH   SOLE   465,619 0 0
KURA ONCOLOGY INC COM 50127T109 2,445 150,000 SH Call SOLE   150,000 0 0
LEGEND BIOTECH CORP SPONSORED ADS 52490G102 213 5,000 SH   SOLE   5,000 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 9,592 84,700 SH Call SOLE   84,700 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 4,819 42,554 SH   SOLE   42,554 0 0
MAGENTA THERAPEUTICS INC COM 55910K108 65 8,674 SH   SOLE   8,674 0 0
MEDICAL PPTYS TRUST INC COM 58463J304 11,280 600,000 SH Put SOLE   600,000 0 0
MILLENDO THERAPEUTICS INC COM 60040X103 238 135,193 SH   SOLE   135,193 0 0
MINERVA NEUROSCIENCES INC COM 603380106 2,316 641,600 SH Call SOLE   641,600 0 0
MINERVA NEUROSCIENCES INC COM 603380106 1,250 346,300 SH Put SOLE   346,300 0 0
MIRATI THERAPEUTICS INC COM 60468T105 17,126 150,000 SH Put SOLE   150,000 0 0
MODERNA INC COM 60770K107 1,926 30,000 SH Call SOLE   30,000 0 0
MODERNA INC COM 60770K107 19,263 300,000 SH Put SOLE   300,000 0 0
MUSTANG BIO INC COM 62818Q104 1,134 356,475 SH   SOLE   356,475 0 0
MYOKARDIA INC COM 62857M105 17,450 180,600 SH Put SOLE   180,600 0 0
MYOVANT SCIENCES LTD COM G637AM102 536 25,999 SH   SOLE   25,999 0 0
NEKTAR THERAPEUTICS COM 640268108 3,474 150,000 SH Call SOLE   150,000 0 0
NOVAVAX INC COM 670002901 13,694 164,300 SH Put SOLE   164,300 0 0
OBSEVA SA COM H5861P103 486 82,573 SH   SOLE   82,573 0 0
OCULAR THERAPEUTIX INC COM 67576A100 17,126 2,055,977 SH   SOLE   2,055,977 0 0
OMEGA HEALTHCARE INVS INC COM 681936100 14,865 500,000 SH Put SOLE   500,000 0 0
OTONOMY INC COM 68906L105 1,086 300,000 SH Call SOLE   300,000 0 0
OTONOMY INC COM 68906L105 3,864 1,067,271 SH   SOLE   1,067,271 0 0
PRECISION BIOSCIENCES INC COM 74019P108 73 8,812 SH   SOLE   8,812 0 0
PROTARA THERAPEUTICS INC COM STK 74365U107 15,480 527,964 SH   SOLE   527,964 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 573 54,901 SH   SOLE   54,901 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 13,059 83,700 SH Put SOLE   83,700 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 26,071 167,100 SH Call SOLE   167,100 0 0
RESTORBIO INC COM 76133L103 3,123 1,452,551 SH   SOLE   1,452,551 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 3,075 1,680,529 SH   SOLE   1,680,529 0 0
SAGE THERAPEUTICS INC COM 78667J108 8,364 201,151 SH   SOLE   201,151 0 0
SAGE THERAPEUTICS INC COM 78667J108 9,534 229,300 SH Call SOLE   229,300 0 0
SAREPTA THERAPEUTICS INC COM 803607100 417 2,600 SH Call SOLE   2,600 0 0
SATSUMA PHARMACEUTICALS INC COM 80405P107 9,457 328,824 SH   SOLE   328,824 0 0
SCPHARMACEUTICALS INC COM 810648105 10,809 1,468,647 SH   SOLE   1,468,647 0 0
SELECT SECTOR SPDR TR ENERGY 81369Y506 9,201 243,100 SH Put SOLE   243,100 0 0
SELECT SECTOR SPDR TR SBI INT-FINL 81369Y605 13,884 600,000 SH Put SOLE   600,000 0 0
SERES THERAPEUTICS INC COM 81750R102 1,677 352,300 SH Put SOLE   352,300 0 0
SERES THERAPEUTICS INC COM 81750R102 1,190 250,000 SH Call SOLE   250,000 0 0
SIERRA ONCOLOGY INC COM NEW 82640U404 118 9,658 SH   SOLE   9,658 0 0
SOLENO THERAPEUTICS INC COM NEW 834203200 748 336,801 SH   SOLE   336,801 0 0
SOLENO THERAPEUTICS INC COM NEW 834203200 2,331 1,050,000 SH Call SOLE   1,050,000 0 0
SOLENO THERAPEUTICS INC COM NEW 834203200 2,617 1,178,800 SH Put SOLE   1,178,800 0 0
SOLID BIOSCIENCES INC COM 83422E105 2,309 788,008 SH   SOLE   788,008 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 215,852 700,000 SH Put SOLE   700,000 0 0
SPDR SER TR S&P BIOTECH 78464A870 27,988 250,000 SH Put SOLE   250,000 0 0
STEALTH BIOTHERAPEUTICS CORP SPONSORED ADS 85789A105 69 37,597 SH   SOLE   37,597 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 12,365 3,271,238 SH   SOLE   3,271,238 0 0
SUNESIS PHARMACEUTICALS INC COM 867328700 29 111,445 SH   SOLE   111,445 0 0
SYNDAX PHARMACEUTICALS INC COM 87164F105 237 16,000 SH   SOLE   16,000 0 0
TRICIDA INC COM 89610F101 4,864 177,002 SH   SOLE   177,002 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 181 2,313 SH   SOLE   2,313 0 0
ULTRAGENYX PHARMACEUTICAL IN COM 90400D108 5,749 73,500 SH Call SOLE   73,500 0 0
VANGUARD INDEX FDS REAL ESTATE ETF 922908553 19,633 250,000 SH Put SOLE   250,000 0 0
VAXCYTE INC COM 92243G108 4,419 139,813 SH   SOLE   139,813 0 0
VERASTEM INC COM 92337C104 3,291 1,913,327 SH   SOLE   1,913,327 0 0
VIKING THERAPEUTICS INC COM 92686J106 8 1,159 SH   SOLE   1,159 0 0
X4 PHARMACEUTICALS INC COM 98420X103 47 5,000 SH   SOLE   5,000 0 0
XENON PHARMACEUTICALS INC COM 98420N105 3,739 298,173 SH   SOLE   298,173 0 0
ZOGENIX INC COM NEW 98978L204 13,709 507,559 SH   SOLE   507,559 0 0
ZOGENIX INC COM NEW 98978L204 3,314 122,700 SH Call SOLE   122,700 0 0
ZOGENIX INC COM NEW 98978L204 11,865 439,300 SH Put SOLE   439,300 0 0
ZYMEWORKS INC COM 98985W102 7,676 212,800 SH Put SOLE   212,800 0 0
ZYMEWORKS INC COM 98985W102 25,249 700,000 SH Call SOLE   700,000 0 0
ZYNERBA PHARMACEUTICALS INC COM 98986X109 2,182 647,400 SH   SOLE   647,400 0 0
ZYNERBA PHARMACEUTICALS INC COM 98986X109 2,334 692,500 SH Put SOLE   692,500 0 0
ZYNERBA PHARMACEUTICALS INC COM 98986X109 3,240 961,400 SH Call SOLE   961,400 0 0