The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
ACUTUS MED INC COM 005111109 7,599 255,000 SH   SOLE   255,000 0 0
AERIE PHARMACEUTICALS INC COM 00771V108 9,506 807,656 SH   SOLE   807,656 0 0
AKEBIA THERAPEUTICS INC COM 00972D105 4,989 1,987,506 SH   SOLE   1,987,506 0 0
AKOUOS INC COM 00973J101 10,488 458,606 SH   SOLE   458,606 0 0
AMICUS THERAPEUTICS INC COM 03152W109 32,759 2,320,026 SH   SOLE   2,320,026 0 0
APPLE INC COM 037833100 145,006 1,252,104 SH   SOLE   1,252,104 0 0
BIOHAVEN PHARMACTL HLDG CO L COM G11196105 5,500 84,600 SH   SOLE   84,600 0 0
BLUEPRINT MEDICINES CORP COM 09627Y109 21,783 234,979 SH   SOLE   234,979 0 0
BROOKFIELD ASSET MGMT INC CL A LTD VT SH 112585104 101,526 3,070,957 SH   SOLE   3,070,957 0 0
CABLE ONE INC COM 12685J105 108,018 57,291 SH   SOLE   57,291 0 0
CATALENT INC COM 148806102 139,283 1,626,000 SH   SOLE   1,626,000 0 0
CHECKMATE PHARMACEUTICALS IN COM 162818108 24,978 2,170,100 SH   SOLE   2,170,100 0 0
CONSTELLATION PHARMCETICLS I COM 210373106 11,713 578,134 SH   SOLE   578,134 0 0
CORVUS PHARMACEUTICALS INC COM 221015100 5,572 1,389,498 SH   SOLE   1,389,498 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 4,252 271,378 SH   SOLE   271,378 0 0
CUREVAC N V COM N2451R105 9,386 201,642 SH   SOLE   201,642 0 0
ENTASIS THERAPEUTICS HLDGS I COM 293614103 2,354 1,153,911 SH   SOLE   1,153,911 0 0
FLEXION THERAPEUTICS INC COM 33938J106 14,609 1,403,370 SH   SOLE   1,403,370 0 0
FREELINE THERAPEUTICS HLDGS SPONSORED ADS 35655L107 10,381 665,000 SH   SOLE   665,000 0 0
GALERA THERAPEUTICS INC COM 36338D108 30,818 3,409,021 SH   SOLE   3,409,021 0 0
HARMONY BIOSCIENCES HLDGS IN COM 413197104 127,294 3,754,973 SH   SOLE   3,754,973 0 0
INARI MED INC COM 45332Y109 5,211 75,500 SH   SOLE   75,500 0 0
INOGEN INC COM 45780L104 102,930 3,549,320 SH   SOLE   3,549,320 0 0
INSPIRE MED SYS INC COM 457730109 7,697 59,645 SH   SOLE   59,645 0 0
INSMED INC COM PAR $.01 457669307 13,824 430,107 SH   SOLE   430,107 0 0
INTERSECT ENT INC COM 46071F103 8,375 513,515 SH   SOLE   513,515 0 0
INOZYME PHARMA INC COM 45790W108 67,549 2,569,379 SH   SOLE   2,569,379 0 0
IOVANCE BIOTHERAPEUTICS INC COM 462260100 12,672 384,938 SH   SOLE   384,938 0 0
MEDTRONIC PLC SHS G5960L103 102,687 988,136 SH   SOLE   988,136 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 15,230 2,080,585 SH   SOLE   2,080,585 0 0
MIRUM PHARMACEUTICALS INC COM 604749101 47,118 2,445,147 SH   SOLE   2,445,147 0 0
MORPHIC HLDG INC COM 61775R105 72,326 2,645,446 SH   SOLE   2,645,446 0 0
NKARTA INC COM 65487U108 83,984 2,793,864 SH   SOLE   2,793,864 0 0
PROTAGONIST THERAPEUTICS INC COM 74366E102 15,530 794,369 SH   SOLE   794,369 0 0
SEASPINE HLDGS CORP COM 81255T108 23,988 1,677,492 SH   SOLE   1,677,492 0 0
SI BONE INC COM 825704109 16,569 698,504 SH   SOLE   698,504 0 0
SILK RD MED INC COM 82710M100 8,430 125,428 SH   SOLE   125,428 0 0
SPERO THERAPEUTICS INC COM 84833T103 10,391 931,099 SH   SOLE   931,099 0 0
VAXCYTE INC COM 92243G108 32,159 651,255 SH   SOLE   651,255 0 0
VANGUARD INDEX FDS TOTAL STK MKT 922908769 522,920 3,070,400 SH   SOLE   3,070,400 0 0
VERONA PHARMA PLC SPONSORED ADS 925050106 11,237 1,800,747 SH   SOLE   1,800,747 0 0
ZOGENIX INC COM NEW 98978L204 5,842 325,814 SH   SOLE   325,814 0 0