The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE
OMB APPROVAL
OMB Number: 3235-0006
Estimated average burden
hours per response: 23.8
COLUMN 1 COLUMN 2 COLUMN 3 COLUMN 4 COLUMN 5 COLUMN 6 COLUMN 7 COLUMN 8
VALUE SHRS OR SH/ PUT/ INVESTMENT OTHER VOTING AUTHORITY
NAME OF ISSUER TITLE OF CLASS CUSIP (x$1000) PRN AMT PRN CALL DISCRETION MANAGER SOLE SHARED NONE
89BIO INC COM 282559103 8,730 340,236 SH   SOLE   340,236 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 2,310 56,008 SH   SOLE   56,008 0 0
ACADIA PHARMACEUTICALS INC COM 004225108 4,126 100,000 SH Put SOLE   100,000 0 0
ACHIEVE LIFE SCIENCES INC COM 004468500 2,379 284,151 SH   SOLE   284,151 0 0
ADICET BIO INC COM 007002108 3,261 274,277 SH   SOLE   274,277 0 0
ADMA BIOLOGICS INC COM 000899104 478 200,000 SH   SOLE   200,000 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 4,155 403,400 SH Call SOLE   403,400 0 0
ADVERUM BIOTECHNOLOGIES INC COM 00773U108 3,036 294,800 SH Put SOLE   294,800 0 0
AERPIO PHARMACEUTICALS INC COM 00810B105 5,914 3,942,460 SH   SOLE   3,942,460 0 0
AGENUS INC COM NEW 00847G705 3,800 950,000 SH   SOLE   950,000 0 0
AIMMUNE THERAPEUTICS INC COM 00900T107 11,248 326,500 SH Put SOLE   326,500 0 0
AIR LEASE CORP CL A 00912X302 518 17,600 SH Put SOLE   17,600 0 0
ALECTOR INC COM 014442107 3 321 SH   SOLE   321 0 0
ALNYLAM PHARMACEUTICALS INC COM 02043Q107 7,280 50,000 SH Put SOLE   50,000 0 0
ALPINE IMMUNE SCIENCES INC COM 02083G100 41 4,739 SH   SOLE   4,739 0 0
ALTIMMUNE INC COM NEW 02155H200 1,502 113,768 SH   SOLE   113,768 0 0
ANAPTYSBIO INC COM 032724106 738 50,000 SH   SOLE   50,000 0 0
APELLIS PHARMACEUTICALS INC COM 03753U106 565 18,726 SH   SOLE   18,726 0 0
APPLIED GENETIC TECHNOLOGIES COM 03820J100 2,654 545,884 SH   SOLE   545,884 0 0
APTINYX INC COM 03836N103 1,675 495,490 SH   SOLE   495,490 0 0
APTOSE BIOSCIENCES INC COM NEW 03835T200 23 3,904 SH   SOLE   3,904 0 0
ARBUTUS BIOPHARMA CORP COM 03879J100 360 115,000 SH   SOLE   115,000 0 0
ARDELYX INC COM 039697107 8,036 1,530,436 SH   SOLE   1,530,436 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 373 5,000 SH   SOLE   5,000 0 0
ARENA PHARMACEUTICALS INC COM NEW 040047607 19,446 260,000 SH Call SOLE   260,000 0 0
ARGENX SE SPONSORED ADR 04016X101 209 800 SH Put SOLE   800 0 0
ARROWHEAD PHARMACEUTICALS IN COM 04280A100 6,459 150,000 SH Call SOLE   150,000 0 0
ARVINAS INC COM 04335A105 3,771 159,700 SH Call SOLE   159,700 0 0
ARYA SCIENCES ACQUISTION CO UNIT 06/09/2027 G31655114 3,501 318,206 SH   SOLE   318,206 0 0
ASCENDIS PHARMA A/S SPONSORED ADR 04351P101 22,376 145,000 SH Call SOLE   145,000 0 0
ASSEMBLY BIOSCIENCES INC COM 045396108 2,589 157,468 SH   SOLE   157,468 0 0
ATARA BIOTHERAPEUTICS INC COM 046513107 5,531 426,800 SH   SOLE   426,800 0 0
AURINIA PHARMACEUTICALS INC COM 05156V102 1,474 100,000 SH Call SOLE   100,000 0 0
AVADEL PHARMACEUTICALS PLC SPONSORED ADR 05337M104 275 54,694 SH   SOLE   54,694 0 0
AVROBIO INC COM 05455M100 1,628 125,000 SH   SOLE   125,000 0 0
AXOVANT SCIENCES LTD COM G0750W203 820 177,684 SH   SOLE   177,684 0 0
BAUDAX BIO INC COM 07160F107 277 100,000 SH   SOLE   100,000 0 0
BCTG ACQUISITION CORP COM 05492W103 2 250 SH   SOLE   250 0 0
BELLUS HEALTH INC NEW COM NEW 07987C204 227 100,000 SH   SOLE   100,000 0 0
BIOGEN INC COM 09062X103 852 3,000 SH   SOLE   3,000 0 0
BIOGEN INC COM 09062X103 39,375 138,800 SH Put SOLE   138,800 0 0
BIOGEN INC COM 09062X103 28,368 100,000 SH Call SOLE   100,000 0 0
BIOXCEL THERAPEUTICS INC COM 09075P105 6,504 150,000 SH Call SOLE   150,000 0 0
BIOXCEL THERAPEUTICS INC COM 09075P105 117 2,714 SH   SOLE   2,714 0 0
BLACK DIAMOND THERAPEUTICS I COM 09203E105 10,851 358,941 SH   SOLE   358,941 0 0
BLUEBIRD BIO INC COM 09609G100 2,173 40,281 SH   SOLE   40,281 0 0
BRAINSTORM CELL THERAPEUTICS COM NEW 10501E201 19,797 1,170,100 SH Put SOLE   1,170,100 0 0
BRISTOL-MYERS SQUIBB CO RIGHT 99/99/9999 110122157 4,050 1,800,000 SH   SOLE   1,800,000 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 18,087 300,000 SH Call SOLE   300,000 0 0
BRISTOL-MYERS SQUIBB CO COM 110122108 6,028 100,000 SH   SOLE   100,000 0 0
CARA THERAPEUTICS INC COM 140755109 3,481 273,524 SH   SOLE   273,524 0 0
CARA THERAPEUTICS INC COM 140755109 738 58,000 SH Call SOLE   58,000 0 0
CASI PHARMACEUTICALS INC COM 14757U109 2,356 1,539,910 SH   SOLE   1,539,910 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 21,796 1,469,730 SH   SOLE   1,469,730 0 0
CELLDEX THERAPEUTICS INC NEW COM NEW 15117B202 946 63,800 SH Call SOLE   63,800 0 0
CERECOR INC COM 15671L109 460 202,865 SH   SOLE   202,865 0 0
CHARDAN HEALTHCR ACQSTN 2 CO UNIT 99/99/9999 15957T206 4,221 400,000 SH   SOLE   400,000 0 0
CHEMOCENTRYX INC COM 16383L106 5,480 100,000 SH Call SOLE   100,000 0 0
CHEMOCENTRYX INC COM 16383L106 1 37 SH   SOLE   37 0 0
CHIASMA INC COM 16706W102 7,008 1,629,633 SH   SOLE   1,629,633 0 0
CHIMERIX INC COM 16934W106 3,397 1,364,044 SH   SOLE   1,364,044 0 0
CLOVIS ONCOLOGY INC COM 189464100 4,408 756,236 SH   SOLE   756,236 0 0
CLOVIS ONCOLOGY INC COM 189464100 2,332 400,000 SH Call SOLE   400,000 0 0
COMPASS PATHWAYS PLC SPONSORED ADS 20451W101 5,342 153,048 SH   SOLE   153,048 0 0
CORBUS PHARMACEUTICALS HLDGS COM 21833P103 397 220,100 SH Call SOLE   220,100 0 0
CORTEXYME INC COM 22053A107 2,000 40,000 SH   SOLE   40,000 0 0
CORTEXYME INC COM 22053A107 150 3,000 SH Call SOLE   3,000 0 0
CORTEXYME INC COM 22053A107 150 3,000 SH Put SOLE   3,000 0 0
CRINETICS PHARMACEUTICALS IN COM 22663K107 784 50,000 SH   SOLE   50,000 0 0
CRISPR THERAPEUTICS AG NAMEN AKT H17182108 9,644 115,300 SH Put SOLE   115,300 0 0
CRYOPORT INC COM PAR $0.001 229050307 11,850 250,000 SH Put SOLE   250,000 0 0
CRYOPORT INC COM PAR $0.001 229050307 12,935 272,900 SH Call SOLE   272,900 0 0
CYTOKINETICS INC COM NEW 23282W605 1,190 55,000 SH   SOLE   55,000 0 0
CYTOKINETICS INC COM NEW 23282W605 25,364 1,171,600 SH Call SOLE   1,171,600 0 0
CYTOKINETICS INC COM NEW 23282W605 6,927 320,000 SH Put SOLE   320,000 0 0
DBV TECHNOLOGIES S A SPONSORED ADR 23306J101 596 164,730 SH   SOLE   164,730 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 7,183 140,000 SH Call SOLE   140,000 0 0
DECIPHERA PHARMACEUTICALS IN COM 24344T101 5,131 100,000 SH Put SOLE   100,000 0 0
DELCATH SYS INC COM NEW 24661P807 1,092 94,000 SH   SOLE   94,000 0 0
DIAMEDICA THERAPEUTICS INC COM NEW 25253X207 1,759 415,000 SH   SOLE   415,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 179 10,000 SH Put SOLE   10,000 0 0
DICERNA PHARMACEUTICALS INC COM 253031108 179 10,000 SH Call SOLE   10,000 0 0
EIDOS THERAPEUTICS INC COM 28249H104 3,184 63,011 SH   SOLE   63,011 0 0
EIGER BIOPHARMACEUTICALS INC COM 28249U105 2,771 340,318 SH   SOLE   340,318 0 0
EPIZYME INC COM 29428V104 347 29,080 SH   SOLE   29,080 0 0
FATE THERAPEUTICS INC COM 31189P102 2,003 50,100 SH Put SOLE   50,100 0 0
FATE THERAPEUTICS INC COM 31189P102 2,003 50,100 SH Call SOLE   50,100 0 0
FIBROGEN INC COM 31572Q808 8,222 200,000 SH Call SOLE   200,000 0 0
FIBROGEN INC COM 31572Q808 8,301 201,900 SH Put SOLE   201,900 0 0
GLOBAL BLOOD THERAPEUTICS IN COM 37890U108 117 2,100 SH Put SOLE   2,100 0 0
GOSSAMER BIO INC COM 38341P102 1,009 81,300 SH Call SOLE   81,300 0 0
GOSSAMER BIO INC COM 38341P102 7,229 582,494 SH   SOLE   582,494 0 0
HARROW HEALTH INC COM 415858109 2,563 458,607 SH   SOLE   458,607 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 205 2,641 SH   SOLE   2,641 0 0
HORIZON THERAPEUTICS PUB L SHS G46188101 30,023 386,500 SH Call SOLE   386,500 0 0
HOST HOTELS & RESORTS INC COM 44107P104 4,317 400,000 SH Put SOLE   400,000 0 0
I MAB SPONSORED ADS 44975P103 7,054 150,000 SH   SOLE   150,000 0 0
ICAD INC COM NEW 44934S206 1,596 181,337 SH   SOLE   181,337 0 0
IGM BIOSCIENCES INC COM 449585108 23,124 313,300 SH Put SOLE   313,300 0 0
IGM BIOSCIENCES INC COM 449585108 18,452 250,000 SH Call SOLE   250,000 0 0
IMMATICS N.V SHS N44445109 6,770 638,094 SH   SOLE   638,094 0 0
IMMUNOMEDICS INC COM 452907108 1,369 16,100 SH Call SOLE   16,100 0 0
IMMUNOVANT INC COM 45258J102 11,328 321,887 SH   SOLE   321,887 0 0
INCYTE CORP COM 45337C102 8,974 100,000 SH Put SOLE   100,000 0 0
INCYTE CORP COM 45337C102 13,461 150,000 SH Call SOLE   150,000 0 0
INFLARX NV COM N44821101 637 149,750 SH   SOLE   149,750 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 6,415 250,000 SH Call SOLE   250,000 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 2,567 100,000 SH Put SOLE   100,000 0 0
INTRA CELLULAR THERAPIES INC COM 46116X101 6,183 240,989 SH   SOLE   240,989 0 0
INVENTIVA SA ADS 46124U107 177 15,000 SH   SOLE   15,000 0 0
KADMON HLDGS INC COM 48283N106 3,673 936,615 SH   SOLE   936,615 0 0
KALA PHARMACEUTICALS INC COM 483119103 3,387 451,531 SH   SOLE   451,531 0 0
KALVISTA PHARMACEUTICALS INC COM 483497103 15,554 1,235,471 SH   SOLE   1,235,471 0 0
KINIKSA PHARMACEUTICALS LTD COM CL A G5269C101 5,254 342,998 SH   SOLE   342,998 0 0
KODIAK SCIENCES INC COM 50015M109 14,802 250,000 SH Put SOLE   250,000 0 0
KURA ONCOLOGY INC COM 50127T109 189 6,203 SH   SOLE   6,203 0 0
KURA ONCOLOGY INC COM 50127T109 6,721 219,400 SH Call SOLE   219,400 0 0
LIFESCI ACQUISITION CORP COM 53228P109 2,999 241,762 SH   SOLE   241,762 0 0
LYRA THERAPEUTICS INC COM 55234L105 4,338 387,939 SH   SOLE   387,939 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 13,642 114,900 SH Call SOLE   114,900 0 0
MADRIGAL PHARMACEUTICALS INC COM 558868105 2,809 23,654 SH   SOLE   23,654 0 0
MEDICAL PPTYS TRUST INC COM 58463J304 10,579 600,000 SH Put SOLE   600,000 0 0
MEREO BIOPHARMA GROUP PLC ADS 589492107 688 1,196,308 SH   SOLE   1,196,308 0 0
MESOBLAST LTD SPONS ADR 590717104 145 7,800 SH Put SOLE   7,800 0 0
MILESTONE PHARMACEUTICALS IN COM 59935V107 12,764 1,743,545 SH   SOLE   1,743,545 0 0
MILLENDO THERAPEUTICS INC COM 60040X103 220 135,193 SH   SOLE   135,193 0 0
MIRATI THERAPEUTICS INC COM 60468T105 91,161 549,000 SH Put SOLE   549,000 0 0
MIRATI THERAPEUTICS INC COM 60468T105 6,402 38,557 SH   SOLE   38,557 0 0
MODERNA INC COM 60770K107 77,394 1,093,900 SH Put SOLE   1,093,900 0 0
MUSTANG BIO INC COM 62818Q104 2,541 806,475 SH   SOLE   806,475 0 0
MYOVANT SCIENCES LTD COM G637AM102 2,810 200,000 SH Call SOLE   200,000 0 0
NEKTAR THERAPEUTICS COM 640268108 2,488 150,000 SH Call SOLE   150,000 0 0
NEXTCURE INC COM 65343E108 1,760 200,000 SH   SOLE   200,000 0 0
NOVAVAX INC COM NEW 670002401 40,675 375,400 SH Put SOLE   375,400 0 0
NOVAVAX INC COM NEW 670002401 286 2,636 SH   SOLE   2,636 0 0
OCULAR THERAPEUTIX INC COM 67576A100 13,061 1,716,293 SH   SOLE   1,716,293 0 0
OTONOMY INC COM 68906L105 1,761 434,786 SH   SOLE   434,786 0 0
OVID THERAPEUTICS INC COM 690469101 92 16,000 SH Call SOLE   16,000 0 0
PANDION THERAPEUTICS INC COM 698340106 2,978 260,000 SH   SOLE   260,000 0 0
POSEIDA THERAPEUTICS INC COM 73730P108 2,022 228,000 SH   SOLE   228,000 0 0
PRECISION BIOSCIENCES INC COM 74019P108 55 8,812 SH   SOLE   8,812 0 0
PROTARA THERAPEUTICS INC COM STK 74365U107 12,158 722,443 SH   SOLE   722,443 0 0
PROTEOSTASIS THERAPEUTICS IN COM 74373B109 2,628 2,389,891 SH   SOLE   2,389,891 0 0
PUMA BIOTECHNOLOGY INC COM 74587V107 554 54,901 SH   SOLE   54,901 0 0
RAPT THERAPEUTICS INC COM 75382E109 503 15,600 SH Put SOLE   15,600 0 0
RAPT THERAPEUTICS INC COM 75382E109 170 5,300 SH Call SOLE   5,300 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 5,592 57,400 SH Put SOLE   57,400 0 0
REATA PHARMACEUTICALS INC CL A 75615P103 11,408 117,100 SH Call SOLE   117,100 0 0
REPARE THERAPEUTICS INC COM 760273102 5,858 190,410 SH   SOLE   190,410 0 0
RIGEL PHARMACEUTICALS INC COM NEW 766559603 1,668 695,529 SH   SOLE   695,529 0 0
SAGE THERAPEUTICS INC COM 78667J108 7,099 116,151 SH   SOLE   116,151 0 0
SAGE THERAPEUTICS INC COM 78667J108 4,847 79,300 SH Call SOLE   79,300 0 0
SAREPTA THERAPEUTICS INC COM 803607100 74,441 530,100 SH Put SOLE   530,100 0 0
SAREPTA THERAPEUTICS INC COM 803607100 14,407 102,600 SH Call SOLE   102,600 0 0
SCPHARMACEUTICALS INC COM 810648105 11,033 1,481,147 SH   SOLE   1,481,147 0 0
SERES THERAPEUTICS INC COM 81750R102 21,585 762,400 SH Call SOLE   762,400 0 0
SERES THERAPEUTICS INC COM 81750R102 2,701 95,430 SH   SOLE   95,430 0 0
SIERRA ONCOLOGY INC COM NEW 82640U404 3,350 313,890 SH   SOLE   313,890 0 0
SOLID BIOSCIENCES INC COM 83422E105 1,600 788,008 SH   SOLE   788,008 0 0
SPDR S&P 500 ETF TR TR UNIT 78462F103 66,977 200,000 SH Put SOLE   200,000 0 0
SPDR SER TR S&P BIOTECH 78464A870 94,716 850,000 SH Put SOLE   850,000 0 0
STEALTH BIOTHERAPEUTICS CORP SPONSORED ADS 85789A105 50 37,597 SH   SOLE   37,597 0 0
STRONGBRIDGE BIOPHARMA PLC SHS USD G85347105 7,061 3,362,242 SH   SOLE   3,362,242 0 0
SUTRO BIOPHARMA INC COM 869367102 4,904 488,000 SH   SOLE   488,000 0 0
TRACON PHARMACEUTICALS INC COM NEW 89237H209 11,180 2,162,549 SH   SOLE   2,162,549 0 0
TRICIDA INC COM 89610F101 210 23,193 SH   SOLE   23,193 0 0
VAXCYTE INC COM 92243G108 796 16,110 SH   SOLE   16,110 0 0
VERASTEM INC COM 92337C104 1,710 1,413,327 SH   SOLE   1,413,327 0 0
X4 PHARMACEUTICALS INC COM 98420X103 4,907 724,680 SH   SOLE   724,680 0 0
XENON PHARMACEUTICALS INC COM 98420N105 2,470 223,173 SH   SOLE   223,173 0 0
ZOGENIX INC COM NEW 98978L204 16,137 900,000 SH Call SOLE   900,000 0 0
ZOGENIX INC COM NEW 98978L204 3,274 182,591 SH   SOLE   182,591 0 0
ZYMEWORKS INC COM 98985W102 23,290 500,000 SH Call SOLE   500,000 0 0
ZYMEWORKS INC COM 98985W102 11,414 245,000 SH Put SOLE   245,000 0 0